Osama Harraz
@osamaharraz.bsky.social
Assistant Professor, Bloomfield Professor in Cardiovascular Research - decoding the complexity of vascular physiology and blood flow control, one ion channel at a time. Univ. of Vermont
www.HarrazLab.com
www.HarrazLab.com
Reposted by Osama Harraz
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome
Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...
www.jneurosci.org
November 6, 2025 at 8:03 PM
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
Reposted by Osama Harraz
The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2
October 21, 2025 at 9:47 PM
The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2
Reposted by Osama Harraz
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
November 5, 2025 at 11:51 PM
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
This is sad, to say the least...
Some doctoral programmes in the US are admitting no students at all amid uncertainty about federal science funding
go.nature.com/4o63boK
go.nature.com/4o63boK
US PhD admissions shrink as fears over Trump’s cuts take hold
Some doctoral programmes are admitting no students at all amid uncertainty about federal science funding.
go.nature.com
October 22, 2025 at 11:06 AM
This is sad, to say the least...
Reposted by Osama Harraz
I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!
Congratulations to @ishmailsaboor.bsky.social on receiving the NIH Director’s Pioneer Award, celebrating “scientists with outstanding records of creativity.” His lab will explore how the sense of touch can help build relationships. 🫶🧠💡
See zuckermaninstitute.columbia.edu/zuckerman-in...
See zuckermaninstitute.columbia.edu/zuckerman-in...
October 8, 2025 at 8:45 PM
I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!
Reposted by Osama Harraz
Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!
BREAKING: The Nobel Prize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal-organic frameworks”
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 8, 2025 at 1:46 PM
Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!
Reposted by Osama Harraz
Last week at the Dean’s Celebration of Excellence in Research, the annual #UVMLarnerMed Research Rally showcased inspiring research by faculty scientists. Learn more about #larnerresearch at go.uvm.edu/lcomresearch #medicalresearch #research
@uvmvermont.bsky.social
@osamaharraz.bsky.social
@uvmvermont.bsky.social
@osamaharraz.bsky.social
September 29, 2025 at 9:08 PM
Last week at the Dean’s Celebration of Excellence in Research, the annual #UVMLarnerMed Research Rally showcased inspiring research by faculty scientists. Learn more about #larnerresearch at go.uvm.edu/lcomresearch #medicalresearch #research
@uvmvermont.bsky.social
@osamaharraz.bsky.social
@uvmvermont.bsky.social
@osamaharraz.bsky.social
Reposted by Osama Harraz
Received a Dean’s excellence in research award and I’m pretty chuffed about it. Thanks to friends, family and colleagues who keep me going.
September 26, 2025 at 9:46 AM
Received a Dean’s excellence in research award and I’m pretty chuffed about it. Thanks to friends, family and colleagues who keep me going.
Reposted by Osama Harraz
Today, UVM President Marlene Tromp announced that the University of Vermont has named Richard L. Page, M.D., Dean of the Larner College of Medicine, as its inaugural Chief Medical Affairs Officer. Read more: go.uvm.edu/medaffairs
@uvmvermont.bsky.social photo: Andy Duback
@uvmvermont.bsky.social photo: Andy Duback
University of Vermont Names Dr. Richard L. Page as Chief Medical Affairs Officer | Office of Medical Communications | The University of Vermont
go.uvm.edu
September 12, 2025 at 2:51 PM
Today, UVM President Marlene Tromp announced that the University of Vermont has named Richard L. Page, M.D., Dean of the Larner College of Medicine, as its inaugural Chief Medical Affairs Officer. Read more: go.uvm.edu/medaffairs
@uvmvermont.bsky.social photo: Andy Duback
@uvmvermont.bsky.social photo: Andy Duback
Reposted by Osama Harraz
✨VERY EXCITED to share groundbreaking research by Luyue Zhang, Ana M. Franceschi, John Crary, Frank Provenzano✨Here, they suggest a previously unrecognized biomechanical contribution to initiation of tau pathology in aging & sporadic AD. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
September 11, 2025 at 5:42 PM
✨VERY EXCITED to share groundbreaking research by Luyue Zhang, Ana M. Franceschi, John Crary, Frank Provenzano✨Here, they suggest a previously unrecognized biomechanical contribution to initiation of tau pathology in aging & sporadic AD. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
We are delighted to welcome Caroline Kehlet to our lab. Caroline is an undergraduate student at UVM double majoring in Anthropology and Neuroscience. Welcome Caroline!
