Claire Dessalles
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clairedessalles.bsky.social
Claire Dessalles
@clairedessalles.bsky.social
1.5K followers 1K following 26 posts
Postdoc @RouxLab.bsky.social investigating topological defects and morphogenesis. PhD was on tensile stresses and endothelial cells.
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clairedessalles.bsky.social
Claire Dessalles @clairedessalles.bsky.social · Apr 18
Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi

@ipparis.bsky.social @polytechniqueparis.bsky.social
Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics
Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...
rdcu.be
Reposted by Claire Dessalles
epimechfc.bsky.social
Hi, I’m David Brückner @davidbrueckner.bsky.social.

I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.

buff.ly/RFxVeHh
November 15, 2025 at 8:00 AM
Reposted by Claire Dessalles
pauguillamat.bsky.social
Microfluidic pumping with active nematics! Self-organized and self-sustained. No external pumps.

@pnas.org @ub.edu

www.pnas.org/doi/10.1073/...

#ActiveMatter #Microfluidics #SoftMatter
Active nematic pumps | PNAS
Microfluidics involves the manipulation of flows at the microscale, typically requiring external power sources to generate pressure gradients. Alte...
www.pnas.org
November 12, 2025 at 7:20 PM
Reposted by Claire Dessalles
juanmagararc.bsky.social
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
Main - Cell Dynamics and Fragmentation Lab
The Cell Dynamics and Fragmentation lab at We study how single cells move and fragment in complex environments using microfluidics. We bring tools and concep...
celldynamicslab.com
November 11, 2025 at 5:10 PM
Reposted by Claire Dessalles
haoyin.bsky.social
Amazing story 😍
Just scan through it. Sophisticate, delicate and elegant 💥
Will read it in details again when time allows😋
campaslab.bsky.social Campàs Lab @campaslab.bsky.social · 18d
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩

We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species

➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 6:43 PM
Reposted by Claire Dessalles
campaslab.bsky.social
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩

We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species

➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Reposted by Claire Dessalles
epimechfc.bsky.social
Borges, A., Miranda-Rodriguez, J. R., Ceccarelli, A., Ventura, G., Sedzinski, J., Lopez-Schier, H., & Chara, O. (2025). ForSys: non-invasive stress inference from time-lapse microscopy. iScience, 28, 113685. #EpithelialMechanics
buff.ly/jQ96TCK
October 24, 2025 at 7:02 AM
Reposted by Claire Dessalles
gautamdey.bsky.social
If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back.

I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support
October 4, 2025 at 5:47 AM
Reposted by Claire Dessalles
ebisuyamiki.bsky.social
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
October 8, 2025 at 1:05 PM
Reposted by Claire Dessalles
joachimgoedhart.bsky.social
Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM by Juan Manuel Garcia-Arcos and team: www.biorxiv.org/content/10.1...
Frequency dependence of fast-lifetime FLIM and fits for C2C12 cells.
September 26, 2025 at 1:29 PM
Reposted by Claire Dessalles
spirochrome.com
An incredibly comprehensive and meticulous study of Flipper-TR lifetime analysis to make your membrane tension measurements using Flipper-TR more robust and reliable.

Thanks to @juanmagararc.bsky.social and @rouxlab.bsky.social for this very valuable resource!
October 7, 2025 at 8:21 AM
clairedessalles.bsky.social
All you've ever wanted to know about FLIM analysis (and its application in Flipper-TR)!😱🤩🔬
October 7, 2025 at 1:54 PM
Reposted by Claire Dessalles
dev-journal.bsky.social
Modifying mechanical constraint guides gastruloid patterning

This Research Highlight showcases the work from Judith Pineau @judithpineau.bsky.social, Jerome Wong-Ng @jeromewongng.bsky.social, Thomas Gregor @thomasgregor.bsky.social and colleagues:

journals.biologists.com/dev/article/...
Figure 2 - Gene expression patterning and transcriptional profiles in hydrogel-grown gastruloids. (A) Representative immunofluorescence images of gastruloids at 120 h. Gastruloids were grown in standard culture conditions (Ctrl, no hydrogel) or embedded in hydrogels with increasing concentrations (0.7 mM, 0.8 mM and 1.0 mM) at 96 h post-seeding. Nuclei (blue), BRA (purple) and SOX2 (yellow) are labeled. (B,C) Normalized expression profiles of SOX2 (B) and BRA (C) along the AP axis, demonstrating consistent expression patterns across conditions. (D) Principal component analysis of bulk RNA-seq experiments (three replicates), revealing clear separation between Ctrl and noCHI (red), a negative control for gastruloid formation, while hydrogel-embedded conditions cluster near Ctrl. (E) Number of significantly differentially expressed (DE) genes compared to Ctrl, showing substantial transcriptional changes in noCHI and minimal changes in hydrogel-embedded conditions (0.7 mM, 0.8 mM and 1.0 mM). Shown here are representative data and analysis for one experimental replicate. See Fig. S3 for two additional replicates.
October 2, 2025 at 12:10 PM
Reposted by Claire Dessalles
judithpineau.bsky.social
In this beautiful system, we could show uncoupling of gene expression profiles, morphology and patterning… #NotInTheGenes 😉 (also includes a method to do long term 🔬 of elongating gastruloids)
Thank you to all involved @jeromewongng.bsky.social @thomasgregor.bsky.social @alexandremayran.bsky.social
dev-journal.bsky.social Development @dev-journal.bsky.social · Oct 2
Modifying mechanical constraint guides gastruloid patterning

