Bryan Roth
@zenbrainest.bsky.social
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Pinned
Bryan Roth
@zenbrainest.bsky.social
· Dec 20
Psychedelics can both cause brain cancer and heart disease?
Perhaps.....
open.substack.com
My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease: open.substack.com/pub/zendudes...
Reposted by Bryan Roth
Re: media. I've not tried this and the paper focuses on lines with driver mutants that therefore shouldn't need growth factors, but would love someone to show if hek293, cho, etc. perform well with this composition.
pubmed.ncbi.nlm.nih.gov/40930249/
pubmed.ncbi.nlm.nih.gov/40930249/
Defined media reveal the essential role of lipid scavenging in supporting cancer cell proliferation - PubMed
Fetal bovine serum (FBS) is an undefined additive that is ubiquitous to mammalian cell culture media and whose functional contributions to promoting cell proliferation remain poorly understood. Efforts to replace serum supplementation in culture media have been hindered by an incomplete understandin …
pubmed.ncbi.nlm.nih.gov
February 7, 2026 at 2:02 PM
Re: media. I've not tried this and the paper focuses on lines with driver mutants that therefore shouldn't need growth factors, but would love someone to show if hek293, cho, etc. perform well with this composition.
pubmed.ncbi.nlm.nih.gov/40930249/
pubmed.ncbi.nlm.nih.gov/40930249/
If only we knew which aspects of the polypharmacology to keep and what to discard
February 7, 2026 at 12:50 PM
If only we knew which aspects of the polypharmacology to keep and what to discard
Reposted by Bryan Roth
New lab logo from former postdoc Dewran
February 2, 2026 at 2:25 PM
New lab logo from former postdoc Dewran
New lab logo from former postdoc Dewran
February 2, 2026 at 2:25 PM
New lab logo from former postdoc Dewran
Why do you do science @superkash.bsky.social @mbeisen.bsky.social @odedrechavi.bsky.social ?
Here are my unvarnished thoughts:
open.substack.com/pub/zendudes...
Here are my unvarnished thoughts:
open.substack.com/pub/zendudes...
Why do I do science?
For the über-Nerds only...
open.substack.com
February 1, 2026 at 9:19 PM
Why do you do science @superkash.bsky.social @mbeisen.bsky.social @odedrechavi.bsky.social ?
Here are my unvarnished thoughts:
open.substack.com/pub/zendudes...
Here are my unvarnished thoughts:
open.substack.com/pub/zendudes...
Nice review!
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin: Cell www.cell.com/cell/fulltex...
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin: Cell www.cell.com/cell/fulltex...
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin
Sympathetic nerves regulate skin immunity by engaging keratinocytes to modulate the
density of tissue-resident memory T cells. This neuro-epithelial axis can enable the
nervous system to dynamically t...
www.cell.com
January 29, 2026 at 4:45 PM
Nice review!
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin: Cell www.cell.com/cell/fulltex...
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin: Cell www.cell.com/cell/fulltex...
Reposted by Bryan Roth
A triple-node heart-brain neuroimmune loop underlying myocardial infarction: Cell www.cell.com/cell/fulltex...
A triple-node heart-brain neuroimmune loop underlying myocardial infarction
This study explores the dissection of a neuroimmune pathway involving the sensory
vagus nerve, the hypothalamic paraventricular nucleus, and the sympathetic superior
cervical ganglia underlying myocar...
www.cell.com
January 28, 2026 at 10:01 PM
A triple-node heart-brain neuroimmune loop underlying myocardial infarction: Cell www.cell.com/cell/fulltex...
A triple-node heart-brain neuroimmune loop underlying myocardial infarction: Cell www.cell.com/cell/fulltex...
A triple-node heart-brain neuroimmune loop underlying myocardial infarction
This study explores the dissection of a neuroimmune pathway involving the sensory
vagus nerve, the hypothalamic paraventricular nucleus, and the sympathetic superior
cervical ganglia underlying myocar...
www.cell.com
January 28, 2026 at 10:01 PM
A triple-node heart-brain neuroimmune loop underlying myocardial infarction: Cell www.cell.com/cell/fulltex...
cool!
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance
www.nature.com/articles/s42...
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance
www.nature.com/articles/s42...
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
www.nature.com
January 22, 2026 at 5:25 PM
cool!
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance
www.nature.com/articles/s42...
