Shaz (Shahrzad) Bahrampour
@shahrzadbahrampour.bsky.social
Neuroscience researcher exploring neurodegenerative diseases through the lens of light microscopy — and always curious about the unseen 🧠✨
Going for a rollercoaster ride on the spinal cord! 🤩
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
November 7, 2025 at 9:14 PM
Going for a rollercoaster ride on the spinal cord! 🤩
Reposted by Shaz (Shahrzad) Bahrampour
Great to be in Toronto for the Second AG meeting for @tridentpct.bsky.social where our 🐁 molecular and cognition core will show what we are up to in the last 2 years facilitated by @touchscreencog.bsky.social and we will continue to learn about our organoid and marmoset models.
November 3, 2025 at 1:00 PM
Great to be in Toronto for the Second AG meeting for @tridentpct.bsky.social where our 🐁 molecular and cognition core will show what we are up to in the last 2 years facilitated by @touchscreencog.bsky.social and we will continue to learn about our organoid and marmoset models.
Reposted by Shaz (Shahrzad) Bahrampour
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
October 31, 2025 at 1:53 PM
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
Reposted by Shaz (Shahrzad) Bahrampour
Is it candy? Nope, it is a spooky 👻 cleared mouse 🧠 used for #fluorescencefriday movies
October 24, 2025 at 5:04 PM
Is it candy? Nope, it is a spooky 👻 cleared mouse 🧠 used for #fluorescencefriday movies
Lightsheet Meeting Series in Oct, @mind-western.bsky.social , pleasure to host Christopher Pfeiffer-Kelly of LifeCanvas Technologies Inc. @lifecanvastech.bsky.social @braincanada.bsky.social @maximoprado.bsky.social🔬🤩🧠
Had a great time at the @mind-western.bsky.social Lightsheet Meeting Series this week, an amazing, interactive talk led by Christopher Pfeiffer-Kelly of LifeCanvas Technologies Inc. @braincanada.bsky.social @maximoprado.bsky.social🔬🖥️🤩
October 25, 2025 at 1:39 AM
Lightsheet Meeting Series in Oct, @mind-western.bsky.social , pleasure to host Christopher Pfeiffer-Kelly of LifeCanvas Technologies Inc. @lifecanvastech.bsky.social @braincanada.bsky.social @maximoprado.bsky.social🔬🤩🧠
Reposted by Shaz (Shahrzad) Bahrampour
#fluorescencefriday Side by side comparison of alpha synuclein S129 (magenta), a marker of #parkinson’s , in M83 hemyzigous mice injected with human pre formed fibrils @shahrzadbahrampour.bsky.social Vlad Novikov clearing with SHIELD @lifecanvastech.bsky.social imaged at MIND platform @westernu.ca
October 24, 2025 at 4:56 PM
#fluorescencefriday Side by side comparison of alpha synuclein S129 (magenta), a marker of #parkinson’s , in M83 hemyzigous mice injected with human pre formed fibrils @shahrzadbahrampour.bsky.social Vlad Novikov clearing with SHIELD @lifecanvastech.bsky.social imaged at MIND platform @westernu.ca
Reposted by Shaz (Shahrzad) Bahrampour
Had a great time at the @mind-western.bsky.social Lightsheet Meeting Series this week, an amazing, interactive talk led by Christopher Pfeiffer-Kelly of LifeCanvas Technologies Inc. @braincanada.bsky.social @maximoprado.bsky.social🔬🖥️🤩
October 15, 2025 at 1:55 PM
Had a great time at the @mind-western.bsky.social Lightsheet Meeting Series this week, an amazing, interactive talk led by Christopher Pfeiffer-Kelly of LifeCanvas Technologies Inc. @braincanada.bsky.social @maximoprado.bsky.social🔬🖥️🤩
Reposted by Shaz (Shahrzad) Bahrampour
Follow an exciting new brain imaging platform, @mind-western.bsky.social, partnering group of #TRIDENT. Article about it linked below! 👇🔬👀
www.schulich.uwo.ca/about/news-e...
www.schulich.uwo.ca/about/news-e...
