Helen Willsey
@goodfrognosis.bsky.social
Dissecting psychiatric disorders using frogs (she/her)
willseylab.com
willseylab.com
Pinned
Helen Willsey
@goodfrognosis.bsky.social
· Dec 10
Check out our new ✨preprint ✨📝 describing extraordinary convergence of autism proteins at the cilium, a 🧵
www.biorxiv.org/content/10.1... (1/ )
www.biorxiv.org/content/10.1... (1/ )
Convergence of autism proteins at the cilium
Hundreds of high confidence autism genes have been identified, yet the relevant etiological mechanisms remain unclear. Gene ontology analyses have repeatedly identified enrichment of proteins with ann...
www.biorxiv.org
Check out our new preprint led by @elinakosty.bsky.social identifying convergence of autism proteins at the cilium (including chromatin regulators and synaptic proteins)! Makes us realize the deep similarity between neuronal synapses and cilia. Power of 🐸 for discovery
I can confirm the NIH is still working well enough to score my R01 terribly 😂🤪
February 13, 2025 at 4:52 PM
I can confirm the NIH is still working well enough to score my R01 terribly 😂🤪
Congratulations to newly PhD'ed
@pieceofkate.bsky.social Dr. McCluskey!! She gave a fantastic thesis seminar to cap it off 👏🎓🐸✨
@pieceofkate.bsky.social Dr. McCluskey!! She gave a fantastic thesis seminar to cap it off 👏🎓🐸✨
January 21, 2025 at 6:49 PM
Congratulations to newly PhD'ed
@pieceofkate.bsky.social Dr. McCluskey!! She gave a fantastic thesis seminar to cap it off 👏🎓🐸✨
@pieceofkate.bsky.social Dr. McCluskey!! She gave a fantastic thesis seminar to cap it off 👏🎓🐸✨
My New Year’s resolution is to be kind… of a bitch.
January 3, 2025 at 4:04 PM
My New Year’s resolution is to be kind… of a bitch.
Check out our new preprint led by @elinakosty.bsky.social identifying convergence of autism proteins at the cilium (including chromatin regulators and synaptic proteins)! Makes us realize the deep similarity between neuronal synapses and cilia. Power of 🐸 for discovery
Check out our new ✨preprint ✨📝 describing extraordinary convergence of autism proteins at the cilium, a 🧵
www.biorxiv.org/content/10.1... (1/ )
www.biorxiv.org/content/10.1... (1/ )
Convergence of autism proteins at the cilium
Hundreds of high confidence autism genes have been identified, yet the relevant etiological mechanisms remain unclear. Gene ontology analyses have repeatedly identified enrichment of proteins with ann...
www.biorxiv.org
December 10, 2024 at 5:26 AM
Check out our new preprint led by @elinakosty.bsky.social identifying convergence of autism proteins at the cilium (including chromatin regulators and synaptic proteins)! Makes us realize the deep similarity between neuronal synapses and cilia. Power of 🐸 for discovery
Reposted by Helen Willsey
It's #FluorescenceFriday again!
Some more #Xenopus... This time a #gastruloid formed by treating an explant of blastula presumptive ectoderm cells with Activin.
Nuclei labelled with H2B-mCherry with colour indicating size.
Some more #Xenopus... This time a #gastruloid formed by treating an explant of blastula presumptive ectoderm cells with Activin.
Nuclei labelled with H2B-mCherry with colour indicating size.
November 22, 2024 at 8:18 PM
It's #FluorescenceFriday again!
Some more #Xenopus... This time a #gastruloid formed by treating an explant of blastula presumptive ectoderm cells with Activin.
Nuclei labelled with H2B-mCherry with colour indicating size.
Some more #Xenopus... This time a #gastruloid formed by treating an explant of blastula presumptive ectoderm cells with Activin.
Nuclei labelled with H2B-mCherry with colour indicating size.
Reposted by Helen Willsey
Another preprint from the lab and a collaboration with Miriam Schmidts and her lab from Uniklinik_Fr pediatrics. This work was carried out mostly by fantastic MD MOTIVATE student Henrike Berns. Funded by @dfgpublic.bsky.social @cibss.bsky.social and SFB1453_NephGen.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A homozygous human WNT11 loss-of-function variant associated with laterality, heart and renal defects
Wnt signaling plays important roles during vertebrate development, including left-right axis specification as well as heart and kidney organogenesis. We identified a homozygous human WNT11 variant in ...
