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devbiol.bsky.social
Developmental Biology
@devbiol.bsky.social
3.4K followers 51 following 330 posts
https://www.sciencedirect.com/journal/developmental-biology
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Reposted by Developmental Biology
ijmonod.bsky.social
✍️The Konstantinides Lab ( @nkonst4.bsky.social ) published a new article

📖 @devbiol.bsky.social
📃 Gene expression cartography of a developing neuronal structure
🔗 www.sciencedirect.com/science/arti...
February 9, 2026 at 1:01 PM
devbiol.bsky.social
#Postdocs! Going on academic job market?

Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview.

< 1 month till Deadline: March 5

@socdevbio.bsky.social

www.sdbonline.org/gethired
February 9, 2026 at 1:29 PM
devbiol.bsky.social
#DBfeature 🪱

Wnt/β-catenin signaling promotes posterior axial regeneration in non-regenerative tissue of the annelid C. teleta, enabling the prospect of increasing regeneration ability in regeneration-deficient tissues

By Lauren Kunselman, Elaine Seaver

tinyurl.com/2bxpecek
Comparison of regeneration responses to Wnt signaling perturbation in different species. In both panels, the cladogram indicates phylogenetic relationships. P. fluviatilis and D. lacteum are most closely related to each other and share the same response to canonical Wnt activation and inhibition, so they are represented by one graphic. A(+)/P(+) = anterior and posterior regeneration ability present. A(±)/P(+) = anterior regeneration ability present if cut in anterior 2/3 of body, posterior regeneration ability present. A(−)/P(+) = no anterior regeneration ability, posterior regeneration ability present. Light blue color represents regenerated tissue. (a) Increasing canonical Wnt signaling after amputation results in ectopic posterior axis formation in all species. (b) Decreasing canonical Wnt signaling after amputation results in ectopic head formation in H. miamia and S. mediterranea and rescued anterior regeneration ability in P. fluviatilis and D. lacteum, whereas in C. teleta, no ectopic heads form and anterior regeneration is not rescued.
February 9, 2026 at 9:36 AM
devbiol.bsky.social
#Postdocs! Going on academic job market? Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview. Deadline: March 5

@socdevbio.bsky.social

www.sdbonline.org/gethired
February 4, 2026 at 6:48 PM
devbiol.bsky.social
#DBfeature 🐟

Fold-and-fuse neurulation in zebrafish requires vangl2

Anterior neural tube closure is delayed and abnormal in 🐟embryos lacking PCP gene vangl2

by Jacalyn MacGowan, Mara Cardenas, Margot Kossmann Williams
www.sciencedirect.com/science/arti...
Neural fold fusion proceeds bidirectionally from a central “pinch point”
February 2, 2026 at 3:23 PM
devbiol.bsky.social
#DBfeature 🌍

Planetary Health and Indigenous perspectives into the discipline of Developmental Biology exposes students to critical and global challenges that emerging scientists will need to address.

By Sonja McKeown, Marcus Mohr, Tara Moynihan, Beau Cubillo, Liza Barbour

tinyurl.com/yc2m6ncw
A text flow chart about the inclusion of planetary health in developmental biology education. In red: "co-design codevelop a workshop on planetary health" with a double way arrow between students and educators. Red arrow towards purple box "workshop delivered by educator and students", with a contribution in green of an arrow from "consultation with indigenous colleagues". Blue: "pre-class poll" and "post=class poll".
January 30, 2026 at 12:26 PM
devbiol.bsky.social
#DBfeature 🧠

In our recent article, researchers explored the intersection of developmental biology and social change, offering strategies to teach autism genetics through a neurodiversity-affirming lens.
-Patra, Aindri H., Katherine Bonefas, Eirene Markenscoff-Papadimitriou.
doi.org/10.1016/j.yd...
Timeline of key genetics discoveries in autism spectrum disorder.
January 29, 2026 at 3:37 PM
devbiol.bsky.social
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Bones, brains, and bias—neural crest cell contribution to craniofacial structure

Active Learning Assignments for craniofacial perception & normal phenotypic variation

by Jeffrey Carmichael, Diane Darland et al
www.sciencedirect.com/science/arti...
Neural crest contribution to craniofacial structures and phenotypic variation
January 29, 2026 at 10:05 AM
devbiol.bsky.social
#DBfeature #EvoDevo

Exploring early extraembryonic cells of epiblast origin: Questions on human amniotic ectoderm & extraembryonic mesoderm

How does cellular density regulate the sequential specification of non-neural ectoderm?

by Shota Nakanoh
www.sciencedirect.com/science/arti...
Schematic summary of developmental stages in the formation of amniotic ectoderm and extraembryonic mesoderm in mouse and human
January 27, 2026 at 11:09 AM
devbiol.bsky.social
🚨Next DevBioConnect on the way‼️
Developmental Biology Author webinar

by Dr. Alexa Burger & Dr. Robert Huebner

🗓️ Feb 10th, 2026
⏰ 11 am–12 pm CST

To Register
forms.gle/4J192L42y6sg...

