Ted Price
@tedpricethepainguy.bsky.social
Dad, husband and pain scientist. Better guard me beyond the arc. Education should not cause debt
Reposted by Ted Price
Lambert High School in Georgia was the only U.S. school to place in the high school top 10 at iGEM, an international synthetic biology competition. The other top teams included one from South Korea, one from Taiwan, and seven from China. cbsn.ws/4otdEKq
December 1, 2025 at 1:05 AM
Lambert High School in Georgia was the only U.S. school to place in the high school top 10 at iGEM, an international synthetic biology competition. The other top teams included one from South Korea, one from Taiwan, and seven from China. cbsn.ws/4otdEKq
Great story about some amazing young scientists and an important message on failing leadership in America
“They are so smart I can’t keep up,” says Kate Sharer, biotechnology teacher at Lambert High School in Suwanee, Georgia. “Because they are still teenagers, so they're thinking so far out of the box.” cbsn.ws/48mMTRB
December 1, 2025 at 1:06 AM
Great story about some amazing young scientists and an important message on failing leadership in America
This is really impressive stuff.
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission www.nature.com/articles/d41...
‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission
Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.
www.nature.com
November 29, 2025 at 9:22 PM
This is really impressive stuff.
So many of the peptide receptor targets I learned about from Victor Hruby, Josef Vagner, and Robin Polt (none of whom are involved in this exciting work) when I was at UA now zooming toward the clinic www.biorxiv.org/content/10.1...
Dual Activation of MC3R and MC4R Drives Weight Loss and Reduces Food Intake in Obese Primates
The melanocortin system plays a central role in regulating hunger and satiety, making it an attractive target for treating metabolic disease. However, the limited clinical success of selective melanoc...
www.biorxiv.org
November 29, 2025 at 5:07 PM
So many of the peptide receptor targets I learned about from Victor Hruby, Josef Vagner, and Robin Polt (none of whom are involved in this exciting work) when I was at UA now zooming toward the clinic www.biorxiv.org/content/10.1...
Happy Thanksgiving!
November 28, 2025 at 1:53 AM
Happy Thanksgiving!
This is so true. Academics are totally committed to creating meaningless work for ourselves.
Begging PhD programs to agree on a common app with only letters of rec that writers upload once. These inane likert scales when students are applying to 15-20 programs is destroying my soul
November 27, 2025 at 5:43 PM
This is so true. Academics are totally committed to creating meaningless work for ourselves.
Reposted by Ted Price
You are correct. In the past, it was okay to say that the application was funded because it received a 4th percentile and the payline was the 10th percentile.
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
November 24, 2025 at 12:59 AM
You are correct. In the past, it was okay to say that the application was funded because it received a 4th percentile and the payline was the 10th percentile.
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
Now additional justification must be provided.
But, in the past, if a 4th %ile app was not funded, documentation was required. Now, nothing
I agree that this is a tragedy. The pessimistic part of me thinks this is intentional because they want all biotech scientific founders to be beholden to rich investors at lower valuations.
November 21, 2025 at 7:48 PM
I agree that this is a tragedy. The pessimistic part of me thinks this is intentional because they want all biotech scientific founders to be beholden to rich investors at lower valuations.
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...
www.science.org
November 21, 2025 at 6:13 PM
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
Reposted by Ted Price
Kelly: "I never expected after serving 25 years in the Navy flying combat missions over Iraq and Kuwait, flying the Space Shuttle, that now I've got to worry about my personal safety and that of my wife, Gabby Giffords, who was already nearly assassinated, because of something the president said."
November 21, 2025 at 2:08 AM
Kelly: "I never expected after serving 25 years in the Navy flying combat missions over Iraq and Kuwait, flying the Space Shuttle, that now I've got to worry about my personal safety and that of my wife, Gabby Giffords, who was already nearly assassinated, because of something the president said."
This is totally nuts. Also, not a good idea to piss off every nurse in the nation.
November 21, 2025 at 2:08 AM
This is totally nuts. Also, not a good idea to piss off every nurse in the nation.
Reposted by Ted Price
Want to flow-analyze or FACS your sensory neurons without relying on reporter mice? Check out our new short report 👇https://www.biorxiv.org/content/10.1101/2025.11.19.688847v1
A novel method to sort and enrich sensory neurons
Peripheral sensory neurons, residing in the dorsal root ganglia (DRG), relay sensory information from the periphery to the central nervous system. Although single-cell transcriptomic studies have iden...
www.biorxiv.org
November 20, 2025 at 7:29 AM
Want to flow-analyze or FACS your sensory neurons without relying on reporter mice? Check out our new short report 👇https://www.biorxiv.org/content/10.1101/2025.11.19.688847v1
I read this in disbelief. so much disbarment surely to come in a sane world www.cnn.com/politics/liv...
Lindsey Halligan says full grand jury never saw final indictment it handed up against Comey | CNN Politics
Interim US Attorney Lindsey Halligan said only two grand jurors reviewed the final indictment it handed up against former FBI Director James Comey. “There is no indictment,” Comey’s attorney replied.
www.cnn.com
November 19, 2025 at 6:17 PM
I read this in disbelief. so much disbarment surely to come in a sane world www.cnn.com/politics/liv...