This Research Highlight showcases the work from Judith Pineau @judithpineau.bsky.social, Jerome Wong-Ng @jeromewongng.bsky.social, Thomas Gregor @thomasgregor.bsky.social and colleagues:

journals.biologists.com/dev/article/...
Figure 2 - Gene expression patterning and transcriptional profiles in hydrogel-grown gastruloids. (A) Representative immunofluorescence images of gastruloids at 120 h. Gastruloids were grown in standard culture conditions (Ctrl, no hydrogel) or embedded in hydrogels with increasing concentrations (0.7 mM, 0.8 mM and 1.0 mM) at 96 h post-seeding. Nuclei (blue), BRA (purple) and SOX2 (yellow) are labeled. (B,C) Normalized expression profiles of SOX2 (B) and BRA (C) along the AP axis, demonstrating consistent expression patterns across conditions. (D) Principal component analysis of bulk RNA-seq experiments (three replicates), revealing clear separation between Ctrl and noCHI (red), a negative control for gastruloid formation, while hydrogel-embedded conditions cluster near Ctrl. (E) Number of significantly differentially expressed (DE) genes compared to Ctrl, showing substantial transcriptional changes in noCHI and minimal changes in hydrogel-embedded conditions (0.7 mM, 0.8 mM and 1.0 mM). Shown here are representative data and analysis for one experimental replicate. See Fig. S3 for two additional replicates.
October 3, 2025 at 8:18 AM
Reposted by Claire Dessalles
christlet.bsky.social
#FluorescenceFriday: getting ready for #GEF25, playing with Ciarán's stunning ExM data
September 26, 2025 at 11:48 AM
Reposted by Claire Dessalles
eloscicomm.bsky.social
👩‍🔬J'ai commencé un kit de démarrage "chercheuses en France" go.bsky.app/TBEzKC #FemmesEnScience

J'ai besoin de votre aide pour le remplir et donner de la visibilité aux chercheuses que vous connaissez et qui sont sur Bluesky !
▶️Taguez celles que vous connaissez, je les ajoute !
September 23, 2025 at 2:22 PM
clairedessalles.bsky.social
Super clear thread for super cool science!
bucklingmt.bsky.social Shweta Nandakumar @bucklingmt.bsky.social · Sep 14
Despite their high rigidity, microtubules (MTs) dynamically bend and buckle in cells. MT-self repair is inherent to their metastable nature, but it remains unclear whether just inherent repair mechanisms are sufficient to maintain MT integrity🧵 (1/9)
www.biorxiv.org/content/10.1...
September 15, 2025 at 8:36 AM
clairedessalles.bsky.social
I love the pearling instability at the end ! 😍 What happens in the happy attached flagellum to stabilize its tubular shape?
thibautbrunet.bsky.social Thibaut Brunet @thibautbrunet.bsky.social · Sep 9
Most striking, in some instances of spontaneous flagellar detachment, the flagellum can glide on its own - mercilessly leaving the cell body behind, stabbing it on the way if need be (don't do this at home).
September 11, 2025 at 1:49 PM
Reposted by Claire Dessalles
thibautbrunet.bsky.social
Most striking, in some instances of spontaneous flagellar detachment, the flagellum can glide on its own - mercilessly leaving the cell body behind, stabbing it on the way if need be (don't do this at home).
September 9, 2025 at 6:12 PM
Reposted by Claire Dessalles
haoyin.bsky.social
#SmoothMuscleCell #Piezo1 Small intestinal motility

SMC Piezo1 KO in 4~6 wk-old🐭
👉Muscularis thinning
👉⏬Food consumption
👉⏬SMC density w/o⏫apoptosis
👉⏬small intestinal motility
👉⏬Muscularis Orai1/3 Trpc4 IP3R ⏫Cav1.2 Ano1
👉⏬carbachol-induced tension

#CommsBio 2025
www.nature.com/articles/s42...
September 11, 2025 at 11:21 AM
Reposted by Claire Dessalles
biophysj.bsky.social
In the New and Notable "Pulling Frank-Starling into another dimension,"
Megan L. McCain highlights the paper "Biaxial length-tension relationship in single cardiac myocytes ." buff.ly/XliGXNu
September 10, 2025 at 6:03 PM
Reposted by Claire Dessalles
barnabalab.bsky.social
CellPose 4.0 is a beast. Segmented human microglia, in brightfield. Credit to Sydney Houser.
Human microglia bright field image segmented with CellPose 4.
September 11, 2025 at 1:34 PM
Reposted by Claire Dessalles
davidbrueckner.bsky.social
Super excited that our group will be supported by an ERC Starting Grant!

In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.

We'll have PhD and Postdoc positions available, please get in touch if interested!
September 4, 2025 at 11:27 AM
Reposted by Claire Dessalles
xaviertrepat.bsky.social
New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...
September 1, 2025 at 3:31 PM
Reposted by Claire Dessalles
juliaeckert.bsky.social
Now published in @natcomms.nature.com! 🥳

👉 rdcu.be/eATn3

We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
August 15, 2025 at 12:13 PM
Reposted by Claire Dessalles
blacoste.bsky.social
Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling
Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial gap junctions, enabling coordinated dilation of the arterial network during neurovascular coupling.
www.cell.com
July 25, 2025 at 7:17 AM