Osama Harraz
@osamaharraz.bsky.social
Assistant Professor, Bloomfield Professor in Cardiovascular Research - decoding the complexity of vascular physiology and blood flow control, one ion channel at a time. Univ. of Vermont
www.HarrazLab.com
www.HarrazLab.com
Reposted by Osama Harraz
📣 #CallForPapers 📣 Submit your research on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on #IonChannels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...
August 8, 2025 at 6:45 PM
📣 #CallForPapers 📣 Submit your research on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on #IonChannels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...
Reposted by Osama Harraz
Leukocyte stalling in 🐭Retinal microvasculature
2PM
In 20 s, "~7% tracked leukocytes stalled for at least one time along their path", up to 9 stalls
87% stalls occur at vessel junctions, where 71% occupied with #Pericyte
⏫RBC flow irregularity
#JCBFM 2025
journals.sagepub.com/doi/10.1177/...
2PM
In 20 s, "~7% tracked leukocytes stalled for at least one time along their path", up to 9 stalls
87% stalls occur at vessel junctions, where 71% occupied with #Pericyte
⏫RBC flow irregularity
#JCBFM 2025
journals.sagepub.com/doi/10.1177/...
January 13, 2026 at 12:42 PM
Leukocyte stalling in 🐭Retinal microvasculature
2PM
In 20 s, "~7% tracked leukocytes stalled for at least one time along their path", up to 9 stalls
87% stalls occur at vessel junctions, where 71% occupied with #Pericyte
⏫RBC flow irregularity
#JCBFM 2025
journals.sagepub.com/doi/10.1177/...
2PM
In 20 s, "~7% tracked leukocytes stalled for at least one time along their path", up to 9 stalls
87% stalls occur at vessel junctions, where 71% occupied with #Pericyte
⏫RBC flow irregularity
#JCBFM 2025
journals.sagepub.com/doi/10.1177/...
😖
NOEM: “We can’t trust the government anymore.”
BASH: “You are the government.”
NOEM: “Yes, that’s what I’m saying.”🤔
The only honest thing @KristiNoem said today
BASH: “You are the government.”
NOEM: “Yes, that’s what I’m saying.”🤔
The only honest thing @KristiNoem said today
January 12, 2026 at 12:21 PM
😖
Reposted by Osama Harraz
My Name is Doddie Foundation Catalyst Awards 2026 are now open. Funding bold early stage MND research ideas with up to £100k to generate data and open new treatment pathways.
www.dementiaresearcher.nihr.ac.uk/funding/my-n...
www.dementiaresearcher.nihr.ac.uk/funding/my-n...
January 12, 2026 at 12:14 PM
My Name is Doddie Foundation Catalyst Awards 2026 are now open. Funding bold early stage MND research ideas with up to £100k to generate data and open new treatment pathways.
www.dementiaresearcher.nihr.ac.uk/funding/my-n...
www.dementiaresearcher.nihr.ac.uk/funding/my-n...
🎉 New Publication in @pnas.org
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
December 30, 2025 at 7:38 AM
🎉 New Publication in @pnas.org
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy
pnas.org/doi/abs/10.1... (Open Access)
Reposted by Osama Harraz
Restoring levels of the phospholipid PIP₂ may help normalize brain blood flow and reduce symptoms in vascular dementia by regulating the activity of the Piezo1 protein.
Key phospholipid points to potential treatment for vascular dementia
A possible new treatment for impaired brain blood flow and related dementias is on the horizon. Research by scientists at the University of Vermont Robert Larner, M.D. College of Medicine provides novel insights into the mechanisms that regulate brain blood flow and highlights a potential therapeutic strategy to correct vascular dysfunction.
medicalxpress.com
December 22, 2025 at 8:00 PM
Restoring levels of the phospholipid PIP₂ may help normalize brain blood flow and reduce symptoms in vascular dementia by regulating the activity of the Piezo1 protein.
