Tal Nuriel, PhD
@talnuriel.bsky.social
Assistant Professor at Columbia University Irving Medical Center. My lab studies the role of APOE4 in Alzheimer’s disease pathogenesis. Opinions are my own.
Love this story (although the headline’s a little misleading). apple.news/A5noSQhLDRdu...
6-year-old girl comes to the rescue of Harvard researchers studying the axolotl — CBS News
Earlier this year, a Harvard research team studying the axolotl, a salamander with the superpower to regrow body parts, lost almost all its government funding.
apple.news
November 8, 2025 at 11:17 AM
Love this story (although the headline’s a little misleading). apple.news/A5noSQhLDRdu...
I feel slightly less guilty about using AI to help me write a grant about an AI-based project. But that might be how the machines want me to feel.
November 6, 2025 at 10:35 PM
I feel slightly less guilty about using AI to help me write a grant about an AI-based project. But that might be how the machines want me to feel.
Reposted by Tal Nuriel, PhD
While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
Sex-specific factors and APOEε4 genotype alter functional connectivity at middle age
Cognitive aging is influenced by sex and sex-specific factors. Indeed, research has shown that parity (pregnancy and parenthood) uniquely alters bioma…
www.sciencedirect.com
October 31, 2025 at 5:59 PM
While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...
Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.
and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz
October 31, 2025 at 4:12 PM
Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.
Reposted by Tal Nuriel, PhD
In the mood for something sciency and spooky? How about the Halloween special of @uclbrainstories.bsky.social - where me and @caswell.bsky.social talk to @drjlange.bsky.social on some of the gothic stories in neuroscience! 👻 🧠 🎃 💀🧟♂️
spotify.link/2lHT9pLQRXb
spotify.link/2lHT9pLQRXb
Episode 23- Jenny Lange on the gothic history of neuroscience, a Halloween special
spotify.link
October 29, 2025 at 6:56 PM
In the mood for something sciency and spooky? How about the Halloween special of @uclbrainstories.bsky.social - where me and @caswell.bsky.social talk to @drjlange.bsky.social on some of the gothic stories in neuroscience! 👻 🧠 🎃 💀🧟♂️
spotify.link/2lHT9pLQRXb
spotify.link/2lHT9pLQRXb
Don't worry folks! Pretty soon we'll go from having a 0% chance of getting grants (govt shutdown) to having a 5% chance of getting grants (continuing resolution and multi-year funding). But that's only temporary...eventually, it'll go back to the easy-peasy 10-15% funding lines we all know and love.
October 29, 2025 at 6:32 PM
Don't worry folks! Pretty soon we'll go from having a 0% chance of getting grants (govt shutdown) to having a 5% chance of getting grants (continuing resolution and multi-year funding). But that's only temporary...eventually, it'll go back to the easy-peasy 10-15% funding lines we all know and love.
Very interesting
'Interplay between #astrocyte reactivity and #APOE ε4 status is associated with accelerated #pTau-related tau pathology in #AlzheimersDisease'
Xiaoxie Mao, Yan Wang, Ying Luan, Ying Wang...Binyin Li, Zijing Li, Qihao Guo, Fang Xie
molecularneurodegeneration.biomedcentral.com/articles/10....
Xiaoxie Mao, Yan Wang, Ying Luan, Ying Wang...Binyin Li, Zijing Li, Qihao Guo, Fang Xie
molecularneurodegeneration.biomedcentral.com/articles/10....
Interplay between astrocyte reactivity and APOE ε4 status is associated with accelerated pTau-related tau pathology in Alzheimer’s disease - Molecular Neurodegeneration
Various plasma phosphorylated tau species have been shown to be associated with amyloid-β (Aβ) PET and Tau PET in Alzheimer’s disease (AD), but whether APOE ε4 affects the interaction between glial fi...
molecularneurodegeneration.biomedcentral.com
October 29, 2025 at 4:06 PM
Very interesting
That's a hell of a figure. www.alzforum.org/news/researc...
October 28, 2025 at 7:24 PM
That's a hell of a figure. www.alzforum.org/news/researc...
Hmm. Reading about oxygen administration for preterm babies and the potential for hyperoxia and oxidative stress, and that is a topic that I’ve heard zero info about up until now.
October 27, 2025 at 3:51 PM
Hmm. Reading about oxygen administration for preterm babies and the potential for hyperoxia and oxidative stress, and that is a topic that I’ve heard zero info about up until now.
Pushing through my skepticism to review these K99 and K01 applications I've been assigned. The good news is that there are some tremendous applicants that could contribute so much if given the chance. The bad news is that there's no way to give them a chance if the govt doesn't open back up.
October 24, 2025 at 3:48 PM
Pushing through my skepticism to review these K99 and K01 applications I've been assigned. The good news is that there are some tremendous applicants that could contribute so much if given the chance. The bad news is that there's no way to give them a chance if the govt doesn't open back up.
