Elizabeth McKenna
@elizsmckenna.bsky.social
Executive Editor of Cancer Discovery, published by AACR. Harvard BBS/Dana-Farber alum. Native New Yorker. Posts are my own. She/her https://aacrjournals.org/cancerdiscovery
Pinned
One of the best parts about my recent trip to China was meeting so many previous Cancer Discovery @aacrjournals.bsky.social authors, including those who have now started their own labs! a 🧵👇
Now online in Cancer Discovery @aacrjournals.bsky.social: DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated with Increased LSC Frequency - by Thomas Köhnke, Daiki Karigane, Ravi Majeti, et al. doi.org/10.1158/2159... @stanfordmedicine.bsky.social
November 24, 2025 at 3:02 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated with Increased LSC Frequency - by Thomas Köhnke, Daiki Karigane, Ravi Majeti, et al. doi.org/10.1158/2159... @stanfordmedicine.bsky.social
You can read more about sevabertinib in the recent Cancer Discovery @aacrjournals.bsky.social article by Franziska Siegel, Matthew Meyerson, Heidi Greulich, and colleagues: doi.org/10.1158/2159...
November 21, 2025 at 8:09 PM
You can read more about sevabertinib in the recent Cancer Discovery @aacrjournals.bsky.social article by Franziska Siegel, Matthew Meyerson, Heidi Greulich, and colleagues: doi.org/10.1158/2159...
Now online in Cancer Discovery @aacrjournals.bsky.social: Spatial Multiomic Analyses Reveal Carcinogenic Pathways in End-Stage Renal Disease - by Jun Takahashi, Yosuke Tanaka, Hiroyuki Mano, and colleagues doi.org/10.1158/2159...
November 20, 2025 at 6:24 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Spatial Multiomic Analyses Reveal Carcinogenic Pathways in End-Stage Renal Disease - by Jun Takahashi, Yosuke Tanaka, Hiroyuki Mano, and colleagues doi.org/10.1158/2159...
Reposted by Elizabeth McKenna
The Cancer Discovery Early Career Award recognizes outstanding early career investigators who have authored peer-reviewed, original articles published in the journal that have made a significant impact in one or more of the fields represented by the journal.
Nominations are open! buff.ly/jUwZsdd
Nominations are open! buff.ly/jUwZsdd
November 17, 2025 at 2:33 PM
The Cancer Discovery Early Career Award recognizes outstanding early career investigators who have authored peer-reviewed, original articles published in the journal that have made a significant impact in one or more of the fields represented by the journal.
Nominations are open! buff.ly/jUwZsdd
Nominations are open! buff.ly/jUwZsdd
Now online in Cancer Discovery @aacrjournals.bsky.social: PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis - by Shuang Tang, Qian Zhou, Jean, Zhao, and colleagues doi.org/10.1158/2159... #FUSCC @danafarber.bsky.social
November 17, 2025 at 5:41 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis - by Shuang Tang, Qian Zhou, Jean, Zhao, and colleagues doi.org/10.1158/2159... #FUSCC @danafarber.bsky.social
Reposted by Elizabeth McKenna
AACR Shares Key Updates from AACR on Campus Malaysia
@theaacr.bsky.social
oncodaily.com/voices/aacr-...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
@theaacr.bsky.social
oncodaily.com/voices/aacr-...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
AACR Shares Key Updates from AACR on Campus Malaysia - OncoDaily
AACR Shares Key Updates from AACR on Campus Malaysia / AACR, AACR26, American Association for Cancer Research, cancer, Cancer Research Malaysia, Electra
oncodaily.com
November 13, 2025 at 9:44 PM
AACR Shares Key Updates from AACR on Campus Malaysia
@theaacr.bsky.social
oncodaily.com/voices/aacr-...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
@theaacr.bsky.social
oncodaily.com/voices/aacr-...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Reposted by Elizabeth McKenna
The abstract deadline for the AACR Annual Meeting 2026 is 11:59 PM ET on Tuesday, November 18. Submit an abstract and join the cancer research community in San Diego, April 17-22. Learn more:
buff.ly/dzZnhJr
#AACR26
buff.ly/dzZnhJr
#AACR26
November 14, 2025 at 2:25 PM
The abstract deadline for the AACR Annual Meeting 2026 is 11:59 PM ET on Tuesday, November 18. Submit an abstract and join the cancer research community in San Diego, April 17-22. Learn more:
buff.ly/dzZnhJr
#AACR26
buff.ly/dzZnhJr
#AACR26
New office Lego flower 🌺
November 12, 2025 at 6:24 PM
New office Lego flower 🌺
Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social
November 10, 2025 at 6:15 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social
Reposted by Elizabeth McKenna
In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding
Abstract. T-DXd is clinically beneficial in HER2 positive and HER2 low metastatic breast cancer. However, therapeutic resistance emerges over time in most patients, with poorly defined resistance mech...
