Mahmoud Pouladi
@pouladilab.bsky.social
Associate Professor, BCCHRI, University of British Columbia :: Neurogenetics :: NDDs :: Disease Modelling :: Drug Discovery :: iPSCs
Excited to announce the publication of a special issue on "Glia and non-neuronal cells in Huntington’s disease" that I co-edited with Dr. Asa Petersen in the Journal of Huntington's Disease (Volume 14, Issue 3)!
journals.sagepub.com/toc/huna/14/3
1/3
journals.sagepub.com/toc/huna/14/3
1/3
August 8, 2025 at 12:54 AM
Excited to announce the publication of a special issue on "Glia and non-neuronal cells in Huntington’s disease" that I co-edited with Dr. Asa Petersen in the Journal of Huntington's Disease (Volume 14, Issue 3)!
journals.sagepub.com/toc/huna/14/3
1/3
journals.sagepub.com/toc/huna/14/3
1/3
Reposted by Mahmoud Pouladi
Can we identify biomarkers responsive to mHTT lowering?
In this new study, we investigated 💧 #CSF and ☢️ #PET biomarkers that could be used non-invasively to track 📈 the temporal response to #mHTT modulation in mice 🐭.
#openaccess article: 👉 lnkd.in/eqTirauF
In this new study, we investigated 💧 #CSF and ☢️ #PET biomarkers that could be used non-invasively to track 📈 the temporal response to #mHTT modulation in mice 🐭.
#openaccess article: 👉 lnkd.in/eqTirauF
April 16, 2025 at 10:22 AM
Can we identify biomarkers responsive to mHTT lowering?
In this new study, we investigated 💧 #CSF and ☢️ #PET biomarkers that could be used non-invasively to track 📈 the temporal response to #mHTT modulation in mice 🐭.
#openaccess article: 👉 lnkd.in/eqTirauF
In this new study, we investigated 💧 #CSF and ☢️ #PET biomarkers that could be used non-invasively to track 📈 the temporal response to #mHTT modulation in mice 🐭.
#openaccess article: 👉 lnkd.in/eqTirauF
Reposted by Mahmoud Pouladi
A new study has ranked Canada 3rd on a list of the top countries with social purpose, seen as being “the most progressive and inclusive” countries in the world.
Denmark and Sweden occupy the top 2 spots on the list, while Norway and New Zealand round out the top 5.
Via @cultmtl.bsky.social
Denmark and Sweden occupy the top 2 spots on the list, while Norway and New Zealand round out the top 5.
Via @cultmtl.bsky.social
Canada named among top countries with social purpose
A study by U.S. News & World Report has ranked Canada third on a list of the top countries with social purpose.
cultmtl.com
March 15, 2025 at 3:14 PM
A new study has ranked Canada 3rd on a list of the top countries with social purpose, seen as being “the most progressive and inclusive” countries in the world.
Denmark and Sweden occupy the top 2 spots on the list, while Norway and New Zealand round out the top 5.
Via @cultmtl.bsky.social
Denmark and Sweden occupy the top 2 spots on the list, while Norway and New Zealand round out the top 5.
Via @cultmtl.bsky.social
Reposted by Mahmoud Pouladi
Changes to MSc, PhD and postdoc funding programs from 🇨🇦 tri councils. Harmonization across councils, more awards, and new eligibility for international PhD and postdoc applicants!
NSERC - Latest News - Launch of the new Harmonized Tri-agency Scholarship and Fellowship programs
As announced in Budget 2024, the scholarship and fellowship programs administered by the three federal research funding agencies – the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC), and the Social Sciences and Humanities Research Council (SSHRC) – have been streamlined into a new harmonized talent program called the Canada Research Training Awards Suite (CRTAS) that will open for applications in summer 2025.
www.nserc-crsng.gc.ca
March 14, 2025 at 11:06 PM
Changes to MSc, PhD and postdoc funding programs from 🇨🇦 tri councils. Harmonization across councils, more awards, and new eligibility for international PhD and postdoc applicants!
