E John Wherry
@ejohnwherry.bsky.social
Immunologist. T cell exhaustion, immunotherapy, Immune Health.
Reposted by E John Wherry
A very special thanks to Dr. Vera Moiseenkova-Bell and Dr. John Wherry @ejohnwherry.bsky.social for their extraordinary support in making this happen.
September 28, 2025 at 9:32 PM
A very special thanks to Dr. Vera Moiseenkova-Bell and Dr. John Wherry @ejohnwherry.bsky.social for their extraordinary support in making this happen.
What a huge loss. I am so sorry to hear this news. David was a tremendous positive presence across all biomedical science. A once in a generation kind of scientist. www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 8, 2025 at 3:08 AM
What a huge loss. I am so sorry to hear this news. David was a tremendous positive presence across all biomedical science. A once in a generation kind of scientist. www.nytimes.com/2025/09/07/s...
Yesterday we opened a new home for Immunology at Penn. Part of our large vibrant immunology community will move into this amazing space. This includes our #ColtonCenter for Autoimmunity, #ImmuneHealth and more.
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youtu.be/Ryv2AxPtb_E?...
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September 6, 2025 at 2:16 PM
Yesterday we opened a new home for Immunology at Penn. Part of our large vibrant immunology community will move into this amazing space. This includes our #ColtonCenter for Autoimmunity, #ImmuneHealth and more.
youtu.be/Ryv2AxPtb_E?...
youtu.be/Ryv2AxPtb_E?...
Great article in the @inquirer.com om about the importance of NIH funding. www.inquirer.com/health/medic...
CHOP, Wistar and other Philly-area research institutions urge legislators to reject NIH cuts
The Pennsylvania Ad Hoc NIH Funding Advocacy Coalition brings together institutions from across the state’s eds and meds sector.
www.inquirer.com
August 20, 2025 at 12:29 PM
Great article in the @inquirer.com om about the importance of NIH funding. www.inquirer.com/health/medic...
What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...
Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential
Persistent antigen stimulation promotes differentiation of exhausted CD8+ T (TEX) cells. TEX cells are distinct from circulating memory T (TCIRCM) cells but share many features with tissue-resident me...
www.biorxiv.org
August 14, 2025 at 5:30 PM
What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...
A great Keystone meeting on Long COVID this week in Santa Fe. The field has made great progress recently, but there is much more to do. Exciting science presented about viral and immune mechanisms, clinical data and future clinical trials. www.keystonesymposia.org/conferences/...
Long COVID and Other Post-Acute Infection Syndromes | Keystone Symposia
Join us at the Keystone Symposia on Long COVID and Other Post-Acute Infection Syndromes, August 2025, in Santa Fe, with field leaders!
www.keystonesymposia.org
August 14, 2025 at 5:30 PM
A great Keystone meeting on Long COVID this week in Santa Fe. The field has made great progress recently, but there is much more to do. Exciting science presented about viral and immune mechanisms, clinical data and future clinical trials. www.keystonesymposia.org/conferences/...
Reposted by E John Wherry
Ozzy Osbourne was an agent of darkness and a beloved family man alike. “This cognitive dissonance is precisely why he was regarded as a titan,” Spencer Kornhaber writes: https://theatln.tc/7b1rHz12
July 24, 2025 at 11:15 AM
Ozzy Osbourne was an agent of darkness and a beloved family man alike. “This cognitive dissonance is precisely why he was regarded as a titan,” Spencer Kornhaber writes: https://theatln.tc/7b1rHz12
Highly recommend this book
www.goodreads.com/book/show/21...
www.goodreads.com/book/show/21...
More Everything Forever: AI Overlords, Space Empires, a…
How Silicon Valley’s heartless, baseless, and foolish o…
www.goodreads.com
July 24, 2025 at 9:45 AM
Highly recommend this book
www.goodreads.com/book/show/21...
www.goodreads.com/book/show/21...
Reposted by E John Wherry
Reposted by E John Wherry
I’ve been in academic medicine for 45 years. This is the first time I’m seeing a perfect storm, as proposed federal funding cuts threaten our ability to provide patient care, train the next generation of doctors, and conduct life-saving research. More from my conversation with @cnn.com last week.
June 16, 2025 at 4:36 PM
I’ve been in academic medicine for 45 years. This is the first time I’m seeing a perfect storm, as proposed federal funding cuts threaten our ability to provide patient care, train the next generation of doctors, and conduct life-saving research. More from my conversation with @cnn.com last week.
A useful distraction this weekend....
May 27, 2025 at 12:49 PM
A useful distraction this weekend....
Reposted by E John Wherry
A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...
A Path Forward to Save American Bio-Medical Research
Over the past four months I’ve spoken to dozens of biomedical researchers...
talkingpointsmemo.com
May 16, 2025 at 5:32 PM
A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...