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance
www.nature.com/articles/s42...
Reposted by Bryan Roth
Revisiting the SSRI-TRKB Mechanism: Lack of Evidence for Interaction in the Human Brain https://www.biorxiv.org/content/10.64898/2026.01.07.698082v1
January 7, 2026 at 3:15 PM
Revisiting the SSRI-TRKB Mechanism: Lack of Evidence for Interaction in the Human Brain https://www.biorxiv.org/content/10.64898/2026.01.07.698082v1
Reposted by Bryan Roth
Reposted by Bryan Roth
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
January 4, 2026 at 6:17 AM
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice: Cell Reports www.cell.com/cell-reports...
An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice
Song et al. find a subpopulation of neurotensin (NTS)-expressing neurons in the interpeduncular
nucleus (IPN) that co-release NTS and GABA in the dorsal raphe nucleus, and they demonstrate
the neurons...
www.cell.com
January 1, 2026 at 10:25 PM
An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice: Cell Reports www.cell.com/cell-reports...
The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice: Cell Reports www.cell.com/cell-reports...
The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice
Xia et al. reveal two separate pathways that regulate chronic pain and comorbid depression.
They demonstrate that NAcMedD1-MSNs regulate comorbid depressive symptoms via the
NAcMedD1-MSNs→MD circuit, ...
www.cell.com
January 1, 2026 at 10:22 PM
The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice: Cell Reports www.cell.com/cell-reports...
The sigma enigma revealed:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SigmaR1 is an auxiliary translocon factor with lipid-binding activity that regulates protein and lipid droplet homeostasis - Nature Communications
This study identifies the ER sheet protein SigmaR1 as an auxiliary translocon factor. By directly binding phosphatidylcholine and specific translocon components, SigmaR1 maintains protein and lipid ho...
www.nature.com
January 1, 2026 at 6:06 PM
The sigma enigma revealed:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bryan Roth
This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective).
Read!
elizabethginexi.substack.com/p/the-quiet-...
Read!
elizabethginexi.substack.com/p/the-quiet-...
The Quiet Power of Program Officers
How invisible decisions shape what science gets done—and whether it matters
elizabethginexi.substack.com
December 28, 2025 at 11:56 AM
This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective).
Read!
elizabethginexi.substack.com/p/the-quiet-...
Read!
elizabethginexi.substack.com/p/the-quiet-...
Reposted by Bryan Roth
Is the 5-HT2A Receptor the Key to Psychedelic Effects?
YouTube video by Xylo Bio
www.youtube.com
December 23, 2025 at 6:47 PM
Reposted by Bryan Roth
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT
Please RT
December 27, 2025 at 3:51 PM
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT
Please RT
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT
Please RT
December 27, 2025 at 3:51 PM
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT
Please RT
Reposted by Bryan Roth
Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex https://www.biorxiv.org/content/10.64898/2025.12.22.696123v1
December 26, 2025 at 4:15 PM
Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex https://www.biorxiv.org/content/10.64898/2025.12.22.696123v1
Is the 5-HT2A Receptor the Key to Psychedelic Effects?
YouTube video by Xylo Bio
www.youtube.com
December 23, 2025 at 6:47 PM
Mapping cellular targets of covalent cancer drugs in the entire mammalian body: Cell www.cell.com/cell/fulltex...
Mapping cellular targets of covalent cancer drugs in the entire mammalian body
vCATCH is a volumetric tissue labeling technique enabling cellular-resolution mapping
of covalent drug targets throughout the entire mammalian body.
www.cell.com
December 22, 2025 at 6:29 PM
Mapping cellular targets of covalent cancer drugs in the entire mammalian body: Cell www.cell.com/cell/fulltex...
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats www.jneurosci.org/content/earl...
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats
N , N -dimethyltryptamine (DMT) is a serotonergic psychedelic that is being investigated clinically for the treatment of psychiatric disorders. Although the neurophysiological effects of DMT in humans...
www.jneurosci.org
December 22, 2025 at 5:57 PM
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats www.jneurosci.org/content/earl...
Reposted by Bryan Roth
New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice - Molecular Psychiatry
Molecular Psychiatry - The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
www.nature.com
December 21, 2025 at 7:50 PM
New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice.
www.nature.com/articles/s41...
www.nature.com/articles/s41...