Tim Petzold
@timpetzold.bsky.social
Developmental Biologist | Postdoc in Holger Gerhardt's Lab at MDC in Berlin | Vasculogenesis | Angiogenesis | Hematopoiesis | Zebrafish | Former Embryo
Reposted by Tim Petzold
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted by Tim Petzold
Blood stem and progenitor cells give rise to all blood cell types. Tim Petzold & co show that when Connexin 41.8 is present but impaired, it delays their initial formation and disrupts the timely activation of a key signalling pathway in #zebrafish embryos. doi.org/10.1242/bio....
October 16, 2025 at 12:17 PM
Blood stem and progenitor cells give rise to all blood cell types. Tim Petzold & co show that when Connexin 41.8 is present but impaired, it delays their initial formation and disrupts the timely activation of a key signalling pathway in #zebrafish embryos. doi.org/10.1242/bio....
Reposted by Tim Petzold
Our work exploring a new explanation for the regulation of Hoxd genes and the #fin-to-limb transition. 🧪
It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social
#evo-devo #InHoxWeTrust
It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social
#evo-devo #InHoxWeTrust
How Did Hands Evolve? The Answer Is Behind You.
www.nytimes.com
September 17, 2025 at 5:31 PM
Our work exploring a new explanation for the regulation of Hoxd genes and the #fin-to-limb transition. 🧪
It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social
#evo-devo #InHoxWeTrust
It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social
#evo-devo #InHoxWeTrust
Reposted by Tim Petzold
Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...
Is enhancer-driven gene regulation all wrapped up? - Nature Reviews Genetics
In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.
www.nature.com
September 17, 2025 at 12:41 PM
Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...
Reposted by Tim Petzold
Living organisms are assumed to produce same-species offspring. A study in Nature reports a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species. go.nature.com/3V68MP0 🧪
September 7, 2025 at 7:14 PM
Living organisms are assumed to produce same-species offspring. A study in Nature reports a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species. go.nature.com/3V68MP0 🧪
Our humble gata2b in situ hybridization image made it onto the cover of @biologyopen.bsky.social!
If you'd like to check out the story behind the image, the link to our new paper is:
journals.biologists.com/bio/article/...
If you'd like to check out the story behind the image, the link to our new paper is:
journals.biologists.com/bio/article/...
September 3, 2025 at 8:23 AM
Our humble gata2b in situ hybridization image made it onto the cover of @biologyopen.bsky.social!
If you'd like to check out the story behind the image, the link to our new paper is:
journals.biologists.com/bio/article/...
If you'd like to check out the story behind the image, the link to our new paper is:
journals.biologists.com/bio/article/...
Excited to share that the final version of our work on Connexin 41.8 in HSPC specification is out now in @biologyopen.bsky.social!
If you're curious about how a connexin helps turn endothelial cells into blood stem cells, please have a read!
journals.biologists.com/bio/article/...
If you're curious about how a connexin helps turn endothelial cells into blood stem cells, please have a read!
journals.biologists.com/bio/article/...
Connexin 41.8 governs timely haematopoietic stem and progenitor cell specification
Summary: Cx41.8 is necessary to launch the haemogenic program and induce HSPC formation at the correct time during zebrafish development via a ROS-Hif-Notch-Gata2b pathway.
journals.biologists.com
September 1, 2025 at 7:10 AM
Excited to share that the final version of our work on Connexin 41.8 in HSPC specification is out now in @biologyopen.bsky.social!
If you're curious about how a connexin helps turn endothelial cells into blood stem cells, please have a read!
journals.biologists.com/bio/article/...
If you're curious about how a connexin helps turn endothelial cells into blood stem cells, please have a read!
journals.biologists.com/bio/article/...
Reposted by Tim Petzold
How the functional architecture of the zebrafish heart is shaped during development
📹 @tobyandrews.bsky.social et al @rashmi-priya.bsky.social
lab @crick.ac.uk in @cellpress.bsky.social Developmental Cell
➡️ bpod.org.uk/archive/2025...
📹 @tobyandrews.bsky.social et al @rashmi-priya.bsky.social
lab @crick.ac.uk in @cellpress.bsky.social Developmental Cell
➡️ bpod.org.uk/archive/2025...