September 9, 2025 at 1:55 PM
We are delighted to welcome Caroline Kehlet to our lab. Caroline is an undergraduate student at UVM double majoring in Anthropology and Neuroscience. Welcome Caroline!
Reposted by Osama Harraz
Membrane Biology: Nothing can replace polyunsaturated lipids
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
August 23, 2025 at 1:59 PM
Membrane Biology: Nothing can replace polyunsaturated lipids
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
Reposted by Osama Harraz
#FluorescenceFriday
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye
doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye
doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social
August 14, 2025 at 8:51 PM
#FluorescenceFriday
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye
doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye
doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social
Reposted by Osama Harraz
Thrilled to share this amazing work from Marie Blanchette & team in the Daneman Lab!!! We found that differences in the BBB across brain regions help regulate local brain function 🧠 Honored to have contributed to the study & to have had Marie as a mentor during my PhD💕
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Regional heterogeneity of the blood-brain barrier - Nature Communications
The blood-brain barrier (BBB) regulates the extracellular composition of the central nervous system (CNS), but it is not known whether its properties differ across CNS regions. Here, the authors show ...
www.nature.com
August 8, 2025 at 3:57 PM
Thrilled to share this amazing work from Marie Blanchette & team in the Daneman Lab!!! We found that differences in the BBB across brain regions help regulate local brain function 🧠 Honored to have contributed to the study & to have had Marie as a mentor during my PhD💕
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Osama Harraz
This is amazing.
And it's not just math talent: she is a mature communicator now.
She blossomed when moving from homeschooling to math communities in Chicago and at Berkeley.
This is a story that should inspire us.
🧪
And it's not just math talent: she is a mature communicator now.
She blossomed when moving from homeschooling to math communities in Chicago and at Berkeley.
This is a story that should inspire us.
🧪
At 17, Hannah Cairo Solved a Major Math Mystery | Quanta Magazine
After finding the homeschooling life confining, the teen petitioned her way into a graduate class at Berkeley, where she ended up disproving a 40-year-old conjecture.
www.quantamagazine.org
August 6, 2025 at 3:15 PM
This is amazing.
And it's not just math talent: she is a mature communicator now.
She blossomed when moving from homeschooling to math communities in Chicago and at Berkeley.
This is a story that should inspire us.
🧪
And it's not just math talent: she is a mature communicator now.
She blossomed when moving from homeschooling to math communities in Chicago and at Berkeley.
This is a story that should inspire us.
🧪
Reposted by Osama Harraz
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience
Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...
www.nature.com
August 5, 2025 at 10:26 AM
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
Reposted by Osama Harraz
We are excited to report:
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
July 2, 2025 at 12:13 PM
We are excited to report:
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
📰Latest from our lab (Open Access)!
Brain Capillary Ion Channels: Physiology and Channelopathies
This review attempts to concisely cover a fast-evolving research field on channels in🧠capillaries
@apspublications.bsky.social
journals.physiology.org/doi/abs/10.1...
Brain Capillary Ion Channels: Physiology and Channelopathies
This review attempts to concisely cover a fast-evolving research field on channels in🧠capillaries
@apspublications.bsky.social
journals.physiology.org/doi/abs/10.1...
August 6, 2025 at 5:02 PM
📰Latest from our lab (Open Access)!
Brain Capillary Ion Channels: Physiology and Channelopathies
This review attempts to concisely cover a fast-evolving research field on channels in🧠capillaries
@apspublications.bsky.social
journals.physiology.org/doi/abs/10.1...
Brain Capillary Ion Channels: Physiology and Channelopathies
This review attempts to concisely cover a fast-evolving research field on channels in🧠capillaries
@apspublications.bsky.social
journals.physiology.org/doi/abs/10.1...
