Bryan Roth
@zenbrainest.bsky.social
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Pinned
Bryan Roth
@zenbrainest.bsky.social
· Mar 20
The structural diversity of psychedelic drug actions revealed - Nature Communications
The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto ligand specificity and sig...
www.nature.com
Congrats to all —essential reading for those interested in #psychedelics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bryan Roth
He is focused on winning the race to the structure rather than finding out what the structure is. He objectifies women and treats them quite disrespectfully. He is quick to point out the flaws of many of his colleagues.
19/41
19/41
November 8, 2025 at 1:58 PM
He is focused on winning the race to the structure rather than finding out what the structure is. He objectifies women and treats them quite disrespectfully. He is quick to point out the flaws of many of his colleagues.
19/41
19/41
Reposted by Bryan Roth
Reposted by Bryan Roth
Sickness engrams modulate anticipatory immune responses https://www.biorxiv.org/content/10.1101/2025.11.03.686140v1
November 5, 2025 at 4:15 PM
Sickness engrams modulate anticipatory immune responses https://www.biorxiv.org/content/10.1101/2025.11.03.686140v1
Reposted by Bryan Roth
A chemogenetic ligand-receptor pair for voltage-gated sodium channel subtype-selective inhibition https://www.biorxiv.org/content/10.1101/2025.11.03.686046v1
November 5, 2025 at 4:15 PM
A chemogenetic ligand-receptor pair for voltage-gated sodium channel subtype-selective inhibition https://www.biorxiv.org/content/10.1101/2025.11.03.686046v1
Reposted by Bryan Roth
Am looking for a cloud storage solution that is European / non-US - anyone experience with jottacloud? Other recommendations?
jottacloud.com/en/
jottacloud.com/en/
Jottacloud – Cloud storage made easy
Innovative and secure cloud storage for private and business use. Your files are stored on environmentally friendly servers, protected by Scandinavian privacy laws.
jottacloud.com
November 2, 2025 at 11:33 AM
Am looking for a cloud storage solution that is European / non-US - anyone experience with jottacloud? Other recommendations?
jottacloud.com/en/
jottacloud.com/en/
Great review of chemogenetics:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders - Molecular Psychiatry
Molecular Psychiatry - Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders
www.nature.com
November 4, 2025 at 12:13 AM
Great review of chemogenetics:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Before you throw tomatoes at me, please read the F***ing literature, dude
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
November 1, 2025 at 1:18 PM
Before you throw tomatoes at me, please read the F***ing literature, dude
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
Reposted by Bryan Roth
My parting thought to all my scientific friends in Germany
October 31, 2025 at 7:29 AM
My parting thought to all my scientific friends in Germany
My parting thought to all my scientific friends in Germany
October 31, 2025 at 7:29 AM
My parting thought to all my scientific friends in Germany
Be there or be square
October 30, 2025 at 9:19 AM
Be there or be square
Reposted by Bryan Roth
@mbeisen.bsky.social This one's for you
"Science in the time of cholera"
open.substack.com/pub/zendudes...
"Science in the time of cholera"
open.substack.com/pub/zendudes...
Science in the time of cholera
This one's for you @mbeisen
open.substack.com
October 26, 2025 at 3:40 PM
@mbeisen.bsky.social This one's for you
"Science in the time of cholera"
open.substack.com/pub/zendudes...
"Science in the time of cholera"
open.substack.com/pub/zendudes...
@mbeisen.bsky.social This one's for you
"Science in the time of cholera"
open.substack.com/pub/zendudes...
"Science in the time of cholera"
open.substack.com/pub/zendudes...
Science in the time of cholera
This one's for you @mbeisen
open.substack.com
October 26, 2025 at 3:40 PM
@mbeisen.bsky.social This one's for you
"Science in the time of cholera"
open.substack.com/pub/zendudes...
"Science in the time of cholera"
open.substack.com/pub/zendudes...
Reposted by Bryan Roth
Preoptic activation induces a torpor-like hypothermic and hypometabolic state that is cerebroprotective https://www.biorxiv.org/content/10.1101/2025.10.24.684192v1
October 25, 2025 at 10:15 AM
Preoptic activation induces a torpor-like hypothermic and hypometabolic state that is cerebroprotective https://www.biorxiv.org/content/10.1101/2025.10.24.684192v1
Discovery of Highly Selective 5-HT2A Agonists Using Structure-Guided Design | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Discovery of Highly Selective 5-HT2A Agonists Using Structure-Guided Design
With a resurgence in interest in psychedelics as rapid-acting and durable neuroplastic therapies, there is a critical need to develop more selective 5-HT2A agonists to investigate the basic neurobiolo...
pubs.acs.org
October 24, 2025 at 6:51 PM
Discovery of Highly Selective 5-HT2A Agonists Using Structure-Guided Design | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
Reposted by Bryan Roth
I also experienced this “arrogance” from the former Director—I had the sense of “who the hell is that ant making noise over there?” My guess is this was closer to his true self rather than his “awe shucks, I’m just an old timey Christian “ public persona.
I also felt disappointment that someone who I had held in high regard would be so arrogant to place his own perspectives on such an issue ahead of appropriate open scrutiny.
I understand that he had to lead, but I always found that I made my biggest mistakes when I did not seek good input.
28/n
I understand that he had to lead, but I always found that I made my biggest mistakes when I did not seek good input.
