Julie Miesch
@juliemiesch.bsky.social
Postdoc in the Derivery Lab at the MRC-LMB/#Postdoc.Mobility
Reposted by Julie Miesch
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:35 AM
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Reposted by Julie Miesch
Considering the LMB for your PhD?
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
November 10, 2025 at 2:03 PM
Considering the LMB for your PhD?
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
Reposted by Julie Miesch
Lots of exciting PhD projects on offer at the LMB, including in our group 😊
Considering the LMB for your PhD?
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int...
Apply by 2nd DEC for Autumn 2026 admission.
November 10, 2025 at 2:30 PM
Lots of exciting PhD projects on offer at the LMB, including in our group 😊
Reposted by Julie Miesch
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by Julie Miesch
📣 Two week left to apply! 👇
Apply in the link below or, if you have specific questions, reach out!
Apply in the link below or, if you have specific questions, reach out!
Job alert in neuro-immunology!
In case the internal link I shared last week does not work for some, here is an external link to apply for our postdoc position at the @mrclmb.bsky.social PNAC Division.
www.nature.com/naturecareer...
In case the internal link I shared last week does not work for some, here is an external link to apply for our postdoc position at the @mrclmb.bsky.social PNAC Division.
www.nature.com/naturecareer...
Postdoctoral Scientist - PNAC - Dr Noe Rodriguez - LMB 2717 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12845398
Postdoctoral Scientist Salary £41,344 per annum pro rata (for PD/CDF) MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a motiv...
www.nature.com
October 14, 2025 at 9:06 AM
📣 Two week left to apply! 👇
Apply in the link below or, if you have specific questions, reach out!
Apply in the link below or, if you have specific questions, reach out!
Reposted by Julie Miesch
Join us at @pborostemfest.bsky.social on Oct 18 to test your detective skills in an interactive game, matching what you see under a microscope with different areas of LMB’s science #PSF2025
📍 ARU Peterborough
🕚 11:00 – 16:00 (Quiet time 9.30-11)
www.peterboroughstemfestival.co.uk/exhibitors/m...
📍 ARU Peterborough
🕚 11:00 – 16:00 (Quiet time 9.30-11)
www.peterboroughstemfestival.co.uk/exhibitors/m...
MRC Laboratory of Molecular Biology - Beauty is in the detail - Peterborough STEM Festival
Have a go at coding with Peterborough CoderDojo!
www.peterboroughstemfestival.co.uk
October 13, 2025 at 10:46 AM
Join us at @pborostemfest.bsky.social on Oct 18 to test your detective skills in an interactive game, matching what you see under a microscope with different areas of LMB’s science #PSF2025
📍 ARU Peterborough
🕚 11:00 – 16:00 (Quiet time 9.30-11)
www.peterboroughstemfestival.co.uk/exhibitors/m...
📍 ARU Peterborough
🕚 11:00 – 16:00 (Quiet time 9.30-11)
www.peterboroughstemfestival.co.uk/exhibitors/m...
Reposted by Julie Miesch
🚨 New preprint out!
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.
www.biorxiv.org/content/10.1...
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.
www.biorxiv.org/content/10.1...
Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM
Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...
www.biorxiv.org
October 5, 2025 at 4:04 PM
🚨 New preprint out!
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.
www.biorxiv.org/content/10.1...
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.
www.biorxiv.org/content/10.1...
Reposted by Julie Miesch
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
October 2, 2025 at 9:04 AM
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
Reposted by Julie Miesch
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
September 16, 2025 at 4:22 PM
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
Reposted by Julie Miesch
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
September 16, 2025 at 7:43 AM
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
Reposted by Julie Miesch
🚨Publication alert🚨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics
A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...
www.nature.com
September 16, 2025 at 10:20 AM
🚨Publication alert🚨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
Reposted by Julie Miesch
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
September 15, 2025 at 8:42 AM
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
Reposted by Julie Miesch
Microtubule lattice conformation and integrity regulate α-tubulin acetylation https://www.biorxiv.org/content/10.1101/2025.09.09.675099v1
September 10, 2025 at 11:30 AM
Microtubule lattice conformation and integrity regulate α-tubulin acetylation https://www.biorxiv.org/content/10.1101/2025.09.09.675099v1
Reposted by Julie Miesch
Our humble gata2b in situ hybridization image made it onto the cover of @biologyopen.bsky.social!