Reposted by Osama Harraz
When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.
November 14, 2025 at 8:34 PM
When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.
Reposted by Osama Harraz
Grateful to @pewtrusts.org for funding our snow fly work, in collaboration with Sebastian Brauchi at Universidad Austral de Chile.
We are now looking for post-docs to work on the biophysical mechanisms that allow snow fly neurons and muscles to function below zero.
newsroom.uw.edu/news-release...
We are now looking for post-docs to work on the biophysical mechanisms that allow snow fly neurons and muscles to function below zero.
newsroom.uw.edu/news-release...
Most insects slow down in bitter cold. Not snow flies. - UW Medicine | Newsroom
newsroom.uw.edu
December 18, 2025 at 10:48 PM
Grateful to @pewtrusts.org for funding our snow fly work, in collaboration with Sebastian Brauchi at Universidad Austral de Chile.
We are now looking for post-docs to work on the biophysical mechanisms that allow snow fly neurons and muscles to function below zero.
newsroom.uw.edu/news-release...
We are now looking for post-docs to work on the biophysical mechanisms that allow snow fly neurons and muscles to function below zero.
newsroom.uw.edu/news-release...
🧵Excited to share our work with the Bracko @bloodflowlab.bsky.social lab published in Alzheimer's & Dementia @alzassociation.bsky.social :
Systemic Piezo1 activation improves cerebrovascular function in Alzheimer’s disease
🔗https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71016
Systemic Piezo1 activation improves cerebrovascular function in Alzheimer’s disease
🔗https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71016
December 18, 2025 at 11:25 AM
🧵Excited to share our work with the Bracko @bloodflowlab.bsky.social lab published in Alzheimer's & Dementia @alzassociation.bsky.social :
Systemic Piezo1 activation improves cerebrovascular function in Alzheimer’s disease
🔗https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71016
Systemic Piezo1 activation improves cerebrovascular function in Alzheimer’s disease
🔗https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71016
Reposted by Osama Harraz
#UVMLarnerMed research publication alert! #Brainresearch by authors Osama Harraz, Ph.D., and Ahmed Hashad, Ph.D., Department of Pharmacology, Larner College of Medicine, Vermont Center for Cardiovascular and Brain Health.
@uvmvermont.bsky.social @apspublications.bsky.social
@uvmvermont.bsky.social @apspublications.bsky.social
Excited to share the latest from our lab (final version, open access):
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
November 19, 2025 at 5:46 PM
#UVMLarnerMed research publication alert! #Brainresearch by authors Osama Harraz, Ph.D., and Ahmed Hashad, Ph.D., Department of Pharmacology, Larner College of Medicine, Vermont Center for Cardiovascular and Brain Health.
@uvmvermont.bsky.social @apspublications.bsky.social
@uvmvermont.bsky.social @apspublications.bsky.social
Excited to share the latest from our lab (final version, open access):
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
November 19, 2025 at 1:38 PM
Excited to share the latest from our lab (final version, open access):
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Reposted by Osama Harraz
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome
Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...
www.jneurosci.org
November 6, 2025 at 8:03 PM
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
Reposted by Osama Harraz
The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2
October 21, 2025 at 9:47 PM
The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2
Reposted by Osama Harraz
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
November 5, 2025 at 11:51 PM
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
This is sad, to say the least...
Some doctoral programmes in the US are admitting no students at all amid uncertainty about federal science funding
go.nature.com/4o63boK
go.nature.com/4o63boK
US PhD admissions shrink as fears over Trump’s cuts take hold
Some doctoral programmes are admitting no students at all amid uncertainty about federal science funding.
go.nature.com
October 22, 2025 at 11:06 AM
This is sad, to say the least...
Reposted by Osama Harraz
I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!
Congratulations to @ishmailsaboor.bsky.social on receiving the NIH Director’s Pioneer Award, celebrating “scientists with outstanding records of creativity.” His lab will explore how the sense of touch can help build relationships. 🫶🧠💡
See zuckermaninstitute.columbia.edu/zuckerman-in...
