Ale Mongera
@mongeralab.bsky.social
Pinned
Ale Mongera
@mongeralab.bsky.social
· Sep 11
📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Reposted by Ale Mongera
🎉 The Developmental Mechanics Seminar Series is back!
🗓️ Thurs, Jan 22
🎙️ Opening talks:
🧬Guy Tanentzapf (UBC)
— How cell adhesion molecules wire into the cytoskeleton
🌀Juan Manuel Gomez Elliff (EMBL)
@gomezjm-devmech.bsky.social
— Mapping tissue mechanics with Brillouin microscopy
🗓️ Thurs, Jan 22
🎙️ Opening talks:
🧬Guy Tanentzapf (UBC)
— How cell adhesion molecules wire into the cytoskeleton
🌀Juan Manuel Gomez Elliff (EMBL)
@gomezjm-devmech.bsky.social
— Mapping tissue mechanics with Brillouin microscopy
International Developmental Mechanics Seminar Series
Please fill out the following survey if you are interested in the 2025-2026 International Zoom Seminars on Developmental Mechanics.
tinyurl.com
January 19, 2026 at 11:13 AM
🎉 The Developmental Mechanics Seminar Series is back!
🗓️ Thurs, Jan 22
🎙️ Opening talks:
🧬Guy Tanentzapf (UBC)
— How cell adhesion molecules wire into the cytoskeleton
🌀Juan Manuel Gomez Elliff (EMBL)
@gomezjm-devmech.bsky.social
— Mapping tissue mechanics with Brillouin microscopy
🗓️ Thurs, Jan 22
🎙️ Opening talks:
🧬Guy Tanentzapf (UBC)
— How cell adhesion molecules wire into the cytoskeleton
🌀Juan Manuel Gomez Elliff (EMBL)
@gomezjm-devmech.bsky.social
— Mapping tissue mechanics with Brillouin microscopy
Reposted by Ale Mongera
Using fluorescence live imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction.
With @hansclevers.bsky.social.
Great work by @tnoordzij.bsky.social & @martinacelotti.bsky.social
www.biorxiv.org/content/10.6...
With @hansclevers.bsky.social.
Great work by @tnoordzij.bsky.social & @martinacelotti.bsky.social
www.biorxiv.org/content/10.6...
December 24, 2025 at 7:49 PM
Using fluorescence live imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction.
With @hansclevers.bsky.social.
Great work by @tnoordzij.bsky.social & @martinacelotti.bsky.social
www.biorxiv.org/content/10.6...
With @hansclevers.bsky.social.
Great work by @tnoordzij.bsky.social & @martinacelotti.bsky.social
www.biorxiv.org/content/10.6...
Super cool paper! Presomitic mesoderm, oxygen levels, segmentation clock
HIF1α controls somitogenesis and spine development by regulating levels of intracellular oxygen in the presomitic mesoderm https://www.biorxiv.org/content/10.64898/2025.12.19.694009v1
December 23, 2025 at 1:35 PM
Super cool paper! Presomitic mesoderm, oxygen levels, segmentation clock
Reposted by Ale Mongera
🚨Seeking developmental or cell biologists🔬!🚨
Our department @ucl-cdb.bsky.social is looking to support scientists seeking to establish their lab with a fellowship. Deadline: 30 Jan. Apply here: www.ucl.ac.uk/work-at-ucl/...
Our department @ucl-cdb.bsky.social is looking to support scientists seeking to establish their lab with a fellowship. Deadline: 30 Jan. Apply here: www.ucl.ac.uk/work-at-ucl/...
December 18, 2025 at 6:38 PM
🚨Seeking developmental or cell biologists🔬!🚨
Our department @ucl-cdb.bsky.social is looking to support scientists seeking to establish their lab with a fellowship. Deadline: 30 Jan. Apply here: www.ucl.ac.uk/work-at-ucl/...
