Matyas Bubna-Litic
@matyasbl.bsky.social
Interested in mechanobiology, morphogenesis, organisers and synthetic embryo models.
Research Fellow in Mongera lab UCL | PhD in Mayor and Charras labs | YEN Committee
Research Fellow in Mongera lab UCL | PhD in Mayor and Charras labs | YEN Committee
Pinned
Matyas Bubna-Litic
@matyasbl.bsky.social
· Apr 11
Embryonic induction of fate is a core concept in developmental biology. But, cells can also modify the physical state of surrounding tissues a process we call 'actuation'.
I reviewed with
@mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.
I reviewed with
@mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.
Reposted by Matyas Bubna-Litic
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
@poldresden.bsky.social @mpi-cbg.de
January 7, 2026 at 4:02 PM
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
@poldresden.bsky.social @mpi-cbg.de
Reposted by Matyas Bubna-Litic
My group will investigate the stochastic morphodynamics of living systems at the interface of biophysical modelling and computational biology.
I will announce positions for PhD students and postdocs in the coming months! Feel free to DM me if you are interested!
I will announce positions for PhD students and postdocs in the coming months! Feel free to DM me if you are interested!
January 5, 2026 at 11:49 AM
My group will investigate the stochastic morphodynamics of living systems at the interface of biophysical modelling and computational biology.
I will announce positions for PhD students and postdocs in the coming months! Feel free to DM me if you are interested!
I will announce positions for PhD students and postdocs in the coming months! Feel free to DM me if you are interested!
Reposted by Matyas Bubna-Litic
We're in love with this cover image! 🧡
Part II of our Special Collection celebrating the Centennial of the Discovery of The Organiser is here. This issue focuses on the work presented at the Centennial Symposium at the University of Freiburg in September 2024:
www.sciencedirect.com/journal/cell...
Part II of our Special Collection celebrating the Centennial of the Discovery of The Organiser is here. This issue focuses on the work presented at the Centennial Symposium at the University of Freiburg in September 2024:
www.sciencedirect.com/journal/cell...
December 17, 2025 at 3:45 PM
We're in love with this cover image! 🧡
Part II of our Special Collection celebrating the Centennial of the Discovery of The Organiser is here. This issue focuses on the work presented at the Centennial Symposium at the University of Freiburg in September 2024:
www.sciencedirect.com/journal/cell...
Part II of our Special Collection celebrating the Centennial of the Discovery of The Organiser is here. This issue focuses on the work presented at the Centennial Symposium at the University of Freiburg in September 2024:
www.sciencedirect.com/journal/cell...
Reposted by Matyas Bubna-Litic
#Mastodon, the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets, is finally heading for publication (well, let's see). To #cite or not to cite shall no longer be the question 🙃, because the #preprint. Software is available in every #Fiji near you.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 13, 2025 at 6:14 PM
#Mastodon, the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets, is finally heading for publication (well, let's see). To #cite or not to cite shall no longer be the question 🙃, because the #preprint. Software is available in every #Fiji near you.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Matyas Bubna-Litic
Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking.
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
December 8, 2025 at 9:48 AM
Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking.
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
Reposted by Matyas Bubna-Litic
🌈 Rainbow neurons on the move!🧠
MultiColor FlpOut of L3 optic lobe neurons projecting into the medulla neuropil. 📸 Image by Isabel Holguera.
#FluorescenceFriday #DevBio
MultiColor FlpOut of L3 optic lobe neurons projecting into the medulla neuropil. 📸 Image by Isabel Holguera.
#FluorescenceFriday #DevBio
November 21, 2025 at 3:30 PM
🌈 Rainbow neurons on the move!🧠
MultiColor FlpOut of L3 optic lobe neurons projecting into the medulla neuropil. 📸 Image by Isabel Holguera.
#FluorescenceFriday #DevBio
MultiColor FlpOut of L3 optic lobe neurons projecting into the medulla neuropil. 📸 Image by Isabel Holguera.
#FluorescenceFriday #DevBio
Reposted by Matyas Bubna-Litic
Searching for physical principles of morphogenesis
In this #OpenAccess Spotlight, Nikolas Claussen, Fridtjof Brauns and @streichan.bsky.social highlight the ‘physics of development’, focusing on the interplay between quantitative experiments and mathematical theory
doi.org/10.1242/dev....
In this #OpenAccess Spotlight, Nikolas Claussen, Fridtjof Brauns and @streichan.bsky.social highlight the ‘physics of development’, focusing on the interplay between quantitative experiments and mathematical theory
doi.org/10.1242/dev....
November 19, 2025 at 10:28 AM
Searching for physical principles of morphogenesis
In this #OpenAccess Spotlight, Nikolas Claussen, Fridtjof Brauns and @streichan.bsky.social highlight the ‘physics of development’, focusing on the interplay between quantitative experiments and mathematical theory
doi.org/10.1242/dev....
