François Lallemend
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flallemend.bsky.social
François Lallemend
@flallemend.bsky.social
590 followers 160 following 43 posts
Professor of neurobiology of sensory systems @karolinska Institute, Stockholm, Sweden • single cell • development • cell state • system homeostasis • aging • auditory • vestibular • somatosensory • translational
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flallemend.bsky.social
"Not Just Neurons: Pain Is Orchestrated in Partnership with Many Non-neuronal Cells"
psalmotoxin.bsky.social Ewan St. John Smith @psalmotoxin.bsky.social · 2d
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch

Here's our accompanying review!
www.jneurosci.org/content/45/4...
Figure 1. Non-neuronal–neuron communication in the skin. (1) Non-neuronal cells and extracellular matrix in the skin. (2) When in ammatory events such as IL-6, ATP, and protease production from injury or infection are introduced, it causes an activation of cells, a disruption in extracellular matrix, and damage to sensory neurons. (3) During in ammatory cascades, injured or sensitized neurons potentiate pain and the development of a chronic pain state. Figure 2. Cell–cell interactions in joint pain. Numerous pathogenic changes occur within the OA joint and other musculoskeletal conditions that can contribute to pain, including cartilage degradation, synovitis, and bone remodeling (1). Within the joint evidence has established the role of some key non-neuronal cell types that contribute to pain (2) and some of the signaling nociceptor activation and sensitization mechanisms involved (3). There is also growing evidence for cell–cell interactions within the DRG that contribute to pain (4). See text for more details. Figure 3. Keratinocytes contribute to normal touch and chemotherapy-induced mechanical sensitivity through PIEZO1. Keratinocytes in the most super cial layer of the skin respond to mechanical forces via their expression of PIEZO1 channels and activated keratinocytes release ATP which signals to P2X4 channels on cutaneous sensory nerve endings. After a patient is treated with the chemotherapeutic paclitaxel, keratinocyte PIEZO1 is sensitized; the keratinocytes release more ATP and additional mediators, resulting in greater action potential signaling in sensory neurons that is sent to the spinal cord and brain through touch and pain pathways.
November 13, 2025 at 8:38 PM
Reposted by François Lallemend
carlstrom.bsky.social
New preprint from
@gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes.
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 13, 2025 at 8:35 AM
Reposted by François Lallemend
ki.se
The study is a collaboration between KI, @stockholm-uni.bsky.social and @au.dk. Link to publication: www.cell.com/cell-reports...
Maternal diabetes programs sexually dimorphic early-onset cardiovascular dysfunction in metabolically healthy offspring
Zhao et al. translationally demonstrate how maternal diabetes induces early-onset endothelial dysfunction in sons, but not daughters, even when offspring are metabolically healthy. This challenges pri...
www.cell.com
November 12, 2025 at 11:34 AM
Reposted by François Lallemend
ki.se
Maternal #diabetes may predispose sons, but not daughters, to early #cardiovascular dysfunction, even without metabolic disease. Study in @cp-cellrepmed.bsky.social by @qiaolindeng.bsky.social and @zhaoallan.bsky.social highlights oxidative stress as a key driver🧪 news.ki.se/sons-of-moth...
A boy looking out of a window. Photo: Getty Images
November 12, 2025 at 11:34 AM
Reposted by François Lallemend
sergiuppasca.bsky.social
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
November 7, 2025 at 12:12 PM
Reposted by François Lallemend
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
biorxiv.org
November 7, 2025 at 4:43 AM
Reposted by François Lallemend
gocastelobranco.bsky.social
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Reposted by François Lallemend
jonathanamichaels.bsky.social
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:11 PM
Reposted by François Lallemend
thetransmitter.bsky.social
How is it that some nociceptors—the sensory neurons that detect heat, chemical irritants and toxins—can withstand a lifespan’s worth of exposure to noxious stimuli, whereas others die? New findings reveal how they do it.