Looking forward to reading this!! Painless NGF seems to have moved away from p75 and onto TrkA biased signaling. www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 9:47 PM
Looking forward to reading this!! Painless NGF seems to have moved away from p75 and onto TrkA biased signaling. www.biorxiv.org/content/10.1...
not surprising, but still shocking to read these accounts of the continued degradation of the rule of law in our nation.
November 17, 2025 at 3:14 PM
not surprising, but still shocking to read these accounts of the continued degradation of the rule of law in our nation.
One of the all time greats
On this day, 33 years ago, Bram Stoker’s Dracula was released in cinemas.
Starring #GaryOldman, #WinonaRyder, #KeanuReeves and #AnthonyHopkins it was an Oscar-winning, critically acclaimed success and one of the most revered #vampire movies ever.
Starring #GaryOldman, #WinonaRyder, #KeanuReeves and #AnthonyHopkins it was an Oscar-winning, critically acclaimed success and one of the most revered #vampire movies ever.
November 13, 2025 at 2:31 PM
One of the all time greats
Reposted by Ted Price
Well, it's a little clearer now why billionaires are so invested in technology that produces better written emails.
November 12, 2025 at 10:23 PM
Well, it's a little clearer now why billionaires are so invested in technology that produces better written emails.
Looks like Nico is finally going to get the ax, but I hope the owners know that we will never forgive them for trading the favorite son of our fair city, Luka.
November 11, 2025 at 1:38 PM
Looks like Nico is finally going to get the ax, but I hope the owners know that we will never forgive them for trading the favorite son of our fair city, Luka.
The return of PKMzeta?
PKMζ-PKC{iota}/{lambda} double-knockout reveals the atypical PKCs are crucial for hippocampal late-LTP and spatial long-term memory https://www.biorxiv.org/content/10.1101/2025.11.10.687514v1
November 11, 2025 at 1:27 PM
The return of PKMzeta?
Reposted by Ted Price
Breaking News: The company Merck said it had created a powerful new cholesterol pill that could be a more affordable alternative to other treatments.
Merck PCSK9 Pill Results Point to Extremely Low Cholesterol Future
The drug targets the PCSK9 protein, and could give millions of people a more affordable option to reduce their heart disease risk.
nyti.ms
November 8, 2025 at 8:07 PM
Breaking News: The company Merck said it had created a powerful new cholesterol pill that could be a more affordable alternative to other treatments.
He should be!
With Dallas' 2-7 start, is general manager Nico Harrison in trouble?
www.nbcsports.com/nba/news/wit...
www.nbcsports.com/nba/news/wit...
With Dallas' 2-7 start, is general manager Nico Harrison in trouble?
With Kyrie Irving out to start the season, the roster is imbalanced (leading to the Cooper Flagg at point guard experiment).
www.nbcsports.com
November 8, 2025 at 5:07 PM
He should be!
Reposted by Ted Price
#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
www.biorxiv.org
November 7, 2025 at 8:17 PM
#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.
Totally agree with Rob. Being part of this has been a dream come true.
#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.
The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
November 8, 2025 at 12:00 AM
Totally agree with Rob. Being part of this has been a dream come true.
Seriously impressive effects of a prolactin blocking antibody treatment in endometriosis pain: www.thelancet.com/journals/lan... Now let's see a CGRP antibody trial to see which is better (and I want to see the prolactin antibody in a migraine trial too). The pain field is moving fast!
Safety and efficacy of subcutaneous injection with HMI-115 versus placebo in endometriosis-associated pain in premenopausal women: a multicentre, double-blind, randomised, proof-of-concept phase 2 tri...
In this proof-of-concept phase 2 trial, blocking the prolactin receptor with HMI-115
showed an acceptable tolerability profile and promising efficacy in alleviating endometriosis-associated
pain. Thes...
www.thelancet.com
November 7, 2025 at 7:02 PM
Seriously impressive effects of a prolactin blocking antibody treatment in endometriosis pain: www.thelancet.com/journals/lan... Now let's see a CGRP antibody trial to see which is better (and I want to see the prolactin antibody in a migraine trial too). The pain field is moving fast!
Also happy to see that our rat DRG dataset is now online at Journal of Pain. www.jpain.org/article/S152... Big thanks to Sydney Caparaso and Becky Wachs for leading this effort along with @ish1789.bsky.social and I. Rats and mice and humans are not the same, oh my!
Single-nuclei RNA Sequencing Reveals Distinct Transcriptomic Signatures of Rat Dorsal Root Ganglia in a Chronic Discogenic Low Back Pain Model
Chronic low back pain (LBP), often correlated with intervertebral disc degeneration,
is a leading source of disability worldwide, yet remains poorly understood. Current
treatments often fail to provid...
www.jpain.org
November 7, 2025 at 5:51 PM
Also happy to see that our rat DRG dataset is now online at Journal of Pain. www.jpain.org/article/S152... Big thanks to Sydney Caparaso and Becky Wachs for leading this effort along with @ish1789.bsky.social and I. Rats and mice and humans are not the same, oh my!