LifeCanvas Technologies
@lifecanvastech.bsky.social
Pioneering end-to-end solutions for 3D spatial biology.
www.lifecanvastech.com
www.lifecanvastech.com
How did we create this multi-sample, multi-label video for #FluorescenceFriday? 🤔 Actually, pretty easily. These samples were imaged together in a 12-well plate with our new DALISPIM light sheet microscope. No re-plating, no immersion bath.
January 23, 2026 at 2:31 PM
How did we create this multi-sample, multi-label video for #FluorescenceFriday? 🤔 Actually, pretty easily. These samples were imaged together in a 12-well plate with our new DALISPIM light sheet microscope. No re-plating, no immersion bath.
Astrocytes 🌟 have been shown to play a role in β-amyloid plaque clearance, making them a prospective target for treating neurodegenerative diseases. This #FluorescenceFriday video provides a close-up of astrocytes + plaques in a thick section of human brain tissue imaged w/ #MegaSPIM.
January 16, 2026 at 3:13 PM
Astrocytes 🌟 have been shown to play a role in β-amyloid plaque clearance, making them a prospective target for treating neurodegenerative diseases. This #FluorescenceFriday video provides a close-up of astrocytes + plaques in a thick section of human brain tissue imaged w/ #MegaSPIM.
Congrats to newly-minted PhD Dr. Anne Wells! Her work examines the neurodevelopmental role of transcription factor TBX1 in 22q11.2 deletion syndrome, a genetic disorder characterized by cognitive defects & psychiatric symptoms. Read her latest preprint to learn more: bit.ly/4sCURiZ
January 14, 2026 at 5:06 PM
Congrats to newly-minted PhD Dr. Anne Wells! Her work examines the neurodevelopmental role of transcription factor TBX1 in 22q11.2 deletion syndrome, a genetic disorder characterized by cognitive defects & psychiatric symptoms. Read her latest preprint to learn more: bit.ly/4sCURiZ
Calling all MA-based biologists: want to learn about LifeCanvas resources near you? 🔬 Join us at the Massachusetts Life Sciences Center's Convening of the Cores, a free event highlighting core facilities available to the local life sciences community. Learn more and RSVP: bit.ly/4sxfsFr
January 12, 2026 at 2:06 PM
Calling all MA-based biologists: want to learn about LifeCanvas resources near you? 🔬 Join us at the Massachusetts Life Sciences Center's Convening of the Cores, a free event highlighting core facilities available to the local life sciences community. Learn more and RSVP: bit.ly/4sxfsFr
Safely and thoroughly removing lipids from tissues (like these mouse 🫁s) is crucial for high-quality data worthy of #MicroscopyMonday. From now til the end of Jan, you can share your samples cleared with SmartBatch+, tag us, and kick off your 2026 experiments with a fresh set of discounted reagents.
January 5, 2026 at 6:38 PM
Safely and thoroughly removing lipids from tissues (like these mouse 🫁s) is crucial for high-quality data worthy of #MicroscopyMonday. From now til the end of Jan, you can share your samples cleared with SmartBatch+, tag us, and kick off your 2026 experiments with a fresh set of discounted reagents.
What a great start to the New Year! 🎉 Thrilled to see the MLSC funding #innovation across the state. We're proud to collaborate with Dr. Peter Sorger's lab, where our tech will enable deep spatial profiling of solid tumors to improve health outcomes. Stay tuned for more details...
bit.ly/49ohTBp
bit.ly/49ohTBp
Healey-Driscoll Administration Announces More Than $20 Million in Life Sciences Funding to Support Advancements in Research Infrastructure, Data Science, and Drug Delivery
Stay up to date with news, announcements, and insights from the Massachusetts Life Sciences Center, including programs, funding initiatives, and industry updates.
bit.ly
January 2, 2026 at 3:02 PM
What a great start to the New Year! 🎉 Thrilled to see the MLSC funding #innovation across the state. We're proud to collaborate with Dr. Peter Sorger's lab, where our tech will enable deep spatial profiling of solid tumors to improve health outcomes. Stay tuned for more details...
bit.ly/49ohTBp
bit.ly/49ohTBp
Reposted by LifeCanvas Technologies
2026 Light Sheet Fluorescence Microscopy, May 31–June 6
This course brings together academic, industry and lab innovators to share the latest developments taking place in light-sheet research and its biological applications.