28/n
October 23, 2025 at 12:14 PM
I also experienced this “arrogance” from the former Director—I had the sense of “who the hell is that ant making noise over there?” My guess is this was closer to his true self rather than his “awe shucks, I’m just an old timey Christian “ public persona.
Reposted by Bryan Roth
This experience was far from an isolated incident
As the translational center (NCATS) moved forward, Collins spoke of approaching drug development "the way an engineer would" for the first time.
Even my eyes rolled so hard that it hurt.
I believe @dereklowe.bsky.social had a bit to say about this
As the translational center (NCATS) moved forward, Collins spoke of approaching drug development "the way an engineer would" for the first time.
Even my eyes rolled so hard that it hurt.
I believe @dereklowe.bsky.social had a bit to say about this
October 23, 2025 at 12:23 PM
This experience was far from an isolated incident
As the translational center (NCATS) moved forward, Collins spoke of approaching drug development "the way an engineer would" for the first time.
Even my eyes rolled so hard that it hurt.
I believe @dereklowe.bsky.social had a bit to say about this
As the translational center (NCATS) moved forward, Collins spoke of approaching drug development "the way an engineer would" for the first time.
Even my eyes rolled so hard that it hurt.
I believe @dereklowe.bsky.social had a bit to say about this
@jeremymberg.bsky.social
Your recent thread regarding Collins reminds me of many scientists and administrators who gain positions of power or influence (or perceived influence) Some value a “bubbling up” approach while others are “my way or the highway “.
Your recent thread regarding Collins reminds me of many scientists and administrators who gain positions of power or influence (or perceived influence) Some value a “bubbling up” approach while others are “my way or the highway “.
October 23, 2025 at 12:31 PM
@jeremymberg.bsky.social
Your recent thread regarding Collins reminds me of many scientists and administrators who gain positions of power or influence (or perceived influence) Some value a “bubbling up” approach while others are “my way or the highway “.
Your recent thread regarding Collins reminds me of many scientists and administrators who gain positions of power or influence (or perceived influence) Some value a “bubbling up” approach while others are “my way or the highway “.
I also experienced this “arrogance” from the former Director—I had the sense of “who the hell is that ant making noise over there?” My guess is this was closer to his true self rather than his “awe shucks, I’m just an old timey Christian “ public persona.
I also felt disappointment that someone who I had held in high regard would be so arrogant to place his own perspectives on such an issue ahead of appropriate open scrutiny.
I understand that he had to lead, but I always found that I made my biggest mistakes when I did not seek good input.
28/n
I understand that he had to lead, but I always found that I made my biggest mistakes when I did not seek good input.
28/n
October 23, 2025 at 12:14 PM
I also experienced this “arrogance” from the former Director—I had the sense of “who the hell is that ant making noise over there?” My guess is this was closer to his true self rather than his “awe shucks, I’m just an old timey Christian “ public persona.
Reposted by Bryan Roth
Astrocytic PIEZO activation by heartbeat sound promotes extracellular matrix and maturation in human brain organoids https://www.biorxiv.org/content/10.1101/2025.10.21.683816v1
October 22, 2025 at 8:15 AM
Astrocytic PIEZO activation by heartbeat sound promotes extracellular matrix and maturation in human brain organoids https://www.biorxiv.org/content/10.1101/2025.10.21.683816v1
Reposted by Bryan Roth
The serotonin 1B receptor modulates striatal activity differentially based on behavioral context https://www.biorxiv.org/content/10.1101/2025.10.21.683729v1
October 22, 2025 at 8:16 AM
The serotonin 1B receptor modulates striatal activity differentially based on behavioral context https://www.biorxiv.org/content/10.1101/2025.10.21.683729v1
Reposted by Bryan Roth
Don't miss this if you are going to #SfN2025 and interested in cross-species psychedelic neuroscience research
Looking forward to hearing the talks and the discussions, and excited about presenting some of the lab's unpublished data and how we are thinking about future research
Looking forward to hearing the talks and the discussions, and excited about presenting some of the lab's unpublished data and how we are thinking about future research
Excited to speak in San Diego on Nov 14 at this SfN Sattelite!
If you're curious about cross-species approaches to #psychedelics, #hallucinations and #consciousness, join us! 🐀👤🧠
Limited spots, register here:
hopkinspsychedelic.org/sfn2025
If you're curious about cross-species approaches to #psychedelics, #hallucinations and #consciousness, join us! 🐀👤🧠
Limited spots, register here:
hopkinspsychedelic.org/sfn2025
October 17, 2025 at 9:33 PM
Don't miss this if you are going to #SfN2025 and interested in cross-species psychedelic neuroscience research
Looking forward to hearing the talks and the discussions, and excited about presenting some of the lab's unpublished data and how we are thinking about future research
Looking forward to hearing the talks and the discussions, and excited about presenting some of the lab's unpublished data and how we are thinking about future research
Reposted by Bryan Roth
I note that the past two NIMH directors were Associate Professors with (they would admit) minimal administrative experience. They both were exceptional directors. I’m guessing that personal connections had a role in their pick as well.
October 17, 2025 at 10:55 PM
I note that the past two NIMH directors were Associate Professors with (they would admit) minimal administrative experience. They both were exceptional directors. I’m guessing that personal connections had a role in their pick as well.