Dorien Pastoors
@dpastoors.bsky.social
Postdoc at DFCI, Boston, USA | molecular biology & hematology 🧫 | data visualization in #ggplot | swimming, running, baking | HemeSky feed
Pinned
MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia
Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECOM expression in an aggressive subtype of acute myeloid leukemia (AML). Direct depletion of MECOM using an endogenous auxin...
www.biorxiv.org
Excited to share our preprint on #HemeSky: "MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia"! @delwelruud.bsky.social and co-authors! www.biorxiv.org/content/10.1... [1/15]
Excited to share that I started as a Postdoctoral Fellow in @tothovalab.bsky.social at @danafarber.bsky.social in Boston! Looking forward to the next years of molecular & myeloid biology in Boston 🤩🌇
September 20, 2025 at 2:05 AM
Excited to share that I started as a Postdoctoral Fellow in @tothovalab.bsky.social at @danafarber.bsky.social in Boston! Looking forward to the next years of molecular & myeloid biology in Boston 🤩🌇
Yesterday I successfully defended my PhD thesis!!! It was a fantastic day where I got to celebrate with many colleagues, friends and family (this smile was on my face all day long)
June 27, 2025 at 5:56 PM
Yesterday I successfully defended my PhD thesis!!! It was a fantastic day where I got to celebrate with many colleagues, friends and family (this smile was on my face all day long)
Thanks for the opportunity to present our work at the last day of #EHA2025 🤩 on MECOM as a repressor of CEBPA - also see our recent preprint: www.biorxiv.org/content/10.1... and I very much hope you can stay tuned for the final version soon-ish) #erasmusmcblood #hemesky
June 15, 2025 at 8:34 PM
Thanks for the opportunity to present our work at the last day of #EHA2025 🤩 on MECOM as a repressor of CEBPA - also see our recent preprint: www.biorxiv.org/content/10.1... and I very much hope you can stay tuned for the final version soon-ish) #erasmusmcblood #hemesky
My HemeSky feed is now also picking up #EHA2025! bsky.app/profile/dpas...
June 14, 2025 at 6:56 AM
My HemeSky feed is now also picking up #EHA2025! bsky.app/profile/dpas...
🤣 🔥
Sweaty or not, here we go day 2! The program is 🤩🤩🤩 today.
#EHA2025.
#EHA2025.
a woman sitting in a chair with the words melting behind her
ALT: a woman sitting in a chair with the words melting behind her
media.tenor.com
June 13, 2025 at 2:23 PM
🤣 🔥
Check out poster 1115 on MBD4 deficiency to model clonal hematopoeisis ⬇️⬇️ #EHA2025 🩸🧪
June 13, 2025 at 2:21 PM
Check out poster 1115 on MBD4 deficiency to model clonal hematopoeisis ⬇️⬇️ #EHA2025 🩸🧪
Congratulations!! 🧪🩸
Well deserved recognition for team Clotterdam's very own @mandylauw.bsky.social #YoungEHA Congratulations Mandy!
