Sergiu P. Pasca
@sergiuppasca.bsky.social
Professor at Stanford & Director of Stanford Brain Organogenesis
Lab: https://pascalab.org
Center: http://www.brainorganogenesis.org
TED: https://go.ted.com/6WJy
Instagram: https://www.instagram.com/sergiu.p.pasca/
Lab: https://pascalab.org
Center: http://www.brainorganogenesis.org
TED: https://go.ted.com/6WJy
Instagram: https://www.instagram.com/sergiu.p.pasca/
Pinned
Sergiu P. Pasca
@sergiuppasca.bsky.social
· Nov 16
This spring, we reported in Nature a therapeutic approach for Timothy syndrome
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
An amazing group of scientists, philosophers, legal scholars, ethicists, policy makers, patient advocates, funders and trainees convened at Asilomar for one of the most stimulating meetings I have had the privilege to organize, focused on the ethics of research with neural #organoids & #assembloids
November 14, 2025 at 6:56 PM
An amazing group of scientists, philosophers, legal scholars, ethicists, policy makers, patient advocates, funders and trainees convened at Asilomar for one of the most stimulating meetings I have had the privilege to organize, focused on the ethics of research with neural #organoids & #assembloids
Reposted by Sergiu P. Pasca
Scientists and ethicists, including Wu Tsai Neuro affiliates @sergiuppasca.bsky.social and Hank Greely, call for an international process to guide the field of human neural organoids.
Read the full @statnews.com story: www.statnews.com/2025/11/06/n...
Read the full @statnews.com story: www.statnews.com/2025/11/06/n...
November 12, 2025 at 11:30 PM
Scientists and ethicists, including Wu Tsai Neuro affiliates @sergiuppasca.bsky.social and Hank Greely, call for an international process to guide the field of human neural organoids.
Read the full @statnews.com story: www.statnews.com/2025/11/06/n...
Read the full @statnews.com story: www.statnews.com/2025/11/06/n...
Last day of discussions at this thought-provoking conference at Asilomar on the ethics and societal implications of neural organoids and assembloids, which I co-organized with @hankgreely.bsky.social
November 13, 2025 at 1:14 AM
Last day of discussions at this thought-provoking conference at Asilomar on the ethics and societal implications of neural organoids and assembloids, which I co-organized with @hankgreely.bsky.social
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
November 7, 2025 at 12:12 PM
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
Reposted by Sergiu P. Pasca
(1/2) Considering a career in neuroscience? In this bonus clip from NeuroSociety Stories, @sergiuppasca.bsky.social, a neuroscientist pioneering technology to recreate human brain tissue and neural circuits in the lab, shares why this is a pivotal moment for neuroscience. #neurosociety #neuroscience
October 27, 2025 at 3:19 PM
(1/2) Considering a career in neuroscience? In this bonus clip from NeuroSociety Stories, @sergiuppasca.bsky.social, a neuroscientist pioneering technology to recreate human brain tissue and neural circuits in the lab, shares why this is a pivotal moment for neuroscience. #neurosociety #neuroscience
October 23, 2025 at 10:40 PM
By popular demand — the next edition of our hands-on @Stanford @BrOrganogenesis course is coming in 2026!
This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease.
🧠 Deadline: mid-December
This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease.
🧠 Deadline: mid-December
October 16, 2025 at 5:29 PM
By popular demand — the next edition of our hands-on @Stanford @BrOrganogenesis course is coming in 2026!
This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease.
🧠 Deadline: mid-December
This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease.
🧠 Deadline: mid-December
Reposted by Sergiu P. Pasca
The 2nd Int'l Personalised Medicine Conference is coming up, including keynote talks from @natrajanlabicr.bsky.social, @goldlabcharite.bsky.social , @sergiuppasca.bsky.social , Naomi Wray, Ewan Pearson and Richard Dobson @kingscollegelondon.bsky.social
✍️ conferences.au.dk/internationa...
✍️ conferences.au.dk/internationa...
October 13, 2025 at 11:56 AM
The 2nd Int'l Personalised Medicine Conference is coming up, including keynote talks from @natrajanlabicr.bsky.social, @goldlabcharite.bsky.social , @sergiuppasca.bsky.social , Naomi Wray, Ewan Pearson and Richard Dobson @kingscollegelondon.bsky.social
✍️ conferences.au.dk/internationa...
✍️ conferences.au.dk/internationa...
We are getting closer to this special event at Asilomar
(1/2) On Nov. 10-12, scientists, ethicists, policymakers, patient advocates, and science communicators will convene to explore the ethical and societal questions posed by #organoid and #assembloid research.