By @vcallier.bsky.social

#neuroskyence
www.thetransmitter.org/sensory-syst...
Neurons modulate sensitivity via electron transport chain
Some nociceptors can survive a lifetime’s worth of exposure to noxious stimuli by reducing their mitochondria’s production of reactive oxygen species.
www.thetransmitter.org
October 22, 2025 at 4:57 PM
Reposted by François Lallemend
junnagai.bsky.social
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
October 15, 2025 at 4:11 PM
Reposted by François Lallemend
gioelelamanno.bsky.social
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
Reposted by François Lallemend
o-andersson-lab.bsky.social
Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives)
novonordiskfonden.dk/en/grant/pos...
Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden
novonordiskfonden.dk
October 4, 2025 at 10:19 AM
Reposted by François Lallemend
niccolozampieri.bsky.social
I really like this one 🤓. Work led by Elisa Toscano with invaluable help from many 🙏 @alesantuz.bsky.social, @lowensteined.bsky.social. A spinal circuit for skilled locomotion www.cell.com/current-biol...
A spinal circuit for skilled locomotion
Toscano et al. identify glutamatergic Pitx2+ V0 ascending neurons (V0g-aNs) that receive input from cerebrospinal fluid (CSF)-contacting neurons and target spinal premotor and motor neurons. Eliminati...
www.cell.com
October 3, 2025 at 3:21 PM
Reposted by François Lallemend
anderssonlab.bsky.social
👩‍🔬👨‍💻 Postdoc recruitment! 👨‍🔬👩‍💻

Join us to use next generation single cell lineage tracing (de Haan & He et al Science 2025) to resolve dermis developmental dynamics & mechanisms.

🚨 Deadline Oct 1st!! 🚨

Please re-post and help us spread the word far and wide! ✈

ki.varbi.com/en/what:job/...
Postdoctoral studies in next generation single cell lineage tracing of skin (scholarship)
Do you want to contribute to top quality medical research? A postdoctoral scholarship is available in the lab of Emma R Andersson at the Department of Cell and Molecular Biology, Karolinska Institutet
ki.varbi.com
September 27, 2025 at 7:41 AM
flallemend.bsky.social
Immune-neuron circuits let pain jump between organs. Potential new treatment for bladder-gut disorders
doi.org/10.21203/rs....
An interorgan neuroimmune circuit promotes visceral hypersensitivity
Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis...
doi.org
September 27, 2025 at 8:53 AM
Reposted by François Lallemend
aliibarry.bsky.social
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception #PainResearch

www.science.org/doi/10.1126/...
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
September 9, 2025 at 3:20 PM
Reposted by François Lallemend
cyrilpedia.bsky.social
'Here, we detail the biological, environmental and experimental factors that can affect circadian rhythms of mice and provide recommendations for designing and reporting experiments for in vivo metabolic studies.'
www.nature.com/articles/s42...
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
www.nature.com
September 3, 2025 at 2:00 AM
Reposted by François Lallemend
ppimentel-coelho.bsky.social
Maternal stress triggers early-life eczema through fetal mast cell programming

Nadine Serhan et al. 🧪

www.nature.com/articles/s41...
Maternal stress triggers early-life eczema through fetal mast cell programming - Nature
Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...
www.nature.com
August 29, 2025 at 10:02 PM
Reposted by François Lallemend
biorxiv-neursci.bsky.social
Social Touch Suppresses Aggression via Thalamic Mechanisms https://www.biorxiv.org/content/10.1101/2025.08.23.670446v1
August 24, 2025 at 7:15 AM
Reposted by François Lallemend
alleslab.bsky.social
Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.nature.com
August 21, 2025 at 3:06 PM
Reposted by François Lallemend
hunterschone.bsky.social
Now out in @natneuro.nature.com

What happens to the brain’s body map when a body-part is removed?

Scanning patients before and up to 5 yrs after arm amputation, we discovered the brain’s body map is strikingly preserved despite amputation

www.nature.com/articles/s41593-025-02037-7

🧵1/18
August 21, 2025 at 9:20 AM
flallemend.bsky.social
Gut bacteria produce proteins that could seve as new drugs for metabolism disorders, including diabetes or obesity
www.nature.com/articles/s41...
Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism - Nature Microbiology
Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.
www.nature.com
August 13, 2025 at 1:22 PM
flallemend.bsky.social
Deep neural network analysis is a powerful tool, biological experimentation remains however essential: it reveals principles that AI can't infer on its own, yet.
agreco.bsky.social Antonino Greco @agreco.bsky.social · Aug 9
🔵 Proud to share our new preprint 🔵

We compared humans and deep neural networks on sound localization 👂📍

Humans robustly localized OOD sounds even without primary interaural cues (ITD & ILD)

Models localized well only in-training distribution sounds, failing on OOD regime

Link & full story 🧵👇
August 11, 2025 at 11:14 AM
Reposted by François Lallemend
natmethods.nature.com
An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social

www.nature.com/articles/s41...
Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines - Nature Methods
The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...
www.nature.com
August 4, 2025 at 4:07 PM