#lightsheet #fluorescencemicroscopy #microscopy 🧪 🍎 #microscopymonday
This course brings together academic, industry and lab innovators to share the latest developments taking place in light-sheet research and its biological applications.
#lightsheet #fluorescencemicroscopy #microscopy 🧪 🍎 #microscopymonday
Light Sheet Fluorescence Microscopy 2026
mdibl.org
December 23, 2025 at 3:00 PM
2026 Light Sheet Fluorescence Microscopy, May 31–June 6
This course brings together academic, industry and lab innovators to share the latest developments taking place in light-sheet research and its biological applications.
#lightsheet #fluorescencemicroscopy #microscopy 🧪 🍎 #microscopymonday
This course brings together academic, industry and lab innovators to share the latest developments taking place in light-sheet research and its biological applications.
#lightsheet #fluorescencemicroscopy #microscopy 🧪 🍎 #microscopymonday
We're thankful for our scientific community and all of the opportunities we've had to learn, experiment, and see the world. Our team has collaborated on amazing projects that are both expanding our knowledge of biological systems and improving lives. Check out some highlights in this 🧵 (1/2)
December 22, 2025 at 2:45 PM
We're thankful for our scientific community and all of the opportunities we've had to learn, experiment, and see the world. Our team has collaborated on amazing projects that are both expanding our knowledge of biological systems and improving lives. Check out some highlights in this 🧵 (1/2)
This festive #FluorescenceFriday 🎄 image shows a close up of CTIP2 (green) and IBA-1 (red) in the striatum of a whole mouse brain. In adults, CTIP2 marks medium spiny neurons in the striatum and some cortical layers. IBA-1 marks microglia, which are key neural immune cells.
December 19, 2025 at 1:32 PM
This festive #FluorescenceFriday 🎄 image shows a close up of CTIP2 (green) and IBA-1 (red) in the striatum of a whole mouse brain. In adults, CTIP2 marks medium spiny neurons in the striatum and some cortical layers. IBA-1 marks microglia, which are key neural immune cells.
Before we all clear our minds of 2026, we want to see what else you’ve cleared! Show us your SmartBatch+ processed tissue and receive 25% off your next full pipeline reagent kit order.
#3DThursday #tissueclearing
#3DThursday #tissueclearing
December 18, 2025 at 3:06 PM
Before we all clear our minds of 2026, we want to see what else you’ve cleared! Show us your SmartBatch+ processed tissue and receive 25% off your next full pipeline reagent kit order.
#3DThursday #tissueclearing
#3DThursday #tissueclearing
We had a great time co-hosting a workshop on our 3D #bioimaging pipeline with Dr. @hjchoimd.bsky.social's lab at Seoul National University! We also held a #biotech career mentorship session with members of our Data Engineering & Analysis team. Pictured below: Dr. Younghee Lee introducing our team.
December 17, 2025 at 6:45 PM
We had a great time co-hosting a workshop on our 3D #bioimaging pipeline with Dr. @hjchoimd.bsky.social's lab at Seoul National University! We also held a #biotech career mentorship session with members of our Data Engineering & Analysis team. Pictured below: Dr. Younghee Lee introducing our team.
Reposted by LifeCanvas Technologies
“Basic neuroscience hasn’t produced new drugs.” 💊
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
How basic neuroscience has paved the path to new drugs
A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research.
www.thetransmitter.org
December 15, 2025 at 3:15 PM
“Basic neuroscience hasn’t produced new drugs.” 💊
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
In this study led by Professors Eric Hwang (NYCU), Li-An Chu (NTHU), & Shang-Hsiu Hu (NTHU), Wan-Chi Pan et al. used the LifeCanvas pipeline to demonstrate how electrical stimulation combined with a conductive granular scaffold can promote nerve repair in traumatic #braininjury: bit.ly/44tU8X3
In Situ Magnetoelectric Generation of miRNA Sponges and Wireless Electric Stimulus by Conductive Granular Scaffolds for Nerve Regeneration
A conductive granular scaffold (cGRAS) is developed to enable wireless electrical stimulation and targeted miRNA modulation for traumatic brain injury (TBI) repair. Acting as both an antenna and a ge....
bit.ly
December 15, 2025 at 4:40 PM
In this study led by Professors Eric Hwang (NYCU), Li-An Chu (NTHU), & Shang-Hsiu Hu (NTHU), Wan-Chi Pan et al. used the LifeCanvas pipeline to demonstrate how electrical stimulation combined with a conductive granular scaffold can promote nerve repair in traumatic #braininjury: bit.ly/44tU8X3
Fabulous #SmartSPIM video of a mouse spinal cord!
