HDBuzz
@hdbuzzfeed.bsky.social
Huntington’s disease research news. In plain language. Written by scientists. hdbuzz.net
Editors - @sjh508 @rjharding
Editors - @sjh508 @rjharding
A newly revealed structure of the MutSβ molecular machine offers fresh insight into how CAG repeats expand, and how we might one day stop them.
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Unzipping the Secrets of DNA Repair – HDBuzz
en.hdbuzz.net
November 13, 2025 at 2:42 PM
A newly revealed structure of the MutSβ molecular machine offers fresh insight into how CAG repeats expand, and how we might one day stop them.
en.hdbuzz.net/unzipping-th...
en.hdbuzz.net/unzipping-th...
To close out 2025, we're celebrating those who move Huntington's disease research forward, from scientists to families, closing this year with the gratitude we feel for the HD community.
November 11, 2025 at 5:18 PM
To close out 2025, we're celebrating those who move Huntington's disease research forward, from scientists to families, closing this year with the gratitude we feel for the HD community.
November 10, 2025 at 4:28 PM
A new study uses ultra-sensitive tools to map DNA changes across the full range of CAG repeat lengths, shedding light on where intermediate repeats fit within the genetic landscape of Huntington’s disease.
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New insights into intermediate CAG repeats: Mapping the expansion continuum – HDBuzz
en.hdbuzz.net
November 6, 2025 at 7:43 PM
A new study uses ultra-sensitive tools to map DNA changes across the full range of CAG repeat lengths, shedding light on where intermediate repeats fit within the genetic landscape of Huntington’s disease.
en.hdbuzz.net/new-insights...
en.hdbuzz.net/new-insights...
October 20, 2025 at 2:02 PM
Welcome back for the final day of #HDCongress2025! We’re rested, well caffeinated, and excited to share the first session with you on translational issues in HD - how we get research to people that need it most, HD families.
October 13, 2025 at 1:53 PM
Welcome back for the final day of #HDCongress2025! We’re rested, well caffeinated, and excited to share the first session with you on translational issues in HD - how we get research to people that need it most, HD families.
Welcome to Day 2 of #HDCongress2025! Daniel Claassen from HSG and Cristina Sampaio from CHDI kick off the meeting with an overview of what we’ll hear about today in HD clinical research and discovery.
October 12, 2025 at 2:10 PM
Welcome to Day 2 of #HDCongress2025! Daniel Claassen from HSG and Cristina Sampaio from CHDI kick off the meeting with an overview of what we’ll hear about today in HD clinical research and discovery.
Good morning from Nashville, Tennessee, where HDBuzz is attending the first Huntington’s Disease Clinical Research Congress, where hundreds of scientists, doctors, and industry representatives have gathered to talk about HD clinical research and care. #HDCongress2025
October 11, 2025 at 2:43 PM
Good morning from Nashville, Tennessee, where HDBuzz is attending the first Huntington’s Disease Clinical Research Congress, where hundreds of scientists, doctors, and industry representatives have gathered to talk about HD clinical research and care. #HDCongress2025
Scientists have found small molecules that can target a crucial DNA repair machine, paving the way for therapies that could delay the onset of Huntington’s disease.
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Controlling DNA Scanning Machines to Slow Expansion of CAG Repeats – HDBuzz
en.hdbuzz.net
October 10, 2025 at 6:14 PM
Scientists have found small molecules that can target a crucial DNA repair machine, paving the way for therapies that could delay the onset of Huntington’s disease.
en.hdbuzz.net/controlling-...
en.hdbuzz.net/controlling-...
The Huntington Study Group (HSG) Clinical Research Congress is this weekend in Nashville. HDBuzz will be front and center, live posting updates from the event on Bluesky!
Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!
tinyurl.com/5h6hcssx
Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!
tinyurl.com/5h6hcssx
Unsupported client – Canva
Unsupported client – Canva
tinyurl.com
October 8, 2025 at 10:13 PM
The Huntington Study Group (HSG) Clinical Research Congress is this weekend in Nashville. HDBuzz will be front and center, live posting updates from the event on Bluesky!
Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!
tinyurl.com/5h6hcssx
Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!
tinyurl.com/5h6hcssx
We’re proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! Her article covers work that shows that boosting a protein called SGTA can ease signs of Huntington’s disease, opening a potential new therapeutic path.
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2025 HDBuzz Prize: On the Frontlines: Trusting the Hall Monitors of the Cell – HDBuzz
en.hdbuzz.net
October 2, 2025 at 7:38 PM
We’re proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! Her article covers work that shows that boosting a protein called SGTA can ease signs of Huntington’s disease, opening a potential new therapeutic path.
en.hdbuzz.net/2025-hdbuzz-...
en.hdbuzz.net/2025-hdbuzz-...
September’s research highlights: gene therapy that may slow HD, new biomarkers for tracking, deeper mechanistic understanding, and advances in mental health. Progress in HD science continues to accelerate with your support!
