Igor Tascón
@igortascon.bsky.social
Structural biologist @Biofisika Insitutua, Basque Country
#membraneproteins #cryoEM
#membraneproteins #cryoEM
Reposted by Igor Tascón
Extremely happy to share our lab’s first paper now published in @NatureSMB! We determined the cryo-EM structures of GluA4, both alone and in complex with TARP2, capturing the receptor in different functional states.
New online: GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins
GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins
Nature Structural & Molecular Biology, Published online: 15 September 2025; doi:10.1038/s41594-025-01666-7Vega-Gutiérrez et al. present cryo-electron microscopy structures of GluA4-containing AMPA receptors, which are key for brain signaling. They show GluA4-specific conformations and explain how subunit composition shapes receptor architecture, dynamics and function.
go.nature.com
September 15, 2025 at 11:03 AM
Extremely happy to share our lab’s first paper now published in @NatureSMB! We determined the cryo-EM structures of GluA4, both alone and in complex with TARP2, capturing the receptor in different functional states.
Reposted by Igor Tascón
Proud to share this great story is out now! A huge Thank You to the whole team but especially to my co-first author Janina Stautz. The results were often surprising but we managed to unpuzzle how a short IDR and its membrane interaction are involved in channel opening.
This took us a while and I am all the happier it is finally out! I thought that simply adding ATP to purified potassium channel KtrAB should be sufficient to stabilize its active state. I was so wrong...
Read the full story on how an IDR facilitates channel opening upon membrane interaction.
Read the full story on how an IDR facilitates channel opening upon membrane interaction.
A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB
Nature Communications - KtrAB is a major potassium uptake system that has been linked to the pathogenesis of many infectious bacteria. Here the authors show that KtrB from Vibrio alginolyticus...
www.nature.com
May 13, 2025 at 7:04 AM
Proud to share this great story is out now! A huge Thank You to the whole team but especially to my co-first author Janina Stautz. The results were often surprising but we managed to unpuzzle how a short IDR and its membrane interaction are involved in channel opening.
Reposted by Igor Tascón
"Our LPD-3 complex structural data reveal protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid transport proteins (BLTPs)." 🤯🤯😍
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature
The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...
www.nature.com
April 25, 2025 at 7:48 AM
"Our LPD-3 complex structural data reveal protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid transport proteins (BLTPs)." 🤯🤯😍
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Igor Tascón
Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain.
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Structural insights into allosteric mechanism of glycine transporter-mediated analgesia
Chronic neuropathic pain, caused by nerve damage or disease, affects 10% of the population with rising incidence. The burden is exacerbated by ineffective treatments and overreliance on opioids. Neuro...
www.biorxiv.org
April 24, 2025 at 8:14 PM
Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain.
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Igor Tascón
I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY
Molecular basis of human GABA transporter 3 inhibition
Nature Communications - GABA transporters maintain GABA homeostasis and regulate synaptic signaling. Here, the authors determined the cryoEM structures of GABA transporter 3 (GAT3) in its apo form...
urldefense.com
April 23, 2025 at 9:37 PM
I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY
Reposted by Igor Tascón
Congratulations to Franco Li, Shaun Peters and colleagues from the Strynadka Lab at UBC for their recent publication showcasing cryo-EM structures of S. aureus TarGH in the presence of targocil-II!
HRMEM is proud to have supported this work! 🔬🫶
www.nature.com/articles/s41...
HRMEM is proud to have supported this work! 🔬🫶
www.nature.com/articles/s41...
Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH - Nature Communications
Cryo-EM illuminates atomic binding details and far-ranging conformational effects of the inhibitor targocil-II on wall teichoic acid ABC transporter TarGH, a virulence target from the antibiotic resis...
www.nature.com
April 12, 2025 at 12:25 AM
Congratulations to Franco Li, Shaun Peters and colleagues from the Strynadka Lab at UBC for their recent publication showcasing cryo-EM structures of S. aureus TarGH in the presence of targocil-II!
HRMEM is proud to have supported this work! 🔬🫶
www.nature.com/articles/s41...
HRMEM is proud to have supported this work! 🔬🫶
www.nature.com/articles/s41...
Reposted by Igor Tascón
A broad call for a PhD researcher/ postdoc in our group at the MDC in Berlin. An ideal PhD student - a computational scientist, a postdoc - a structural biologist, but feel free to re-convince me!
