Elisa Fadda
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elisafadda.bsky.social
Elisa Fadda
@elisafadda.bsky.social
2.5K followers 1.5K following 1.4K posts
Associate Professor in the School of Biological Sciences at the University of Southampton, head chef at https://GlycoShape.org, Salem's butler, fucose fanatic #glycotime everyday! She/Her
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elisafadda.bsky.social
Elisa Fadda @elisafadda.bsky.social · Nov 13
As we (my lab and I) are new here 😻, let me introduce some exciting #glycotime work we recently published in Nature Methods doi.org/10.1038/s415... GlycoShape is a completely OA database and toolbox to restore the 3D structure of glycans on glycoproteins 🥳 You can find it at glycoshape.org 1/2
artistic rendition of glycoproteins 3D structures anchored on the cell surface and soluble with the glycans restored with https://glycoshape.org
Reposted by Elisa Fadda
janinebrunner.bsky.social
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.

Or from a single dish of HEK cell culture in the case of two membrane proteins.

Out in Nature Methods now! lnkd.in/gpyBSceg

Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
Reposted by Elisa Fadda
treasurymog.bsky.social
Happy #Caturday
November 15, 2025 at 8:08 AM
Reposted by Elisa Fadda
musefoundry.bsky.social
Deezer ran a study with 9,000 listeners and found that only 3 percent could tell the difference between a fully AI-generated song and a human-made one.

I dig into the implications here:

medium.com/the-riff/dee...
Deezer Reports Only 3% of Users Can Accurately Identify AI-Generated Tracks
130 days' worth of AI “music” floods the platform every day
medium.com
November 14, 2025 at 7:26 PM
Reposted by Elisa Fadda
scurry.bsky.social
Regretfully (for the sake of the authors and journal staff), I have this morning declined an invitation to review for a @royalsociety.org journal because of the Society’s continued refusal to stand up for its values in dealing with Elon Musk FRS.
Text of letter reads: “With apologies to the authors and to the staff at Royal Society Open Science who are blameless in all this, but I am not willing to devote time to review a Royal Society that continues to honour Elon Musk with its fellowship. Mr Musk stands in clear breach of the code of conduct which applies to all Fellows. He runs one of the most voluminous sources of misinformation on the planet (his social media platform X), to which he personally contributes without any regard for the Society's values of truth and evidence. Moreover, as head of DOGE he presided gleefully over the dismantling of USAID, an action hat has already lead to the deaths of an estimated 600,000 people, two-thirds of them children. In the coming years millions more will die because of his actions. I am truly sickened by the Royal Society's failure to sand up for its values or indeed for umanity. Until I see a clear demonstration that it is prepared to enforce its code of conduct, I cannot see myself devoting time to reviewing for the Society's journals. Yours faithfully, Stephen Curry” P.S. Please feel free to forward this communication to the President of the Royal Society
November 14, 2025 at 8:02 AM
Reposted by Elisa Fadda
carlbergstrom.com
Twin cities friends: I'll be speaking tomorrow at the Minnesota Center for Philosophy of Science on how AI disrupts the sometimes precarious balance of scientific incentives.
November 13, 2025 at 9:02 PM
Reposted by Elisa Fadda
carlbergstrom.com
EverythingIsFine.gif
Meta said on Wednesday that it cut approximately 600 jobs in its artificial intelligence division, according to a memo sent to employees that was relayed to The New York Times, as the company seeks to keep pace with competitors in the furious contest over the technology. The layoffs were in Meta’s so-called Superintelligence Labs, which is the umbrella name for the company’s A.I. efforts. The division has around 3,000 employees, though the exact number of workers was unclear. Mark Zuckerberg, Meta’s chief executive, has been on a hiring spree to stack his company with top A.I. researchers, including a new chief A.I. officer, Alexandr Wang, earlier this year. The cuts on Wednesday did not affect these newest hires, who have been empowered to develop “superintelligence,” or artificial intelligence that exceeds the human brain. Instead, the job cuts were aimed at cleaning up the organizational bloat that resulted from three years of building up Meta’s A.I. efforts too quickly, two people with knowledge of the matter said. The layoffs aimed to help Meta develop A.I. products more rapidly, they said.
November 14, 2025 at 4:59 AM
Reposted by Elisa Fadda
jlsteenwyk.bsky.social
Just gonna put this here for now
www.science.org/doi/10.1126/...
bsky.app/profile/jlst...
November 13, 2025 at 7:23 PM
Reposted by Elisa Fadda
erictopol.bsky.social
Dismantling pandemic preparedness
@science.org
www.science.org/content/arti...
November 13, 2025 at 7:23 PM
Reposted by Elisa Fadda
dirktrauner.bsky.social
As my memory is not as good anymore as it once was, I am excited to share this exciting collaboration with Cristina Alberini (NYU) with you: www.nature.com/articles/s41...
A prodrug targeting CIM6P/IGF2R enhances memory in healthy mice and reverses deficits in an Angelman syndrome mouse model - Translational Psychiatry
Translational Psychiatry - A prodrug targeting CIM6P/IGF2R enhances memory in healthy mice and reverses deficits in an Angelman syndrome mouse model
www.nature.com
November 13, 2025 at 9:37 PM
Reposted by Elisa Fadda
richardsever.bsky.social
The recent openRxiv meeting was a chance to present a vision for the future: a network of organizations working together to improve science communication and an ‘article of the future’ that is a constellation of linked web objects.
openrxiv.org/openrxiv-day/
November 13, 2025 at 7:14 PM
Reposted by Elisa Fadda
lindorfflarsen.bsky.social
😱 I worry the next step is to allow spaces in filenames
jtullock.bsky.social Janice Tullock @jtullock.bsky.social · 3d
No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?
Screen grab from Dropbox saying Emojis in file names are finally here!
November 12, 2025 at 8:21 PM
Reposted by Elisa Fadda
carolynbertozzi.bskyverified.social
Check out this interview with @jeremymberg.bsky.social, at 43:15 he talks about the late Ben Barres, shouts out screenwriter Pamela Green who is producing documentary “Ask the Question” about Ben’s life. Donate here:

