ImmuNoah's Ark (Noe Rodriguez)
@immunoah.bsky.social
Group Leader @MRC LMB. Passionate about (neuro)immunology, the universe & every now & then some good old fashion fantasy🏳️🌈(he/him). Opinions are my own.
https://www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/noe-rodriguez/
https://orcid.org/0000-0001-7825-5634
https://www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/noe-rodriguez/
https://orcid.org/0000-0001-7825-5634
Reposted by ImmuNoah's Ark (Noe Rodriguez)
To complement the launch of our new LMB website, we’ve shared a new introductory video on our YouTube channel.
Meet some of our scientists and support staff, take a look around our wonderful building and see how we come together to unravel how life works.
youtu.be/JmC17_4bEMA?...
Meet some of our scientists and support staff, take a look around our wonderful building and see how we come together to unravel how life works.
youtu.be/JmC17_4bEMA?...
Through the doors of discovery - an introduction to the MRC Laboratory of Molecular Biology
YouTube video by MRC Laboratory of Molecular Biology
youtu.be
January 23, 2026 at 3:28 PM
To complement the launch of our new LMB website, we’ve shared a new introductory video on our YouTube channel.
Meet some of our scientists and support staff, take a look around our wonderful building and see how we come together to unravel how life works.
youtu.be/JmC17_4bEMA?...
Meet some of our scientists and support staff, take a look around our wonderful building and see how we come together to unravel how life works.
youtu.be/JmC17_4bEMA?...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
🌐Our new LMB website is live!🌐
Fresh design, better navigation, same first-class science.
Take a look around ➡️ mrclmb.ac.uk
Fresh design, better navigation, same first-class science.
Take a look around ➡️ mrclmb.ac.uk
January 19, 2026 at 5:25 PM
🌐Our new LMB website is live!🌐
Fresh design, better navigation, same first-class science.
Take a look around ➡️ mrclmb.ac.uk
Fresh design, better navigation, same first-class science.
Take a look around ➡️ mrclmb.ac.uk
Reposted by ImmuNoah's Ark (Noe Rodriguez)
AAI congratulates 2026 Career Awardees for outstanding research and career achievements! Join us to honor them at IMMUNOLOGY2026™. Learn more: https://ow.ly/CwaR50Y0Rr8.
January 21, 2026 at 8:01 PM
AAI congratulates 2026 Career Awardees for outstanding research and career achievements! Join us to honor them at IMMUNOLOGY2026™. Learn more: https://ow.ly/CwaR50Y0Rr8.
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 19, 2026 at 7:09 PM
Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Join Paul Nurse from the Francis Crick Institute at the LMB on Monday 26th January at 11am (GMT) for a #LMBSeminar on ‘New Perspectives on CDKs and Cell Cycle Control’
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
January 14, 2026 at 9:55 AM
Join Paul Nurse from the Francis Crick Institute at the LMB on Monday 26th January at 11am (GMT) for a #LMBSeminar on ‘New Perspectives on CDKs and Cell Cycle Control’
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
🚨New pre-print🚨
We found before that mesenchymal stem cell extracellular vesicles (MSC-EV) ⬇️ pain/neuronal sensitisation in 🐭 osteoarthritis (OA)
See: x.com/psalmotoxin/... & acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Now we've an idea how MSC-EVs work!
www.biorxiv.org/content/10.6...
We found before that mesenchymal stem cell extracellular vesicles (MSC-EV) ⬇️ pain/neuronal sensitisation in 🐭 osteoarthritis (OA)
See: x.com/psalmotoxin/... & acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Now we've an idea how MSC-EVs work!
www.biorxiv.org/content/10.6...
a cartoon penguin is holding a light bulb above his head
ALT: a cartoon penguin is holding a light bulb above his head
media.tenor.com
January 13, 2026 at 8:55 AM
🚨New pre-print🚨
We found before that mesenchymal stem cell extracellular vesicles (MSC-EV) ⬇️ pain/neuronal sensitisation in 🐭 osteoarthritis (OA)
See: x.com/psalmotoxin/... & acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Now we've an idea how MSC-EVs work!
www.biorxiv.org/content/10.6...