We are HemaSphere proud at #EHA2025, where 2 of our editors received special EHA awards! Congrats to Jan Cools, Ed in Chief, for the education & mentoring award; and to Mandy Lauw, Scientific Ed, for the YoungEHA award. Well deserved 👏 @jancools.bsky.social @mandylauw.bsky.social
June 13, 2025 at 8:29 AM
Congratulations!! 🧪🩸
Really enjoying #EHA2025 so far. And also how many people list there BlueSky as social media!! Posts are collected on this HemeSky feed: 🩸🧪https://bsky.app/profile/dpastoors.bsky.social/feed/aaagr4h5mq62a
June 13, 2025 at 8:29 AM
Really enjoying #EHA2025 so far. And also how many people list there BlueSky as social media!! Posts are collected on this HemeSky feed: 🩸🧪https://bsky.app/profile/dpastoors.bsky.social/feed/aaagr4h5mq62a
Spotted fellow #erasmusmcblood PhD candidate @shordijk.bsky.social at the #EHA wall of fame for her Mobility grant 🤩🤩 Congratulations !! @clotterdam.bsky.social
June 12, 2025 at 10:49 AM
Spotted fellow #erasmusmcblood PhD candidate @shordijk.bsky.social at the #EHA wall of fame for her Mobility grant 🤩🤩 Congratulations !! @clotterdam.bsky.social
SUPER excited to share that I got my PhD thesis - thanks to a special delivery from @massaarsanne.bsky.social to Milan!! On the 26th of June, I will defend my thesis at 15:30 CET. You can follow online at eur.cloud.panopto.eu/Panopto/Page... #hemesky
June 8, 2025 at 1:08 PM
SUPER excited to share that I got my PhD thesis - thanks to a special delivery from @massaarsanne.bsky.social to Milan!! On the 26th of June, I will defend my thesis at 15:30 CET. You can follow online at eur.cloud.panopto.eu/Panopto/Page... #hemesky
This Thursday, I will be part of the @oncodeinstitute.bsky.social team to cycle up the Alpe d'Huez - a (very steep!!!!) mountain in the French Alps - to raise money for the Dutch Cancer Society @liting-chen.bsky.social
June 3, 2025 at 4:32 PM
This Thursday, I will be part of the @oncodeinstitute.bsky.social team to cycle up the Alpe d'Huez - a (very steep!!!!) mountain in the French Alps - to raise money for the Dutch Cancer Society @liting-chen.bsky.social
Reposted by Dorien Pastoors
Together with more than a hundred cancer researchers, we are up for the challenge for going up to >6000m elevation with cycling, running, and walking in one day at Alpe d'HuZes event this Thursday to support research --> to outsmart cancer!
#outsmartingcancer
@oncodeinstitute.bsky.social
#outsmartingcancer
@oncodeinstitute.bsky.social
June 3, 2025 at 12:00 PM
Together with more than a hundred cancer researchers, we are up for the challenge for going up to >6000m elevation with cycling, running, and walking in one day at Alpe d'HuZes event this Thursday to support research --> to outsmart cancer!
#outsmartingcancer
@oncodeinstitute.bsky.social
#outsmartingcancer
@oncodeinstitute.bsky.social
Wow this is so cool! Congratulations !!
our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity
many are "negative regulators" & misexpressed in cancer
www.sciencedirect.com/science/arti...
March 27, 2025 at 6:40 AM
Wow this is so cool! Congratulations !!
Really enjoyed the meeting too and was very happy to be awarded the presentation prize 🤩!! Extra festive touch added by @bloodadvances.bsky.social which published @massaarsanne.bsky.social 's article on this project DURING her talk 👏 @oncodeinstitute.bsky.social #oncode #kwf #hemesky
Enjoyed last week's KWF Dutch Cancer Biology Meeting in the forests 🌳 of Lunteren where I got the opportunity to present on DNMT3A double mutant AML.
@dpastoors.bsky.social gave nice talk on p300&CBP regulating enhancer activity in AML which was awarded with the Best Presentation Award! 🤩🥳
#Hemesky
@dpastoors.bsky.social gave nice talk on p300&CBP regulating enhancer activity in AML which was awarded with the Best Presentation Award! 🤩🥳
#Hemesky
March 21, 2025 at 10:42 AM
Really enjoyed the meeting too and was very happy to be awarded the presentation prize 🤩!! Extra festive touch added by @bloodadvances.bsky.social which published @massaarsanne.bsky.social 's article on this project DURING her talk 👏 @oncodeinstitute.bsky.social #oncode #kwf #hemesky
Wooo - check the cover image of the current issue of Blood Advances by @massaarsanne.bsky.social & Emma Boertjes et al!!! Congratulations - methylation damage repair is impaired by double mutations in DNMT3A in AML
March 21, 2025 at 7:26 AM
Wooo - check the cover image of the current issue of Blood Advances by @massaarsanne.bsky.social & Emma Boertjes et al!!! Congratulations - methylation damage repair is impaired by double mutations in DNMT3A in AML
Reposted by Dorien Pastoors
Mike spotted this before the rest of us. 🫡
Publications from 2025 are shared more on Bluesky than on X/Twitter.