If you'd like to check out the story behind the image, the link to our new paper is:
journals.biologists.com/bio/article/...
If you'd like to check out the story behind the image, the link to our new paper is:
journals.biologists.com/bio/article/...
September 3, 2025 at 8:23 AM
Our humble gata2b in situ hybridization image made it onto the cover of @biologyopen.bsky.social!
If you'd like to check out the story behind the image, the link to our new paper is:
journals.biologists.com/bio/article/...
If you'd like to check out the story behind the image, the link to our new paper is:
journals.biologists.com/bio/article/...
Reposted by Julie Miesch
Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...
August 11, 2025 at 5:15 PM
Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...
Reposted by Julie Miesch
Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...
Cryo-EM structures of Egl-BicD-RNA complexes reveal how diverse mRNAs are selected for subcellular localization https://www.biorxiv.org/content/10.1101/2025.08.02.668268v1
August 5, 2025 at 8:13 AM
Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...
Reposted by Julie Miesch
🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability
Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...
www.biorxiv.org
July 30, 2025 at 12:20 PM
🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
Reposted by Julie Miesch
📢 Deadline extended to Join Arolla 2025!
📅 Aug 25–29, Grand Hotel, Arolla
🌍 For junior & senior scientists in cutting-edge bio research
🧬 Abstracts + reg close August 11
💸 Discounts for LS2 members!
👉 Info & reg: meetings.ls2.ch/arolla2025
📅 Aug 25–29, Grand Hotel, Arolla
🌍 For junior & senior scientists in cutting-edge bio research
🧬 Abstracts + reg close August 11
💸 Discounts for LS2 members!
👉 Info & reg: meetings.ls2.ch/arolla2025
July 30, 2025 at 12:02 PM
📢 Deadline extended to Join Arolla 2025!
📅 Aug 25–29, Grand Hotel, Arolla
🌍 For junior & senior scientists in cutting-edge bio research
🧬 Abstracts + reg close August 11
💸 Discounts for LS2 members!
👉 Info & reg: meetings.ls2.ch/arolla2025
📅 Aug 25–29, Grand Hotel, Arolla
🌍 For junior & senior scientists in cutting-edge bio research
🧬 Abstracts + reg close August 11
💸 Discounts for LS2 members!
👉 Info & reg: meetings.ls2.ch/arolla2025
Reposted by Julie Miesch
Designed protein pockets recognize intrinsically disordered protein regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...
Disorder meets its match
Designed protein pockets recognize intrinsically disordered protein regions
www.science.org
July 17, 2025 at 7:42 PM
Designed protein pockets recognize intrinsically disordered protein regions @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.statnews.com/2025/07/17/n...
Reposted by Julie Miesch
How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!
www.cell.com/current-biol...
www.cell.com/current-biol...
Mosaic evolution of clathrin-mediated endocytosis in fungi
Picco et al. take an evolutionary approach to study clathrin-mediated endocytosis
in a fungal clade and discover that the process is evolving in a mosaic fashion. The
early phase of endocytosis has sh...
www.cell.com
July 10, 2025 at 3:31 PM
How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Julie Miesch
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
June 30, 2025 at 7:53 AM
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
Reposted by Julie Miesch
We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Postdoctoral Scientist - Structural Studies - Dr Sjors Scheres - LMB 2640 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12840844
Postdoctoral Scientist Starting Salary: £41,344 Fixed term: 3 years MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a postdoc...
www.nature.com
June 25, 2025 at 2:01 PM
We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Julie Miesch
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 24, 2025 at 7:22 PM
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Julie Miesch
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
June 23, 2025 at 1:00 PM
🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...
#STEMCareers #ResearchJobs
Reposted by Julie Miesch
Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
June 23, 2025 at 3:11 PM
Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes.
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs
More info: www.nature.com/naturecareer...
Apply by 10 JUL
#ScienceJobs