We found before that mesenchymal stem cell extracellular vesicles (MSC-EV) ⬇️ pain/neuronal sensitisation in 🐭 osteoarthritis (OA)
See: x.com/psalmotoxin/... & acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Now we've an idea how MSC-EVs work!
www.biorxiv.org/content/10.6...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Come & join us 😃👇
We have a new funded #PhD opportunity available!
This is supervised by Prof. Ewan St. John Smith, titled Regulation of neuronal excitability using IgG targeting of ion channels and GPCRs 🔬
The deadline to apply is on Thursday 26 February. Apply here: www.phar.cam.ac.uk/postgraduate...
This is supervised by Prof. Ewan St. John Smith, titled Regulation of neuronal excitability using IgG targeting of ion channels and GPCRs 🔬
The deadline to apply is on Thursday 26 February. Apply here: www.phar.cam.ac.uk/postgraduate...
January 12, 2026 at 11:16 AM
Come & join us 😃👇
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Sensory neurons innervating bones can modulate the healing process (bone regeneration) after a fracture!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mapping somatosensory afferent circuitry to bone identifies neurotrophic signals required for fracture healing
The pain associated with bone fracture is mediated by somatosensory neurons, which also appear to be required to initiate bone regeneration. To characterize neuroanatomical circuitry mediating skeleta...
www.science.org
January 9, 2026 at 7:55 AM
Sensory neurons innervating bones can modulate the healing process (bone regeneration) after a fracture!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Neuro-epithelial circuits promote sensory convergence and intestinal immunity @nature.com @weillcornell.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 7, 2026 at 10:22 PM
Neuro-epithelial circuits promote sensory convergence and intestinal immunity @nature.com @weillcornell.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Lots of talk/mandates for open data but there should be more done by funders about the fragility of repositories - SRA, GISAID, flybase, etc.
As noted at our NA/RS data summit, everyone loves the glittering fountain the but no-one wants to pay for the plumbing...
www.science.org/content/arti...
As noted at our NA/RS data summit, everyone loves the glittering fountain the but no-one wants to pay for the plumbing...
www.science.org/content/arti...
Fresh conflicts erupt around giant database for flu and COVID-19 sequences
Critics say “autocratic” behavior by GISAID could hamper response to a future pandemic
www.science.org
January 8, 2026 at 4:48 PM
Lots of talk/mandates for open data but there should be more done by funders about the fragility of repositories - SRA, GISAID, flybase, etc.
As noted at our NA/RS data summit, everyone loves the glittering fountain the but no-one wants to pay for the plumbing...
www.science.org/content/arti...
As noted at our NA/RS data summit, everyone loves the glittering fountain the but no-one wants to pay for the plumbing...
www.science.org/content/arti...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
While the lunatic-in-chief deviates the world’s attention, the 70+ years apartheid and genocide by the occupation forces continue at full speed apple.news/Abbh-m89ES6m...
'Systematic asphyxiation of Palestinian rights' | UN report urges Israel to eradicate 'racial segregation and apartheid' in West Bank — Haaretz
Israel dismissed the 42-page report as a 'politically driven vilification,' which said tightened movement restrictions on Palestinians have fractured the West Bank, easing Israeli military control and...
apple.news
January 8, 2026 at 4:20 PM
While the lunatic-in-chief deviates the world’s attention, the 70+ years apartheid and genocide by the occupation forces continue at full speed apple.news/Abbh-m89ES6m...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Vaccines, the most impressive public health intervention in medical history, and where we could be headed if there was not efforts to negate truth, facts, and evidence
A great, open-access, review and perspective by @scientificdiscovery.dev
A great, open-access, review and perspective by @scientificdiscovery.dev
January 7, 2026 at 8:17 PM
Vaccines, the most impressive public health intervention in medical history, and where we could be headed if there was not efforts to negate truth, facts, and evidence
A great, open-access, review and perspective by @scientificdiscovery.dev
A great, open-access, review and perspective by @scientificdiscovery.dev
Reposted by ImmuNoah's Ark (Noe Rodriguez)
I'm old enough to remember when immunological defectors went over to Neuro because they thought they'd demonstrate olfactory receptor diversity derived from somatic recombination
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
www.biorxiv.org
January 7, 2026 at 7:41 AM
I'm old enough to remember when immunological defectors went over to Neuro because they thought they'd demonstrate olfactory receptor diversity derived from somatic recombination
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Revealing the hidden switch behind aggressive cancers.
