Baptiste Lacoste
@blacoste.bsky.social
Senior Scientist, Associate Professor & Program Director @ OHRI & uOttawa 🇨🇦. Fascinated by vascular & metabolic causes of neurodevelopmental disorders, SciArt and the night sky 🔬 🎨 🔭 Follow for 🧪 news and more! Look for #cerebrovascular
Reposted by Baptiste Lacoste
🎉 New Publication in @pnas.org
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
December 30, 2025 at 7:38 AM
🎉 New Publication in @pnas.org
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
On his way to bring « the dream of clean, near-limitless fusion power closer to reality », Nuno Loureiro was shot at his home. A brilliant mind, husband, father and mentor is gone.
Nuno Loureiro, professor and director of MIT’s Plasma Science and Fusion Center, dies at 47
Nuno Loureiro, an MIT professor of nuclear science and engineering and of physics, has died at 47. A theoretical physicist and fusion scientist, and director of the MIT Plasma Science and Fusion Cente...
news.mit.edu
December 21, 2025 at 7:24 PM
On his way to bring « the dream of clean, near-limitless fusion power closer to reality », Nuno Loureiro was shot at his home. A brilliant mind, husband, father and mentor is gone.
New preprint from the lab! For those who love astrocytes 🤩. We welcome feedback! #preprint #openaccess #astrocytes #autism
Metabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2 deficient murine astrocytes
Autism Spectrum Disorders (ASD) are associated with metabolic dysregulation. While astrocytes are integral to cerebral metabolism, their molecular and functional changes in ASD are poorly known. Using...
www.biorxiv.org
December 17, 2025 at 12:59 PM
New preprint from the lab! For those who love astrocytes 🤩. We welcome feedback! #preprint #openaccess #astrocytes #autism
Happy holidays and best wishes from our lab!
December 16, 2025 at 1:54 PM
Happy holidays and best wishes from our lab!
A beautiful paper from my friend @naguibmechawar.bsky.social's team ! www.nature.com/articles/s41... #cerebrovascular
Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse - Molecular Psychiatry
Molecular Psychiatry - Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse
www.nature.com
December 3, 2025 at 6:09 PM
A beautiful paper from my friend @naguibmechawar.bsky.social's team ! www.nature.com/articles/s41... #cerebrovascular
PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
PDGFRα is required for postnatal cerebral perivascular fibroblast development
Perivascular fibroblasts (PVFs) are a cell type associated with large diameter blood vessels in the brain and spinal cord parenchyma and leptomeninges…
www.sciencedirect.com
November 20, 2025 at 3:30 AM
PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
Reposted by Baptiste Lacoste
Excited to share the latest from our lab (final version, open access):
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
November 19, 2025 at 1:38 PM
Excited to share the latest from our lab (final version, open access):
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution @cp-neuron.bsky.social #cerebrovascular #hypertension
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution
Hypertension is a leading cause of cognitive impairment, attributed to cerebrovascular insufficiency, blood-brain barrier disruption, and white matter…
www.sciencedirect.com
November 18, 2025 at 2:51 PM
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution @cp-neuron.bsky.social #cerebrovascular #hypertension
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
Dynamic modulation of the blood–brain barrier in the healthy brain - Nature Reviews Neuroscience
The blood–brain barrier was conventionally seen as a static protective structure, but a more complex, dynamic view of this barrier has now emerged. In this Review, Friedman et al. discuss the dynamic ...
www.nature.com
November 16, 2025 at 3:48 PM
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
The brain neurovascular epigenome and its association with dementia. #cerebrovascular #epigenetics
The brain neurovascular epigenome and its association with dementia
Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s
disease and cerebral small vessel disease within neurovascular cells, identifying
immune-related AD risk and bro...