Hear more from @sergiuppasca.bsky.social in this clip from #NeuroSociety Stories.
Hear more from @sergiuppasca.bsky.social in this clip from #NeuroSociety Stories.
October 8, 2025 at 8:39 PM
We are getting closer to this special event at Asilomar
Less than two weeks left to register for the inaugural conference on Assembloids & Complex Cell-Cell Interactions at @cshlnews.bsky.social
Check out the topics and amazing lineup of speakers!
Check out the topics and amazing lineup of speakers!
October 3, 2025 at 8:04 AM
Less than two weeks left to register for the inaugural conference on Assembloids & Complex Cell-Cell Interactions at @cshlnews.bsky.social
Check out the topics and amazing lineup of speakers!
Check out the topics and amazing lineup of speakers!
A bittersweet day as another postdoc leaves to start an independent lab at St Jude’s Children Hospital.
Xiaoyu Chen led fearless work on developing a therapeutic approach for Timothy syndrome—now advancing toward clinical trial.
Xiaoyu Chen led fearless work on developing a therapeutic approach for Timothy syndrome—now advancing toward clinical trial.
October 1, 2025 at 6:18 PM
A bittersweet day as another postdoc leaves to start an independent lab at St Jude’s Children Hospital.
Xiaoyu Chen led fearless work on developing a therapeutic approach for Timothy syndrome—now advancing toward clinical trial.
Xiaoyu Chen led fearless work on developing a therapeutic approach for Timothy syndrome—now advancing toward clinical trial.
Recent conversation at the @danafoundation.bsky.social about neural assembloids and organoids, their applications and ethical challenges (including more on the upcoming Asilomar conference)
Our new episode of NeuroSociety Stories is officially live! @sergiuppasca.bsky.social discusses his pioneering work using human stem cells to create neural #organoids and #assembloids for studying brain development and psychiatric disorders.
#neurosociety #neuroscience #neuroethics #brainresearch
#neurosociety #neuroscience #neuroethics #brainresearch
Sergiu Pasca: Brain Organoids, Ethics, and the Future of Psychiatric Therapies
YouTube video by Dana Foundation
youtu.be
September 24, 2025 at 4:27 PM
Recent conversation at the @danafoundation.bsky.social about neural assembloids and organoids, their applications and ethical challenges (including more on the upcoming Asilomar conference)
One week left to register for the 1st conference on assembloids at @cshlnews.bsky.social this December. Spectacular list of speakers (see below) tackling cell-cell interactions across tissues and organs
Two amazing keynotes:
Ruslan M. Medzhitov & Joanna Wysocka
#assembloids #organoids
Two amazing keynotes:
Ruslan M. Medzhitov & Joanna Wysocka
#assembloids #organoids
September 12, 2025 at 6:28 PM
One week left to register for the 1st conference on assembloids at @cshlnews.bsky.social this December. Spectacular list of speakers (see below) tackling cell-cell interactions across tissues and organs
Two amazing keynotes:
Ruslan M. Medzhitov & Joanna Wysocka
#assembloids #organoids
Two amazing keynotes:
Ruslan M. Medzhitov & Joanna Wysocka
#assembloids #organoids
I wanted to share a quick update on this call, which has received an overwhelmingly positive response. While I will carefully review the hundreds of applications received, I sincerely apologize that I won’t be able to respond to everyone. Those selected for an interview will be notified soon.
Consider joining us at Stanford as a postdoctoral fellow!
If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.
If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.
September 5, 2025 at 3:17 AM
I wanted to share a quick update on this call, which has received an overwhelmingly positive response. While I will carefully review the hundreds of applications received, I sincerely apologize that I won’t be able to respond to everyone. Those selected for an interview will be notified soon.
Reposted by Sergiu P. Pasca
Yesterday we had a brilliant start to #ARNASydney2025. We kicked off with the #RNA in neuroscience & RNA tech, AI & Bioinformatics sessions. Speakers included @sergiuppasca.bsky.social, Mike Clark, @sabaaltaf.bsky.social, Nicole Green and several others
#RNASky @unswrna.bsky.social
#RNASky @unswrna.bsky.social
September 2, 2025 at 1:05 AM
Yesterday we had a brilliant start to #ARNASydney2025. We kicked off with the #RNA in neuroscience & RNA tech, AI & Bioinformatics sessions. Speakers included @sergiuppasca.bsky.social, Mike Clark, @sabaaltaf.bsky.social, Nicole Green and several others
#RNASky @unswrna.bsky.social
#RNASky @unswrna.bsky.social
Last day to sign up for the Asilomar meeting 👇
Great news about our upcoming meeting at Asilomar on the Ethics of Neural #Organoids and #Assembloids Research!
