Shweta Nandakumar
@bucklingmt.bsky.social
She/her, PhD Student @schaedellab.bsky.social | Microtubules 🧑🔬 | Motors ⚡| Bibliophile
Pinned
Shweta Nandakumar
@bucklingmt.bsky.social
· Sep 14
Despite their high rigidity, microtubules (MTs) dynamically bend and buckle in cells. MT-self repair is inherent to their metastable nature, but it remains unclear whether just inherent repair mechanisms are sufficient to maintain MT integrity🧵 (1/9)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Shweta Nandakumar
Dick is one of the most thoughtful folks in cell biology--this is a must read for anyone interested in microtubules!
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
October 15, 2025 at 6:23 PM
Dick is one of the most thoughtful folks in cell biology--this is a must read for anyone interested in microtubules!
Playing around with @kwolbachia.bsky.social 's LUT manager plugin. Absolutely love the campfire LUT🔥 😍#microtubulemonday
October 6, 2025 at 9:30 AM
Playing around with @kwolbachia.bsky.social 's LUT manager plugin. Absolutely love the campfire LUT🔥 😍#microtubulemonday
Reposted by Shweta Nandakumar
Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D https://www.biorxiv.org/content/10.1101/2025.09.18.677142v1
September 19, 2025 at 11:48 AM
Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D https://www.biorxiv.org/content/10.1101/2025.09.18.677142v1
Reposted by Shweta Nandakumar
Have you ever wondered how microtubules withstand and respond to mechanical stress in cells?
Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.
Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.
September 16, 2025 at 6:43 AM
Have you ever wondered how microtubules withstand and respond to mechanical stress in cells?
Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.
Here we show by in vitro reconstitution assays that MAP65-1 and PRC1 promote microtubule nucleation on existing lattices, especially on those with structural irregularities linked to mechanical stress.
Here's some more exciting new news from the microtubule world ✨Great work from @marianattom.bsky.social the @schaedellab.bsky.social showing how MAP65-1/PRC-1 reinforce microtubules under mechanical stress.
Look at them microtubule arrays in plant cells 😍 ( To quote Verstappen, "Simply lovely")
Look at them microtubule arrays in plant cells 😍 ( To quote Verstappen, "Simply lovely")
MAP65-1/PRC1 reinforces microtubules through nucleation https://www.biorxiv.org/content/10.1101/2025.09.14.676082v1
September 16, 2025 at 6:44 AM
Here's some more exciting new news from the microtubule world ✨Great work from @marianattom.bsky.social the @schaedellab.bsky.social showing how MAP65-1/PRC-1 reinforce microtubules under mechanical stress.
Look at them microtubule arrays in plant cells 😍 ( To quote Verstappen, "Simply lovely")
Look at them microtubule arrays in plant cells 😍 ( To quote Verstappen, "Simply lovely")
Despite their high rigidity, microtubules (MTs) dynamically bend and buckle in cells. MT-self repair is inherent to their metastable nature, but it remains unclear whether just inherent repair mechanisms are sufficient to maintain MT integrity🧵 (1/9)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 14, 2025 at 9:53 AM
Despite their high rigidity, microtubules (MTs) dynamically bend and buckle in cells. MT-self repair is inherent to their metastable nature, but it remains unclear whether just inherent repair mechanisms are sufficient to maintain MT integrity🧵 (1/9)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Congratulations, Subham 🎉🎉🎉 Great study and uber cool microtubule self-repair images that I can stare at for hours 😍😍😍
Excited to share that my paper on Tau–Microtubule interactions is now published in Nature Physics!🎉
Our work shows that tau goes beyond stabilizing microtubules—it also promotes the removal of defects in the microtubule lattice.
www.nature.com/articles/s41...
Our work shows that tau goes beyond stabilizing microtubules—it also promotes the removal of defects in the microtubule lattice.
www.nature.com/articles/s41...
Tau accelerates tubulin exchange in the microtubule lattice - Nature Physics
Beyond its known role in stabilizing microtubules, it is now shown that tau protein actively promotes lattice defect repair by enhancing tubulin turnover at topological defects.
www.nature.com
September 10, 2025 at 6:49 PM
Congratulations, Subham 🎉🎉🎉 Great study and uber cool microtubule self-repair images that I can stare at for hours 😍😍😍
Reposted by Shweta Nandakumar
Upcoming interdisciplinary meeting: Cell Physics 2025
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de
June 21, 2025 at 7:25 PM
Upcoming interdisciplinary meeting: Cell Physics 2025
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de
When? October 7-9, 2025
Where? Saarbruecken, Germany
Relevant dates? Early-bird deadline: June 30, regular registration by August 31
Several opportunities for short-talks selected from abstracts
More info at: cell-physics.uni-saarland.de