Spinal motor neurons in dazzling detail. ✨
Each green dot is a spinal motor neuron - crucial but rare cells making up just 1% of neurons in the spinal cord. In diseases like ALS, they are selectively damaged, making them of special interest to neuroscientists.
#neuroskyence #FluorescenceFriday
Each green dot is a spinal motor neuron - crucial but rare cells making up just 1% of neurons in the spinal cord. In diseases like ALS, they are selectively damaged, making them of special interest to neuroscientists.
#neuroskyence #FluorescenceFriday
December 12, 2025 at 9:13 PM
Fabulous #SmartSPIM video of a mouse spinal cord!
Psilocybin can have profound effects on #neuroplasticity. But how exactly does it alter the brain’s circuitry? This #FluorescenceFriday, we’re sharing brand new data from @alexkwan.bsky.social’s lab showing distinct brain-wide effects of psilocybin on two neuronal subpopulations. 🧵 (1/4)
December 12, 2025 at 2:05 PM
Psilocybin can have profound effects on #neuroplasticity. But how exactly does it alter the brain’s circuitry? This #FluorescenceFriday, we’re sharing brand new data from @alexkwan.bsky.social’s lab showing distinct brain-wide effects of psilocybin on two neuronal subpopulations. 🧵 (1/4)
We kicked off this month by co-hosting two workshops in Texas at @mdanderson.bsky.social & @utaustin.bsky.social #Microscopy Cores. Thanks Drs. Collene Jeter, Chad Quarles, Han Yang, and Anna Webb for your support and expertise! (Peep the #SmartSPIM mouse head image behind Han in the left photo 👀)
December 11, 2025 at 2:27 PM
We kicked off this month by co-hosting two workshops in Texas at @mdanderson.bsky.social & @utaustin.bsky.social #Microscopy Cores. Thanks Drs. Collene Jeter, Chad Quarles, Han Yang, and Anna Webb for your support and expertise! (Peep the #SmartSPIM mouse head image behind Han in the left photo 👀)
Congratulations to Jesleen Saini on her recent thesis defense! A Master's student at @westernu.ca, Jesleen used SmartBatch+ #tissueclearing of intact marmoset brains to investigate how synucleinopathies develop in this model species: bit.ly/4aC30NS
@mind-western.bsky.social @tridentpct.bsky.social
@mind-western.bsky.social @tridentpct.bsky.social
December 10, 2025 at 3:11 PM
Congratulations to Jesleen Saini on her recent thesis defense! A Master's student at @westernu.ca, Jesleen used SmartBatch+ #tissueclearing of intact marmoset brains to investigate how synucleinopathies develop in this model species: bit.ly/4aC30NS
@mind-western.bsky.social @tridentpct.bsky.social
@mind-western.bsky.social @tridentpct.bsky.social
Catch us on the last day of #CellBio25 at booth 228!
Check out some cleared tissues, explore 3D datasets, and learn how our end-to-end pipeline for #spatialbiology can add a new dimension to your research. Let's expand the boundaries of #cellbiology and explore cellular processes in context 🔬
Check out some cleared tissues, explore 3D datasets, and learn how our end-to-end pipeline for #spatialbiology can add a new dimension to your research. Let's expand the boundaries of #cellbiology and explore cellular processes in context 🔬
December 9, 2025 at 2:04 PM
Catch us on the last day of #CellBio25 at booth 228!
Check out some cleared tissues, explore 3D datasets, and learn how our end-to-end pipeline for #spatialbiology can add a new dimension to your research. Let's expand the boundaries of #cellbiology and explore cellular processes in context 🔬
Check out some cleared tissues, explore 3D datasets, and learn how our end-to-end pipeline for #spatialbiology can add a new dimension to your research. Let's expand the boundaries of #cellbiology and explore cellular processes in context 🔬
Congratulations! 🥳 Check out this exciting application of whole-brain FOS mapping 👇
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
December 9, 2025 at 1:35 PM
Congratulations! 🥳 Check out this exciting application of whole-brain FOS mapping 👇
Reposted by LifeCanvas Technologies
This is what’s under the skin of DALISPIM, the new opentop #lightsheet #microscope from @lifecanvastech.bsky.social. What’s tough to see is the chamber with deformable interfaces allowing plates or dishes to translate in XY&Z and multimmersion objectives to collect photons. Legit, right?
