Marco A. Maximo Prado
@maximoprado.bsky.social
Canada Research Chair. Misfolding proteins, chaperones and cholinergic function in neurodegeneration. Interested in reproducibility, translational research and open science. ORCID: 0000-0002-3028-5778
I also post pics of sunsets and bikes.
I also post pics of sunsets and bikes.
Pinned
Stress-inducible phosphoprotein 1 (STIP1) is a critical stemness regulator in mouse embryonic stem cells and early mammalian development - Communications Biology
Combined in silico and in vitro approaches reveal that the co-chaperone STIP1 supports pluripotent stem cell identity, proliferation, and stress resilience, highlighting proteostasis as a key mechanis...
www.nature.com
Just out. Work by Marilene Lopes who did a sabbatical in the lab and her student Camila Fernandes We explored the mechanisms by which the co chaperone STIP1 affects embryogenesis and early development following the phenotypes of STIP1 KO mice 🐁 www.nature.com/articles/s42...
Reposted by Marco A. Maximo Prado
If you know an anti-vaxxer, you can congratulate them on this hard-earned "win".
Honourable mentions to the universities & political leaders who have been so instrumental in making it easier for them to succeed.
This was truly a team effort.
www.reuters.com/business/hea...
Honourable mentions to the universities & political leaders who have been so instrumental in making it easier for them to succeed.
This was truly a team effort.
www.reuters.com/business/hea...
Canada loses measles elimination status after three decades, health agency says
Canada has lost its measles elimination status after nearly three decades due to its failure to curb a year-long outbreak, the country's public health agency said on Monday.
www.reuters.com
November 10, 2025 at 5:12 PM
If you know an anti-vaxxer, you can congratulate them on this hard-earned "win".
Honourable mentions to the universities & political leaders who have been so instrumental in making it easier for them to succeed.
This was truly a team effort.
www.reuters.com/business/hea...
Honourable mentions to the universities & political leaders who have been so instrumental in making it easier for them to succeed.
This was truly a team effort.
www.reuters.com/business/hea...
Reposted by Marco A. Maximo Prado
Great observation! Here’s an image from our dataset — the OB has a much higher vessel density than the rest of the brain, suggesting distinct vascular architecture. The video focus was set for brain contrast, causing overexposure in the highly vascular OBs.
November 10, 2025 at 3:09 PM
Great observation! Here’s an image from our dataset — the OB has a much higher vessel density than the rest of the brain, suggesting distinct vascular architecture. The video focus was set for brain contrast, causing overexposure in the highly vascular OBs.
Reposted by Marco A. Maximo Prado
Going for a rollercoaster ride on the spinal cord! 🤩
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
November 7, 2025 at 9:14 PM
Going for a rollercoaster ride on the spinal cord! 🤩
Reposted by Marco A. Maximo Prado
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
November 7, 2025 at 7:42 PM
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
Reposted by Marco A. Maximo Prado
One of my favorite jokes ever:
What did Watson and Crick discover?
Rosalind Franklin's notebooks
What did Watson and Crick discover?
Rosalind Franklin's notebooks
Hey folks, as news of Watson's demise spreads, please don't set aside his weighty legacy of misogyny and racism. He was truly among the worst of us. www.vox.com/2019/1/15/18...
DNA scientist James Watson has a remarkably long history of sexist, racist public comments
“People say it would be terrible if we made all girls pretty,” he said in 2003. “I think it would be great.”
www.vox.com
November 7, 2025 at 7:54 PM
One of my favorite jokes ever:
What did Watson and Crick discover?
Rosalind Franklin's notebooks
What did Watson and Crick discover?
Rosalind Franklin's notebooks
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
November 7, 2025 at 7:42 PM
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
Reposted by Marco A. Maximo Prado
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 7, 2025 at 1:25 PM
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marco A. Maximo Prado
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience
Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...
www.nature.com
November 7, 2025 at 10:16 AM
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Reposted by Marco A. Maximo Prado
Great to be in Toronto for the Second AG meeting for @tridentpct.bsky.social where our 🐁 molecular and cognition core will show what we are up to in the last 2 years facilitated by @touchscreencog.bsky.social and we will continue to learn about our organoid and marmoset models.
November 3, 2025 at 1:00 PM
Great to be in Toronto for the Second AG meeting for @tridentpct.bsky.social where our 🐁 molecular and cognition core will show what we are up to in the last 2 years facilitated by @touchscreencog.bsky.social and we will continue to learn about our organoid and marmoset models.
Reposted by Marco A. Maximo Prado
Bottom line of systematic assessment of studies on Covid vaccinations/boosters:
~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised
Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents
www.nejm.org/doi/full/10....
~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised
Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents
www.nejm.org/doi/full/10....
October 31, 2025 at 8:17 PM
Bottom line of systematic assessment of studies on Covid vaccinations/boosters:
~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised
Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents
www.nejm.org/doi/full/10....
~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised
Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents
www.nejm.org/doi/full/10....
