Yahaya Yabo
@yahayayabo.bsky.social
Brain tumors | Spatial transcriptomics | scRNA-seq | Al
Reposted by Yahaya Yabo
Just wrapped up an incredible few days in Prague for the @eanoassociation.bsky.social meeting! Truly inspiring sessions, great discussions, and exciting new collaborations. The MILO Lab shined with engaging talks and eye-catching posters! Ready to keep pushing the boundaries of science together!
October 20, 2025 at 4:41 PM
Just wrapped up an incredible few days in Prague for the @eanoassociation.bsky.social meeting! Truly inspiring sessions, great discussions, and exciting new collaborations. The MILO Lab shined with engaging talks and eye-catching posters! Ready to keep pushing the boundaries of science together!
Reposted by Yahaya Yabo
📢 @eanoassociation.bsky.social 2025 kicks off today in Prague!
Proud to see strong #EORTC representation with six abstracts and a joint session with BTG featuring EORTC-led projects on clinical trial planning.
More info 👉 www.eortc.org/blog/2025/10...
#EANO2025 #NeuroOncology @qol.eortc.org
Proud to see strong #EORTC representation with six abstracts and a joint session with BTG featuring EORTC-led projects on clinical trial planning.
More info 👉 www.eortc.org/blog/2025/10...
#EANO2025 #NeuroOncology @qol.eortc.org
October 16, 2025 at 8:32 AM
📢 @eanoassociation.bsky.social 2025 kicks off today in Prague!
Proud to see strong #EORTC representation with six abstracts and a joint session with BTG featuring EORTC-led projects on clinical trial planning.
More info 👉 www.eortc.org/blog/2025/10...
#EANO2025 #NeuroOncology @qol.eortc.org
Proud to see strong #EORTC representation with six abstracts and a joint session with BTG featuring EORTC-led projects on clinical trial planning.
More info 👉 www.eortc.org/blog/2025/10...
#EANO2025 #NeuroOncology @qol.eortc.org
Reposted by Yahaya Yabo
Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1...
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas
Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profil...
www.biorxiv.org
September 16, 2025 at 8:00 AM
Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1...
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
Reposted by Yahaya Yabo
NEW content online!
Combining spatial transcriptomics and AI to enhance brain tumour diagnosis
Nature Reviews Cancer, Published online: 04 July 2025; doi:10.1038/s41568-025-00851-6In this Tools of the Trade article, Yahaya A. Yabo describes the development of neuropathology spatial transcriptomic analysis (NePSTA), an artificial intelligence (AI)-based tool to identify and map unique spatial patterns within tissues.
www.nature.com
July 4, 2025 at 12:02 PM
NEW content online!
Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...
July 5, 2025 at 9:49 AM
Happy to share a short "tools of the trade" piece on our NeuroPathology Spatial Transcriptomic Analysis (NePSTA) tool. Now available @natrevcancer.nature.com www.nature.com/articles/s41...
Reposted by Yahaya Yabo
#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com
May 20, 2025 at 12:57 PM
#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com
Reposted by Yahaya Yabo
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
May 16, 2025 at 11:44 AM
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
Reposted by Yahaya Yabo
Two massive glioblastoma papers, datasets, trajectories, insights, and.. a very cool new method for GRN inference - scDORI -from @steglelab.bsky.social @oliverstegle.bsky.social @bayraktarlab.bsky.social & Moritz Mall www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics
Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...
www.biorxiv.org
May 16, 2025 at 7:31 AM
Two massive glioblastoma papers, datasets, trajectories, insights, and.. a very cool new method for GRN inference - scDORI -from @steglelab.bsky.social @oliverstegle.bsky.social @bayraktarlab.bsky.social & Moritz Mall www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...
Reposted by Yahaya Yabo
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...
The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics
Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...
www.nature.com
May 9, 2025 at 10:14 AM
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...
Finally, the GBmap paper is out after over 80 citations of the preprint version. Congratulations @ccruizm.bsky.social 🎉
Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma!
doi.org/10.1093/neuo...
doi.org/10.1093/neuo...
