Sergiu P. Pasca
@sergiuppasca.bsky.social
Professor at Stanford & Director of Stanford Brain Organogenesis
Lab: https://pascalab.org
Center: http://www.brainorganogenesis.org
TED: https://go.ted.com/6WJy
Instagram: https://www.instagram.com/sergiu.p.pasca/
Lab: https://pascalab.org
Center: http://www.brainorganogenesis.org
TED: https://go.ted.com/6WJy
Instagram: https://www.instagram.com/sergiu.p.pasca/
Pinned
Sergiu P. Pasca
@sergiuppasca.bsky.social
· Nov 16
This spring, we reported in Nature a therapeutic approach for Timothy syndrome
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
A recent @npr.org piece by highlights the recent Asilomar meeting we organized on ethical considerations surrounding human stem cell models (#organoids & #assembloids and their transplantation), focusing on emergent questions and the potential to uncover new biology and therapeutics.
Audio below 👇
Audio below 👇
January 9, 2026 at 8:32 PM
A recent @npr.org piece by highlights the recent Asilomar meeting we organized on ethical considerations surrounding human stem cell models (#organoids & #assembloids and their transplantation), focusing on emergent questions and the potential to uncover new biology and therapeutics.
Audio below 👇
Audio below 👇
In our most recent publication in Nature Protocols, we outline detailed methods for performing CRISPR screens in neural #organoids and #assembloids.
The integration of these approaches is becoming increasingly powerful for uncovering human biology and gaining mechanistic insights into disease.
The integration of these approaches is becoming increasingly powerful for uncovering human biology and gaining mechanistic insights into disease.
December 23, 2025 at 11:32 PM
In our most recent publication in Nature Protocols, we outline detailed methods for performing CRISPR screens in neural #organoids and #assembloids.
The integration of these approaches is becoming increasingly powerful for uncovering human biology and gaining mechanistic insights into disease.
The integration of these approaches is becoming increasingly powerful for uncovering human biology and gaining mechanistic insights into disease.
Reposted by Sergiu P. Pasca
Applications closing at 6pm PT today!
Applications are pouring in for our international course on neural #assembloids taking place next spring on our beautiful Stanford campus
This is the LAST day to apply! No deadline extensions.
Please share 👇
This is the LAST day to apply! No deadline extensions.
Please share 👇
December 12, 2025 at 10:13 PM
Applications closing at 6pm PT today!
Applications are pouring in for our international course on neural #assembloids taking place next spring on our beautiful Stanford campus
This is the LAST day to apply! No deadline extensions.
Please share 👇
This is the LAST day to apply! No deadline extensions.
Please share 👇
December 12, 2025 at 6:44 PM
Applications are pouring in for our international course on neural #assembloids taking place next spring on our beautiful Stanford campus
This is the LAST day to apply! No deadline extensions.
Please share 👇
This is the LAST day to apply! No deadline extensions.
Please share 👇
Remarkable energy at the inaugural @cshlnews.bsky.social conference on Assembloids and complex cell–cell interactions across tissues and systems
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
December 10, 2025 at 8:50 PM
Remarkable energy at the inaugural @cshlnews.bsky.social conference on Assembloids and complex cell–cell interactions across tissues and systems
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
A wonderful series of talks so far highlighting advances & discoveries being made with these self-organizing systems and a few common themes are emerging
Reposted by Sergiu P. Pasca
Great meeting!!! Amazing talks and posters today also.
The inaugural conference on #assembloids and complex cell-cell interactions starting tonight at @cshlnews.bsky.social ! Amazing energy and inspiring opening keynote by Ruslan Medzhitov.
December 10, 2025 at 1:53 AM
Great meeting!!! Amazing talks and posters today also.
The inaugural conference on #assembloids and complex cell-cell interactions starting tonight at @cshlnews.bsky.social ! Amazing energy and inspiring opening keynote by Ruslan Medzhitov.
December 9, 2025 at 6:52 AM
The inaugural conference on #assembloids and complex cell-cell interactions starting tonight at @cshlnews.bsky.social ! Amazing energy and inspiring opening keynote by Ruslan Medzhitov.
In a recent with Jan Carette’s lab, we introduce an #assembloid model for studying neuro-infection with enteroviruses including poliovirus.
The videos below capture the loss of human muscle contraction, which is under the control of spinal cord neurons, after a week of infection.
The videos below capture the loss of human muscle contraction, which is under the control of spinal cord neurons, after a week of infection.
December 6, 2025 at 7:16 AM
In a recent with Jan Carette’s lab, we introduce an #assembloid model for studying neuro-infection with enteroviruses including poliovirus.