Researchers launch brain imaging platform with $2.9M boost from Brain Canada - Schulich School of Medicine & Dentistry - Western University
A new high-resolution imaging platform is revealing the brain in extraordinary detail – and sharing the data with scientists worldwide.
www.schulich.uwo.ca
October 1, 2025 at 5:14 PM
Follow an exciting new brain imaging platform, @mind-western.bsky.social, partnering group of #TRIDENT. Article about it linked below! 👇🔬👀
www.schulich.uwo.ca/about/news-e...
www.schulich.uwo.ca/about/news-e...
Reposted by Shaz (Shahrzad) Bahrampour
#fluorescencefriday special. Half marmoset 🧠 cleared and stained using SHIELD and imaged by lightsheet microscopy. Courtesy of Jesleen Saini @shahrzadbahrampour.bsky.social and @stefan-everling.bsky.social
October 3, 2025 at 4:00 PM
#fluorescencefriday special. Half marmoset 🧠 cleared and stained using SHIELD and imaged by lightsheet microscopy. Courtesy of Jesleen Saini @shahrzadbahrampour.bsky.social and @stefan-everling.bsky.social
Reposted by Shaz (Shahrzad) Bahrampour
Great collaborative effort to get this done
#fluorescencefriday special. Half marmoset 🧠 cleared and stained using SHIELD and imaged by lightsheet microscopy. Courtesy of Jesleen Saini @shahrzadbahrampour.bsky.social and @stefan-everling.bsky.social
October 3, 2025 at 4:03 PM
Great collaborative effort to get this done
Reposted by Shaz (Shahrzad) Bahrampour
How does the brain work?
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
April 9, 2025 at 3:03 PM
How does the brain work?
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
🧠📈
Reposted by Shaz (Shahrzad) Bahrampour
It is #fluorescencefriday and the MIND platform @touchscreencog.bsky.social @tridentpct.bsky.social invites you to see brain blood vessels stained with CD31 and imaged by lightsheet. 🐁 🧠 cleared with SHIELD . thanks as always to @shahrzadbahrampour.bsky.social @arashsalah.bsky.social and company.
September 12, 2025 at 2:11 PM
It is #fluorescencefriday and the MIND platform @touchscreencog.bsky.social @tridentpct.bsky.social invites you to see brain blood vessels stained with CD31 and imaged by lightsheet. 🐁 🧠 cleared with SHIELD . thanks as always to @shahrzadbahrampour.bsky.social @arashsalah.bsky.social and company.
Reposted by Shaz (Shahrzad) Bahrampour
Hey #AAIC25 check out Arash’s presentation today at 8 AM and see some cool whole brain videos of the vasculaturs and plaques plus touchscreen testing
room 106
Evaluating the Efficacy and Risks of Early Lecanemab Treatment in APOE4 Humanized Alzheimer’s Disease Mouse Models
also poster 151
room 106
Evaluating the Efficacy and Risks of Early Lecanemab Treatment in APOE4 Humanized Alzheimer’s Disease Mouse Models
also poster 151
July 28, 2025 at 10:57 AM
Hey #AAIC25 check out Arash’s presentation today at 8 AM and see some cool whole brain videos of the vasculaturs and plaques plus touchscreen testing
room 106
Evaluating the Efficacy and Risks of Early Lecanemab Treatment in APOE4 Humanized Alzheimer’s Disease Mouse Models
also poster 151
room 106
Evaluating the Efficacy and Risks of Early Lecanemab Treatment in APOE4 Humanized Alzheimer’s Disease Mouse Models
also poster 151
Reposted by Shaz (Shahrzad) Bahrampour
#FluorescenceFriday Testing a new microscope. Microglia (yellow) and S129 alpha synuclein (magenta) and nuclei (blue) spinning disc confocal image @leicamicrosystems.bsky.social
August 29, 2025 at 5:47 PM
#FluorescenceFriday Testing a new microscope. Microglia (yellow) and S129 alpha synuclein (magenta) and nuclei (blue) spinning disc confocal image @leicamicrosystems.bsky.social
Reposted by Shaz (Shahrzad) Bahrampour
Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by abnormal accumulation of the RNA-binding protein TDP-43. Using a mouse model that mildly overexpresses human ...
onlinelibrary.wiley.com
August 23, 2025 at 11:25 AM
Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Shaz (Shahrzad) Bahrampour
a second rendering for #fluorescencefriday
August 15, 2025 at 6:32 PM
a second rendering for #fluorescencefriday
Reposted by Shaz (Shahrzad) Bahrampour
Our new interest: blood vessels and amyloid plaque interactions after lecanemab treatment of an ApoE4 AD mouse line #fluorescenceFriday @arashsalah.bsky.social and @shahrzadbahrampour.bsky.social for credits
August 15, 2025 at 6:11 PM
Our new interest: blood vessels and amyloid plaque interactions after lecanemab treatment of an ApoE4 AD mouse line #fluorescenceFriday @arashsalah.bsky.social and @shahrzadbahrampour.bsky.social for credits
Reposted by Shaz (Shahrzad) Bahrampour
Hot off the press Huge congrats to Alycia Crook a PhD student from the lab www.nature.com/articles/s41...