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September 2025: This Month in Huntington’s Disease Research – HDBuzz
en.hdbuzz.net
September 30, 2025 at 8:13 PM
September’s research highlights: gene therapy that may slow HD, new biomarkers for tracking, deeper mechanistic understanding, and advances in mental health. Progress in HD science continues to accelerate with your support!
en.hdbuzz.net/september-20...
en.hdbuzz.net/september-20...
Hope is building—over $10k raised toward our $30,000 goal! Every dollar helps bring clear science to the HD community. Spread the word or donate to keep the momentum!
Donate here: en.hdbuzz.net/donate
Donate here: en.hdbuzz.net/donate
Donate – HDBuzz
en.hdbuzz.net
September 27, 2025 at 10:34 PM
Hope is building—over $10k raised toward our $30,000 goal! Every dollar helps bring clear science to the HD community. Spread the word or donate to keep the momentum!
Donate here: en.hdbuzz.net/donate
Donate here: en.hdbuzz.net/donate
uniQure reports promising results from a key clinical study, showing that its experimental gene therapy, AMT-130, may slow the progress of Huntington's disease
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September 24, 2025 at 6:01 PM
uniQure reports promising results from a key clinical study, showing that its experimental gene therapy, AMT-130, may slow the progress of Huntington's disease
en.hdbuzz.net/the-first-do...
en.hdbuzz.net/the-first-do...
SKY-0515, an oral drug, safely lowers huntingtin in people with HD—and may also reduce PMS1, a DNA repair protein. This two-pronged approach could open new doors for HD treatment. A larger Phase 2/3 trial is now underway.
Full article: en.hdbuzz.net/sky-0515-low...
Full article: en.hdbuzz.net/sky-0515-low...
SKY-0515 Lowers Huntingtin In People With Huntington’s Disease In Trial Update – HDBuzz
en.hdbuzz.net
September 19, 2025 at 3:16 PM
SKY-0515, an oral drug, safely lowers huntingtin in people with HD—and may also reduce PMS1, a DNA repair protein. This two-pronged approach could open new doors for HD treatment. A larger Phase 2/3 trial is now underway.
Full article: en.hdbuzz.net/sky-0515-low...
Full article: en.hdbuzz.net/sky-0515-low...
We’re proud to announce Jenna Hanrahan as a 2025 HDBuzz Prize winner!
She covers research showing that people with HD may not always recognize their symptoms, not from denial, but because of real brain changes. New MRI scans are helping uncover why.
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She covers research showing that people with HD may not always recognize their symptoms, not from denial, but because of real brain changes. New MRI scans are helping uncover why.
en.hdbuzz.net/2025-hdbuzz-...
2025 HDBuzz Prize: MR-“why” am I feeling this way? How MRI is helping us understand why people with HD may sometimes be unaware of their symptoms – HDBuzz
en.hdbuzz.net
September 15, 2025 at 9:45 PM
We’re proud to announce Jenna Hanrahan as a 2025 HDBuzz Prize winner!
She covers research showing that people with HD may not always recognize their symptoms, not from denial, but because of real brain changes. New MRI scans are helping uncover why.
en.hdbuzz.net/2025-hdbuzz-...
She covers research showing that people with HD may not always recognize their symptoms, not from denial, but because of real brain changes. New MRI scans are helping uncover why.
en.hdbuzz.net/2025-hdbuzz-...
Reposted by HDBuzz
Webinar: Could DNA repair hold the key to treating Huntingtons disease?🧬
Join UK DRI Group Leaders Profs Sarah Tabrizi & Gabriel Balmus as they dig into the latest discoveries and therapeutic breakthroughs from the field
🗓️ Mon 29 Sep 🕓 4-5pm (BST)
Register free 👉 www.ukdri.ac.uk/events/rethi...
Join UK DRI Group Leaders Profs Sarah Tabrizi & Gabriel Balmus as they dig into the latest discoveries and therapeutic breakthroughs from the field
🗓️ Mon 29 Sep 🕓 4-5pm (BST)
Register free 👉 www.ukdri.ac.uk/events/rethi...
Rethinking neurodegeneration: Could DNA repair hold the key to treating Huntington's disease?
With Prof Sarah Tabrizi & Prof Prof Gabriel Balmus
www.ukdri.ac.uk
September 10, 2025 at 4:41 PM
Webinar: Could DNA repair hold the key to treating Huntingtons disease?🧬
Join UK DRI Group Leaders Profs Sarah Tabrizi & Gabriel Balmus as they dig into the latest discoveries and therapeutic breakthroughs from the field
🗓️ Mon 29 Sep 🕓 4-5pm (BST)
Register free 👉 www.ukdri.ac.uk/events/rethi...
Join UK DRI Group Leaders Profs Sarah Tabrizi & Gabriel Balmus as they dig into the latest discoveries and therapeutic breakthroughs from the field
🗓️ Mon 29 Sep 🕓 4-5pm (BST)
Register free 👉 www.ukdri.ac.uk/events/rethi...
