Keri Martinowich
@martinowk.bsky.social
Director, Translational Neuroscience at Lieber Institute and Professor, Johns Hopkins School of Medicine studying molecular regulation across species in circuits impacted in complex brain disorders. Native plants/flowers/wetland habitats. Own opinions.
Pinned
Keri Martinowich
@martinowk.bsky.social
· Nov 10
For all the new followers (thank you!!), I love to post images about our science - team #FluorescenceFriday - as well as DC city stuff, #nativeplants, sunsets, sunrises, paddling and all things Chesapeake!
Reposted by Keri Martinowich
Looks like a chair position in the Department of Pharmacology and Chemical Biology at the University of Pittsburgh School of Medicine has opened up.
Any peeps looking to relocate to Pittsburgh?
Any peeps looking to relocate to Pittsburgh?
November 10, 2025 at 5:47 PM
Looks like a chair position in the Department of Pharmacology and Chemical Biology at the University of Pittsburgh School of Medicine has opened up.
Any peeps looking to relocate to Pittsburgh?
Any peeps looking to relocate to Pittsburgh?
Reposted by Keri Martinowich
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Keri Martinowich
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports
imageimageHuman progenitors are programmed into ependymal cells in brain organoids via GEMC1
and MCIDAS expression. This strategy recapitulates hallmarks of the adult human V-SVZ
niche, providing a pl...
www.embopress.org
November 10, 2025 at 12:22 PM
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....
Reposted by Keri Martinowich
This image shows a mass of human stem cells, collectively known as an ‘organoid’.
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
November 10, 2025 at 9:27 AM
This image shows a mass of human stem cells, collectively known as an ‘organoid’.
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma.
Image credit: @carmenmorenogon.bsky.social
Reposted by Keri Martinowich
Was embarrassed to have never been after being here so many years - Rawlings Conservatory definitely lives up to the hidden gem definition, especially the Orchid Room 🤩
November 8, 2025 at 11:25 PM
Was embarrassed to have never been after being here so many years - Rawlings Conservatory definitely lives up to the hidden gem definition, especially the Orchid Room 🤩
Was embarrassed to have never been after being here so many years - Rawlings Conservatory definitely lives up to the hidden gem definition, especially the Orchid Room 🤩
November 8, 2025 at 11:25 PM
Was embarrassed to have never been after being here so many years - Rawlings Conservatory definitely lives up to the hidden gem definition, especially the Orchid Room 🤩
Arrival of chilly weekend mornings = start of my puzzle season
November 8, 2025 at 1:35 PM
Arrival of chilly weekend mornings = start of my puzzle season
Reposted by Keri Martinowich
The brain is over 50% lipid—but this vital component remains a mystery. JAX scientist Kristen O’Connell uses high-res mass spectrometry to study how these molecules support memory and cognition—and what happens when they don’t. 🧠 go.jax.org/OConnell
The memory link
How lipids can change the course of Alzheimer's disease
go.jax.org
November 8, 2025 at 9:58 AM
The brain is over 50% lipid—but this vital component remains a mystery. JAX scientist Kristen O’Connell uses high-res mass spectrometry to study how these molecules support memory and cognition—and what happens when they don’t. 🧠 go.jax.org/OConnell
Reposted by Keri Martinowich
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 7, 2025 at 1:25 PM
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Keri Martinowich
For #FluorescenceFriday - one of my favorites from the archives of a neuron ⚪ and astrocyte 🟢 co-culture. Image credit to Stephanie Page and former research assistant Beth Pattie 🧠🔬🧪
November 7, 2025 at 12:37 PM
For #FluorescenceFriday - one of my favorites from the archives of a neuron ⚪ and astrocyte 🟢 co-culture. Image credit to Stephanie Page and former research assistant Beth Pattie 🧠🔬🧪
Reposted by Keri Martinowich
The winner of OneNeuro's October #FotoFriday #FluorescenceFriday contest is "Purkinje cell complex spikes & simple spikes," submitted by Chenhao Bao in the Cullen lab at JHU Biomedical Engineering. @thecullenlab.bsky.social @chenhaobao.bsky.social
Complete gallery: www.oneneurojhu.org/art/
Complete gallery: www.oneneurojhu.org/art/
November 7, 2025 at 11:27 PM
The winner of OneNeuro's October #FotoFriday #FluorescenceFriday contest is "Purkinje cell complex spikes & simple spikes," submitted by Chenhao Bao in the Cullen lab at JHU Biomedical Engineering. @thecullenlab.bsky.social @chenhaobao.bsky.social
Complete gallery: www.oneneurojhu.org/art/
Complete gallery: www.oneneurojhu.org/art/
Reposted by Keri Martinowich
#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
www.biorxiv.org
November 7, 2025 at 8:17 PM
#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.