Our department @ucl-cdb.bsky.social is looking to support scientists seeking to establish their lab with a fellowship. Deadline: 30 Jan. Apply here: www.ucl.ac.uk/work-at-ucl/...
Congrats to the leading author @agrigas.bsky.social!
❗PREPRINT ALERT❗
doi.org/10.64898/202...
The lab of M. Lisa Manning at @syracuseu.bsky.social in collaboration with Ale Mongera at @ucl-cdb.bsky.social show that in the avian presomitic mesoderm, Contact Inhibition of Locomotion has a tissue-wide effect, making tissue act like a fluid under tension.
doi.org/10.64898/202...
The lab of M. Lisa Manning at @syracuseu.bsky.social in collaboration with Ale Mongera at @ucl-cdb.bsky.social show that in the avian presomitic mesoderm, Contact Inhibition of Locomotion has a tissue-wide effect, making tissue act like a fluid under tension.
December 17, 2025 at 5:46 PM
Congrats to the leading author @agrigas.bsky.social!
Reposted by Ale Mongera
❗PREPRINT ALERT❗
doi.org/10.64898/202...
The lab of M. Lisa Manning at @syracuseu.bsky.social in collaboration with Ale Mongera at @ucl-cdb.bsky.social show that in the avian presomitic mesoderm, Contact Inhibition of Locomotion has a tissue-wide effect, making tissue act like a fluid under tension.
doi.org/10.64898/202...
The lab of M. Lisa Manning at @syracuseu.bsky.social in collaboration with Ale Mongera at @ucl-cdb.bsky.social show that in the avian presomitic mesoderm, Contact Inhibition of Locomotion has a tissue-wide effect, making tissue act like a fluid under tension.
December 17, 2025 at 5:20 PM
❗PREPRINT ALERT❗
doi.org/10.64898/202...
The lab of M. Lisa Manning at @syracuseu.bsky.social in collaboration with Ale Mongera at @ucl-cdb.bsky.social show that in the avian presomitic mesoderm, Contact Inhibition of Locomotion has a tissue-wide effect, making tissue act like a fluid under tension.
doi.org/10.64898/202...
The lab of M. Lisa Manning at @syracuseu.bsky.social in collaboration with Ale Mongera at @ucl-cdb.bsky.social show that in the avian presomitic mesoderm, Contact Inhibition of Locomotion has a tissue-wide effect, making tissue act like a fluid under tension.
Reposted by Ale Mongera
Contact Inhibition coordinating tissues made sparsely of mesenchymal cells.
From Alex Grigas @ ManningGroup and @mongeralab.bsky.social
www.biorxiv.org/content/10.6...
From Alex Grigas @ ManningGroup and @mongeralab.bsky.social
www.biorxiv.org/content/10.6...
Sparse mesenchymal cell networks as a fluid under tension
Sparse mesenchymal cellular networks are ubiquitous across animals, shaping both embryonic and adult structures through dynamic interactions with epithelia. Yet, the physical principles underlying the...
www.biorxiv.org
December 17, 2025 at 10:20 AM
Contact Inhibition coordinating tissues made sparsely of mesenchymal cells.
From Alex Grigas @ ManningGroup and @mongeralab.bsky.social
www.biorxiv.org/content/10.6...
From Alex Grigas @ ManningGroup and @mongeralab.bsky.social
www.biorxiv.org/content/10.6...
Super cool work spearheaded by the amazing @agrigas.bsky.social! Excited for this collaboration with @manningresearch.bsky.social and for everything still to come! 🎉 Also thank you to @emaniou.bsky.social and @glgalea.bsky.social for your help!
How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...
Sparse mesenchymal cell networks as a fluid under tension
Sparse mesenchymal cellular networks are ubiquitous across animals, shaping both embryonic and adult structures through dynamic interactions with epithelia. Yet, the physical principles underlying the...
www.biorxiv.org
December 12, 2025 at 2:50 PM
Super cool work spearheaded by the amazing @agrigas.bsky.social! Excited for this collaboration with @manningresearch.bsky.social and for everything still to come! 🎉 Also thank you to @emaniou.bsky.social and @glgalea.bsky.social for your help!
