ImmuNoah's Ark (Noe Rodriguez)
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immunoah.bsky.social
ImmuNoah's Ark (Noe Rodriguez)
@immunoah.bsky.social
2.5K followers 720 following 56 posts
Group Leader @MRC LMB. Passionate about (neuro)immunology, the universe & every now & then some good old fashion fantasy🏳️‍🌈(he/him). Opinions are my own.
https://www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/noe-rodriguez/
https://orcid.org/0000-0001-7825-5634
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Reposted by ImmuNoah's Ark (Noe Rodriguez)
psalmotoxin.bsky.social
Acid-induced pain is complex: there are LOTS of acid sensors; acid-induced pain is common in the animal kingdom, but not naked mole-rats, see @interlukein.bsky.social’s review royalsocietypublishing.org/doi/10.1098/...
Membrane topologies of proton-sensitive receptor subunits. Schematic diagram of the basic structure of proton-sensitive receptors, with residues or regions important for proton sensitivity annotated (yellow—highly conserved among family members; white—less conserved or important in some, but not all, family members). Functional ASICs, K2Ps and TRPs are multimeric, but for simplicity only one subunit of each receptor is shown. Phylogeny of general nociception and acid nociception. Annotated phylogenetic tree indicating the presence of general nociceptors, observation of acid nociception and functional expression of proton-sensitive receptors. Annotation is limited by the rarity of molecular studies focusing on lower-order species. Expression of proton-sensitive receptors is only acknowledged for those species where proton sensitivity of at least one member of the group in question has been empirically proven. Naked mole-rat sitting on a glove
November 4, 2025 at 4:49 PM