@socdevbio.bsky.social
@aburger2009.bsky.social
January 23, 2026 at 6:28 PM
devbiol.bsky.social
#DBfeature 🐦

Coilin-containing nuclear biomolecular condensates in zebra finch Taeniopygia guttata growing oocytes

The coilin condensates reveal components of the nucleoli and centromeric protein bodies

by Svetlana Galkina et al
www.sciencedirect.com/science/arti...
Coilin bodies in zebra finch can lie at centromere regions of LBCs and contain cohesin proteins, markers of centromeric protein bodies
January 23, 2026 at 2:18 PM
devbiol.bsky.social
#DBfeature 🐣

With the rise of omics data, identifying tissue-specific enhancers is easier than ever—but validation is key. Ruth M. Williams discusses why the chicken embryo is the ideal in vivo sandbox for testing human regulatory elements in our recent review.
www.sciencedirect.com/science/arti...
Identifying enhancers in the chicken embryo.
January 22, 2026 at 2:53 PM
devbiol.bsky.social
#DBfeature 🐣

BMP and WNT signaling are involved in tracheal cartilage development in chicken embryos

COL2A1 co-localises with BMP2 but not with BMP4 in the tracheal cartilages

by Romman Muntzar, Tamara Anne Franz-Odendaal, et al
www.sciencedirect.com/science/arti...
Multiplex fluorescent in situ hybridization gene expression for Col2a1, Bmp2, Bmp4, Wnt2 on untreated tracheas, HH36.5
January 21, 2026 at 1:02 PM
devbiol.bsky.social
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Centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium

By Jennifer Sheridan, Aline Grata, Julia Dorr, Eve E. Suva, Enzo Bresteau, Linus R. Mitchell, Osama Hassan, Brian Mitchell

tinyurl.com/c88cax5z
AK7 deletion causes an impairment of fluid flow and ciliary function. (A) Representative images of MCCs stained with anti-AK7 (magenta, white) and anti-acetylated tubulin (cyan) antibodies together with phalloidin (green) showing strong ciliary staining in controls (Cas9 alone or gRNA alone) that is missing in AK7 KO cells (Cas9 + gRNAs). Scale is 5 μm.
January 20, 2026 at 3:06 PM
devbiol.bsky.social
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Centralspindlin is required for C. elegans anchor cell specification, vulval induction and morphogenesis, with different requirements during postembryonic gonad development compared to early embryogenesis

By Tatsuya Kato, Olga Skorobogata, Christian E. Rocheleau

tinyurl.com/ywjmjsj9
Knockdown of centralspindlin results in binucleate anchor cells. LIN-12/Notch reporter lin-12::mNeongreen (yellow) and Notch ligand LAG-2/DSL nuclear reporter lag-2::H2B::::mTurquoise (cyan) expression at mid L2 (A,B), mid L3 (A',B') and late L3 (A",B") in EV(RNAi) (A-A") and zen-4(RNAi) (B-B") treated larvae. White arrowheads denote AC nuclei. Clear arrowheads denote VU nuclei. Asterisks denote primary vulva cell nuclei expressing lag-2::H2B::mTurquoise which is also expressed in some ventral cord neurons.
January 19, 2026 at 12:19 PM
devbiol.bsky.social
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EPHRIN-A1 and -A2 act as positive growth factors for developing spiral ganglion radial bundles

Loss of Efna1 and Efna2 leads to defects in radial bundle extension in vivo

by Mansa Gurjar, Thomas Coate
www.sciencedirect.com/science/arti...
Efna1 and Efna2 loss leads to shorter radial bundles during cochlear development
January 16, 2026 at 2:34 PM
devbiol.bsky.social
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Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance

By Anna Zike, Madison Abel, Sophie Fleck, Emily DeWitt, Lesley Weaver

tinyurl.com/3wfmkcfc
(A) The adult Drosophila ovary is composed of 15–20 ovarioles that contain progressively developing egg chambers. Each egg chamber consists of a germline cyst (15 nurse cells and one oocyte; blue) that is surrounded by somatic follicle cells (purple), which is produced in the anterior germarium. (B) Each germarium contains 2-to-3 germline stem cells (GSCs, dark blue) that are maintained by a somatic niche that is primarily composed of cap cells (green). GSCs divide to self-renew and give rise to a cystoblast that will undergo four mitoses with incomplete cytokinesis, generating a germline cyst. GSC and germline cysts are identified by the morphology of the fusome (pink), an ER-like organelle that changes morphology with differentiation. Germline cysts are surrounded by somatic follicle cells (purple) to form a follicle that ultimately buds from the germarium. (C,D) Ovariole (C) and germaria (D) from ERR::GFP.FSTF females showing the expression pattern of ERR::GFP.FSTF based on anti-GFP staining (green). α-Spectrin (magenta), fusome; LamC (magenta), nuclear lamina; DAPI (blue), DNA. Scale bar for (c), 100 μm; scale bar for (d), 10 μm. The germarium (G) and egg chamber stages are labeled in panel (c).
January 15, 2026 at 9:43 AM
devbiol.bsky.social
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Geometric, cell cycle & maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development