We secured additional support to waive the registration fee for at least 30 participants, which is especially beneficial for trainees
If interested, complete the form at the link below
We secured additional support to waive the registration fee for at least 30 participants, which is especially beneficial for trainees
If interested, complete the form at the link below
August 29, 2025 at 10:40 PM
Last day to sign up for the Asilomar meeting 👇
Great news about our upcoming meeting at Asilomar on the Ethics of Neural #Organoids and #Assembloids Research!
We secured additional support to waive the registration fee for at least 30 participants, which is especially beneficial for trainees
If interested, complete the form at the link below
We secured additional support to waive the registration fee for at least 30 participants, which is especially beneficial for trainees
If interested, complete the form at the link below
August 21, 2025 at 5:42 PM
Great news about our upcoming meeting at Asilomar on the Ethics of Neural #Organoids and #Assembloids Research!
We secured additional support to waive the registration fee for at least 30 participants, which is especially beneficial for trainees
If interested, complete the form at the link below
We secured additional support to waive the registration fee for at least 30 participants, which is especially beneficial for trainees
If interested, complete the form at the link below
Consider joining us at Stanford as a postdoctoral fellow!
If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.
If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.
August 13, 2025 at 10:09 PM
Consider joining us at Stanford as a postdoctoral fellow!
If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.
If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.
Short article on neuronal maturation in the primate cortex with Kent Imaizumi in the lab
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Timing matters: Genetic regulation of neuronal maturation in the primate brain
The molecular mechanisms that govern the extended neuronal maturation in the primate
brain remain incompletely understood. In this issue of Neuron, Gao et al. measure
gene activity, chromatin state, a...
www.cell.com
August 7, 2025 at 6:22 PM
Short article on neuronal maturation in the primate cortex with Kent Imaizumi in the lab
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Sergiu P. Pasca
Brief summary of our lab work and mission! So much more to do!
Stanford neuroscientist @sergiuppasca.bsky.social is pioneering technology to recreate human brain tissue and neural circuits in the lab — giving scientists unprecedented access to human brain development and opening new possibilities for treating disorders from psychiatric disease to chronic pain.
‘The human brain remains the final frontier’
Stanford neuroscientist Sergiu Pasca is pioneering technology to recreate human brain tissue and neural circuits in the lab – giving scientists unprecedented access to human brain development and open...
news.stanford.edu
August 5, 2025 at 7:33 AM
Brief summary of our lab work and mission! So much more to do!
Reposted by Sergiu P. Pasca
This looks like an impressive symposium on #organoids (h/t @sergiuppasca.bsky.social)
Stellar speaker line-up; Osaka, January 2026
🧪🧫
www.takeda-pharma.jp/program.html
Stellar speaker line-up; Osaka, January 2026
🧪🧫
www.takeda-pharma.jp/program.html
Program | The 12th Takeda Science Foundation Symposium on PharmaSciences
www.takeda-pharma.jp
July 27, 2025 at 6:30 AM
This looks like an impressive symposium on #organoids (h/t @sergiuppasca.bsky.social)
Stellar speaker line-up; Osaka, January 2026
🧪🧫
www.takeda-pharma.jp/program.html
Stellar speaker line-up; Osaka, January 2026
🧪🧫
www.takeda-pharma.jp/program.html
A clever forebrain assembloid model! Congratulations!
Ryan’s paper out in Neuron (bit.ly/3IICGFX). He derived bona fide parvalbumin (PV+) cortical interneurons from hPSCs, one the slowest developing neurons, and could capturing interneuron-related disease phenotypes linked to schizophrenia - including impaired gamma-oscillations - in his assembloids.
Redirecting
bit.ly
July 25, 2025 at 5:10 PM
A clever forebrain assembloid model! Congratulations!
Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience
With the great @rebeccalevymdphd.bsky.social
With the great @rebeccalevymdphd.bsky.social
July 19, 2025 at 7:52 PM
Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience
With the great @rebeccalevymdphd.bsky.social
With the great @rebeccalevymdphd.bsky.social
Our latest work is out today in @science.org: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development.
Work led by Massimo Onesto with Neal Amin in the lab
Work led by Massimo Onesto with Neal Amin in the lab
July 17, 2025 at 8:07 PM
Our latest work is out today in @science.org: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development.
Work led by Massimo Onesto with Neal Amin in the lab
Work led by Massimo Onesto with Neal Amin in the lab