Charting the Single-Cell and Spatial Landscape of IDH-Wildtype Glioblastoma with GBmap
AbstractBackground. Glioblastoma (GB), particularly IDH-wildtype, is the most aggressive brain malignancy with a dismal prognosis. Despite advances in mole
doi.org
May 6, 2025 at 2:09 PM
Finally, the GBmap paper is out after over 80 citations of the preprint version. Congratulations @ccruizm.bsky.social 🎉
Reposted by Yahaya Yabo
Putting cancer immunotherapy into spatial context in the clinic - @joakimlundeberg.bsky.social @scilifelab.se @ki.se go.nature.com/4jlus4b
Putting cancer immunotherapy into spatial context in the clinic - Nature Biotechnology
Spatial omics technologies offer insights into the organization of cellular and molecular components and their interactions within the tumor ecosystem. Overcoming the key challenges to integrating the...
go.nature.com
April 22, 2025 at 2:58 PM
Putting cancer immunotherapy into spatial context in the clinic - @joakimlundeberg.bsky.social @scilifelab.se @ki.se go.nature.com/4jlus4b
The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group.
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq
We had an amazing lab retreat Spring 2025! Best team of the world!
April 7, 2025 at 9:29 PM
The @milolab.bsky.social retreat was lit 🔥. I am grateful and lucky to be in this amazing group.
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq
Great people, great science.
#glioblastoma #spatialtranscriptomics
#scRNA-seq
Reposted by Yahaya Yabo
📣 Open computational PhD & Postdoc positions!
Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus
📢 Please RT (what's the bsky equivalent here?) and distribute !
👇A quick instruction on how to apply
Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus
📢 Please RT (what's the bsky equivalent here?) and distribute !
👇A quick instruction on how to apply
February 19, 2025 at 2:42 PM
📣 Open computational PhD & Postdoc positions!
Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus
📢 Please RT (what's the bsky equivalent here?) and distribute !
👇A quick instruction on how to apply
Excited about the open positions as part of our newly funded Emmy Noether Group are online now under
kocakavuklab.vercel.app/joinus
📢 Please RT (what's the bsky equivalent here?) and distribute !
👇A quick instruction on how to apply
Reposted by Yahaya Yabo
Nature research paper: GABAergic neuron-to-glioma synapses in diffuse midline gliomas
https://go.nature.com/434f4ns
https://go.nature.com/434f4ns
GABAergic neuron-to-glioma synapses in diffuse midline gliomas - Nature
Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.
go.nature.com
February 20, 2025 at 7:12 AM
Nature research paper: GABAergic neuron-to-glioma synapses in diffuse midline gliomas
https://go.nature.com/434f4ns
https://go.nature.com/434f4ns
Reposted by Yahaya Yabo
🎗️ Today is #WorldCancerDay – a reminder of the ongoing fight against cancer and the need for research, collaboration & innovation in all types, including #NeuroOncology. At #EANO, we’re dedicated to advancing science and patient care. Together, we can make a difference! 💙
February 4, 2025 at 7:38 AM
🎗️ Today is #WorldCancerDay – a reminder of the ongoing fight against cancer and the need for research, collaboration & innovation in all types, including #NeuroOncology. At #EANO, we’re dedicated to advancing science and patient care. Together, we can make a difference! 💙
Beautiful work from @tobiw2024.bsky.social and @rsankowski.bsky.social
Happy to present our newest work cross-comparing CAR T cells, CAR NK cells and CAR macrophages. Thanks to Thomas Look and our amazing collaborators Roman Sankowski @rsankowski.bsky.social César Nombela Arrieta, Berend Snijder, Steve Pascolo
www.cell.com/cell-reports...
www.cell.com/cell-reports...
CAR T cells, CAR NK cells, and CAR macrophages exhibit distinct traits in glioma models but are similarly enhanced when combined with cytokines
This comparative analysis of CAR T cells, CAR NK cells, and CAR macrophages in glioma
mouse models by Look et al. reveals distinct features for each cell type, emphasizes
the benefit of combinatorial ...
www.cell.com
January 31, 2025 at 7:26 AM
Beautiful work from @tobiw2024.bsky.social and @rsankowski.bsky.social
Reposted by Yahaya Yabo
Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors.