Reposted by Mahmoud Pouladi
From #OUP 's #DATABASE journal | VarGuideAtlas: a repository of variant interpretation guidelines | #Bioinformatics #Genomics 🧬 🖥️ 🧪 🔓
⬇️
academic.oup.com/database/art...
⬇️
academic.oup.com/database/art...
VarGuideAtlas: a repository of variant interpretation guidelines
Abstract. Variant interpretation guidelines guide the process of determining the role of DNA variants in patients’ health. Currently, hundreds of guideline
academic.oup.com
March 13, 2025 at 1:13 PM
From #OUP 's #DATABASE journal | VarGuideAtlas: a repository of variant interpretation guidelines | #Bioinformatics #Genomics 🧬 🖥️ 🧪 🔓
⬇️
academic.oup.com/database/art...
⬇️
academic.oup.com/database/art...
Reposted by Mahmoud Pouladi
Come be my colleague at UBC! A great place to work w/amazing students, a beautiful campus, and…maybe one or two other perks 🇨🇦
We are hiring our next Department Head. If interested, you will be joining a great team of committed researchers and teachers. 👇
www.med.ubc.ca/careers/admi...
www.med.ubc.ca/careers/admi...
Head, Department of Cellular and Physiological Sciences - UBC Faculty of Medicine
Ranked among the world’s top medical schools with the fifth-largest MD enrollment in North America, the UBC Faculty of Medicine is a leader in both the science and the practice of medicine. Across Bri...
www.med.ubc.ca
March 14, 2025 at 3:12 AM
Come be my colleague at UBC! A great place to work w/amazing students, a beautiful campus, and…maybe one or two other perks 🇨🇦
Reposted by Mahmoud Pouladi
Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
December 5, 2024 at 10:13 PM
Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
Women tend to age better cognitively than men, but why? This cool new study finds aging reactivates genes on the inactive X chromosome in the female hippocampus. This shift could contribute to cognitive resilience, with the myelin gene Plp1 playing a major role.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
www.science.org
March 7, 2025 at 5:22 AM
Women tend to age better cognitively than men, but why? This cool new study finds aging reactivates genes on the inactive X chromosome in the female hippocampus. This shift could contribute to cognitive resilience, with the myelin gene Plp1 playing a major role.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mahmoud Pouladi
Bioinformatics Job Opportunity
Research Associate / Staff Scientist
Vancouver Canada
Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis
tinyurl.com/bm4ptux3
Priority to Canadians
Please repost
Research Associate / Staff Scientist
Vancouver Canada
Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis
tinyurl.com/bm4ptux3
Priority to Canadians
Please repost
Research Associate
Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Wasserman Laboratory | Department of Medical Genetics | Faculty of Medicine (Wyeth Wasserman) Posting End Date Febr...
tinyurl.com
February 27, 2025 at 11:59 PM
Bioinformatics Job Opportunity
Research Associate / Staff Scientist
Vancouver Canada
Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis
tinyurl.com/bm4ptux3
Priority to Canadians
Please repost
Research Associate / Staff Scientist
Vancouver Canada
Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis
tinyurl.com/bm4ptux3
Priority to Canadians
Please repost
Reposted by Mahmoud Pouladi
Looking for a postdoc with expertise in genetics and neuroscience. Experience in Drosophila a plus. Get in touch!
www.uwo.ca/research/fun...
www.uwo.ca/research/fun...
Western Postdoctoral Fellowship Program
Western University, in vibrant London, Ontario, delivers an academic and student experience second to none.
www.uwo.ca
March 6, 2025 at 7:21 PM
Looking for a postdoc with expertise in genetics and neuroscience. Experience in Drosophila a plus. Get in touch!
www.uwo.ca/research/fun...
www.uwo.ca/research/fun...
This large multi-omic study links tandem repeat (TR) variations to gene regulation in the human brain. We’ve know for sometime that TRs are not just genomic noise (TRs cause HD, FXS, SCAs, ALS/FTD to name a few), but ~18k TRs as potential causal variants is still a shock. doi.org/10.1038/s415...
Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain - Nature Genetics
Mapping of multi-omic molecular quantitative trait loci associated with tandem repeat size variation in up to 4,412 human brain samples from 1,597 donors offers insights into how these variants affect...
doi.org
March 6, 2025 at 5:44 AM
This large multi-omic study links tandem repeat (TR) variations to gene regulation in the human brain. We’ve know for sometime that TRs are not just genomic noise (TRs cause HD, FXS, SCAs, ALS/FTD to name a few), but ~18k TRs as potential causal variants is still a shock. doi.org/10.1038/s415...
UBC’s Dept of Medical Genetics is hiring a tenure-track Assistant Professor at the Life Sciences Institute.
If you’re interested in joining a strong research community in Vancouver, check out the job posting: medgen.med.ubc.ca/assistant-pr...
Please share with anyone who might be a great fit!
If you’re interested in joining a strong research community in Vancouver, check out the job posting: medgen.med.ubc.ca/assistant-pr...
Please share with anyone who might be a great fit!
Assistant Professor (Tenure-Track) | Department of Medical Genetics | Life Sciences Institute (LSI) - Department of Medical Genetics
The Department of Medical Genetics, in collaboration with the Life Sciences Institute (LSI), invites applications for a full-time faculty position at the rank of Assistant Professor, tenure track with...
medgen.med.ubc.ca
March 4, 2025 at 2:01 AM
UBC’s Dept of Medical Genetics is hiring a tenure-track Assistant Professor at the Life Sciences Institute.
If you’re interested in joining a strong research community in Vancouver, check out the job posting: medgen.med.ubc.ca/assistant-pr...
Please share with anyone who might be a great fit!
If you’re interested in joining a strong research community in Vancouver, check out the job posting: medgen.med.ubc.ca/assistant-pr...
Please share with anyone who might be a great fit!
Reposted by Mahmoud Pouladi
Good morning! Day 1 of #CHDI2025 is kicking of NOW! Get ready to follow along for some exciting Huntington’s disease research over the next 3 days.
February 25, 2025 at 4:36 PM
Good morning! Day 1 of #CHDI2025 is kicking of NOW! Get ready to follow along for some exciting Huntington’s disease research over the next 3 days.
Reposted by Mahmoud Pouladi
Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please):
www.sfu.ca/vpacademic/a...
www.sfu.ca/vpacademic/a...
Canada Research Chair - Indigenous Health and Well-Being
www.sfu.ca
February 22, 2025 at 1:40 AM
Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please):
www.sfu.ca/vpacademic/a...
www.sfu.ca/vpacademic/a...
Reposted by Mahmoud Pouladi
My group would take at least 2 people interested in neurodegeneration as post docs bsky.app/profile/maxi...
We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.
February 15, 2025 at 3:35 PM
My group would take at least 2 people interested in neurodegeneration as post docs bsky.app/profile/maxi...
Reposted by Mahmoud Pouladi
The HD community has come to Bluesky!
Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky.
If you’re an HD researcher and want to be added, reply or DM.
go.bsky.app/UM9WCpA
If you’re an HD researcher and want to be added, reply or DM.
go.bsky.app/UM9WCpA
February 8, 2025 at 7:02 PM
The HD community has come to Bluesky!
Reposted by Mahmoud Pouladi
www.ubc.ca/campus-notif... in-person classes at ubc Vancouver are cancelled tomorrow. I only found out due to a message from a colleague in another department forwarded to me. You can cancel outright or move to online.
UBC Campus Notifications | The University of British Columbia
Campus notification for The University of British Columbia.
www.ubc.ca
February 3, 2025 at 3:01 AM
www.ubc.ca/campus-notif... in-person classes at ubc Vancouver are cancelled tomorrow. I only found out due to a message from a colleague in another department forwarded to me. You can cancel outright or move to online.