Reposted by Keri Martinowich
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 7, 2025 at 6:06 PM
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Reposted by Keri Martinowich
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange).
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
November 7, 2025 at 9:25 PM
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange).
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Reposted by Keri Martinowich
my first #FluorescenceFriday post! Mouse hippocampus showing microglia, a lysosomal marker (CD68), and Aggrecan, a perineuronal net component. 😍 Image by Dr. Julia Dziabis!
November 7, 2025 at 6:55 PM
my first #FluorescenceFriday post! Mouse hippocampus showing microglia, a lysosomal marker (CD68), and Aggrecan, a perineuronal net component. 😍 Image by Dr. Julia Dziabis!
Reposted by Keri Martinowich
Check out this sneaky lamin A knockdown cell (pink dot) swimming against the tide (migration into gap) & slithering between its sisters.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
November 7, 2025 at 4:29 PM
Check out this sneaky lamin A knockdown cell (pink dot) swimming against the tide (migration into gap) & slithering between its sisters.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
It also slides over another nucleus that deforms underneath it.
MCF10A cells, #Spirochrome SPY650-DNA, 20 min time-lapse, taken on a #Zeiss #CellDiscoverer7.
Reposted by Keri Martinowich
Happy #FluorescenceFriday from these primary astrocytes grown on glass slides and robotically stained on the Biocare Oncore Pro X! 🧠🔬🧪
Cyan = GFAP
Royal Purple = ALDH1L1
Salmon = Nuclear Counterstain
Cyan = GFAP
Royal Purple = ALDH1L1
Salmon = Nuclear Counterstain
November 7, 2025 at 7:26 PM
Happy #FluorescenceFriday from these primary astrocytes grown on glass slides and robotically stained on the Biocare Oncore Pro X! 🧠🔬🧪
Cyan = GFAP
Royal Purple = ALDH1L1
Salmon = Nuclear Counterstain
Cyan = GFAP
Royal Purple = ALDH1L1
Salmon = Nuclear Counterstain
Reposted by Keri Martinowich
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
November 7, 2025 at 7:42 PM
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
Reposted by Keri Martinowich
How do VTA DA neurons sculpt downstream representations to reinforce actions? VERY excited about our new preprint (by Alex Pan Vazquez & @czimmerman.bsky.social )
VTA dopamine neuron activity produces spatially organized value representations https://www.biorxiv.org/content/10.1101/2025.11.04.685995v1
November 7, 2025 at 8:46 PM
How do VTA DA neurons sculpt downstream representations to reinforce actions? VERY excited about our new preprint (by Alex Pan Vazquez & @czimmerman.bsky.social )
Reposted by Keri Martinowich
Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41...
#Calicumimaging #miniscopes #rCPT #PrL
#Calicumimaging #miniscopes #rCPT #PrL
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 7, 2025 at 6:42 PM
Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41...
#Calicumimaging #miniscopes #rCPT #PrL
#Calicumimaging #miniscopes #rCPT #PrL
Reposted by Keri Martinowich
Apparently the postings are up for several NIH director positions. Deadlines between 11/14 and 11/21. hr.nih.gov/careers/care...
hr.nih.gov
November 7, 2025 at 5:43 PM
Apparently the postings are up for several NIH director positions. Deadlines between 11/14 and 11/21. hr.nih.gov/careers/care...
Reposted by Keri Martinowich
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
November 7, 2025 at 1:35 PM
This is a glimpse of the cytoskeletal structures we found doing U-ExM in more than 200 species, now in Cell🤩: shorturl.at/6oHvi
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Amazing collaboration between @centriolelab.bsky.social , @dudinlab.bsky.social and @gautamdey.bsky.social labs.
I believe last one is a 🕷️
#FluorescenceFriday
#Microscopy
Reposted by Keri Martinowich
🌀🌪️A fluorescent cyclone in a beaker!🌪️🌀
Fluorescein fluorescence visualized the stirred liquid.
#FluorescenceFriday #RealTimeChem #Chemistry #SciArt #SciComm
Fluorescein fluorescence visualized the stirred liquid.
#FluorescenceFriday #RealTimeChem #Chemistry #SciArt #SciComm
November 7, 2025 at 2:07 PM
🌀🌪️A fluorescent cyclone in a beaker!🌪️🌀
Fluorescein fluorescence visualized the stirred liquid.
#FluorescenceFriday #RealTimeChem #Chemistry #SciArt #SciComm
Fluorescein fluorescence visualized the stirred liquid.
#FluorescenceFriday #RealTimeChem #Chemistry #SciArt #SciComm
Reposted by Keri Martinowich
Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.
November 7, 2025 at 4:43 PM
Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.