August 18, 2025 at 8:40 AM
How the functional architecture of the zebrafish heart is shaped during development
📹 @tobyandrews.bsky.social et al @rashmi-priya.bsky.social
lab @crick.ac.uk in @cellpress.bsky.social Developmental Cell
➡️ bpod.org.uk/archive/2025...
📹 @tobyandrews.bsky.social et al @rashmi-priya.bsky.social
lab @crick.ac.uk in @cellpress.bsky.social Developmental Cell
➡️ bpod.org.uk/archive/2025...
Reposted by Tim Petzold
Thrilled to bits to see our latest work online in Dev Cell! 🥳
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish
Andrews et al. demonstrate that multiscale feedback between mechanical and chemical
cues builds a functional heart to support zebrafish embryonic life. Cell recruitment
and organ-scale forces drive tr...
tinyurl.com
August 6, 2025 at 2:53 PM
Thrilled to bits to see our latest work online in Dev Cell! 🥳
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n
tinyurl.com/cell-stretch
Reposted by Tim Petzold
Got this really cool, ghostly picture by accident the other day in Dillon Beach, CA. It is a Heermann's gull with both it's shadow and reflection.
#birds
#birds
August 8, 2025 at 1:55 PM
Got this really cool, ghostly picture by accident the other day in Dillon Beach, CA. It is a Heermann's gull with both it's shadow and reflection.
#birds
#birds
Reposted by Tim Petzold
Issue 14 is complete!
On the cover: Drosophila eye imaginal discs stained for the pan-neuronal marker Elav (red or blue) and cell fate-specific markers to investigate basic cell-biological processes such as cell proliferation and morphogenesis during development. See:
doi.org/10.1242/dev.204373
On the cover: Drosophila eye imaginal discs stained for the pan-neuronal marker Elav (red or blue) and cell fate-specific markers to investigate basic cell-biological processes such as cell proliferation and morphogenesis during development. See:
doi.org/10.1242/dev.204373
August 5, 2025 at 11:55 AM
Issue 14 is complete!
On the cover: Drosophila eye imaginal discs stained for the pan-neuronal marker Elav (red or blue) and cell fate-specific markers to investigate basic cell-biological processes such as cell proliferation and morphogenesis during development. See:
doi.org/10.1242/dev.204373
On the cover: Drosophila eye imaginal discs stained for the pan-neuronal marker Elav (red or blue) and cell fate-specific markers to investigate basic cell-biological processes such as cell proliferation and morphogenesis during development. See:
doi.org/10.1242/dev.204373
Reposted by Tim Petzold
This is my first time seeing a Monarch on our property! I literally just purchased milkweed seeds and began preparing the area I’m going to plant in this fall. That’s quite the synchronicity. #gardening #bugsky #bloomscrolling #photography
July 30, 2025 at 12:58 PM
This is my first time seeing a Monarch on our property! I literally just purchased milkweed seeds and began preparing the area I’m going to plant in this fall. That’s quite the synchronicity. #gardening #bugsky #bloomscrolling #photography
Beautiful work using lineage-tracing, transplantation experiments and fate mapping to show that somites give rise to nephron progenitors
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Somites are a source of nephron progenitors in zebrafish - Nature Communications
This study reveals that cells of the zebrafish kidney can originate from the somites, structures traditionally held as precursors to the skeletal muscle, challenging a century-old paradigm and prompti...
www.nature.com
July 29, 2025 at 10:50 AM
Beautiful work using lineage-tracing, transplantation experiments and fate mapping to show that somites give rise to nephron progenitors
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tim Petzold
🐌💫 Snail embryos never looked so fabulous!
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
July 25, 2025 at 11:11 PM
🐌💫 Snail embryos never looked so fabulous!
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball.
Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday
Reposted by Tim Petzold
Wow. Scientists have edited mosquito DNA to prevent the spread of malaria to humans "while supporting essential physiological functions... and negligible fitness costs" to the mosquito population.
Potentially ending the mosquito-born spread of malaria to humans.
www.nature.com/articles/s41...
Potentially ending the mosquito-born spread of malaria to humans.
www.nature.com/articles/s41...
July 25, 2025 at 3:23 PM
Wow. Scientists have edited mosquito DNA to prevent the spread of malaria to humans "while supporting essential physiological functions... and negligible fitness costs" to the mosquito population.
Potentially ending the mosquito-born spread of malaria to humans.
www.nature.com/articles/s41...
Potentially ending the mosquito-born spread of malaria to humans.
www.nature.com/articles/s41...