www.kickstarter.com/projects/ask...

youtube.com/watch?v=ouK5...
November 12, 2025 — Interview with Jeremy Berg — "Fifty Shades of Jay" and Much More!
YouTube video by Disrupted Science
youtube.com
November 12, 2025 at 7:39 PM
Reposted by Elisa Fadda
adrianroitberg.bsky.social
This week is “First Generation Week”.

My mother went up to the fifth grade, and a father barely finished high school.

I am the first in my extended family to go to college.

It was only possible because of the free public education in Argentina.

Education opens doors and minds, it matters.
November 12, 2025 at 2:59 PM
Reposted by Elisa Fadda
rorinstitute.bsky.social
Join RoRI Co-Chair @ludowaltman.bsky.social in Cambridge on 3 Dec, where he'll be a keynote at a forum exploring the Publish, Review, Curate model.

The event will showcase initiatives and discuss how this model can shape the future of scholarly communication: coar-repositories.org/news-updates...
November 12, 2025 at 12:44 PM
Reposted by Elisa Fadda
hansonmark.bsky.social
We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing:

a 🧵 1/n

Drain: arxiv.org/abs/2511.04820
Strain: direct.mit.edu/qss/article/...
Oligopoly: direct.mit.edu/qss/article/...
A table showing profit margins of major publishers. A snippet of text related to this table is below. 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year. A figure detailing the drain on researcher time. 1. The four-fold drain 1.2 Time The number of papers published each year is growing faster than the scientific workforce, with the number of papers per researcher almost doubling between 1996 and 2022 (Figure 1A). This reflects the fact that publishers’ commercial desire to publish (sell) more material has aligned well with the competitive prestige culture in which publications help secure jobs, grants, promotions, and awards. To the extent that this growth is driven by a pressure for profit, rather than scholarly imperatives, it distorts the way researchers spend their time. The publishing system depends on unpaid reviewer labour, estimated to be over 130 million unpaid hours annually in 2020 alone (9). Researchers have complained about the demands of peer-review for decades, but the scale of the problem is now worse, with editors reporting widespread difficulties recruiting reviewers. The growth in publications involves not only the authors’ time, but that of academic editors and reviewers who are dealing with so many review demands. Even more seriously, the imperative to produce ever more articles reshapes the nature of scientific inquiry. Evidence across multiple fields shows that more papers result in ‘ossification’, not new ideas (10). It may seem paradoxical that more papers can slow progress until one considers how it affects researchers’ time. While rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work. The result is a treadmill of constant activity with limited progress whereas core scholarly practices – such as reading, reflecting and engaging with others’ contributions – is de-prioritized. What looks like productivity often masks intellectual exhaustion built on a demoralizing, narrowing scientific vision. A table of profit margins across industries. The section of text related to this table is below: 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year. The costs of inaction are plain: wasted public funds, lost researcher time, compromised scientific integrity and eroded public trust. Today, the system rewards commercial publishers first, and science second. Without bold action from the funders we risk continuing to pour resources into a system that prioritizes profit over the advancement of scientific knowledge.
November 11, 2025 at 11:52 AM
Reposted by Elisa Fadda
ottoenglish.bsky.social
Oh look. There really are "no go areas" in England.