The videos below capture the loss of human muscle contraction, which is under the control of spinal cord neurons, after a week of infection.
The videos below capture the loss of human muscle contraction, which is under the control of spinal cord neurons, after a week of infection.
Deadline approaching for participating in the international Stanford Course on Neural Assembloids in spring 2026!
This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.
This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.
December 2, 2025 at 1:09 AM
Deadline approaching for participating in the international Stanford Course on Neural Assembloids in spring 2026!
This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.
This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.
Reposted by Sergiu P. Pasca
We are moving neuroscience forward with the support of our outstanding SAB. @marinlab.bsky.social @mbartos.bsky.social @sergiuppasca.bsky.social Luthi, Heneka, Sanchez-Vives & Moro
The Cajal Neuroscience Center announces the newly approved #ScientificAdvisoryBoard, established by #CSIC.
We welcome its members and appreciate their support to our scientific strategy.
SAB: O. Marín, A. Lüthi, M. Bartos, M. Heneka, M. Sánchez-Vives, S. Pasca, M. Á. Moro.
We welcome its members and appreciate their support to our scientific strategy.
SAB: O. Marín, A. Lüthi, M. Bartos, M. Heneka, M. Sánchez-Vives, S. Pasca, M. Á. Moro.
November 24, 2025 at 10:49 PM
We are moving neuroscience forward with the support of our outstanding SAB. @marinlab.bsky.social @mbartos.bsky.social @sergiuppasca.bsky.social Luthi, Heneka, Sanchez-Vives & Moro
Looking forward to joining this group!
The Cajal Neuroscience Center announces the newly approved #ScientificAdvisoryBoard, established by #CSIC.
We welcome its members and appreciate their support to our scientific strategy.
SAB: O. Marín, A. Lüthi, M. Bartos, M. Heneka, M. Sánchez-Vives, S. Pasca, M. Á. Moro.
We welcome its members and appreciate their support to our scientific strategy.
SAB: O. Marín, A. Lüthi, M. Bartos, M. Heneka, M. Sánchez-Vives, S. Pasca, M. Á. Moro.
December 2, 2025 at 1:02 AM
Looking forward to joining this group!
Reposted by Sergiu P. Pasca
Article in @science.org on the Asilomar neural organoids meeting Sergiu Pasca & I co-organized last week. www.science.org/content/arti...
Good summary...& we are still thinking about what comes next.
Good summary...& we are still thinking about what comes next.
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace?
Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology
www.science.org
November 20, 2025 at 6:42 PM
Article in @science.org on the Asilomar neural organoids meeting Sergiu Pasca & I co-organized last week. www.science.org/content/arti...
Good summary...& we are still thinking about what comes next.
Good summary...& we are still thinking about what comes next.
This week we introduced an #assembloid-based platform to begin studying how #enteroviruses affect human neuromuscular systems.
This is a collaboration with Jan Carette here at Stanford.
Work led by Christine Peters, Jimena Andersen and Min-Yin Li.
This is a collaboration with Jan Carette here at Stanford.
Work led by Christine Peters, Jimena Andersen and Min-Yin Li.
November 20, 2025 at 4:44 PM
This week we introduced an #assembloid-based platform to begin studying how #enteroviruses affect human neuromuscular systems.
This is a collaboration with Jan Carette here at Stanford.
Work led by Christine Peters, Jimena Andersen and Min-Yin Li.
This is a collaboration with Jan Carette here at Stanford.
Work led by Christine Peters, Jimena Andersen and Min-Yin Li.
Perspectives in @ScieMagazine after our Asilomar conferences on neural #organoids and #assembloids
www.science.org/content/arti...
www.science.org/content/arti...
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace?
Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology
www.science.org
November 20, 2025 at 8:17 AM
Perspectives in @ScieMagazine after our Asilomar conferences on neural #organoids and #assembloids
www.science.org/content/arti...
www.science.org/content/arti...
Some ideas and discussions from our recent Asilomar meeting on the ethics and societal implications of neural organoid and assembloid research
www.the-scientist.com/as-neural-or...
www.the-scientist.com/as-neural-or...
As Neural Organoid Research Accelerates, Scientists Discuss Ethics
Neuroscience experts convened in Asilomar to talk through guidelines around ethical research on human neural organoids.
www.the-scientist.com
November 19, 2025 at 6:33 AM
Some ideas and discussions from our recent Asilomar meeting on the ethics and societal implications of neural organoid and assembloid research
www.the-scientist.com/as-neural-or...
www.the-scientist.com/as-neural-or...