Reposted by Ale Mongera
Very excited about this new paper out on bioRxiv, spearheaded by the fantastic Dr. Grigas in collaboration with @mongeralab.bsky.social and Galea labs.
How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...
Sparse mesenchymal cell networks as a fluid under tension
Sparse mesenchymal cellular networks are ubiquitous across animals, shaping both embryonic and adult structures through dynamic interactions with epithelia. Yet, the physical principles underlying the...
www.biorxiv.org
December 12, 2025 at 2:15 PM
Very excited about this new paper out on bioRxiv, spearheaded by the fantastic Dr. Grigas in collaboration with @mongeralab.bsky.social and Galea labs.
Reposted by Ale Mongera
Check out this new preprint on PSM mechanics! Very nice work!
How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...
Sparse mesenchymal cell networks as a fluid under tension
Sparse mesenchymal cellular networks are ubiquitous across animals, shaping both embryonic and adult structures through dynamic interactions with epithelia. Yet, the physical principles underlying the...
www.biorxiv.org
December 12, 2025 at 1:40 PM
Check out this new preprint on PSM mechanics! Very nice work!
Reposted by Ale Mongera
How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...
Sparse mesenchymal cell networks as a fluid under tension
Sparse mesenchymal cellular networks are ubiquitous across animals, shaping both embryonic and adult structures through dynamic interactions with epithelia. Yet, the physical principles underlying the...
www.biorxiv.org
December 12, 2025 at 1:28 PM
How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...
Reposted by Ale Mongera
With more than 2.1k citations, 'The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio' by the CNV Lab highlighted the arduous work that took place during 'The Big Screen'. In total, 1163 mutants were described. #ZebrafishFunFacts 🧪
November 29, 2025 at 6:29 AM
With more than 2.1k citations, 'The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio' by the CNV Lab highlighted the arduous work that took place during 'The Big Screen'. In total, 1163 mutants were described. #ZebrafishFunFacts 🧪
Reposted by Ale Mongera
So called microtubule organizing centers (MTOCs) are not "organizing centers". They don't control their position (network center), nor MT orientation, length and shape (network shape). The actual organizers are MTs, molecular motors and regulators of MT +ends. MTOCs nucleate MTs.
Let's rename MTOCs.
Let's rename MTOCs.
November 27, 2025 at 8:47 AM
So called microtubule organizing centers (MTOCs) are not "organizing centers". They don't control their position (network center), nor MT orientation, length and shape (network shape). The actual organizers are MTs, molecular motors and regulators of MT +ends. MTOCs nucleate MTs.
Let's rename MTOCs.
Let's rename MTOCs.
Reposted by Ale Mongera
Thought I was being really novel when I designed and 3D printed this mold for zebrafish transplants based on the microinjection one, but found out today it already exists…
Bottom: my PLA mold that’s bent from warm agarose
Top: a very kind (more robust looking) gift from @mongeralab.bsky.social
Bottom: my PLA mold that’s bent from warm agarose
Top: a very kind (more robust looking) gift from @mongeralab.bsky.social
November 26, 2025 at 5:58 PM
Thought I was being really novel when I designed and 3D printed this mold for zebrafish transplants based on the microinjection one, but found out today it already exists…
Bottom: my PLA mold that’s bent from warm agarose
Top: a very kind (more robust looking) gift from @mongeralab.bsky.social
Bottom: my PLA mold that’s bent from warm agarose
Top: a very kind (more robust looking) gift from @mongeralab.bsky.social
Reposted by Ale Mongera
Cell type-independent timekeeping gene modules enable embryonic stage prediction in zebrafish https://www.biorxiv.org/content/10.1101/2025.11.12.688039v1
November 13, 2025 at 8:34 PM
Cell type-independent timekeeping gene modules enable embryonic stage prediction in zebrafish https://www.biorxiv.org/content/10.1101/2025.11.12.688039v1
Reposted by Ale Mongera
Stationary and germ layer-specific cellular flows shape the zebrafish gastrula https://www.biorxiv.org/content/10.1101/2025.11.10.687746v1
November 12, 2025 at 3:35 PM
Stationary and germ layer-specific cellular flows shape the zebrafish gastrula https://www.biorxiv.org/content/10.1101/2025.11.10.687746v1
Reposted by Ale Mongera
How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
November 10, 2025 at 6:46 AM
How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
Reposted by Ale Mongera
We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
November 3, 2025 at 7:05 PM
We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
🔗 About our lab: renew.science/principal_in...