In this #OpenAccess Spotlight, Nikolas Claussen, Fridtjof Brauns and @streichan.bsky.social highlight the ‘physics of development’, focusing on the interplay between quantitative experiments and mathematical theory
doi.org/10.1242/dev....
Happy (and spooky) #FluorescenceFriday
Switching from frogs (which are underrated btw) to zebrafish has really made me appreciate transparent tissues! 🐟
28 hpf, ⚪ nuclei, 🔴 F-actin
Switching from frogs (which are underrated btw) to zebrafish has really made me appreciate transparent tissues! 🐟
28 hpf, ⚪ nuclei, 🔴 F-actin
October 31, 2025 at 3:20 PM
Happy (and spooky) #FluorescenceFriday
Switching from frogs (which are underrated btw) to zebrafish has really made me appreciate transparent tissues! 🐟
28 hpf, ⚪ nuclei, 🔴 F-actin
Switching from frogs (which are underrated btw) to zebrafish has really made me appreciate transparent tissues! 🐟
28 hpf, ⚪ nuclei, 🔴 F-actin
Reposted by Matyas Bubna-Litic
📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
September 11, 2025 at 9:36 AM
📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Reposted by Matyas Bubna-Litic
1/12 A very special moment for me! 🎉
My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.
rupress.org/jcb/article/...
#cellbio #devbio #science
🧵for details
My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.
rupress.org/jcb/article/...
#cellbio #devbio #science
🧵for details
September 24, 2025 at 1:06 PM
1/12 A very special moment for me! 🎉
My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.
rupress.org/jcb/article/...
#cellbio #devbio #science
🧵for details
My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.
rupress.org/jcb/article/...
#cellbio #devbio #science
🧵for details
Pretty cool
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
September 22, 2025 at 8:48 PM
Pretty cool
Reposted by Matyas Bubna-Litic
Our new paper is out in Dev Biol! 🎉 🐸🧬
We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning
👉 Read more here: doi.org/10.1016/j.yd...
@devbiol.bsky.social @biouea.bsky.social
We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning
👉 Read more here: doi.org/10.1016/j.yd...
@devbiol.bsky.social @biouea.bsky.social
September 16, 2025 at 9:17 AM
Our new paper is out in Dev Biol! 🎉 🐸🧬
We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning
👉 Read more here: doi.org/10.1016/j.yd...
@devbiol.bsky.social @biouea.bsky.social
We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning
👉 Read more here: doi.org/10.1016/j.yd...
@devbiol.bsky.social @biouea.bsky.social
Reposted by Matyas Bubna-Litic
Mouse (Mus musculus) 🐭 is the powerhouse of mammalian genetics, essential for studying embryogenesis, organ development and gene function using transgenic technologies. 📸 Image by Zhong Hua also featured on the cover of Developmental Biology textbook (11th edition) #ModelMonday
September 15, 2025 at 7:53 PM
Mouse (Mus musculus) 🐭 is the powerhouse of mammalian genetics, essential for studying embryogenesis, organ development and gene function using transgenic technologies. 📸 Image by Zhong Hua also featured on the cover of Developmental Biology textbook (11th edition) #ModelMonday
Thank you for sharing! I'd like to highlight the concept of embryonic 'actuation' where a mechanical state change is caused by cells acting on each other through mechanics and/or biochemical signals but importantly not mediated by fate transitions.
September 4, 2025 at 9:13 AM
Thank you for sharing! I'd like to highlight the concept of embryonic 'actuation' where a mechanical state change is caused by cells acting on each other through mechanics and/or biochemical signals but importantly not mediated by fate transitions.
Reposted by Matyas Bubna-Litic
Got stunning fluorescence microscopy images? 🌈🔬 SDB wants to feature YOUR work for #FluorescenceFriday! We highlight images from SDB members with a short description and the image creators 📸. Fill out the form to be featured: docs.google.com/forms/d/e/1F...
✨If Monet studied mouse ovaries 🎨 Stromal cells 💜 Follicular cells 🔵 and Fatty Cells 🟡. Together, they reveal the cellular architecture and functional zones of the ovary 🔬 Image provided by @shmimberly.bsky.social 🧪 #FluorescenceFriday #ReproductiveBiology
August 24, 2025 at 5:31 AM
Got stunning fluorescence microscopy images? 🌈🔬 SDB wants to feature YOUR work for #FluorescenceFriday! We highlight images from SDB members with a short description and the image creators 📸. Fill out the form to be featured: docs.google.com/forms/d/e/1F...
Reposted by Matyas Bubna-Litic
I'm going to be advertising for a few positions in my group in the next couple of months for a big project on synthetic microbial communities.
I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!
I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!
August 13, 2025 at 9:35 AM
I'm going to be advertising for a few positions in my group in the next couple of months for a big project on synthetic microbial communities.
I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!
I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!
