Pau Guillamat
@pauguillamat.bsky.social
Active Nematics & Synthetic Morphogenesis
Pinned
Pau Guillamat
@pauguillamat.bsky.social
· Jun 30
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
Reposted by Pau Guillamat
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
November 11, 2025 at 11:01 PM
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps.
@pnas.org @ub.edu
www.pnas.org/doi/10.1073/...
#ActiveMatter #Microfluidics #SoftMatter
@pnas.org @ub.edu
www.pnas.org/doi/10.1073/...
#ActiveMatter #Microfluidics #SoftMatter
Active nematic pumps | PNAS
Microfluidics involves the manipulation of flows at the microscale, typically requiring
external power sources to generate pressure gradients. Alte...
www.pnas.org
November 12, 2025 at 7:20 PM
Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps.
@pnas.org @ub.edu
www.pnas.org/doi/10.1073/...
#ActiveMatter #Microfluidics #SoftMatter
@pnas.org @ub.edu
www.pnas.org/doi/10.1073/...
#ActiveMatter #Microfluidics #SoftMatter
Reposted by Pau Guillamat
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
October 24, 2025 at 10:57 AM
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
Reposted by Pau Guillamat
Truly chuffed for our fearless food physicists @mpipks.bsky.social + collabs from AT @istaresearch.bsky.social, IT & ES who won this year’s Ig Nobel - the #NobelPrize of hearts❤️for cracking the science of perfect pasta !🍝Kudos to all for intrepidly consuming lots of cheese in the name of science!😋
The Secret to a Smooth Pasta Sauce Wins Ig Nobel Prize
Italian researchers studied how the ingredients of the traditional Roman dish cacio e pepe emulsify into a creamy sauce, winning the 2025 Physics Ig Nobel Prize.
www.the-scientist.com
September 19, 2025 at 12:40 PM
Truly chuffed for our fearless food physicists @mpipks.bsky.social + collabs from AT @istaresearch.bsky.social, IT & ES who won this year’s Ig Nobel - the #NobelPrize of hearts❤️for cracking the science of perfect pasta !🍝Kudos to all for intrepidly consuming lots of cheese in the name of science!😋
Reposted by Pau Guillamat
Mechanosensation and fast reorientation of ciliary structures: Marvin's work on the surprising locomotion capabilities of Trichoplax, an animal without neurons!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 27, 2025 at 10:50 AM
Mechanosensation and fast reorientation of ciliary structures: Marvin's work on the surprising locomotion capabilities of Trichoplax, an animal without neurons!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pau Guillamat
Now published in @natcomms.nature.com! 🥳
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
August 15, 2025 at 12:13 PM
Now published in @natcomms.nature.com! 🥳
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
Reposted by Pau Guillamat
Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
August 6, 2025 at 1:09 PM
Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
Reposted by Pau Guillamat
Dreaming of a swimming pool? Bacteria are surrounded by water! Water capillary forces organize bacterial colonies into gas, nematic streams, or droplet states. New paper @natphys.nature.com led by Matt Black and Chenyi Fei, with Ned Wingreen and Josh Shaevitz!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Capillary interactions drive the self-organization of bacterial colonies - Nature Physics
Bacteria tend to live in thin layers of water on surfaces. Now the capillary forces in these layers are shown to help organize the bacteria into dense packs.
www.nature.com
August 2, 2025 at 2:59 PM
Dreaming of a swimming pool? Bacteria are surrounded by water! Water capillary forces organize bacterial colonies into gas, nematic streams, or droplet states. New paper @natphys.nature.com led by Matt Black and Chenyi Fei, with Ned Wingreen and Josh Shaevitz!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pau Guillamat
🔬#IBEC researchers create the world’s simplest artificial cell that can navigate using chemistry with just a membrane, an enzyme and a pore.
A breakthrough on how life moves🧬
🧪 @science.org #ScienceAdvances
🤝 @ub.edu @liverpooluni.bsky.social
👉 Read the news: https://f.mtr.cool/tzjomevovt
A breakthrough on how life moves🧬
🧪 @science.org #ScienceAdvances
🤝 @ub.edu @liverpooluni.bsky.social
👉 Read the news: https://f.mtr.cool/tzjomevovt
July 26, 2025 at 8:02 AM
🔬#IBEC researchers create the world’s simplest artificial cell that can navigate using chemistry with just a membrane, an enzyme and a pore.
A breakthrough on how life moves🧬
🧪 @science.org #ScienceAdvances
🤝 @ub.edu @liverpooluni.bsky.social
👉 Read the news: https://f.mtr.cool/tzjomevovt
A breakthrough on how life moves🧬
🧪 @science.org #ScienceAdvances
🤝 @ub.edu @liverpooluni.bsky.social
👉 Read the news: https://f.mtr.cool/tzjomevovt
Reposted by Pau Guillamat
Our study on endothelial mechanics made the news! 🤩
Super nice and clear article on our findings and their implications.
www.snexplores.org/article/how-...
Super nice and clear article on our findings and their implications.
www.snexplores.org/article/how-...
Here’s why your blood vessels don’t burst under pressure
Cells lining the blood vessels reorganize their inner structures to handle stressful boosts in pressure.
www.snexplores.org
July 17, 2025 at 9:27 AM
Our study on endothelial mechanics made the news! 🤩
Super nice and clear article on our findings and their implications.
www.snexplores.org/article/how-...
Super nice and clear article on our findings and their implications.
www.snexplores.org/article/how-...
Reposted by Pau Guillamat
On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
July 4, 2025 at 10:21 AM
On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
Reposted by Pau Guillamat
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
July 3, 2025 at 10:25 AM
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu
www.biorxiv.org/content/10.1...