Characterization of a novel transgenic mouse model to investigate brain-wide activation of astrocyte Gq signaling - Lab Animal
This study uses a transgenic mouse line expressing Cre-inducible astro-hM3Dq to study astrocytes’ role in neuroinflammation and cognition without the use of viral transduction, mitigating the potentia...
www.nature.com
July 24, 2025 at 10:58 AM
Hot off the press Huge congrats to Alycia Crook a PhD student from the lab www.nature.com/articles/s41...
3D STED of PSD95-STAR RED, in cleared mouse brain tissue. 50% TauSTED 3D (left) and 100% TauSTED 3D (right), showing the difference in the axial resolution decrease from 274nm (left) to 143nm(right)! Sample prepared by Thomas Stroh group
Montreal Neurological Institute
(MNI). #MLMC 2025-July.
Montreal Neurological Institute
(MNI). #MLMC 2025-July.
July 27, 2025 at 7:00 PM
3D STED of PSD95-STAR RED, in cleared mouse brain tissue. 50% TauSTED 3D (left) and 100% TauSTED 3D (right), showing the difference in the axial resolution decrease from 274nm (left) to 143nm(right)! Sample prepared by Thomas Stroh group
Montreal Neurological Institute
(MNI). #MLMC 2025-July.
Montreal Neurological Institute
(MNI). #MLMC 2025-July.
Reposted by Shaz (Shahrzad) Bahrampour
late for #fluorescenceFriday. Here are our efforts to look at blood vessels in the 🧠 and of course Abeta plaques @touchscreencog.bsky.social @tridentpct.bsky.social
July 18, 2025 at 10:39 PM
late for #fluorescenceFriday. Here are our efforts to look at blood vessels in the 🧠 and of course Abeta plaques @touchscreencog.bsky.social @tridentpct.bsky.social
Reposted by Shaz (Shahrzad) Bahrampour
#fluorescencefriday blood vessels and amyloid plaques in a 🐭 model of AD. courtesy of @shahrzadbahrampour.bsky.social Luke Smolders and Arash Salahinejad @tridentpct.bsky.social @touchscreencog.bsky.social We will be 🔜 opening up for external services and collaborations via MIND @westernu.ca
July 11, 2025 at 6:58 PM
#fluorescencefriday blood vessels and amyloid plaques in a 🐭 model of AD. courtesy of @shahrzadbahrampour.bsky.social Luke Smolders and Arash Salahinejad @tridentpct.bsky.social @touchscreencog.bsky.social We will be 🔜 opening up for external services and collaborations via MIND @westernu.ca
Reposted by Shaz (Shahrzad) Bahrampour
For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social
June 13, 2025 at 5:35 PM
For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social
Reposted by Shaz (Shahrzad) Bahrampour
#fluorescencefriday a 🧠 full of amyloid courtesy of @shahrzadbahrampour.bsky.social
May 30, 2025 at 6:54 PM
#fluorescencefriday a 🧠 full of amyloid courtesy of @shahrzadbahrampour.bsky.social
Reposted by Shaz (Shahrzad) Bahrampour
#fluorescencefriday we take a look at blood vessels (yellow CD31) and amyloid (blue).
May 23, 2025 at 7:26 PM
#fluorescencefriday we take a look at blood vessels (yellow CD31) and amyloid (blue).
Reposted by Shaz (Shahrzad) Bahrampour
Did you miss @maximoprado.bsky.social and @mallarchak.bsky.social's presentation at #hbhlsymposium2025? You can get a glimpse of their work in this short video that capped their talk.
youtu.be
May 7, 2025 at 1:30 PM
Did you miss @maximoprado.bsky.social and @mallarchak.bsky.social's presentation at #hbhlsymposium2025? You can get a glimpse of their work in this short video that capped their talk.