ADGRL4 in its active state by David Favara in Chris Tate’s group, reveals how a G-protein couples & highlights activation method, paving the way for new cancer therapies.
Read more: www2.mrc-lmb.cam.ac.uk/revealing-th...
#LMBResearch #CryoEM
ADGRL4 in its active state by David Favara in Chris Tate’s group, reveals how a G-protein couples & highlights activation method, paving the way for new cancer therapies.
Read more: www2.mrc-lmb.cam.ac.uk/revealing-th...
#LMBResearch #CryoEM
January 6, 2026 at 3:34 PM
Revealing the hidden switch behind aggressive cancers.
ADGRL4 in its active state by David Favara in Chris Tate’s group, reveals how a G-protein couples & highlights activation method, paving the way for new cancer therapies.
Read more: www2.mrc-lmb.cam.ac.uk/revealing-th...
#LMBResearch #CryoEM
ADGRL4 in its active state by David Favara in Chris Tate’s group, reveals how a G-protein couples & highlights activation method, paving the way for new cancer therapies.
Read more: www2.mrc-lmb.cam.ac.uk/revealing-th...
#LMBResearch #CryoEM
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Protecting our little ones is a top priority this New Year 🌟
Give children the best start by keeping vaccinations up to date. Childhood vaccinations protect against serious diseases and keep our communities safe 🤝
Read our guide to childhood vaccines: https://bit.ly/455bTui
Give children the best start by keeping vaccinations up to date. Childhood vaccinations protect against serious diseases and keep our communities safe 🤝
Read our guide to childhood vaccines: https://bit.ly/455bTui
January 5, 2026 at 10:45 AM
Protecting our little ones is a top priority this New Year 🌟
Give children the best start by keeping vaccinations up to date. Childhood vaccinations protect against serious diseases and keep our communities safe 🤝
Read our guide to childhood vaccines: https://bit.ly/455bTui
Give children the best start by keeping vaccinations up to date. Childhood vaccinations protect against serious diseases and keep our communities safe 🤝
Read our guide to childhood vaccines: https://bit.ly/455bTui
Reposted by ImmuNoah's Ark (Noe Rodriguez)
@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology
Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...
www.nature.com
January 2, 2026 at 7:19 PM
@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Is your New Year's resolution to learn something new? Check out immunologyexplained.org for resources and videos that explain how the immune system impacts all aspects of health.
Learn something new? 👇 Share it below.
#immunologyexplained #NewYearsLearning #WellnessJourney
Learn something new? 👇 Share it below.
#immunologyexplained #NewYearsLearning #WellnessJourney
January 1, 2026 at 4:01 PM
Is your New Year's resolution to learn something new? Check out immunologyexplained.org for resources and videos that explain how the immune system impacts all aspects of health.
Learn something new? 👇 Share it below.
#immunologyexplained #NewYearsLearning #WellnessJourney
Learn something new? 👇 Share it below.
#immunologyexplained #NewYearsLearning #WellnessJourney
Reposted by ImmuNoah's Ark (Noe Rodriguez)
We know it's New Years Eve, but these aren't fireworks 🎇!
Check out this microscopy image of neural progenitor cells — multipotent, self-renewing cells in the central nervous system that generate neurons and glial cells in the 🧠.
Credit: Pera Lab at JAX
Check out this microscopy image of neural progenitor cells — multipotent, self-renewing cells in the central nervous system that generate neurons and glial cells in the 🧠.
Credit: Pera Lab at JAX
January 1, 2026 at 12:15 AM
We know it's New Years Eve, but these aren't fireworks 🎇!
Check out this microscopy image of neural progenitor cells — multipotent, self-renewing cells in the central nervous system that generate neurons and glial cells in the 🧠.
Credit: Pera Lab at JAX
Check out this microscopy image of neural progenitor cells — multipotent, self-renewing cells in the central nervous system that generate neurons and glial cells in the 🧠.
Credit: Pera Lab at JAX
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Analysis concludes that increase in autism (ASD) between 2000 & 2016 driven in large part by increased autism with mild phenotypes, possibly due to improved identification of more mild forms of condition
onlinelibrary.wiley.com/doi/10.1002/...