December 8, 2025 at 10:52 PM
This is what’s under the skin of DALISPIM, the new opentop #lightsheet #microscope from @lifecanvastech.bsky.social. What’s tough to see is the chamber with deformable interfaces allowing plates or dishes to translate in XY&Z and multimmersion objectives to collect photons. Legit, right?
You've seen our transparent samples... now we want to see YOURS! If you're sharing 3D #MicroscopyMonday data, we know you've got some forbidden gummies floating around the lab.
Post your cleared tissues, tag us, and snag a discount for your next order of SmartBatch+ reagent kits! #tissueclearing
Post your cleared tissues, tag us, and snag a discount for your next order of SmartBatch+ reagent kits! #tissueclearing
December 8, 2025 at 3:46 PM
You've seen our transparent samples... now we want to see YOURS! If you're sharing 3D #MicroscopyMonday data, we know you've got some forbidden gummies floating around the lab.
Post your cleared tissues, tag us, and snag a discount for your next order of SmartBatch+ reagent kits! #tissueclearing
Post your cleared tissues, tag us, and snag a discount for your next order of SmartBatch+ reagent kits! #tissueclearing
Change how you see 👀 your samples with #DALISPIM light-sheet imaging. Here, nuclear staining (magenta) shows thick layers of retinal cells on the back of the eyeball connecting to the optic nerve, with a thin layer of cells over the cornea. What else do you want to see labeled? #FluorescenceFriday
December 5, 2025 at 3:20 PM
Change how you see 👀 your samples with #DALISPIM light-sheet imaging. Here, nuclear staining (magenta) shows thick layers of retinal cells on the back of the eyeball connecting to the optic nerve, with a thin layer of cells over the cornea. What else do you want to see labeled? #FluorescenceFriday
We’re gearing up to head to #CellBio2025, the joint annual meeting of @ascbiology.bsky.social and @embo.org. Meet up with our team at booth 228 to learn how whole-tissue imaging can add a new dimension to your #cellbiology research. 🧫
December 4, 2025 at 3:18 PM
We’re gearing up to head to #CellBio2025, the joint annual meeting of @ascbiology.bsky.social and @embo.org. Meet up with our team at booth 228 to learn how whole-tissue imaging can add a new dimension to your #cellbiology research. 🧫
What can you discover with one powerful, streamlined pipeline for 3D #SpatialBiology?
Researchers in @katrinachoe.bsky.social's lab used whole-brain labeling, clearing, imaging, and ML-based cell detection to quantify OXT+ neurons across part of the hypothalamus called the PVN 🧵 (1/4)
Researchers in @katrinachoe.bsky.social's lab used whole-brain labeling, clearing, imaging, and ML-based cell detection to quantify OXT+ neurons across part of the hypothalamus called the PVN 🧵 (1/4)
December 3, 2025 at 3:47 PM
What can you discover with one powerful, streamlined pipeline for 3D #SpatialBiology?
Researchers in @katrinachoe.bsky.social's lab used whole-brain labeling, clearing, imaging, and ML-based cell detection to quantify OXT+ neurons across part of the hypothalamus called the PVN 🧵 (1/4)
Researchers in @katrinachoe.bsky.social's lab used whole-brain labeling, clearing, imaging, and ML-based cell detection to quantify OXT+ neurons across part of the hypothalamus called the PVN 🧵 (1/4)
Our data engineering & analysis team is excited to trade New England winter for sunny San Diego to attend #NeurIPS2025! We're especially looking forward to the workshop on "Imageomics: Discovering Biological Knowledge from Images Using AI". @neuripsconf.bsky.social #bioimaging
December 1, 2025 at 3:07 PM
Our data engineering & analysis team is excited to trade New England winter for sunny San Diego to attend #NeurIPS2025! We're especially looking forward to the workshop on "Imageomics: Discovering Biological Knowledge from Images Using AI". @neuripsconf.bsky.social #bioimaging