@10xGenomics
🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs
t.co/GmA9MLNKy1
@10xGenomics
🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs
t.co/GmA9MLNKy1
January 30, 2025 at 7:19 PM
Happy to share our recent investigation of the spatial architecture of benign and malignant peripheral nerve sheath tumors.
@10xGenomics
🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs
t.co/GmA9MLNKy1
@10xGenomics
🚨Spoiler Alert: We identified APOD in neurofibroma regions as a novel biomarker in hybrid PNSTs
t.co/GmA9MLNKy1
Reposted by Yahaya Yabo
Ever wondered what makes brain tumors tick?
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!
www.instagram.com/the_milolab/...
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!
www.instagram.com/the_milolab/...
Login • Instagram
Welcome back to Instagram. Sign in to check out what your friends, family & interests have been capturing & sharing around the world.
www.instagram.com
January 30, 2025 at 7:22 PM
Ever wondered what makes brain tumors tick?
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!
www.instagram.com/the_milolab/...
Excited by the breakthroughs in spatial transcriptomics and single-cell analysis? Follow @milolab.bsky.social account on Instagram: cutting-edge insights, updates, and engaging content!
www.instagram.com/the_milolab/...
Reposted by Yahaya Yabo
Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer
Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...
www.nature.com
January 30, 2025 at 3:28 PM
Happy to share your latest collaboration with
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
@sahm_lab
leveraging spatial transcriptomics
@10xGenomics
for neuropathology diagnosis #DeepLearning
! 107 patients across 15 CNS tumors!
www.nature.com/articles/s43...
Happy to be part of this beautiful work from @milolab.bsky.social and Sahm lab.
Using deep learning to enhance brain tumor diagnosis. From spatial transcriptomics data you can predict tissue histology, methylation subclass, genotype, immunohistochemistry etc.
Using deep learning to enhance brain tumor diagnosis. From spatial transcriptomics data you can predict tissue histology, methylation subclass, genotype, immunohistochemistry etc.
January 30, 2025 at 10:56 AM
Happy to be part of this beautiful work from @milolab.bsky.social and Sahm lab.
Using deep learning to enhance brain tumor diagnosis. From spatial transcriptomics data you can predict tissue histology, methylation subclass, genotype, immunohistochemistry etc.
Using deep learning to enhance brain tumor diagnosis. From spatial transcriptomics data you can predict tissue histology, methylation subclass, genotype, immunohistochemistry etc.
Reposted by Yahaya Yabo
New insights on #machineLearning #glioblastoma and other brain #tumors by the Heiland and Sahm labs
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics | @naturecancer.bsky.social
www.nature.com/articles/s43...
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics | @naturecancer.bsky.social
www.nature.com/articles/s43...
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer
Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...
www.nature.com
January 30, 2025 at 7:37 AM
New insights on #machineLearning #glioblastoma and other brain #tumors by the Heiland and Sahm labs
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics | @naturecancer.bsky.social
www.nature.com/articles/s43...
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics | @naturecancer.bsky.social
www.nature.com/articles/s43...
Reposted by Yahaya Yabo
new out in Nature: lovely paper www.nature.com/articles/s41...
Brain-wide neuronal circuit connectome of human glioblastoma - Nature
Nature - Brain-wide neuronal circuit connectome of human glioblastoma
www.nature.com
January 16, 2025 at 5:23 PM
new out in Nature: lovely paper www.nature.com/articles/s41...
Reposted by Yahaya Yabo
Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...
Gliomagenesis mimics an injury response orchestrated by neural crest-like cells - Nature
A study using glioblastoma mouse models, serial magnetic resonance imaging and single-cell profiling details changes in the identity and balance of cellular states from initiation of tumorigenesis to ...
www.nature.com
January 3, 2025 at 4:28 AM
Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...
Awesome work.👌
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1
biorxiv.org/content/10.1101/2024.12.11.627935v1
December 13, 2024 at 11:17 AM
Awesome work.👌