Note: Study includes an extensive 'limitations' section
onlinelibrary.wiley.com/doi/10.1002/...
Note: Study includes an extensive 'limitations' section
December 31, 2025 at 8:44 PM
Analysis concludes that increase in autism (ASD) between 2000 & 2016 driven in large part by increased autism with mild phenotypes, possibly due to improved identification of more mild forms of condition
onlinelibrary.wiley.com/doi/10.1002/...
Note: Study includes an extensive 'limitations' section
onlinelibrary.wiley.com/doi/10.1002/...
Note: Study includes an extensive 'limitations' section
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Distinct fibroblast assemblies establish scarless regeneration @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
December 31, 2025 at 2:54 PM
Distinct fibroblast assemblies establish scarless regeneration @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Best wishes for 2026 from the Neuroimmune Crosstalk Lab @mrclmb.bsky.social!
For a new year full of EDI, where we're better & there is no genocide or war.
And also full of new discoveries, cool science and growth!
Image by the cool "Blueskyless" Ksena Longrin from a fluorescent neuron she imaged.
For a new year full of EDI, where we're better & there is no genocide or war.
And also full of new discoveries, cool science and growth!
Image by the cool "Blueskyless" Ksena Longrin from a fluorescent neuron she imaged.
December 31, 2025 at 2:48 PM
Best wishes for 2026 from the Neuroimmune Crosstalk Lab @mrclmb.bsky.social!
For a new year full of EDI, where we're better & there is no genocide or war.
And also full of new discoveries, cool science and growth!
Image by the cool "Blueskyless" Ksena Longrin from a fluorescent neuron she imaged.
For a new year full of EDI, where we're better & there is no genocide or war.
And also full of new discoveries, cool science and growth!
Image by the cool "Blueskyless" Ksena Longrin from a fluorescent neuron she imaged.
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Another great output from a joyful long-term collaboration between Montevideo and Manchester
onlinelibrary.wiley.com/doi/10.1111/...
Published in the excellent journal onlinelibrary.wiley.com/toc/13653024...
onlinelibrary.wiley.com/doi/10.1111/...
Published in the excellent journal onlinelibrary.wiley.com/toc/13653024...
Parasite Immunology: Vol 47, No 12
Click on the title to browse this issue
onlinelibrary.wiley.com
December 29, 2025 at 2:06 PM
Another great output from a joyful long-term collaboration between Montevideo and Manchester
onlinelibrary.wiley.com/doi/10.1111/...
Published in the excellent journal onlinelibrary.wiley.com/toc/13653024...
onlinelibrary.wiley.com/doi/10.1111/...
Published in the excellent journal onlinelibrary.wiley.com/toc/13653024...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"
Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis - Nature Communications
Determining the appropriate sample size (N) for bulk RNA sequencing experiments is critical to ensure reliable results. Here the authors perform an unusually large N experiment (N = 30 per group), ana...
www.nature.com
December 27, 2025 at 3:51 PM
"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Nature’s survey of PhD candidates reveals hard-won wisdom on choosing supervisors, managing mental health and surviving academic culture.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
27 things we wish we’d known when we started our PhDs
Nature’s survey of PhD candidates reveals hard-won wisdom on choosing supervisors, managing mental health and surviving academic culture.
www.nature.com
December 26, 2025 at 5:06 PM
Nature’s survey of PhD candidates reveals hard-won wisdom on choosing supervisors, managing mental health and surviving academic culture.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by ImmuNoah's Ark (Noe Rodriguez)
Calling all glia researchers! 🧬 Registration is open for the UK Glia 2026 meeting (8–9 June). Abstract deadline: 16 Jan. 🔗 www.physoc.org/events/uk-gl... In this post, we highlight one more speaker, Andrew Greenhalgh @headimmume.bsky.social of the University of Manchester @manchester.ac.uk
December 24, 2025 at 12:15 PM
Calling all glia researchers! 🧬 Registration is open for the UK Glia 2026 meeting (8–9 June). Abstract deadline: 16 Jan. 🔗 www.physoc.org/events/uk-gl... In this post, we highlight one more speaker, Andrew Greenhalgh @headimmume.bsky.social of the University of Manchester @manchester.ac.uk