Reposted by E John Wherry
To be clear, these kinds of breakthroughs are going to come to a screeching halt with the current NIH funding cuts. This new treatment is only possible because of decades of basic research. What might be possible 20 years from now if we don't destroy basic research?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
World’s first personalized CRISPR therapy given to baby with genetic disease
Treatment seems to have been effective, but it is not clear whether such bespoke therapies can be widely applied.
www.nature.com
May 16, 2025 at 2:10 PM
To be clear, these kinds of breakthroughs are going to come to a screeching halt with the current NIH funding cuts. This new treatment is only possible because of decades of basic research. What might be possible 20 years from now if we don't destroy basic research?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by E John Wherry
Breaking News: Moody’s has downgraded the credit rating of the U.S., becoming the third major credit rating agency to downgrade the country since 2011.
Trump Administration Live Updates: Supreme Court Extends Freeze on Use of Alien Enemies Act for Deportations
www.nytimes.com
May 16, 2025 at 9:35 PM
Breaking News: Moody’s has downgraded the credit rating of the U.S., becoming the third major credit rating agency to downgrade the country since 2011.
Reposted by E John Wherry
Word.
“The future of biomedical research in the United States comes down to a race to see whether the biomedical research community can mobilize politically, access that vast but latent political power, before the White House can do enough sustained damage to make the whole question moot.”
“The future of biomedical research in the United States comes down to a race to see whether the biomedical research community can mobilize politically, access that vast but latent political power, before the White House can do enough sustained damage to make the whole question moot.”
May 16, 2025 at 6:03 PM
Word.
“The future of biomedical research in the United States comes down to a race to see whether the biomedical research community can mobilize politically, access that vast but latent political power, before the White House can do enough sustained damage to make the whole question moot.”
“The future of biomedical research in the United States comes down to a race to see whether the biomedical research community can mobilize politically, access that vast but latent political power, before the White House can do enough sustained damage to make the whole question moot.”
Reposted by E John Wherry
RFK Jr. said multiple times during his house and senate hearings today that no scientists have been fired from federal agencies. Our reporting has shown that hundreds, if not thousands, of scientists have been let go from NIH/CDC/FDA
May 15, 2025 at 12:11 AM
RFK Jr. said multiple times during his house and senate hearings today that no scientists have been fired from federal agencies. Our reporting has shown that hundreds, if not thousands, of scientists have been let go from NIH/CDC/FDA
So this is not a problem?...But we can't even buy an NIH researcher a cup of coffee because of conflicts of interest!? The hypocrisy is insane. Investigations into universities, but at the White House all gifts and straight up crypto-bribes are fine. WTF www.nytimes.com/2025/05/11/u...
Trump Is Poised to Accept a Luxury 747 From Qatar for Use as Air Force One
www.nytimes.com
May 12, 2025 at 4:41 PM
So this is not a problem?...But we can't even buy an NIH researcher a cup of coffee because of conflicts of interest!? The hypocrisy is insane. Investigations into universities, but at the White House all gifts and straight up crypto-bribes are fine. WTF www.nytimes.com/2025/05/11/u...
Reposted by E John Wherry
Congrats to @ejohnwherry.bsky.social, PhD—pioneer of T cell exhaustion and checkpoint biology—on his election to the National Academy of Sciences. A well-earned honor for work that continues to drive immunotherapy forward.
www.nasonline.org/news/2025-na...
#NAS2025
www.nasonline.org/news/2025-na...
#NAS2025
May 6, 2025 at 10:51 PM
Congrats to @ejohnwherry.bsky.social, PhD—pioneer of T cell exhaustion and checkpoint biology—on his election to the National Academy of Sciences. A well-earned honor for work that continues to drive immunotherapy forward.
www.nasonline.org/news/2025-na...
#NAS2025
www.nasonline.org/news/2025-na...
#NAS2025
Use this link to write to your representatives as often as possible!!
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How Uncertainty About Federal Support for Science Impacts You and Your Institution
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May 4, 2025 at 10:18 AM
Use this link to write to your representatives as often as possible!!
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Reposted by E John Wherry
Dr. Anthony Fauci urges Americans not to accept "Normalization of Untruths".
May 2, 2025 at 2:27 AM
Dr. Anthony Fauci urges Americans not to accept "Normalization of Untruths".
Reposted by E John Wherry
Congratulations to @ejohnwherry.bsky.social and Penn colleagues, Katalin Karikó, Virginia Lee (@pennpathlabmed.bsky.social) and Mark Devlin on being elected as members of the @nasonline.org—one of the highest honors a scientist can receive!
Congratulations to Katalin Karikó (@PennNSG), Virginia Lee (@pennpathlabmed.bsky.social), @ejohnwherry.bsky.social (@PennSysPharmATT) & Mark Devlin (@physatpenn) on their election to @nasonline.org! tinyurl.com/5eehdtms
May 2, 2025 at 6:08 PM
Congratulations to @ejohnwherry.bsky.social and Penn colleagues, Katalin Karikó, Virginia Lee (@pennpathlabmed.bsky.social) and Mark Devlin on being elected as members of the @nasonline.org—one of the highest honors a scientist can receive!