Reposted by Pau Guillamat
How to turn a layer of fibroblasts into a tulip 🌷?
Check out our new pre-print on shape-programmable living surfaces.
Led by @pauguillamat.bsky.social
www.biorxiv.org/content/10.1...
Check out our new pre-print on shape-programmable living surfaces.
Led by @pauguillamat.bsky.social
www.biorxiv.org/content/10.1...
June 30, 2025 at 5:22 PM
How to turn a layer of fibroblasts into a tulip 🌷?
Check out our new pre-print on shape-programmable living surfaces.
Led by @pauguillamat.bsky.social
www.biorxiv.org/content/10.1...
Check out our new pre-print on shape-programmable living surfaces.
Led by @pauguillamat.bsky.social
www.biorxiv.org/content/10.1...
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
June 30, 2025 at 7:53 AM
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
Reposted by Pau Guillamat
📢Excited to share our new paper in Nature Physics
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
April 2, 2025 at 12:14 PM
📢Excited to share our new paper in Nature Physics
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
Reposted by Pau Guillamat
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
March 31, 2025 at 1:11 PM
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
Reposted by Pau Guillamat
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
March 28, 2025 at 11:46 AM
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Pau Guillamat
Peer review completed within 7 days!
Paying peer reviewers!
Yes, it's possible.
Fast & Fair peer review by @biologyopen.bsky.social
More innovation from @biologists.bsky.social
Details here: www.biorxiv.org/content/10.1...
Paying peer reviewers!
Yes, it's possible.
Fast & Fair peer review by @biologyopen.bsky.social
More innovation from @biologists.bsky.social
Details here: www.biorxiv.org/content/10.1...
March 25, 2025 at 12:05 PM
Peer review completed within 7 days!
Paying peer reviewers!
Yes, it's possible.
Fast & Fair peer review by @biologyopen.bsky.social
More innovation from @biologists.bsky.social
Details here: www.biorxiv.org/content/10.1...
Paying peer reviewers!
Yes, it's possible.
Fast & Fair peer review by @biologyopen.bsky.social
More innovation from @biologists.bsky.social
Details here: www.biorxiv.org/content/10.1...
Reposted by Pau Guillamat
What do star fish, snowflakes, and even cells have in common?
I am @juliaeckert.bsky.social and I would like to take you on a journey into the field of soft matter and give you a brief overview of experimental observations on symmetries in biological systems. #EpithelialMechanics
I am @juliaeckert.bsky.social and I would like to take you on a journey into the field of soft matter and give you a brief overview of experimental observations on symmetries in biological systems. #EpithelialMechanics
March 1, 2025 at 7:02 AM
What do star fish, snowflakes, and even cells have in common?
I am @juliaeckert.bsky.social and I would like to take you on a journey into the field of soft matter and give you a brief overview of experimental observations on symmetries in biological systems. #EpithelialMechanics
I am @juliaeckert.bsky.social and I would like to take you on a journey into the field of soft matter and give you a brief overview of experimental observations on symmetries in biological systems. #EpithelialMechanics
Reposted by Pau Guillamat
What a beautiful cover for our #mechanobiology paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer": doi.org/10.1038/s415... - thx @naturephysics.bsky.social !!
News & Views "Tissue wrinkles foreshadow cancer" doi.org/10.1038/s415...
News & Views "Tissue wrinkles foreshadow cancer" doi.org/10.1038/s415...
February 20, 2025 at 5:30 AM
What a beautiful cover for our #mechanobiology paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer": doi.org/10.1038/s415... - thx @naturephysics.bsky.social !!
News & Views "Tissue wrinkles foreshadow cancer" doi.org/10.1038/s415...
News & Views "Tissue wrinkles foreshadow cancer" doi.org/10.1038/s415...
Reposted by Pau Guillamat
Shim, G., Breinyn, I. B., Martínez-Calvo, A., Rao, S., & Cohen, D. J. (2024). Bioelectric stimulation controls tissue shape and size. Nature communications, 15(1), 2938. #EpithelialMechanics
https://www.nature.com/articles/s41467-024-47079-w
https://www.nature.com/articles/s41467-024-47079-w
January 31, 2025 at 7:00 AM
Shim, G., Breinyn, I. B., Martínez-Calvo, A., Rao, S., & Cohen, D. J. (2024). Bioelectric stimulation controls tissue shape and size. Nature communications, 15(1), 2938. #EpithelialMechanics
https://www.nature.com/articles/s41467-024-47079-w
https://www.nature.com/articles/s41467-024-47079-w
Reposted by Pau Guillamat
Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
January 29, 2025 at 11:01 PM
Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
Reposted by Pau Guillamat
Yamini @yamini-ravichan.bsky.social changed the topology of Hydra to show that actin orientational defects of Hydra induce the full program of head regeneration: www.science.org/doi/10.1126/...
Mechanics controls development! Thanks to Dan Pearce, Karsten Kruse, Matthias Vogg & Brigitte Galliot.
Mechanics controls development! Thanks to Dan Pearce, Karsten Kruse, Matthias Vogg & Brigitte Galliot.
January 20, 2025 at 7:19 AM
Yamini @yamini-ravichan.bsky.social changed the topology of Hydra to show that actin orientational defects of Hydra induce the full program of head regeneration: www.science.org/doi/10.1126/...
Mechanics controls development! Thanks to Dan Pearce, Karsten Kruse, Matthias Vogg & Brigitte Galliot.
Mechanics controls development! Thanks to Dan Pearce, Karsten Kruse, Matthias Vogg & Brigitte Galliot.
Reposted by Pau Guillamat
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
December 3, 2024 at 9:18 AM
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1