aacrjournals.org
November 10, 2025 at 4:55 PM
In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Reposted by Elizabeth McKenna
Robert Kruger, PhD, Senior Executive Editor of Cancer Discovery, joined Zhongshan Hospital Assistant President Qiang Gao, PhD, to chair the opening session of the 2025 CACA Cancer Discovery Symposium at CCHIO 2025. We thank all of the speakers for their contributions to an outstanding program.
November 10, 2025 at 4:11 PM
Robert Kruger, PhD, Senior Executive Editor of Cancer Discovery, joined Zhongshan Hospital Assistant President Qiang Gao, PhD, to chair the opening session of the 2025 CACA Cancer Discovery Symposium at CCHIO 2025. We thank all of the speakers for their contributions to an outstanding program.
One week left - please reach out with your ideas, we want to hear from YOU!
📢Exciting news! Cancer Discovery @aacrjournals.bsky.social is issuing another call for commentaries ahead of #AACR26! The meeting's theme is "Precision, Partnership, Purpose: Advancing Cancer Science to Save Lives Globally" - we want to hear YOUR ideas on how to achieve this goal. (1/2)
November 7, 2025 at 6:05 PM
One week left - please reach out with your ideas, we want to hear from YOU!
Reposted by Elizabeth McKenna
Who knew? Sucralose can suppress CPI response by regulating the gut microbiome 🤯. Congrats @overacrelab.bsky.social team for this fascinating study!
The November issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Diwakar Davar, @overacrelab.bsky.social, et al. showing sucralose consumption ablates cancer immunotherapy response via microbiome disruption - read that & more: aacrjournals.org/cancerdiscov...
November 5, 2025 at 11:52 PM
Who knew? Sucralose can suppress CPI response by regulating the gut microbiome 🤯. Congrats @overacrelab.bsky.social team for this fascinating study!
The November issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Diwakar Davar, @overacrelab.bsky.social, et al. showing sucralose consumption ablates cancer immunotherapy response via microbiome disruption - read that & more: aacrjournals.org/cancerdiscov...
November 5, 2025 at 3:57 PM
The November issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Diwakar Davar, @overacrelab.bsky.social, et al. showing sucralose consumption ablates cancer immunotherapy response via microbiome disruption - read that & more: aacrjournals.org/cancerdiscov...
Reposted by Elizabeth McKenna
Nominations for the 2026 Early Career Awards are open for Cancer Discovery, Cancer Research, and Clinical Cancer Research!
View criteria and be the first to submit a nomination: buff.ly/Vhxuyt5
View criteria and be the first to submit a nomination: buff.ly/Vhxuyt5
November 3, 2025 at 5:06 PM
Nominations for the 2026 Early Career Awards are open for Cancer Discovery, Cancer Research, and Clinical Cancer Research!