www.biorxiv.org
November 17, 2024 at 4:38 PM
Another preprint from the lab and a collaboration with Miriam Schmidts and her lab from Uniklinik_Fr pediatrics. This work was carried out mostly by fantastic MD MOTIVATE student Henrike Berns. Funded by @dfgpublic.bsky.social @cibss.bsky.social and SFB1453_NephGen.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Helen Willsey
Hello science peeps
A quick introduction to Miller lab shenanigans 🐸😄 @umichlawlib.bsky.social
We are very demure, very mindful labmates 🧪 🥼
#Scienceisfun
A quick introduction to Miller lab shenanigans 🐸😄 @umichlawlib.bsky.social
We are very demure, very mindful labmates 🧪 🥼
#Scienceisfun
November 16, 2024 at 4:00 PM
Hello science peeps
A quick introduction to Miller lab shenanigans 🐸😄 @umichlawlib.bsky.social
We are very demure, very mindful labmates 🧪 🥼
#Scienceisfun
A quick introduction to Miller lab shenanigans 🐸😄 @umichlawlib.bsky.social
We are very demure, very mindful labmates 🧪 🥼
#Scienceisfun
Check out our new ✨preprint✨ led by James Schmidt! Here we identified a new role for the gene KANSL1 in ciliary biology using Xenopus, with validations in patients with associated Koolen-de Vries Syndrome, which is characterized by hypersociability. www.biorxiv.org/content/10.1...
November 15, 2024 at 3:29 PM
Check out our new ✨preprint✨ led by James Schmidt! Here we identified a new role for the gene KANSL1 in ciliary biology using Xenopus, with validations in patients with associated Koolen-de Vries Syndrome, which is characterized by hypersociability. www.biorxiv.org/content/10.1...
Reposted by Helen Willsey
okay has anybody made one of these for #cilia peeps yet?? go.bsky.app/ELfYqxw please find & add more names below...
November 10, 2024 at 8:27 PM
okay has anybody made one of these for #cilia peeps yet?? go.bsky.app/ELfYqxw please find & add more names below...
Reposted by Helen Willsey
Xenopus researchers (and only Xenopus researchers!)
Open now! Xenbase.org wants to hear from you about how you use Xenbase and what they can do to make Xenbase even better. Just click forms.gle/5WFANQTKA6TuSyg67 to take the survey! #science #biology #devbio #xenopus #frogs
@xenbase.bsky.social
Open now! Xenbase.org wants to hear from you about how you use Xenbase and what they can do to make Xenbase even better. Just click forms.gle/5WFANQTKA6TuSyg67 to take the survey! #science #biology #devbio #xenopus #frogs
@xenbase.bsky.social
July 26, 2024 at 6:24 PM
Xenopus researchers (and only Xenopus researchers!)
Open now! Xenbase.org wants to hear from you about how you use Xenbase and what they can do to make Xenbase even better. Just click forms.gle/5WFANQTKA6TuSyg67 to take the survey! #science #biology #devbio #xenopus #frogs
@xenbase.bsky.social
Open now! Xenbase.org wants to hear from you about how you use Xenbase and what they can do to make Xenbase even better. Just click forms.gle/5WFANQTKA6TuSyg67 to take the survey! #science #biology #devbio #xenopus #frogs
@xenbase.bsky.social
Reposted by Helen Willsey
Let's kick things off with live imaging of Xenopus deep layer blastocoel roof cells imaged using Airyscan 2.
November 9, 2024 at 10:42 AM
Let's kick things off with live imaging of Xenopus deep layer blastocoel roof cells imaged using Airyscan 2.
Reposted by Helen Willsey
Hello world! We’re here to spread the love of our favorite model organism Xenopus. Give us a follow for your daily moment of Xen(opus)!
November 14, 2024 at 4:25 AM
Hello world! We’re here to spread the love of our favorite model organism Xenopus. Give us a follow for your daily moment of Xen(opus)!
Reposted by Helen Willsey
New preprint from the lab 🙌 @biorxiv. We found new foxi1 functions in multipotent mucociliary progenitors in #xenopus. 🐸
www.biorxiv.org/content/10.1...
Congrats to 3 first authors Sarah Bowden, Magdalena Brislinger-Engelhardt, Mona Hansen & team!
Fu dwd by
CIBSS
SFB1453_NephGen
dfg
www.biorxiv.org/content/10.1...
Congrats to 3 first authors Sarah Bowden, Magdalena Brislinger-Engelhardt, Mona Hansen & team!
Fu dwd by
CIBSS
SFB1453_NephGen
dfg
Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms
Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β-ISCs regulate pH- and ion-homeostasis in epithelia. Gain and loss of FOX...
www.biorxiv.org
November 11, 2024 at 6:07 PM
New preprint from the lab 🙌 @biorxiv. We found new foxi1 functions in multipotent mucociliary progenitors in #xenopus. 🐸
www.biorxiv.org/content/10.1...
Congrats to 3 first authors Sarah Bowden, Magdalena Brislinger-Engelhardt, Mona Hansen & team!
Fu dwd by
CIBSS
SFB1453_NephGen
dfg
www.biorxiv.org/content/10.1...
Congrats to 3 first authors Sarah Bowden, Magdalena Brislinger-Engelhardt, Mona Hansen & team!
Fu dwd by
CIBSS
SFB1453_NephGen
dfg