See zuckermaninstitute.columbia.edu/zuckerman-in...
October 8, 2025 at 8:45 PM
I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!
Reposted by Osama Harraz
Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!
BREAKING: The Nobel Prize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal-organic frameworks”
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 8, 2025 at 1:46 PM
Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!
Reposted by Osama Harraz
Last week at the Dean’s Celebration of Excellence in Research, the annual #UVMLarnerMed Research Rally showcased inspiring research by faculty scientists. Learn more about #larnerresearch at go.uvm.edu/lcomresearch #medicalresearch #research
@uvmvermont.bsky.social
@osamaharraz.bsky.social
@uvmvermont.bsky.social
@osamaharraz.bsky.social
September 29, 2025 at 9:08 PM
Last week at the Dean’s Celebration of Excellence in Research, the annual #UVMLarnerMed Research Rally showcased inspiring research by faculty scientists. Learn more about #larnerresearch at go.uvm.edu/lcomresearch #medicalresearch #research
@uvmvermont.bsky.social
@osamaharraz.bsky.social
@uvmvermont.bsky.social
@osamaharraz.bsky.social
Reposted by Osama Harraz
Received a Dean’s excellence in research award and I’m pretty chuffed about it. Thanks to friends, family and colleagues who keep me going.
September 26, 2025 at 9:46 AM
Received a Dean’s excellence in research award and I’m pretty chuffed about it. Thanks to friends, family and colleagues who keep me going.
Reposted by Osama Harraz
Today, UVM President Marlene Tromp announced that the University of Vermont has named Richard L. Page, M.D., Dean of the Larner College of Medicine, as its inaugural Chief Medical Affairs Officer. Read more: go.uvm.edu/medaffairs
@uvmvermont.bsky.social photo: Andy Duback
@uvmvermont.bsky.social photo: Andy Duback
University of Vermont Names Dr. Richard L. Page as Chief Medical Affairs Officer | Office of Medical Communications | The University of Vermont
go.uvm.edu
September 12, 2025 at 2:51 PM
Today, UVM President Marlene Tromp announced that the University of Vermont has named Richard L. Page, M.D., Dean of the Larner College of Medicine, as its inaugural Chief Medical Affairs Officer. Read more: go.uvm.edu/medaffairs
@uvmvermont.bsky.social photo: Andy Duback
@uvmvermont.bsky.social photo: Andy Duback
Reposted by Osama Harraz
✨VERY EXCITED to share groundbreaking research by Luyue Zhang, Ana M. Franceschi, John Crary, Frank Provenzano✨Here, they suggest a previously unrecognized biomechanical contribution to initiation of tau pathology in aging & sporadic AD. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
September 11, 2025 at 5:42 PM
✨VERY EXCITED to share groundbreaking research by Luyue Zhang, Ana M. Franceschi, John Crary, Frank Provenzano✨Here, they suggest a previously unrecognized biomechanical contribution to initiation of tau pathology in aging & sporadic AD. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
We are delighted to welcome Caroline Kehlet to our lab. Caroline is an undergraduate student at UVM double majoring in Anthropology and Neuroscience. Welcome Caroline!
September 9, 2025 at 1:55 PM
We are delighted to welcome Caroline Kehlet to our lab. Caroline is an undergraduate student at UVM double majoring in Anthropology and Neuroscience. Welcome Caroline!
Reposted by Osama Harraz
Membrane Biology: Nothing can replace polyunsaturated lipids
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
August 23, 2025 at 1:59 PM
Membrane Biology: Nothing can replace polyunsaturated lipids
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Reposted by Osama Harraz
#FluorescenceFriday
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye
doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye
doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social
August 14, 2025 at 8:51 PM
#FluorescenceFriday
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye
doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye
doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social