Ted Price
@tedpricethepainguy.bsky.social
Dad, husband and pain scientist. Better guard me beyond the arc. Education should not cause debt
Happy Thanksgiving!
November 28, 2025 at 1:53 AM
Happy Thanksgiving!
Wizard of Oz at The Sphere is astonishingly good. We were all totally blown away and I caught an apple!
November 4, 2025 at 6:05 PM
Wizard of Oz at The Sphere is astonishingly good. We were all totally blown away and I caught an apple!
Also what are we doing in Raider Nation. These fans are scary!!
November 2, 2025 at 11:10 PM
Also what are we doing in Raider Nation. These fans are scary!!
We got to see the longest field goal in NFL history live today. That record might stand for a long time
November 2, 2025 at 11:08 PM
We got to see the longest field goal in NFL history live today. That record might stand for a long time
Finally, we compared mice to humans and saw conservation of most neuronal types, but divergences in neuronal proportions and transcriptomes, in particular for cell surface receptors. If you want to do drug discovery, these details matter!!
November 1, 2025 at 12:23 PM
Finally, we compared mice to humans and saw conservation of most neuronal types, but divergences in neuronal proportions and transcriptomes, in particular for cell surface receptors. If you want to do drug discovery, these details matter!!
We then went to town on the glial populations where we identified some pretty profound sex differences. We did not note sex differences in neurons, but the identification of male and female specific glial populations for astrocytes, microglia, and oligodendrocytes could have important functions.
November 1, 2025 at 12:22 PM
We then went to town on the glial populations where we identified some pretty profound sex differences. We did not note sex differences in neurons, but the identification of male and female specific glial populations for astrocytes, microglia, and oligodendrocytes could have important functions.
And, of course, we did the same with the ventral horn, giving confidence in our identification of motor neuron pools.
November 1, 2025 at 12:20 PM
And, of course, we did the same with the ventral horn, giving confidence in our identification of motor neuron pools.
We used this information to create detailed maps of the locations of cell types in the dorsal horn. This gives great insight into sensory/nociceptive circuits in the human dorsal horn with a resolution that has not been seen before at this scale.
November 1, 2025 at 12:19 PM
We used this information to create detailed maps of the locations of cell types in the dorsal horn. This gives great insight into sensory/nociceptive circuits in the human dorsal horn with a resolution that has not been seen before at this scale.
Of course, we also care about non-neuronal cells and the spatial arrangement of all of these cell types so we used Xenium spatial transcriptomics to map the locations of these cell types using gene markers from our single nucleus work. Our custom panel led to many important insights.
November 1, 2025 at 12:17 PM
Of course, we also care about non-neuronal cells and the spatial arrangement of all of these cell types so we used Xenium spatial transcriptomics to map the locations of these cell types using gene markers from our single nucleus work. Our custom panel led to many important insights.
We did the same thing for ventral horn neurons (we microdissected the dorsal horn from the ventral horn to have clear sequencing) and were able to clearly delineate motor neuron populations.
November 1, 2025 at 12:15 PM
We did the same thing for ventral horn neurons (we microdissected the dorsal horn from the ventral horn to have clear sequencing) and were able to clearly delineate motor neuron populations.
We mapped dorsal horn neurons using single nucleus sequencing and developed detailed transcriptomes for subtypes which we named using a nomenclature system based on work done at the Allen Brain Atlas.
November 1, 2025 at 12:13 PM
We mapped dorsal horn neurons using single nucleus sequencing and developed detailed transcriptomes for subtypes which we named using a nomenclature system based on work done at the Allen Brain Atlas.
We did single nucleus sequencing and Xenium @10xgenomics.bsky.social spatial transcriptomics on male and female spinal cords from organ donor recovered tissues in collaboration with Southwest Transplant Alliance. We started this work about 5 years ago. We optimized and optimized and optimized.
November 1, 2025 at 12:12 PM
We did single nucleus sequencing and Xenium @10xgenomics.bsky.social spatial transcriptomics on male and female spinal cords from organ donor recovered tissues in collaboration with Southwest Transplant Alliance. We started this work about 5 years ago. We optimized and optimized and optimized.
Forrest Gump Point is for lovers
October 12, 2025 at 3:16 AM
Forrest Gump Point is for lovers
Kudos to the rangers keeping this place amazing despite the shutdown
October 12, 2025 at 3:13 AM
Kudos to the rangers keeping this place amazing despite the shutdown
Greetings from Goosenecks State Park Utah
October 12, 2025 at 3:12 AM
Greetings from Goosenecks State Park Utah
Hello from Natural Bridges National Monument
October 12, 2025 at 12:15 AM
Hello from Natural Bridges National Monument
Good morning from a rainy monument valley
October 11, 2025 at 2:06 PM
Good morning from a rainy monument valley
Last night in Tokyo.
July 25, 2025 at 9:42 PM
Last night in Tokyo.
Okinawa Aquarium
Amazing place
Amazing place
July 22, 2025 at 10:04 AM
Okinawa Aquarium
Amazing place
Amazing place
#tokyoskytree 9 years after the first time at this amazing place. Penelope was a baby last time and Max was just an idea.
July 19, 2025 at 10:47 AM
#tokyoskytree 9 years after the first time at this amazing place. Penelope was a baby last time and Max was just an idea.
Developing some good bark, right below 180 F internal
June 28, 2025 at 5:05 PM
Developing some good bark, right below 180 F internal