www.cell.com
November 12, 2025 at 10:42 AM
The brain neurovascular epigenome and its association with dementia. #cerebrovascular #epigenetics
So happy I have been able to witness the incredible growth and success of (now Dr.) Sozerko Yiandiev, who defended his PhD thesis with brio in Lyon this week! It was a true pleasure to co-mentor Sozerko with @jcourchet.bsky.social during the past 5 years 🍻👨🎓 #Thesis #BrainMetabolism
November 8, 2025 at 6:45 PM
So happy I have been able to witness the incredible growth and success of (now Dr.) Sozerko Yiandiev, who defended his PhD thesis with brio in Lyon this week! It was a true pleasure to co-mentor Sozerko with @jcourchet.bsky.social during the past 5 years 🍻👨🎓 #Thesis #BrainMetabolism
When the stars of glial scar borders and stroke recovery “have a baby”, it gives this 😅 #astrocytes #stroke #cerebrovascular
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
www.sciencedirect.com
November 8, 2025 at 7:39 AM
When the stars of glial scar borders and stroke recovery “have a baby”, it gives this 😅 #astrocytes #stroke #cerebrovascular
October 20, 2025 at 1:59 AM
Reposted by Baptiste Lacoste
A privilege to chair symposium ‘Vascular function and cognitive health across the lifespan’ symposium today at @ecnp.eu
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
October 14, 2025 at 11:43 AM
A privilege to chair symposium ‘Vascular function and cognitive health across the lifespan’ symposium today at @ecnp.eu
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
An important advance in vascular biology!! #endothelium #vascular
Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation | PNAS
We previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1),
which produces cGMP, also has the ability to transfer S-nitrosoth...
www.pnas.org
October 6, 2025 at 9:08 PM
An important advance in vascular biology!! #endothelium #vascular
Thanks again Yao Yao for the kind invite to USF! Super fun visit, I learned a lot from you and your colleagues 🙏🙏
October 6, 2025 at 12:26 PM
Thanks again Yao Yao for the kind invite to USF! Super fun visit, I learned a lot from you and your colleagues 🙏🙏
Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EM
Volumetric Analysis of the Blood–Brain Barrier After Ischemic Stroke by Electron Tomography in Mice
Objective Transmission electron microscopy (TEM) enables ultrastructural investigation of both organic and nonorganic samples. However, conventional TEM is limited by the acquisition of two-dimensio...
onlinelibrary.wiley.com
September 28, 2025 at 1:48 PM
Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EM
Very cool new paper from @caglaeroglu.bsky.social's lab showing the mitochondria dynamics regulate astroglial morphogenesis! doi.org/10.1083/jcb.... #Astrocytes #Development
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex | Journal of Cell Biology | Rockefeller University Press
During cortical astrocyte morphogenesis, mitochondria fragment and decrease in size to populate distal astrocyte processes. Drp1-mediated mitochondrial fis
doi.org
September 12, 2025 at 6:27 PM
Very cool new paper from @caglaeroglu.bsky.social's lab showing the mitochondria dynamics regulate astroglial morphogenesis! doi.org/10.1083/jcb.... #Astrocytes #Development
New work establishing a key role for FOXQ1 in the regulation of brain endothelial metabolism. #Cerebrovascular
FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This stud...
doi.org
September 7, 2025 at 7:51 PM
New work establishing a key role for FOXQ1 in the regulation of brain endothelial metabolism. #Cerebrovascular
New paper by Philippe Monnier's team: Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke @natureportfolio.nature.com #Stroke #BBB #cerebrovascular
Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke - Nature Cardiovascular Research
Shabanzadeh et al. identify and validate a pathway whereby RGMa cleavage by SKI-1 modifies gene expression related to blood–brain barrier (BBB) integrity after stroke. SKI-1 inhibition restores BBB in...
www.nature.com
August 28, 2025 at 6:31 PM
New paper by Philippe Monnier's team: Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke @natureportfolio.nature.com #Stroke #BBB #cerebrovascular
Absolutely fascinating science and interactions with families here at the 2025 Synchrony Symposium on #autism in Monterey! A wonderful gathering organized by the Brain Foundation. #TranslationalScience
August 23, 2025 at 5:59 PM
Absolutely fascinating science and interactions with families here at the 2025 Synchrony Symposium on #autism in Monterey! A wonderful gathering organized by the Brain Foundation. #TranslationalScience