🎓 PhD position: jobportal.ku.dk/phd/?show=15...
🧪 Postdoc position: jobportal.ku.dk/videnskabeli...
Reposted by Ale Mongera
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
November 3, 2025 at 2:46 PM
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
Reposted by Ale Mongera
Had the pleasure of working with @mohannad-dardiry.bsky.social to rethink what it means to develop for life. Many thanks to @dev-journal.bsky.social! @embl.org #LifelongDevSI
October 31, 2025 at 11:24 AM
Had the pleasure of working with @mohannad-dardiry.bsky.social to rethink what it means to develop for life. Many thanks to @dev-journal.bsky.social! @embl.org #LifelongDevSI
Reposted by Ale Mongera
Happy birthday to #LaskerLaureate Christiane Nüsslein-Volhard! She identified 120 genes involved in specifying embryonic pattern development.
Read about the epic screen that yielded her Lasker Award-winning results: ow.ly/Pz2050PYFsz #WomenInSTEM 🧪
Read about the epic screen that yielded her Lasker Award-winning results: ow.ly/Pz2050PYFsz #WomenInSTEM 🧪
I Dreamt of Fruit Flies - Lasker Foundation
In the mid-1970s, Christiane Nüsslein-Volhard was struggling. Two years after finishing her PhD in molecular biology, she was working as a postdoctoral researcher in a lab she longed to leave. The…
ow.ly
October 20, 2025 at 4:32 PM
Happy birthday to #LaskerLaureate Christiane Nüsslein-Volhard! She identified 120 genes involved in specifying embryonic pattern development.
Read about the epic screen that yielded her Lasker Award-winning results: ow.ly/Pz2050PYFsz #WomenInSTEM 🧪
Read about the epic screen that yielded her Lasker Award-winning results: ow.ly/Pz2050PYFsz #WomenInSTEM 🧪
Reposted by Ale Mongera
We are hiring ! If you want to become professor of Bioinformatics in the best city of North America, check the announcement below ! Also you do need to speak French (as long as you commit to learning it :) ) www.umontreal.ca/public/www/d...
www.umontreal.ca
October 10, 2025 at 11:48 AM
We are hiring ! If you want to become professor of Bioinformatics in the best city of North America, check the announcement below ! Also you do need to speak French (as long as you commit to learning it :) ) www.umontreal.ca/public/www/d...
Reposted by Ale Mongera
Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.
More here: elifesciences.org/reviewed-pre...
More here: elifesciences.org/reviewed-pre...
elifesciences.org
September 29, 2025 at 8:45 AM
Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.
More here: elifesciences.org/reviewed-pre...
More here: elifesciences.org/reviewed-pre...
Super cool! Looking forward to trying this reporter!
🚨 Excited to introduce FuChi (Fucci chicken), the first avian cell cycle reporter line. Thank you to all those who contributed to putting this paper together. I really think it showcases the power and beauty of the chick embryo as a developmental biology model. 🐥 🥚 🔬 @roslininstitute.bsky.social
September 26, 2025 at 11:26 AM
Super cool! Looking forward to trying this reporter!
📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
September 11, 2025 at 9:36 AM
📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