Reposted by Mahmoud Pouladi
New opportunity posted: Principal Investigator in neurodevelopment/Assistant Professor – CHU Sainte-Justine Azrieli Research Centre, Université de Montréal
can-acn.org/principal-in... #neurojobs
@CRA_CHUSJ
can-acn.org/principal-in... #neurojobs
@CRA_CHUSJ
Principal Investigator in neurodevelopment/Assistant Professor – CHU Sainte-Justine Azrieli Research Centre, Université de Montréal – Canadian Association for Neuroscience
can-acn.org
January 27, 2025 at 9:03 PM
New opportunity posted: Principal Investigator in neurodevelopment/Assistant Professor – CHU Sainte-Justine Azrieli Research Centre, Université de Montréal
can-acn.org/principal-in... #neurojobs
@CRA_CHUSJ
can-acn.org/principal-in... #neurojobs
@CRA_CHUSJ
Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky.
If you’re an HD researcher and want to be added, reply or DM.
go.bsky.app/UM9WCpA
If you’re an HD researcher and want to be added, reply or DM.
go.bsky.app/UM9WCpA
January 26, 2025 at 5:43 PM
Made a starter pack of the Huntington disease researchers/orgs I can find on Bluesky.
If you’re an HD researcher and want to be added, reply or DM.
go.bsky.app/UM9WCpA
If you’re an HD researcher and want to be added, reply or DM.
go.bsky.app/UM9WCpA
Reposted by Mahmoud Pouladi
Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223
Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute
jobs.sciencecareers.org
January 24, 2025 at 11:02 PM
Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
Reposted by Mahmoud Pouladi
This looks useful for Canadian academics
https://universityaffairs.ca/career-advice/how-to-write-a-narrative-cv/
https://universityaffairs.ca/career-advice/how-to-write-a-narrative-cv/
How to write a narrative CV - University Affairs
This document should strongly demonstrate your capability as well as the feasibility of your proposed work.
universityaffairs.ca
January 24, 2025 at 1:00 AM
This looks useful for Canadian academics
https://universityaffairs.ca/career-advice/how-to-write-a-narrative-cv/
https://universityaffairs.ca/career-advice/how-to-write-a-narrative-cv/
Reposted by Mahmoud Pouladi
Beware! AAV libraries prone to length & homology dependent chimerism! Our latest preprint, from the brilliant @jblalanne.bsky.social, was a true surprise as related phenomena are textbook for lentivirus (highly relevant to HIV & Perturb-seq) yet to our reading not known for AAV tinyurl.com/5amc562a
January 17, 2025 at 6:17 PM
Beware! AAV libraries prone to length & homology dependent chimerism! Our latest preprint, from the brilliant @jblalanne.bsky.social, was a true surprise as related phenomena are textbook for lentivirus (highly relevant to HIV & Perturb-seq) yet to our reading not known for AAV tinyurl.com/5amc562a
Reposted by Mahmoud Pouladi
Reposted by Mahmoud Pouladi
Come join us @umontreal.ca - We're looking to recruit a Professor in the field of neurobiology, with a focus on linking neurodevelopment to neural circuit function and dysfunction.
#neuroskyence #neuroscience 🧪
See ad below -
www.fens.org/careers/job-...
#neuroskyence #neuroscience 🧪
See ad below -
www.fens.org/careers/job-...
Principal Investigator in neurodevelopment/Assistant Professor - CHU Sainte-Justine Azrieli Research Centre/ Université de Montréal - Federation of European Neuroscience Societies
www.fens.org
January 17, 2025 at 6:25 PM
Come join us @umontreal.ca - We're looking to recruit a Professor in the field of neurobiology, with a focus on linking neurodevelopment to neural circuit function and dysfunction.
#neuroskyence #neuroscience 🧪
See ad below -
www.fens.org/careers/job-...
#neuroskyence #neuroscience 🧪
See ad below -
www.fens.org/careers/job-...
Reposted by Mahmoud Pouladi
Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published!
👇 Follow 🧵 for quick summary
journals.biologists.com/jcs/article-...
👇 Follow 🧵 for quick summary
journals.biologists.com/jcs/article-...
January 10, 2025 at 5:10 PM
Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published!
👇 Follow 🧵 for quick summary
journals.biologists.com/jcs/article-...
👇 Follow 🧵 for quick summary
journals.biologists.com/jcs/article-...