Reposted by Osama Harraz
Would you like to participate in the peer review process at Communications Biology? Please fill out this form to express your interest to act as a reviewer📝 We particularly encourage early-career researchers and applicants from underrepresented groups in research. forms.office.com/e/fv22f9aRt5
August 6, 2025 at 4:41 PM
Would you like to participate in the peer review process at Communications Biology? Please fill out this form to express your interest to act as a reviewer📝 We particularly encourage early-career researchers and applicants from underrepresented groups in research. forms.office.com/e/fv22f9aRt5
Don't miss this ⭐EpIC⭐ seminar TOMORROW!
Dr. Olivier Romito (Trebak Lab) will present on endothelial Orai1 channels and their role in leukocyte adhesion.
If you are not registered and interested, please register (sgp-epic-seminars.com)
@sgpweb.bsky.social @lejlazubcevic.bsky.social
Dr. Olivier Romito (Trebak Lab) will present on endothelial Orai1 channels and their role in leukocyte adhesion.
If you are not registered and interested, please register (sgp-epic-seminars.com)
@sgpweb.bsky.social @lejlazubcevic.bsky.social
August 4, 2025 at 4:29 PM
Don't miss this ⭐EpIC⭐ seminar TOMORROW!
Dr. Olivier Romito (Trebak Lab) will present on endothelial Orai1 channels and their role in leukocyte adhesion.
If you are not registered and interested, please register (sgp-epic-seminars.com)
@sgpweb.bsky.social @lejlazubcevic.bsky.social
Dr. Olivier Romito (Trebak Lab) will present on endothelial Orai1 channels and their role in leukocyte adhesion.
If you are not registered and interested, please register (sgp-epic-seminars.com)
@sgpweb.bsky.social @lejlazubcevic.bsky.social
Reposted by Osama Harraz
Interested in a neuroscience PhD or postdoc position in Germany? Check out the Brain Algorithms and Circuits Group opening at MPI this Fall!!
And many congrats to my friend Gregor Schuhknecht on opening his lab 🥳
#Neuroscience #Zebrafish #NeuroJobs
brain.mpg.de/schuhknecht
And many congrats to my friend Gregor Schuhknecht on opening his lab 🥳
#Neuroscience #Zebrafish #NeuroJobs
brain.mpg.de/schuhknecht
Gregor Schuhknecht
brain.mpg.de
August 2, 2025 at 11:13 PM
Interested in a neuroscience PhD or postdoc position in Germany? Check out the Brain Algorithms and Circuits Group opening at MPI this Fall!!
And many congrats to my friend Gregor Schuhknecht on opening his lab 🥳
#Neuroscience #Zebrafish #NeuroJobs
brain.mpg.de/schuhknecht
And many congrats to my friend Gregor Schuhknecht on opening his lab 🥳
#Neuroscience #Zebrafish #NeuroJobs
brain.mpg.de/schuhknecht
Reposted by Osama Harraz
Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...
Low-dose metformin requires brain Rap1 for its antidiabetic action
Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.
www.science.org
July 31, 2025 at 6:52 PM
Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...
Reposted by Osama Harraz
That's how I like to start the summer! Our story identifying decorin as a novel player in cardiovascular ageing just got published in #CardiovascularResearch 💃🏻💃🏻 Congratulations to all authors and thanks to @ekfstiftung.bsky.social that made this study possible academic.oup.com/cardiovascre...
Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation
AbstractAims. Cardiovascular disease is the leading cause of death in the European Union and aging is one of its major risk factors resulting in the progre
academic.oup.com
August 1, 2025 at 7:00 AM
That's how I like to start the summer! Our story identifying decorin as a novel player in cardiovascular ageing just got published in #CardiovascularResearch 💃🏻💃🏻 Congratulations to all authors and thanks to @ekfstiftung.bsky.social that made this study possible academic.oup.com/cardiovascre...
Reposted by Osama Harraz
It’s been a long while since I posted an #astrophotography image, but from my vacation in France I have access to clear and deep skies! Below is the heart of M16, and its famous “Pillars of Creation”.🤩
August 1, 2025 at 1:56 PM
It’s been a long while since I posted an #astrophotography image, but from my vacation in France I have access to clear and deep skies! Below is the heart of M16, and its famous “Pillars of Creation”.🤩