YAP behavior depends on cell cycle-nuclei volume dynamics

by Madeleine Chalifoux, Eszter Posfai et al
www.sciencedirect.com/science/arti...
Long-term live imaging of preimplantation embryos expressing endogenously tagged YAP-miRFP670
January 14, 2026 at 1:20 PM
devbiol.bsky.social
#DBfeature ⚡️

Ventral-to-dorsal model for electric organ development of Electrophorus eel

By S Senarat, A Matsumoto, T Nagasawa, S Sakaki, D Tsuzuki, K Uchida, M Kuwahara, M Nikaido, E Hondo, A Iida

tinyurl.com/7c7a266v
This illustration indicates the development of the main electric organ in the adult electric eel. Progenitor cells located in the ventral terminus of the main electric organ segregate and migrate dorsally, forming multinuclear syncytium and layer structure. The NKA ion pump begins to be expressed after the layer formation. The syncytia increase the dorsoventral thickness, differentiate into mature electrocytes, and contribute to the generation of high-voltage discharges via ion transporters, including NKA
January 13, 2026 at 1:11 PM
devbiol.bsky.social
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Review

Integration of the sensory and skeletal systems: A classical perspective on neuromast-bone interactions

Osteogenic potential of neuromast organs

by Alyssa Hamm, Joshua Gross
www.sciencedirect.com/science/arti...
The positions of canal neuromasts, the lateral line canal, and bones of the facial complex are anatomically integrated.
January 12, 2026 at 1:30 PM
devbiol.bsky.social
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Embryonic exposure to Smoothened Agonist overactivates the Hh signaling pathway, affecting the cell cycle and inhibiting proliferation, leading to cleft tongue

By C Mao, Y Jiang, Z Li, W Zhou, Y Lai, C Wang, M Lu, W Chen

tinyurl.com/zeeb95t8
Cartoon of a white pregnant mouse being injected with SAG. Diagram of the developing tongue in control conditions, with mesenchymal cell sin blue and myoblasts in red, and in the SAG condition, with a visible cleft between the my blast cells.
January 9, 2026 at 9:40 AM
devbiol.bsky.social
#DBfeature 🐟🫀

Tbx1-dependent and independent pathways promote six gene expression downstream of retinoic acid signaling to determine cardiomyocyte number in zebrafish

by Tiffany Duong, Joshua Waxman et al
www.sciencedirect.com/science/arti...
RA-deficient DM have a reduction in the number of Nkx2.5+ CMs at 48 hpf
January 8, 2026 at 1:39 PM
Reposted by Developmental Biology
doctorzen.net
Check out the perfect ABT structure in this graphic abstract.

"Pax9 in needed to form teeth in mammals AND you see it in the mouth of fishes
BUT some fish don't form teeth
THEREFORE Pax9 was originally used in mouth development rather than teeth."
devbiol.bsky.social Developmental Biology @devbiol.bsky.social · Jan 7
#DBfeature 🐠

Pax9 has a broader role in initiating development of mesenchymal structures around the mouth during zebrafish development

By Sandhya Paudel, Sarah McLeod, Stefani Gjorcheska, Lindsey Barske

tinyurl.com/yc3jfpux
Cartoon of Pax9 expression (purple) during facial development in mouse (left) and zebrafish (right). Text: Mammals. Pax9 is expressed In tooth-forming mesenchyme around the mouth. Required for tooth formation in mouse and human. Fish. Pax9 is also expressed in oral mesenchyme in fishes. But many fish do not form oral teeth. Vestigial expression or divergent function? Result: pax9 is required for formation of upper jaw bones and barbels in zebrafish, but dispensable for non-oral teeth. Support ancestral function in building peri-oral structures from condensed mesenchyme rather than a specific requirement for teeth
January 7, 2026 at 1:25 PM
devbiol.bsky.social
🚨Introducing DevBioConnect‼️
Developmental Biology launches a new author webinar series showcasing recent publications, presented by the authors

🗓️ Jan 13 • Feb 10 • Mar 10, 2026
⏰ 11am–12pm CST

To Register
www.sdbonline.org/meetings
Or📄 See flyer for details

@socdevbio.bsky.social
January 7, 2026 at 5:59 PM
devbiol.bsky.social
#DBfeature 🐠

Pax9 has a broader role in initiating development of mesenchymal structures around the mouth during zebrafish development

By Sandhya Paudel, Sarah McLeod, Stefani Gjorcheska, Lindsey Barske

tinyurl.com/yc3jfpux
Cartoon of Pax9 expression (purple) during facial development in mouse (left) and zebrafish (right). Text: Mammals. Pax9 is expressed In tooth-forming mesenchyme around the mouth. Required for tooth formation in mouse and human. Fish. Pax9 is also expressed in oral mesenchyme in fishes. But many fish do not form oral teeth. Vestigial expression or divergent function? Result: pax9 is required for formation of upper jaw bones and barbels in zebrafish, but dispensable for non-oral teeth. Support ancestral function in building peri-oral structures from condensed mesenchyme rather than a specific requirement for teeth
January 7, 2026 at 10:34 AM