Pridopidine has been studied for decades as a possible treatment for Huntington’s disease. The PROOF-HD trial didn’t meet its primary goals, but its full results are now published—making valuable data available for the HD community.
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September 10, 2025 at 4:39 PM
Pridopidine has been studied for decades as a possible treatment for Huntington’s disease. The PROOF-HD trial didn’t meet its primary goals, but its full results are now published—making valuable data available for the HD community.
en.hdbuzz.net/proof-in-the...
en.hdbuzz.net/proof-in-the...
We’re proud to announce Nicolo Zarotti as a 2025 HDBuzz Prize winner! He covers a case study shows that Acceptance & Commitment Therapy (ACT) can lift mood, improve quality of life for people with HD, and offer real support for caregivers too.
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2025 HDBuzz Prize: ACTing on HD: Exploring Acceptance and Commitment Therapy to Improve Mental Health in People with Huntington’s Disease and Their Caregiver – HDBuzz
en.hdbuzz.net
September 8, 2025 at 5:34 PM
We’re proud to announce Nicolo Zarotti as a 2025 HDBuzz Prize winner! He covers a case study shows that Acceptance & Commitment Therapy (ACT) can lift mood, improve quality of life for people with HD, and offer real support for caregivers too.
en.hdbuzz.net/2025-hdbuzz-...
en.hdbuzz.net/2025-hdbuzz-...
We’re thrilled to announce Eva Woods as a 2025 HDBuzz Prize winner! She covers how a team discovered subtle brainwave shifts in people with HD before symptoms appear. These early electrical “whispers” of HD could one day help track the disease years ahead of diagnosis.
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2025 HDBuzz Prize: Calm Before the Storm: Early Clues of Huntington’s Disease Found in Brainwaves – HDBuzz
en.hdbuzz.net
September 4, 2025 at 6:58 PM
We’re thrilled to announce Eva Woods as a 2025 HDBuzz Prize winner! She covers how a team discovered subtle brainwave shifts in people with HD before symptoms appear. These early electrical “whispers” of HD could one day help track the disease years ahead of diagnosis.
en.hdbuzz.net/2025-hdbuzz-...
en.hdbuzz.net/2025-hdbuzz-...
This fall, we’re excited to launch our Falling Into Hope campaign! Our goal: raise $30,000 in just 8 weeks, by October 28.
Learn more about the fundraiser here: en.hdbuzz.net/falling-into...
Learn more about the fundraiser here: en.hdbuzz.net/falling-into...
Falling Into Hope: HDBuzz Fundraising Campaign 2025 – HDBuzz
en.hdbuzz.net
September 2, 2025 at 2:51 PM
This fall, we’re excited to launch our Falling Into Hope campaign! Our goal: raise $30,000 in just 8 weeks, by October 28.
Learn more about the fundraiser here: en.hdbuzz.net/falling-into...
Learn more about the fundraiser here: en.hdbuzz.net/falling-into...
From gut microbes to muscle health, August’s HD research uncovered new biomarkers, protein maps, and lifestyle clues. Each finding brings us closer to earlier detection and smarter treatments.
Full Article: en.hdbuzz.net/august-2025-...
Full Article: en.hdbuzz.net/august-2025-...
August 28, 2025 at 2:18 PM
From gut microbes to muscle health, August’s HD research uncovered new biomarkers, protein maps, and lifestyle clues. Each finding brings us closer to earlier detection and smarter treatments.
Full Article: en.hdbuzz.net/august-2025-...
Full Article: en.hdbuzz.net/august-2025-...
Reposted by HDBuzz
Check out my latest article with @hdbuzzfeed.bsky.social l on a very important, but under researched area in the HD field. 💜
August 27, 2025 at 10:09 AM
Check out my latest article with @hdbuzzfeed.bsky.social l on a very important, but under researched area in the HD field. 💜
Two studies reveal how a tiny change in FAN1—a DNA repair protein—weakens its hold on DNA, fueling repeat expansions and speeding up Huntington’s disease symptoms.
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#HDAwareness #huntingtonsdiseaseawareness #huntingtonsdisease #HDResearch
en.hdbuzz.net/when-dna-rep...
#HDAwareness #huntingtonsdiseaseawareness #huntingtonsdisease #HDResearch
When DNA Repair Goes Off Script: How a Small Change in FAN1 Can Accelerate Huntington’s Disease – HDBuzz
en.hdbuzz.net
August 26, 2025 at 3:38 PM
Two studies reveal how a tiny change in FAN1—a DNA repair protein—weakens its hold on DNA, fueling repeat expansions and speeding up Huntington’s disease symptoms.
en.hdbuzz.net/when-dna-rep...
#HDAwareness #huntingtonsdiseaseawareness #huntingtonsdisease #HDResearch
en.hdbuzz.net/when-dna-rep...
#HDAwareness #huntingtonsdiseaseawareness #huntingtonsdisease #HDResearch