View criteria and be the first to submit a nomination: buff.ly/Vhxuyt5
View criteria and be the first to submit a nomination: buff.ly/Vhxuyt5
Now online in Cancer Discovery @aacrjournals.bsky.social: A Prognostic Signature for Lung Adenocarcinoma in Patients Who Have Never Smoked - by Wei Zhao, Maria Teresa Landi, and colleagues doi.org/10.1158/2159...
October 30, 2025 at 5:25 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: A Prognostic Signature for Lung Adenocarcinoma in Patients Who Have Never Smoked - by Wei Zhao, Maria Teresa Landi, and colleagues doi.org/10.1158/2159...
Reposted by Elizabeth McKenna
How can senescent cells, which are damaged and growth arrested, both block tumor initiation as well as fuel its growth? A recent study published in Cancer Discovery @aacrjournals.bsky.social from Lin Zhou in the lab uncovered some new insights into this puzzle.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy
Abstract. Cellular senescence is a well-established tumor-suppressive cell cycle arrest program. However, chronic inflammation through the senescence-associated secretory phenotype (SASP) can alternat...
aacrjournals.org
October 29, 2025 at 2:40 PM
How can senescent cells, which are damaged and growth arrested, both block tumor initiation as well as fuel its growth? A recent study published in Cancer Discovery @aacrjournals.bsky.social from Lin Zhou in the lab uncovered some new insights into this puzzle.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Now online in Cancer Discovery @aacrjournals.bsky.social: p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression & Progression that Can Be Reversed by Senolytic Therapy - by Lin Zhou, @marcus-ruscetti.bsky.social, and colleagues doi.org/10.1158/2159... @umasschan.bsky.social
October 28, 2025 at 3:00 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression & Progression that Can Be Reversed by Senolytic Therapy - by Lin Zhou, @marcus-ruscetti.bsky.social, and colleagues doi.org/10.1158/2159... @umasschan.bsky.social
Now online in Cancer Discovery @aacrjournals.bsky.social: p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program by Mengxiong Wang, @AttardiLaura, and colleagues doi.org/10.1158/2159... @stanfordmedicine.bsky.social
October 27, 2025 at 3:00 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program by Mengxiong Wang, @AttardiLaura, and colleagues doi.org/10.1158/2159... @stanfordmedicine.bsky.social
Reposted by Elizabeth McKenna
One of the best parts about my recent trip to China was meeting so many previous Cancer Discovery @aacrjournals.bsky.social authors, including those who have now started their own labs! a 🧵👇
October 24, 2025 at 3:06 PM
One of the best parts about my recent trip to China was meeting so many previous Cancer Discovery @aacrjournals.bsky.social authors, including those who have now started their own labs! a 🧵👇
One of the best parts about my recent trip to China was meeting so many previous Cancer Discovery @aacrjournals.bsky.social authors, including those who have now started their own labs! a 🧵👇
October 24, 2025 at 3:06 PM
One of the best parts about my recent trip to China was meeting so many previous Cancer Discovery @aacrjournals.bsky.social authors, including those who have now started their own labs! a 🧵👇
Now online in Cancer Discovery @aacrjournals.bsky.social: Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma - by Cheng Huang, Yan Gao, Jianfeng Chen, Choon Kiat Ong, Huiqiang Huang, and Jing Tan doi.org/10.1158/2159...
October 24, 2025 at 3:01 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma - by Cheng Huang, Yan Gao, Jianfeng Chen, Choon Kiat Ong, Huiqiang Huang, and Jing Tan doi.org/10.1158/2159...
Reposted by Elizabeth McKenna
Cancer Discovery Senior Executive Editor Robert Kruger, PhD, will be at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. If you have a question about the journal or want to discuss your research, please reach out to him at robert.kruger@aacr.org. #Targets25
October 24, 2025 at 1:05 PM
Cancer Discovery Senior Executive Editor Robert Kruger, PhD, will be at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. If you have a question about the journal or want to discuss your research, please reach out to him at robert.kruger@aacr.org. #Targets25