And they're marked by St George's flags

www.theguardian.com/society/2025...
NHS staff who visit patients at home say St George’s flags can mean ‘no-go zones’
Black and Asian staff left feeling ‘deliberately intimidated’, according to chief executive of one NHS trust
www.theguardian.com
November 11, 2025 at 8:00 AM
Reposted by Elisa Fadda
london.gov.uk
The world must not look away from the genocide in Sudan.
Statement from the Mayor of London: Many Londoners are horrified by the ongoing genocide in Sudan, which has claimed at least 150,000 lives, displaced millions, and created the world’s largest humanitarian crisis. The videos and images of mass killings circulating online are truly harrowing and heartbreaking, as are the horrific satellite photos that have emerged in recent days. Accounts from survivors that sexual violence continues to be used as a weapon of war - including against children - are deeply distressing. These are crimes against humanity, and the international community must act to ensure they are urgently stopped. This senseless violence and suffering has to end. The world must not look away from this crisis. MAYOR OF LONDON, SADIQ KHAN
November 11, 2025 at 7:01 AM
Reposted by Elisa Fadda
drtobydriver.bsky.social
#TombTuesday A fitting place for the dead 💀: an early Bronze Age cairn- possibly the furthest west on the British mainland - sited close to the sea on Mayon Cliff above Sennen, West Penwith, Cornwall

Built of massive boulders, the central cist has long been disturbed & exposed

📷 My own, last week
A round barrow with boulders in a coastal setting
November 11, 2025 at 6:36 AM
Reposted by Elisa Fadda
fgenovese.bsky.social
During the Great Recession (2008-09) UK GDP fell by 6%. Thankfully, it mostly recovered after 5 years.

Since Brexit referendum (2016) UK GDP has fallen between 6% and 8%. Unclear whether and when it will fully recover.

www.nber.org/papers/w3445...
The Economic Impact of Brexit
Founded in 1920, the NBER is a private, non-profit, non-partisan organization dedicated to conducting economic research and to disseminating research findings among academics, public policy makers, an...
www.nber.org
November 10, 2025 at 10:24 PM
Reposted by Elisa Fadda
euanritchie.bsky.social
We should absolutely do all that we can to prevent toads reaching the Pilbara theconversation.com/cane-toads-a... By @judydunlop.bsky.social and team.
Cane toads are hopping towards the Pilbara, but a water-free containment zone could stop them
Cane toads will reach Broome in the next couple of years. Creating a waterless “containment zone” is the only way to stop them pillaging the Pilbara.
theconversation.com
November 10, 2025 at 9:56 PM
Reposted by Elisa Fadda
zackpolanski.bsky.social
Our entire political conversation - under a labour government - has taken a huge shift to the right.

We can't let this be normalised.

leftfootforward.org/2025/11/excl...
EXCLUSIVE: Zack Polanski and Jeremy Corbyn slam Rupert Lowe’s ‘utterly repulsive’, and ‘deeply un-British’ social media comments
'Beyond disgusting'
leftfootforward.org
November 10, 2025 at 4:42 PM
Reposted by Elisa Fadda
telescoper.bsky.social
The end of an era, to be sure.
virginmedianews.bsky.social Virgin Media News @virginmedianews.bsky.social · 4d
President Michael D. Higgins has left Áras an Uachtaráin for the final time this evening, closing the chapter on 14 years in office.

Before departing, President Higgins was presented with flowers by a member of the Sanctuary Runners, of which he was a patron.

#VMNews
November 10, 2025 at 7:07 PM
Reposted by Elisa Fadda
akelacooper.bsky.social
Found the tweet that Joyce Carol Oates bodied Elon Musk with and it's so beautiful in its eloquent, simple take down. So much so he's crashing out trying to prove he reads books now. Put this in the Louvre.
Screenshot of a tweet from Joyce Carol Oates posted on Sunday, November 9th that reads "so curious that such a wealthy man never posts anything that indicates that he enjoys or is even aware of what virtually everyone appreciates--scenes from nature, pet dog or cat, praise for a movie, music, a book (but doubt that he reads); pride in a friend's or relative's accomplishment; condolences for someone who has died; pleasure in sports, acclaim for a favorite team; references to history. in fact he seems totally uneducated, uncultured. the poorest persons on Twitter may have access to more beauty & meaning in life than the "most wealthy person in the world."
November 10, 2025 at 8:26 PM
Reposted by Elisa Fadda
adrianroitberg.bsky.social
New review on mixed Machine Learning/Molecular mechanics methods just dropped !
Great collaboration between University of Buenos Aires and U Florida.
doi.org/10.1063/5.02...
From QM/MM to ML/MM: A new era in multiscale modeling
Hybrid machine-learning/molecular-mechanics (ML/MM) methods extend the classical QM/MM paradigm by replacing the quantum description with neural network interat
doi.org
November 10, 2025 at 9:03 PM
Reposted by Elisa Fadda
zackpolanski.bsky.social
If this is true - this should have happened a long time ago.

The Green Party alongside campaigners have been calling for this - and it's good to see maybe they've finally listened.

Will reserve relief for all children being lifted out of poverty until we know it's happening.
pippacrerar.bsky.social Pippa Crerar @pippacrerar.bsky.social · 5d
NEW: Rachel Reeves signals she intends to remove the two-child cap *in full*

"I don't think a child should be penalised because they're in a bigger family through no fault of their own," she tells BBC.
November 10, 2025 at 4:51 PM