Chase Bolt
@chasebolt.bsky.social
Chromatin - transcription - genetics - biotech
Dinosaurs and UFOs
Stabby horror movies
Dinosaurs and UFOs
Stabby horror movies
This is the kind of thing that makes me want to go back to academia. The future of experiments is incredible. Just some ideas:
#biotech #AI
#biotech #AI
Evo: DNA foundation modeling from molecular to genome scale | Arc Institute
Introducing Evo, a biological foundation model that generalizes across the fundamental languages of biology: DNA, RNA and proteins. Evo is capable of both prediction tasks, and generative design from ...
arc-website-git-foundation-model-tool-arc-institute.vercel.app
November 7, 2025 at 12:15 AM
November 4, 2025 at 12:07 AM
There are a bunch of kids going down the street trick or treating and a car went past real slow blaring the Halloween theme song. It was fucking awesome. 🎃👻
October 31, 2025 at 11:23 PM
There are a bunch of kids going down the street trick or treating and a car went past real slow blaring the Halloween theme song. It was fucking awesome. 🎃👻
The enshitification continues. I'm not even a Conservative, I just think it is fucking stupid to remove a gun from a picture when the 27 movies are just two hours of guns. There is a person in this world that gets paid - probably a shit ton of money - to make these meaningless decisions.
Amazon/MGM removes all guns from James Bond digital posters on Prime
007 is without his Walther PPK on the latest digital posters featured on Prime Video for the James Bond series.
www.joblo.com
October 6, 2025 at 1:15 PM
The enshitification continues. I'm not even a Conservative, I just think it is fucking stupid to remove a gun from a picture when the 27 movies are just two hours of guns. There is a person in this world that gets paid - probably a shit ton of money - to make these meaningless decisions.
Here is a clue, make anything other than a fucking IPA.
Craft Breweries Struggle as Sales and Appetites Wane
www.nytimes.com
October 5, 2025 at 9:30 PM
Here is a clue, make anything other than a fucking IPA.
Reposted by Chase Bolt
Our work exploring a new explanation for the regulation of Hoxd genes and the #fin-to-limb transition. 🧪
It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social
#evo-devo #InHoxWeTrust
It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social
#evo-devo #InHoxWeTrust
How Did Hands Evolve? The Answer Is Behind You.
www.nytimes.com
September 17, 2025 at 5:31 PM
Our work exploring a new explanation for the regulation of Hoxd genes and the #fin-to-limb transition. 🧪
It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social
#evo-devo #InHoxWeTrust
It was an absolute joy working on this w/ @aurhin.bsky.social and @homeobox.bsky.social @denisduboule.bsky.social @neilshubin.bsky.social
#evo-devo #InHoxWeTrust
There is a lot of concern about leaked genetic data, but what I wonder is, can a "reputable" legal entity like a health insurance company use this information? Or the government? Wouldn't the chain of custody be unreliable? #genetic #privacy
The precarious future of consumer genetic privacy
Congress and other lawmakers must act to robustly protect direct-to-consumer genetic data and biospecimens into the future
www.science.org
September 17, 2025 at 12:47 PM
Reposted by Chase Bolt
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
September 11, 2025 at 6:09 AM
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
"the quest for drug targets have meanwhile reduced much of cancer research from a scholarly biological discipline to a transactional operation concerned more with cataloguing molecular alterations and finding associations, than with understanding fundamental principles using formal theory." Agreed.
The end of the genetic paradigm of cancer
Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...
journals.plos.org
September 11, 2025 at 12:12 AM
"the quest for drug targets have meanwhile reduced much of cancer research from a scholarly biological discipline to a transactional operation concerned more with cataloguing molecular alterations and finding associations, than with understanding fundamental principles using formal theory." Agreed.
Charlie Kirk is dead by assassination. This political violence needs to stop. Things will only continue to get worse. I didn't like him but no one should be killed for their beliefs and speaking them aloud.
Conservative influencer Charlie Kirk shot dead at Utah event
Kirk, an activist and the founder of conservative student group Turning Point USA, played a key role in driving youth support for Trump in November.
www.reuters.com
September 10, 2025 at 11:12 PM
Charlie Kirk is dead by assassination. This political violence needs to stop. Things will only continue to get worse. I didn't like him but no one should be killed for their beliefs and speaking them aloud.
Euchromatin hopping explains how some enhancers seem to initiate the formation of active regulatory landscapes, and why some/many enhancer deletions don't affect transcription quantity; there are driver and passenger enhancers.
#chromatin #enhancers #generegulation
#chromatin #enhancers #generegulation
Enhancers mediate euchromatin hopping at chromatin contact points
Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...
www.biorxiv.org
September 10, 2025 at 5:50 PM
Euchromatin hopping explains how some enhancers seem to initiate the formation of active regulatory landscapes, and why some/many enhancer deletions don't affect transcription quantity; there are driver and passenger enhancers.
#chromatin #enhancers #generegulation
#chromatin #enhancers #generegulation
As a former #evo-devo academic that moved to industry, I can say that people with evolutionary backgrounds are very employable in #biotech. In fact, they tend to do better than people trained in more narrow topics like cell biology. Folks doing genome evo, please come to industry. We need you.
We don't structure our programs to reflect this, but in reality faculty is the alternative career path, not the default.
“Overall, the message from this survey is positive; evolutionary biologists are readily employable outside of academia, generally well-prepared for those jobs, and report high levels of satisfaction” www.biorxiv.org/content/10.1...
September 10, 2025 at 12:35 PM
Reposted by Chase Bolt
#DBfeature
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
September 3, 2025 at 2:02 PM
#DBfeature
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns
by Baraiya, D. H., Kavya, T. T., Mandal, A., Chakraborty, S., Sathish, N., Francis, C. M. R., & Joseph
tiom33.short.gy/DB520,155-170
who will republicans blame for their problems when govt no longer exists?
April 18, 2025 at 4:09 PM
who will republicans blame for their problems when govt no longer exists?
Wouldn’t a sufficiently complex system stochastically produce regions of greater complexity?
February 18, 2025 at 1:19 AM
Wouldn’t a sufficiently complex system stochastically produce regions of greater complexity?
We cut off all foreign aid, stranded 10k people, and saved 1 #%$%#&$ % of the annual budget. Awesome.
www.nytimes.com/2025/02/04/u...
www.nytimes.com/2025/02/04/u...
Trump Officials to Put Almost All U.S.A.I.D. Workers on Leave
Most employees overseas have been told to return to the U.S. Democrats have denounced recent moves to shrink the agency as an illegal power grab.
www.nytimes.com
February 6, 2025 at 12:23 AM
We cut off all foreign aid, stranded 10k people, and saved 1 #%$%#&$ % of the annual budget. Awesome.
www.nytimes.com/2025/02/04/u...
www.nytimes.com/2025/02/04/u...
Reposted by Chase Bolt
November 20, 2024 at 1:27 PM
Reposted by Chase Bolt
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Can someone please train some AI on large biological datasets like this, integrate with zfin database, and let me query it?
#science #zfin
www.biorxiv.org/content/10.1...
#science #zfin
www.biorxiv.org/content/10.1...
www.biorxiv.org
October 24, 2024 at 12:20 AM
Can someone please train some AI on large biological datasets like this, integrate with zfin database, and let me query it?
#science #zfin
www.biorxiv.org/content/10.1...
#science #zfin
www.biorxiv.org/content/10.1...