Reposted by Matyas Bubna-Litic
✨Not a rainbow trout… a rainbow zebrafish 🌈 🐟
The expression of 10 different genes simultaneously including Hox genes along the body axis, somites, brain regions, skeletal muscle, and heart 🔬Image by Alice Sherrard, Gabby Jerz & Nipam Patel 🧪 #FluorescenceFriday
The expression of 10 different genes simultaneously including Hox genes along the body axis, somites, brain regions, skeletal muscle, and heart 🔬Image by Alice Sherrard, Gabby Jerz & Nipam Patel 🧪 #FluorescenceFriday
August 15, 2025 at 6:00 PM
✨Not a rainbow trout… a rainbow zebrafish 🌈 🐟
The expression of 10 different genes simultaneously including Hox genes along the body axis, somites, brain regions, skeletal muscle, and heart 🔬Image by Alice Sherrard, Gabby Jerz & Nipam Patel 🧪 #FluorescenceFriday
The expression of 10 different genes simultaneously including Hox genes along the body axis, somites, brain regions, skeletal muscle, and heart 🔬Image by Alice Sherrard, Gabby Jerz & Nipam Patel 🧪 #FluorescenceFriday
Reposted by Matyas Bubna-Litic
🚨Only 4 days to apply!!!🚨Join the SDB SciComm Internship! Gain hands-on experience writing stories on the latest developmental biology discoveries🔬Connect with top mentors & earn $500 to attend the SDB Annual Meeting 🎉! 👉 www.sdbonline.org/science_comm... #SciComm #DevBio
August 12, 2025 at 1:29 PM
🚨Only 4 days to apply!!!🚨Join the SDB SciComm Internship! Gain hands-on experience writing stories on the latest developmental biology discoveries🔬Connect with top mentors & earn $500 to attend the SDB Annual Meeting 🎉! 👉 www.sdbonline.org/science_comm... #SciComm #DevBio
Reposted by Matyas Bubna-Litic
Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social
thenode.biologists.com/jobs/postdoc...
thenode.biologists.com/jobs/postdoc...
Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node
The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...
thenode.biologists.com
August 5, 2025 at 10:15 AM
Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social
thenode.biologists.com/jobs/postdoc...
thenode.biologists.com/jobs/postdoc...
Reposted by Matyas Bubna-Litic
Got stunning fluorescence microscopy images? 🌈🔬 SDB wants to feature YOUR work for #FluorescenceFriday! We highlight images from SDB members with a short description and the image creators 📸. Fill out the form to be featured: docs.google.com/forms/d/e/1F...
August 8, 2025 at 1:13 PM
Got stunning fluorescence microscopy images? 🌈🔬 SDB wants to feature YOUR work for #FluorescenceFriday! We highlight images from SDB members with a short description and the image creators 📸. Fill out the form to be featured: docs.google.com/forms/d/e/1F...
Reposted by Matyas Bubna-Litic
Interesting review about the role of ECM in development!
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
August 9, 2025 at 10:53 AM
Interesting review about the role of ECM in development!
Reposted by Matyas Bubna-Litic
We are searching for an enthusiastic scientist to join our team and establish annual killifish as a model system for early developmental biology and biophysics! @embl.org @embldbunit.bsky.social
Apply here:
embl.wd103.myworkdayjobs.com/EMBL/job/Hei...
Please re-post 🙏
Apply here:
embl.wd103.myworkdayjobs.com/EMBL/job/Hei...
Please re-post 🙏
August 8, 2025 at 9:01 AM
We are searching for an enthusiastic scientist to join our team and establish annual killifish as a model system for early developmental biology and biophysics! @embl.org @embldbunit.bsky.social
Apply here:
embl.wd103.myworkdayjobs.com/EMBL/job/Hei...
Please re-post 🙏
Apply here:
embl.wd103.myworkdayjobs.com/EMBL/job/Hei...
Please re-post 🙏
Reposted by Matyas Bubna-Litic
Thrilled to bits to see our latest work online in Dev Cell! 🥳
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish
Andrews et al. demonstrate that multiscale feedback between mechanical and chemical
cues builds a functional heart to support zebrafish embryonic life. Cell recruitment
and organ-scale forces drive tr...
tinyurl.com
August 6, 2025 at 2:53 PM
Thrilled to bits to see our latest work online in Dev Cell! 🥳
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
Reposted by Matyas Bubna-Litic
Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
August 6, 2025 at 1:09 PM
Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
Reposted by Matyas Bubna-Litic
I was looking through my old microscopy videos, and found this perfect shot of a macropinosome forming through the collapse of an actin-driven membrane ruffle (cyan). Immediately, CRYI-A (orange) is recruited to the vesicle to finish the job. Still in awe with this process after all those years!
July 31, 2025 at 11:19 PM
I was looking through my old microscopy videos, and found this perfect shot of a macropinosome forming through the collapse of an actin-driven membrane ruffle (cyan). Immediately, CRYI-A (orange) is recruited to the vesicle to finish the job. Still in awe with this process after all those years!