Reposted by Marco A. Maximo Prado
Hippocampus masquerading as a 🦇 for Halloween 🎃
#FluorescenceFriday
Image credit to the @lieberinstitute.bsky.social Microscopy and Spatial Biology Core 🧠🔬🧪
#FluorescenceFriday
Image credit to the @lieberinstitute.bsky.social Microscopy and Spatial Biology Core 🧠🔬🧪
October 31, 2025 at 12:31 PM
Hippocampus masquerading as a 🦇 for Halloween 🎃
#FluorescenceFriday
Image credit to the @lieberinstitute.bsky.social Microscopy and Spatial Biology Core 🧠🔬🧪
#FluorescenceFriday
Image credit to the @lieberinstitute.bsky.social Microscopy and Spatial Biology Core 🧠🔬🧪
Reposted by Marco A. Maximo Prado
Forbidden gummy 🎃
Is it candy? Nope, it is a spooky 👻 cleared mouse 🧠 used for #fluorescencefriday movies
October 31, 2025 at 7:45 PM
Forbidden gummy 🎃
Reposted by Marco A. Maximo Prado
Women experience delayed diagnoses, more adverse drug effects, and spend 25% more time in poor health than men. Yet only 4.5% of CIHR-funded projects over 15 yrs addressed major health burdens affecting women.
📚 Learn more: ow.ly/Cqjx50XkANC
📚 Learn more: ow.ly/Cqjx50XkANC
October 31, 2025 at 7:18 PM
Women experience delayed diagnoses, more adverse drug effects, and spend 25% more time in poor health than men. Yet only 4.5% of CIHR-funded projects over 15 yrs addressed major health burdens affecting women.
📚 Learn more: ow.ly/Cqjx50XkANC
📚 Learn more: ow.ly/Cqjx50XkANC
Reposted by Marco A. Maximo Prado
More necessary awareness: yes, parliament has the legal authority to do this. There are many reasons they should not. That it is legal does not mean it is ethical, necessary, non-destructive, or appropriate. It DEFINITELY doesn't mean it shouldn't be publicly opposed (👀 @u15ca.bsky.social )... /1
Canadian researchers should be aware the there is a motion before the Parliamentary Standing Committee on Science and Research to force Tricouncils to hand over disaggregated peer review data on all applications:
Applicant names, profiles, demographics
Reviewers names, profiles, comments, and scores
Applicant names, profiles, demographics
Reviewers names, profiles, comments, and scores
October 31, 2025 at 4:14 PM
More necessary awareness: yes, parliament has the legal authority to do this. There are many reasons they should not. That it is legal does not mean it is ethical, necessary, non-destructive, or appropriate. It DEFINITELY doesn't mean it shouldn't be publicly opposed (👀 @u15ca.bsky.social )... /1
Reposted by Marco A. Maximo Prado
I see the face!!!!! 😱 😬 🧠 🎃 #FluorescenceFriday imaging from the Lightsheet Microscopy team at Western.
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
October 31, 2025 at 2:00 PM
I see the face!!!!! 😱 😬 🧠 🎃 #FluorescenceFriday imaging from the Lightsheet Microscopy team at Western.
Reposted by Marco A. Maximo Prado
Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
October 31, 2025 at 4:12 PM
Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
October 31, 2025 at 1:53 PM
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
👻 #fluorescencefriday weird microglia (yellow) in a model of synucleinopathy courtesy Anoosha Attaran
October 31, 2025 at 11:30 AM
👻 #fluorescencefriday weird microglia (yellow) in a model of synucleinopathy courtesy Anoosha Attaran
👻 #fluorescencefriday. plaque ghosts attacked by red (astrocytes) and cyan (microglia) Globins
October 31, 2025 at 11:29 AM
👻 #fluorescencefriday. plaque ghosts attacked by red (astrocytes) and cyan (microglia) Globins
And it took me 20 min to get the two shots tonight. Freely available in Ontario.
Even as the anti-vax lobby erodes public trust, new evidence confirms that "immunizations against Covid-19, RSV, and influenza have shown consistent effectiveness & safety and are associated with a substantially reduced risk of hospitalization & severe disease"
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
October 30, 2025 at 12:14 AM
And it took me 20 min to get the two shots tonight. Freely available in Ontario.
Reposted by Marco A. Maximo Prado
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:11 PM
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Reposted by Marco A. Maximo Prado
Reposted by Marco A. Maximo Prado
Double posting for #FluorescenceFriday today, because I am in love w/ this particular astrocyte (marked w/ GFAP in 🔴) that is sitting in dorsal anterior cingulate cortex in the human 🧠. Image credit to Staff Scientist/image analyst Maddy Tippani and JHU grad student @shkwon-bcmbneuro.bsky.social 🔬🧪
October 24, 2025 at 2:35 PM
Double posting for #FluorescenceFriday today, because I am in love w/ this particular astrocyte (marked w/ GFAP in 🔴) that is sitting in dorsal anterior cingulate cortex in the human 🧠. Image credit to Staff Scientist/image analyst Maddy Tippani and JHU grad student @shkwon-bcmbneuro.bsky.social 🔬🧪