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
Scientific Researcher – Method Developments for In situ Structural Biology (F/M/D)
The Max Delbrück Center for Molecular Medicine in the Helmholtz Association aims to transform tomorrow’s medicine through our discoveries of today. At locations in Berlin-Buch, Berlin-Mitte, Heidelber...
www.mdc-berlin.de
April 8, 2025 at 11:19 AM
A broad call for a PhD researcher/ postdoc in our group at the MDC in Berlin. An ideal PhD student - a computational scientist, a postdoc - a structural biologist, but feel free to re-convince me!
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...
Reposted by Igor Tascón
Our work on HIV-1 matrix, led by James Stacey and @dhrebik.bsky.social, is in this week's @nature.com. Extended explanatory video from @margotriggi.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 4, 2025 at 1:03 PM
Our work on HIV-1 matrix, led by James Stacey and @dhrebik.bsky.social, is in this week's @nature.com. Extended explanatory video from @margotriggi.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Igor Tascón
The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 6:20 PM
The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
Reposted by Igor Tascón
Yuge paper! Long awaited CryoEM structures for seven psychedelics.
Congrats to all —essential reading for those interested in #psychedelics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The structural diversity of psychedelic drug actions revealed - Nature Communications
The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto ligand specificity and sig...
www.nature.com
March 20, 2025 at 1:28 PM
Yuge paper! Long awaited CryoEM structures for seven psychedelics.
Reposted by Igor Tascón
How cool is this?? "Structural dynamics of DNA unwinding by a replicative helicase" by #CryoEM Taha Shahid's work at LISCB: le.ac.uk/news/2025/ma...
March 20, 2025 at 9:52 AM
How cool is this?? "Structural dynamics of DNA unwinding by a replicative helicase" by #CryoEM Taha Shahid's work at LISCB: le.ac.uk/news/2025/ma...
Reposted by Igor Tascón
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 13, 2025 at 11:19 PM
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Igor Tascón
Webserver for automated model building: github.com/SBQ-1999/Cry...
Updated preprint: www.biorxiv.org/content/10.1...
Updated preprint: www.biorxiv.org/content/10.1...
GitHub - SBQ-1999/CryFold: From cryo-EM density map to atomic structure
From cryo-EM density map to atomic structure. Contribute to SBQ-1999/CryFold development by creating an account on GitHub.
github.com
March 11, 2025 at 5:28 PM
Webserver for automated model building: github.com/SBQ-1999/Cry...
Updated preprint: www.biorxiv.org/content/10.1...
Updated preprint: www.biorxiv.org/content/10.1...
Reposted by Igor Tascón
Markus from @seegerlab.bsky.social wakes us up with a fresh take on metal metabolism in Mycobacteria... So you think you have an exporter on your hands? Make sure it doesn't import instead - no iron(y) 😁
March 2, 2025 at 8:28 AM
Markus from @seegerlab.bsky.social wakes us up with a fresh take on metal metabolism in Mycobacteria... So you think you have an exporter on your hands? Make sure it doesn't import instead - no iron(y) 😁
Reposted by Igor Tascón
Sad to hear of George Sheldrick's passing. So much is owed to his genius: from small molecules to #protein structures deposited in @pdbeurope.bsky.social that allowed development of #AlphaFold. A kind, humble giant on which the field has been built, he's missed by many.
ecanews.org/blog/2025/02...
ecanews.org/blog/2025/02...
George M. Sheldrick (1942-2025) - European Crystallographic Association
It is with a heavy heart, that we must announce the passing of George Michael Sheldrick. Everyone in crystallography knows George as a giant in the development of computing methods […]
ecanews.org
February 24, 2025 at 4:37 PM
Sad to hear of George Sheldrick's passing. So much is owed to his genius: from small molecules to #protein structures deposited in @pdbeurope.bsky.social that allowed development of #AlphaFold. A kind, humble giant on which the field has been built, he's missed by many.
ecanews.org/blog/2025/02...
ecanews.org/blog/2025/02...
Reposted by Igor Tascón
Welcome to @ccpem.bsky.social on bluesky! The collaborative computing projection for #cryoEM provides support and software for the community!
February 24, 2025 at 3:57 PM
Welcome to @ccpem.bsky.social on bluesky! The collaborative computing projection for #cryoEM provides support and software for the community!
Reposted by Igor Tascón
Our paper "Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica" is published in Science Advances today 🥂 🎊
tinyurl.com/MGuptaSA
Huge congratulations to the team- @nkhandelwal.bsky.social, Andrew Nelson, Peter Hwang, Sergei Pourmal, Jeffrey Bennett, ROBERT M STROUD!
tinyurl.com/MGuptaSA
Huge congratulations to the team- @nkhandelwal.bsky.social, Andrew Nelson, Peter Hwang, Sergei Pourmal, Jeffrey Bennett, ROBERT M STROUD!
Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica
Pathogenic autoantibodies in neuromyelitis optica bind three multiply presented loops on arrays of human aquaporin-4.
tinyurl.com
February 21, 2025 at 8:08 PM
Our paper "Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica" is published in Science Advances today 🥂 🎊
tinyurl.com/MGuptaSA
Huge congratulations to the team- @nkhandelwal.bsky.social, Andrew Nelson, Peter Hwang, Sergei Pourmal, Jeffrey Bennett, ROBERT M STROUD!
tinyurl.com/MGuptaSA
Huge congratulations to the team- @nkhandelwal.bsky.social, Andrew Nelson, Peter Hwang, Sergei Pourmal, Jeffrey Bennett, ROBERT M STROUD!
Reposted by Igor Tascón
🌟 Groundbreaking: AFM reveals #SecYEG-SecA complex mediates protein translocation at nano-scale! 30+ years of research gets visual proof. 🔬👀 #ProteinScience PMID:39779699, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-024-54875-x
February 22, 2025 at 9:10 AM
🌟 Groundbreaking: AFM reveals #SecYEG-SecA complex mediates protein translocation at nano-scale! 30+ years of research gets visual proof. 🔬👀 #ProteinScience PMID:39779699, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-024-54875-x
Reposted by Igor Tascón
Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel pubmed.ncbi.nlm.nih.gov/39971906/ #cryoem
February 20, 2025 at 10:28 AM
Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel pubmed.ncbi.nlm.nih.gov/39971906/ #cryoem
Reposted by Igor Tascón
Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid"
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
Structural insights into TRPV2 modulation by probenecid
Nature Structural & Molecular Biology - The authors reveal that probenecid, an FDA-approved drug, uniquely modulates TRPV2 through an intracellular pocket. Probenecid drives the channel into an...
www.nature.com
February 19, 2025 at 11:02 PM
Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid"
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
Reposted by Igor Tascón
In @justinditrani.bsky.social final postdoc paper (with contributions from many others) we show that forming/purifying vesicles (here from M. smegmatis) allows structure det'n of *endogenous* membrane proteins in their *native lipid bilayer*
🧵 on methods & TB biology...
www.pnas.org/doi/full/10....
🧵 on methods & TB biology...
www.pnas.org/doi/full/10....
February 19, 2025 at 9:13 PM
In @justinditrani.bsky.social final postdoc paper (with contributions from many others) we show that forming/purifying vesicles (here from M. smegmatis) allows structure det'n of *endogenous* membrane proteins in their *native lipid bilayer*
🧵 on methods & TB biology...
www.pnas.org/doi/full/10....
🧵 on methods & TB biology...
www.pnas.org/doi/full/10....
Reposted by Igor Tascón
🔎#CFM_MolMech: a meeting exploring the integration of structural, biochemical, and biophysical insights into cryo-EM advances that reveal molecular machines behind DNA/RNA processes.
👥 Meet the organisers: @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social.
📆May 28-30th
👥 Meet the organisers: @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social.
📆May 28-30th
February 18, 2025 at 12:43 PM
🔎#CFM_MolMech: a meeting exploring the integration of structural, biochemical, and biophysical insights into cryo-EM advances that reveal molecular machines behind DNA/RNA processes.
👥 Meet the organisers: @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social.
📆May 28-30th
👥 Meet the organisers: @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social.
📆May 28-30th
Reposted by Igor Tascón
Excited to share PoET-2, our next breakthrough in protein language modeling. It represents a fundamental shift in how AI learns from evolutionary sequences. 🧵 1/13
February 11, 2025 at 2:30 PM
Excited to share PoET-2, our next breakthrough in protein language modeling. It represents a fundamental shift in how AI learns from evolutionary sequences. 🧵 1/13
Reposted by Igor Tascón
Our #CryoEM study on the binding of a Tarantula toxin to a full-length human voltage-gated sodium channel has been published. Very proud of the awesome people in my lab 🥳🥂
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I - Nature Communications
Animal toxins can modulate action potentials and are important leads for therapeutics. Here, the authors use cryo-EM to show the interaction of the tarantula venom peptide Protoxin-I with a human volt...
www.nature.com
February 7, 2025 at 9:01 PM
Our #CryoEM study on the binding of a Tarantula toxin to a full-length human voltage-gated sodium channel has been published. Very proud of the awesome people in my lab 🥳🥂
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Igor Tascón
I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea - Nature Structural & Molecular Biology
Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interacti...
www.nature.com
January 27, 2025 at 12:18 PM
I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...