Publications from 2025 are shared more on Bluesky than on X/Twitter.
About to talk to medical affairs colleagues, with the news that Bluesky is carrying more posts about new journal publications than X #bluesky #altmetrics #x #xparrot
March 13, 2025 at 3:51 PM
Mike spotted this before the rest of us. 🫡
Publications from 2025 are shared more on Bluesky than on X/Twitter.
Publications from 2025 are shared more on Bluesky than on X/Twitter.
Reposted by Dorien Pastoors
Amazing collection of reviews on developmental hematopoiesis from leaders in the field. Just out in @iseh.bsky.social journal, Experimental Hematology www.exphem.org/content/edit...
Editorial_Making_blood_Early_Hematopoietic_Development
www.exphem.org
March 12, 2025 at 8:15 PM
Amazing collection of reviews on developmental hematopoiesis from leaders in the field. Just out in @iseh.bsky.social journal, Experimental Hematology www.exphem.org/content/edit...
I seem to vaguely remember that hematopoiesis is more active during sleep. Does anyone know if this is true 😅 ? #hemesky. not necessarily hspcs, but also more mature subsets. Is most cell production in the bm at night or during the day? Is it related to sleep or day and night ?
March 5, 2025 at 4:49 PM
I seem to vaguely remember that hematopoiesis is more active during sleep. Does anyone know if this is true 😅 ? #hemesky. not necessarily hspcs, but also more mature subsets. Is most cell production in the bm at night or during the day? Is it related to sleep or day and night ?
Thanks @alessandrodonada.bsky.social for taking this time to discuss the preprints of @tjflemin.bsky.social & @bloodgenes.bsky.social @delwelruud.bsky.social
@alessandrodonada.bsky.social sat down with @dpastoors.bsky.social and @tjflemin.bsky.social for a deep dive on their latest AML biology preprints. Watch the #SimplyBlood 🩸 interview today https://www.simplyblood.org/
February 26, 2025 at 9:22 AM
Thanks @alessandrodonada.bsky.social for taking this time to discuss the preprints of @tjflemin.bsky.social & @bloodgenes.bsky.social @delwelruud.bsky.social
Reposted by Dorien Pastoors
ModelArchive : a repository and archive for computational structure models that are not based on experimental data. #alphafold
modelarchive.org
modelarchive.org
February 21, 2025 at 10:09 AM
ModelArchive : a repository and archive for computational structure models that are not based on experimental data. #alphafold
modelarchive.org
modelarchive.org
Reposted by Dorien Pastoors
Incredibly cool paper linking Acetyl-CoA synthesis and HATs in T cells, with differing mechanisms in 'exhausted' T-cells! Another publication showing the link between metabolism and chromatin modifications driving cellular phenotypes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Nutrient-driven histone code determines exhausted CD8+ T cell fates
Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing their protective capabilities. However, the impact of nutrient metabolism on epige...
www.science.org
February 7, 2025 at 1:10 PM
Incredibly cool paper linking Acetyl-CoA synthesis and HATs in T cells, with differing mechanisms in 'exhausted' T-cells! Another publication showing the link between metabolism and chromatin modifications driving cellular phenotypes
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Dorien Pastoors
PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1
February 5, 2025 at 6:34 PM
PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n
Wow very cool!! Congratulations!!
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...
doi.org
February 5, 2025 at 1:27 PM
Wow very cool!! Congratulations!!
Reposted by Dorien Pastoors
‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection! 👀👇👇
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)
rdcu.be/d8xLv (1/6)
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.
rdcu.be
February 4, 2025 at 4:43 PM
‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection! 👀👇👇