An amazing group of scientists, philosophers, legal scholars, ethicists, policy makers, patient advocates, funders and trainees convened at Asilomar for one of the most stimulating meetings I have had the privilege to organize, focused on the ethics of research with neural #organoids & #assembloids
November 14, 2025 at 6:56 PM
An amazing group of scientists, philosophers, legal scholars, ethicists, policy makers, patient advocates, funders and trainees convened at Asilomar for one of the most stimulating meetings I have had the privilege to organize, focused on the ethics of research with neural #organoids & #assembloids
Reposted by Sergiu P. Pasca
Scientists and ethicists, including Wu Tsai Neuro affiliates @sergiuppasca.bsky.social and Hank Greely, call for an international process to guide the field of human neural organoids.
Read the full @statnews.com story: www.statnews.com/2025/11/06/n...
Read the full @statnews.com story: www.statnews.com/2025/11/06/n...
November 12, 2025 at 11:30 PM
Scientists and ethicists, including Wu Tsai Neuro affiliates @sergiuppasca.bsky.social and Hank Greely, call for an international process to guide the field of human neural organoids.
Read the full @statnews.com story: www.statnews.com/2025/11/06/n...
Read the full @statnews.com story: www.statnews.com/2025/11/06/n...
Last day of discussions at this thought-provoking conference at Asilomar on the ethics and societal implications of neural organoids and assembloids, which I co-organized with @hankgreely.bsky.social
November 13, 2025 at 1:14 AM
Last day of discussions at this thought-provoking conference at Asilomar on the ethics and societal implications of neural organoids and assembloids, which I co-organized with @hankgreely.bsky.social
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
November 7, 2025 at 12:12 PM
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
Reposted by Sergiu P. Pasca
(1/2) Considering a career in neuroscience? In this bonus clip from NeuroSociety Stories, @sergiuppasca.bsky.social, a neuroscientist pioneering technology to recreate human brain tissue and neural circuits in the lab, shares why this is a pivotal moment for neuroscience. #neurosociety #neuroscience
October 27, 2025 at 3:19 PM
(1/2) Considering a career in neuroscience? In this bonus clip from NeuroSociety Stories, @sergiuppasca.bsky.social, a neuroscientist pioneering technology to recreate human brain tissue and neural circuits in the lab, shares why this is a pivotal moment for neuroscience. #neurosociety #neuroscience
October 23, 2025 at 10:40 PM
By popular demand — the next edition of our hands-on @Stanford @BrOrganogenesis course is coming in 2026!
This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease.
🧠 Deadline: mid-December
This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease.
🧠 Deadline: mid-December
October 16, 2025 at 5:29 PM
By popular demand — the next edition of our hands-on @Stanford @BrOrganogenesis course is coming in 2026!
This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease.
🧠 Deadline: mid-December
This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease.
🧠 Deadline: mid-December
Reposted by Sergiu P. Pasca
The 2nd Int'l Personalised Medicine Conference is coming up, including keynote talks from @natrajanlabicr.bsky.social, @goldlabcharite.bsky.social , @sergiuppasca.bsky.social , Naomi Wray, Ewan Pearson and Richard Dobson @kingscollegelondon.bsky.social
✍️ conferences.au.dk/internationa...
✍️ conferences.au.dk/internationa...
October 13, 2025 at 11:56 AM
The 2nd Int'l Personalised Medicine Conference is coming up, including keynote talks from @natrajanlabicr.bsky.social, @goldlabcharite.bsky.social , @sergiuppasca.bsky.social , Naomi Wray, Ewan Pearson and Richard Dobson @kingscollegelondon.bsky.social
✍️ conferences.au.dk/internationa...
✍️ conferences.au.dk/internationa...
We are getting closer to this special event at Asilomar
(1/2) On Nov. 10-12, scientists, ethicists, policymakers, patient advocates, and science communicators will convene to explore the ethical and societal questions posed by #organoid and #assembloid research.
Hear more from @sergiuppasca.bsky.social in this clip from #NeuroSociety Stories.
Hear more from @sergiuppasca.bsky.social in this clip from #NeuroSociety Stories.
October 8, 2025 at 8:39 PM
We are getting closer to this special event at Asilomar
Less than two weeks left to register for the inaugural conference on Assembloids & Complex Cell-Cell Interactions at @cshlnews.bsky.social
Check out the topics and amazing lineup of speakers!
Check out the topics and amazing lineup of speakers!
October 3, 2025 at 8:04 AM
Less than two weeks left to register for the inaugural conference on Assembloids & Complex Cell-Cell Interactions at @cshlnews.bsky.social
Check out the topics and amazing lineup of speakers!
Check out the topics and amazing lineup of speakers!