Reposted by Tal Nuriel, PhD
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics
Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...
pubs.acs.org
October 24, 2025 at 12:17 PM
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Is it sad that my first thought was: a five year cell culture experiment isn't that bad. There would still be two years left to finish up their PhD or postdoc 😭 😭https://www.alzforum.org/news/research-news/neurons-born-and-raised-organoids-act-their-age
Neurons Born and Raised in Organoids Act Their Age | ALZFORUM
www.alzforum.org
October 23, 2025 at 2:53 PM
Is it sad that my first thought was: a five year cell culture experiment isn't that bad. There would still be two years left to finish up their PhD or postdoc 😭 😭https://www.alzforum.org/news/research-news/neurons-born-and-raised-organoids-act-their-age
Reposted by Tal Nuriel, PhD
Link to buy below. Even as a 43yo neuroscientist I enjoyed a lot! I mean… who wouldn’ love a book that has monkeys with robot arms & pirate kittens!
uk.bookshop.org/p/books/insi...
uk.bookshop.org/p/books/insi...
October 22, 2025 at 6:49 AM
Link to buy below. Even as a 43yo neuroscientist I enjoyed a lot! I mean… who wouldn’ love a book that has monkeys with robot arms & pirate kittens!
uk.bookshop.org/p/books/insi...
uk.bookshop.org/p/books/insi...
Currently reviewing grants for a study section that probably won't happen. Whose idea was it to link the success our scientific enterprise with the proper functioning of the federal government?
October 20, 2025 at 4:12 PM
Currently reviewing grants for a study section that probably won't happen. Whose idea was it to link the success our scientific enterprise with the proper functioning of the federal government?
Reposted by Tal Nuriel, PhD
Tenure-track Investigator Vacancy, Brown University Center for Alzheimer’s Disease Research. Join Carney Institute exploring neurodegeneration and dementia. Closing date: 1st November
www.dementiaresearcher.nihr.ac.uk/job/assistan...
www.dementiaresearcher.nihr.ac.uk/job/assistan...
Assistant Professor: Center for Alzheimer’s Research
Tenure-track Investigator, Brown University Center for Alzheimer’s Disease Research. Join Carney Institute exploring neurodegeneration and dementia.
www.dementiaresearcher.nihr.ac.uk
October 12, 2025 at 10:06 PM
Tenure-track Investigator Vacancy, Brown University Center for Alzheimer’s Disease Research. Join Carney Institute exploring neurodegeneration and dementia. Closing date: 1st November
www.dementiaresearcher.nihr.ac.uk/job/assistan...
www.dementiaresearcher.nihr.ac.uk/job/assistan...
Reposted by Tal Nuriel, PhD
PhD position, University of Manchester. Study how APOE genotype, menopause and exercise interact to influence vascular dysfunction and dementia risk in Alzheimer’s. Closing date: 8th November
www.dementiaresearcher.nihr.ac.uk/job/phd-alzh...
www.dementiaresearcher.nihr.ac.uk/job/phd-alzh...
PhD: Alzheimer’s risk in women, menopause, apoe & exercise
PhD position, University of Manchester. Study how APOE genotype, menopause & exercise interact to influence vascular dysfunction & dementia risk in Alzheimer’s
www.dementiaresearcher.nihr.ac.uk
October 12, 2025 at 10:14 PM
PhD position, University of Manchester. Study how APOE genotype, menopause and exercise interact to influence vascular dysfunction and dementia risk in Alzheimer’s. Closing date: 8th November
www.dementiaresearcher.nihr.ac.uk/job/phd-alzh...
www.dementiaresearcher.nihr.ac.uk/job/phd-alzh...
Reposted by Tal Nuriel, PhD
The 2nd of 6 faculty positions open at UNC Biology is for an Asst Professor studying critical questions in Plant Molecular Biology, focusing on molecular mechanisms illuminating fundamental aspects of plant biology, including interactions with other organisms 1/n
unc.peopleadmin.com/postings/307...
unc.peopleadmin.com/postings/307...
October 12, 2025 at 2:31 PM
The 2nd of 6 faculty positions open at UNC Biology is for an Asst Professor studying critical questions in Plant Molecular Biology, focusing on molecular mechanisms illuminating fundamental aspects of plant biology, including interactions with other organisms 1/n
unc.peopleadmin.com/postings/307...
unc.peopleadmin.com/postings/307...
Reposted by Tal Nuriel, PhD
Covid causes brain damage.
Edit: Covid causes serious long term brain damage, and here's a whole lot more data
"COVID-19 infection was associated with a 58% increased risk of all-cause dementia and a 105% increased risk of Vascular Dementia"
Free article:
www.nature.com/articles/s44...
Edit: Covid causes serious long term brain damage, and here's a whole lot more data
"COVID-19 infection was associated with a 58% increased risk of all-cause dementia and a 105% increased risk of Vascular Dementia"
Free article:
www.nature.com/articles/s44...
COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years - npj Dementia
npj Dementia - COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years
www.nature.com
October 5, 2025 at 1:19 AM
Covid causes brain damage.
Edit: Covid causes serious long term brain damage, and here's a whole lot more data
"COVID-19 infection was associated with a 58% increased risk of all-cause dementia and a 105% increased risk of Vascular Dementia"
Free article:
www.nature.com/articles/s44...
Edit: Covid causes serious long term brain damage, and here's a whole lot more data
"COVID-19 infection was associated with a 58% increased risk of all-cause dementia and a 105% increased risk of Vascular Dementia"
Free article:
www.nature.com/articles/s44...
Reposted by Tal Nuriel, PhD
Rocío is an amazing scientist, mentor, and person in general!!! Please share this job opening with anyone who might be interested 🤩🤩
We’re hiring!
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
My new Gut–Brain Axis Lab at Northwestern is looking for a Research Technologist 2 to help build the lab and explore how the nervous system shapes gut health and disease.
🔬 Apply here: myhr.northwestern.edu/psp/hrnu/EMP...
Sign In
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myhr.northwestern.edu
October 1, 2025 at 1:18 AM
Rocío is an amazing scientist, mentor, and person in general!!! Please share this job opening with anyone who might be interested 🤩🤩
Reposted by Tal Nuriel, PhD
Posting on behalf of Tamar Gollan, who is not on Bluesky:
A postdoc position is open and available immediately in Dr. Tamar Gollan’s Laboratory of Aging Bilingualism at the University of California, San Diego, funded by NIH & NSF. See link for details!
psychiatry.ucsd.edu/about/LAB_Go...
A postdoc position is open and available immediately in Dr. Tamar Gollan’s Laboratory of Aging Bilingualism at the University of California, San Diego, funded by NIH & NSF. See link for details!
psychiatry.ucsd.edu/about/LAB_Go...
psychiatry.ucsd.edu
September 30, 2025 at 8:29 PM
Posting on behalf of Tamar Gollan, who is not on Bluesky:
A postdoc position is open and available immediately in Dr. Tamar Gollan’s Laboratory of Aging Bilingualism at the University of California, San Diego, funded by NIH & NSF. See link for details!
psychiatry.ucsd.edu/about/LAB_Go...
A postdoc position is open and available immediately in Dr. Tamar Gollan’s Laboratory of Aging Bilingualism at the University of California, San Diego, funded by NIH & NSF. See link for details!
psychiatry.ucsd.edu/about/LAB_Go...
Attended a conference yesterday, and one of the speakers spent his whole talk airing his personal grievances about other scientists who he felt had wronged him throughout his career. Made me want to crawl out of my skin.
September 28, 2025 at 10:08 AM
Attended a conference yesterday, and one of the speakers spent his whole talk airing his personal grievances about other scientists who he felt had wronged him throughout his career. Made me want to crawl out of my skin.
Reposted by Tal Nuriel, PhD
Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks.
Huntington's disease successfully treated for first time www.bbc.com/news/article...
Huntington's disease successfully treated for first time www.bbc.com/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that could transform lives, tearful doctors tell BBC
www.bbc.com
September 24, 2025 at 12:20 PM
Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks.
Huntington's disease successfully treated for first time www.bbc.com/news/article...
Huntington's disease successfully treated for first time www.bbc.com/news/article...
I just read the paper out of Harvard that prompted this tylenol autism announcement. They make a strong argument that acetaminophen use during pregnancy may be causal for neurodevelopmental disorders and that its use should be limited ehjournal.biomedcentral.com/articles/10....
Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - Environmental Health
Background Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed...
ehjournal.biomedcentral.com
September 24, 2025 at 1:09 PM
I just read the paper out of Harvard that prompted this tylenol autism announcement. They make a strong argument that acetaminophen use during pregnancy may be causal for neurodevelopmental disorders and that its use should be limited ehjournal.biomedcentral.com/articles/10....
Sadly…and all so that they could meet some arbitrary September deadline that RFK Jr randomly blurted out.
"Americans cannot trust the federal government’s health advice" www.statnews.com/2025/09/23/t...
The U.S. government has jumped the public health shark
“The Trump regime sees science as an enemy and public health as only fit for personal anecdotes and conspiracy,” writes Arthur Caplan.
www.statnews.com
September 23, 2025 at 9:49 PM
Sadly…and all so that they could meet some arbitrary September deadline that RFK Jr randomly blurted out.
Reposted by Tal Nuriel, PhD
New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com
#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
New landscape of the diagnosis of Alzheimer's disease
Alzheimer's disease involves a drastic departure from the cognitive, functional, and
behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent
cause of disability to individu...
www.thelancet.com
September 23, 2025 at 7:25 PM
New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com
#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence