Gaetano Gargiulo
@ggargiul.bsky.social
Scientist, cancer researcher, studying brain & lung tumors and synthetic genetics, occasionally cooking and supporting Inter FC
Pinned
Gaetano Gargiulo
@ggargiul.bsky.social
· Dec 31
End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?
Reposted by Gaetano Gargiulo
Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...
August 13, 2025 at 11:30 AM
Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...
Reposted by Gaetano Gargiulo
Very excited to see our new study out today - just in time for my talk annual EACR conference @helloeacr.bsky.social
Christophe Marine @marinelab.bsky.social @vib-ccb.bsky.social presenting his hot-off-the-presses Cancer Discovery paper today at #EACR2025!
June 18, 2025 at 11:12 AM
Very excited to see our new study out today - just in time for my talk annual EACR conference @helloeacr.bsky.social
Reposted by Gaetano Gargiulo
🚨We want your abstract! Submit your Late Breaking Abstract to #EANO2025 by June 25, 2025 to become an essential part of the state-of-the art scientific programme. 👉 Learn more: eano.eu/eano2025/abs... #NeuroOncology #NeuroSurgery #cancernurse #braintumor #btsm
June 17, 2025 at 7:19 PM
🚨We want your abstract! Submit your Late Breaking Abstract to #EANO2025 by June 25, 2025 to become an essential part of the state-of-the art scientific programme. 👉 Learn more: eano.eu/eano2025/abs... #NeuroOncology #NeuroSurgery #cancernurse #braintumor #btsm
Reposted by Gaetano Gargiulo
first post on bluesky, and it's a big one: our single-cell study on ETMR, a terrible brain tumor that occurs in young children, now out in @natcancer.nature.com: www.nature.com/articles/s43.... tremendous effort by @alexbeck, @lisagblr.bsky.social and many others. please check it out!
Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer
Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...
www.nature.com
May 27, 2025 at 2:22 PM
first post on bluesky, and it's a big one: our single-cell study on ETMR, a terrible brain tumor that occurs in young children, now out in @natcancer.nature.com: www.nature.com/articles/s43.... tremendous effort by @alexbeck, @lisagblr.bsky.social and many others. please check it out!
Glad to see this out, very helpful resource for the community!
Finally, the GBmap paper is out after over 80 citations of the preprint version. Congratulations @ccruizm.bsky.social 🎉
Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma!
doi.org/10.1093/neuo...
doi.org/10.1093/neuo...
May 6, 2025 at 11:44 PM
Glad to see this out, very helpful resource for the community!
Reposted by Gaetano Gargiulo
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
www.nature.com
March 5, 2025 at 5:38 PM
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
"EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!
Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature
Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...
doi.org
March 6, 2025 at 7:49 AM
"EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!
Understanding the basics is key to developing effective treatments. This framework on the myeloid side of brain tumors offers a systematic POV, with the dexa angle being particularly intriguing.
Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature
A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...
www.nature.com
February 26, 2025 at 11:18 PM
Understanding the basics is key to developing effective treatments. This framework on the myeloid side of brain tumors offers a systematic POV, with the dexa angle being particularly intriguing.
Reposted by Gaetano Gargiulo
“We are almost ready for the test flight. All we need is the license." ...in Germany that may take much longer than developing and building the rocket 😂
February 22, 2025 at 8:28 AM
“We are almost ready for the test flight. All we need is the license." ...in Germany that may take much longer than developing and building the rocket 😂
Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.
RNA polymerase II at histone genes predicts outcome in human cancer
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...
www.science.org
February 22, 2025 at 8:50 AM
Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.
Reposted by Gaetano Gargiulo
@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...
February 16, 2025 at 11:25 PM
@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...
Reposted by Gaetano Gargiulo
🔬 #FundamentalResearch is key for #EUcompetitiveness
🔬 #FundamentalResearch is key for #EUcompetitiveness and to address global societal challenges 🌍 #Innovation leaders from the #biotech sector highlight the crucial role of #research for their work ⬇️
Since 2014, EU-LIFE institutes have contributed to #EU innovation ecosystem with over 80 #startups!
Since 2014, EU-LIFE institutes have contributed to #EU innovation ecosystem with over 80 #startups!
February 20, 2025 at 10:58 AM
🔬 #FundamentalResearch is key for #EUcompetitiveness
Reposted by Gaetano Gargiulo
Someone finally said it out loud.
“After we’ve discriminated against, deported, or disparaged all the immigrants, the gay and lesbian and transgender people, the developmentally disabled, the women, and minorities. Once we’ve ostracized our neighbors and betrayed our friends… what comes next?” - Gov. JB Pritzker
February 20, 2025 at 12:29 PM
Someone finally said it out loud.
Reposted by Gaetano Gargiulo
Amazing
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
go.nature.com
February 20, 2025 at 12:12 PM
Amazing
Reposted by Gaetano Gargiulo
Normalize calling Republicans Nazis.
🔥🔥🔥 Former Vikings punter Chris Kluwe was arrested for civil disobedience after speaking against a MAGA display that the city council of Huntington Beach agreed to put up at the public library…..that’s what’s up….every word👇
February 20, 2025 at 11:51 AM
Normalize calling Republicans Nazis.
Reposted by Gaetano Gargiulo
Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...
Open access link:
www.nature.com/articles/s41...
February 19, 2025 at 9:41 PM
Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...
Open access link:
www.nature.com/articles/s41...
Reposted by Gaetano Gargiulo
1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...
February 17, 2025 at 7:23 PM
1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
@faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
Injectable fluorescent retro-tracing of pancreatic cancer innervation. Denervation sensitizes PDAC to immunotherapy by counteracting neuronal suppression of acute inflammation in CAFs. Plus, tumor denervation as a novel mechanism behind the old nab-paclitaxel combo. Quite a characterization indeed!
Characterization of single neurons reprogrammed by #PancreaticCancer 🧪 www.nature.com/articles/s41...
Characterization of single neurons reprogrammed by pancreatic cancer - Nature
Nature - Characterization of single neurons reprogrammed by pancreatic cancer
www.nature.com
February 18, 2025 at 2:49 PM
Injectable fluorescent retro-tracing of pancreatic cancer innervation. Denervation sensitizes PDAC to immunotherapy by counteracting neuronal suppression of acute inflammation in CAFs. Plus, tumor denervation as a novel mechanism behind the old nab-paclitaxel combo. Quite a characterization indeed!
Cell identity lives from constraints and dies from freedom
#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology
February 14, 2025 at 10:18 PM
Cell identity lives from constraints and dies from freedom
Who knew they’d give you more than cavities? 😅 - great to see this on the cover @GuccioneLab!
February 12, 2025 at 9:31 PM
Who knew they’d give you more than cavities? 😅 - great to see this on the cover @GuccioneLab!
Proud to see our lab’s work contribute to this fantastic study, and specifically: "[...]We have recently developed a new strategy to genetically trace cell fate transitions within a heterogeneous tissue37,38 [...]" Check it out! 👇
Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
February 10, 2025 at 6:58 PM
Proud to see our lab’s work contribute to this fantastic study, and specifically: "[...]We have recently developed a new strategy to genetically trace cell fate transitions within a heterogeneous tissue37,38 [...]" Check it out! 👇
Reposted by Gaetano Gargiulo
1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
February 10, 2025 at 3:18 PM
1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
Reposted by Gaetano Gargiulo
Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
February 10, 2025 at 3:15 PM
Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social
Reposted by Gaetano Gargiulo
Now online in Cancer Discovery: PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State - by Shane Killarney, Kris Wood and colleagues doi.org/10.1158/2159...
November 20, 2024 at 3:00 PM
Now online in Cancer Discovery: PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State - by Shane Killarney, Kris Wood and colleagues doi.org/10.1158/2159...
Reposted by Gaetano Gargiulo
Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...
onlinelibrary.wiley.com
January 17, 2025 at 11:53 AM
Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...