Reposted by Tim Petzold
Mustering the courage to share my latest scicomm endeavour: I channelled my love for writing into a blog where I can hopefully bring the marvels of evolutionary biology and non-coding DNA to all Science lovers!
darkgenomevo.wordpress.com/2025/06/22/i...
darkgenomevo.wordpress.com/2025/06/22/i...
It just takes one change
Here, I run though three examples of evolutionary novelty driven by single non-coding DNA changes: limb loss in snakes, gliding in sugar gliders, and coat coloration in African striped mice. These …
darkgenomevo.wordpress.com
June 23, 2025 at 5:06 PM
Mustering the courage to share my latest scicomm endeavour: I channelled my love for writing into a blog where I can hopefully bring the marvels of evolutionary biology and non-coding DNA to all Science lovers!
darkgenomevo.wordpress.com/2025/06/22/i...
darkgenomevo.wordpress.com/2025/06/22/i...
Reposted by Tim Petzold
No new genes needed to fly - just rewire what you have! 🦇🧬
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
July 16, 2025 at 1:49 PM
No new genes needed to fly - just rewire what you have! 🦇🧬
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Great new paper from the labs of @fany-real.bsky.social @stemundi.bsky.social @dariloops.bsky.social
doi.org/10.1038/s415...
#EvoDevo #SingleCell #BatWings
Reposted by Tim Petzold
In her Perspective, Emilie Snell-Rood discusses the value of basic science, using the Morpho butterfly as an example of how this type of research has driven later innovation & highlights the value of government and institutional support for basic research
journals.biologists.com/jeb/article/...
journals.biologists.com/jeb/article/...
June 26, 2025 at 7:30 AM
In her Perspective, Emilie Snell-Rood discusses the value of basic science, using the Morpho butterfly as an example of how this type of research has driven later innovation & highlights the value of government and institutional support for basic research
journals.biologists.com/jeb/article/...
journals.biologists.com/jeb/article/...
Reposted by Tim Petzold
The first 22 hours of #Zebrafish development. Blood vessels labeled in green #WeinsteinLab 🔬🧪
November 11, 2024 at 8:45 PM
The first 22 hours of #Zebrafish development. Blood vessels labeled in green #WeinsteinLab 🔬🧪
Reposted by Tim Petzold
Excited to share our new research in @cp-iscience.bsky.social! We reveal that tortoise head scales are sculpted through two distinct developmental processes - chemical signalling and mechanical folding 🐢🔬🧪
@lanevol.bsky.social @genevunige.bsky.social
www.cell.com/iscience/ful...
@lanevol.bsky.social @genevunige.bsky.social
www.cell.com/iscience/ful...
Chemical and mechanical patterning of tortoise skin scales occur in different regions of the head
Biological sciences; Zoology; Evolutionary biology
www.cell.com
June 4, 2025 at 2:39 PM
Excited to share our new research in @cp-iscience.bsky.social! We reveal that tortoise head scales are sculpted through two distinct developmental processes - chemical signalling and mechanical folding 🐢🔬🧪
@lanevol.bsky.social @genevunige.bsky.social
www.cell.com/iscience/ful...
@lanevol.bsky.social @genevunige.bsky.social
www.cell.com/iscience/ful...
Reposted by Tim Petzold
Reposted by Tim Petzold
Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
May 7, 2025 at 3:32 PM
Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
Reposted by Tim Petzold
A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility. www.nature.com/articles/s42...
Zebrafishology, study design guidelines for rigorous and reproducible data using zebrafish - Communications Biology
A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental ...
www.nature.com
May 15, 2025 at 7:06 PM
A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility. www.nature.com/articles/s42...
Reposted by Tim Petzold
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 6, 2025 at 8:39 PM
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Reposted by Tim Petzold
Look familiar? This beautiful video of #zebrafish embryogenesis was used for a 'one-frame per page' flipbook in the December 1996 edition of @dev-journal.bsky.social. Credit to Rolf Karlstrom and Don Kane. #ZebrafishFunFacts 🧪
April 24, 2025 at 8:31 AM
Look familiar? This beautiful video of #zebrafish embryogenesis was used for a 'one-frame per page' flipbook in the December 1996 edition of @dev-journal.bsky.social. Credit to Rolf Karlstrom and Don Kane. #ZebrafishFunFacts 🧪