Barbara Marte
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barbmarte.bsky.social
Barbara Marte
@barbmarte.bsky.social
5.2K followers 950 following 140 posts
Senior Editor @Nature for cancer and cell cycle. Views my own
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Reposted by Barbara Marte
johannajoyce.bsky.social
New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬

An amazing set of resources for all scientists working on the brain!

🧠 Immersive feature:
www.nature.com/immersive/d4...

🧠 Perspective:
www.nature.com/articles/s41...
Cover of this week's Nature showing a brain rendering Cover caption from the journal: Brain development: Our ability to process information into complex emotions, behaviours and decisions relies on the rich diversity of cell types that make up the human brain. Uncovering the molecular and cellular events that take place during brain development could reveal not only the mechanisms that give rise to this diversity but also shed light on how this process might go awry in neurodevelopmental disorders such as autism and schizophrenia. In this week’s issue, the BRAIN Initiative Cell Atlas Network (BICAN) builds on its previous work creating atlases of cell types in the adult mouse, non-human primate (NHP) and human brains to present cell-type atlases of the developing human, mouse and NHP brains. Across a suite of papers, nine of which are published in Nature, the researchers uncover the complex programs through which cell types emerge during brain development in humans and animals, revealing both the shared and unique features of the human brain. The latest work, along with future research directions, is summed up in a Perspective article by Tomasz Nowakowski and colleagues
November 5, 2025 at 6:53 PM
Reposted by Barbara Marte
robclarkelab.bsky.social
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
urldefense.com
November 5, 2025 at 9:07 PM
Reposted by Barbara Marte
natureportfolio.nature.com
Draft atlases of the developing brain of humans and other mammals are presented in a collection of papers from BICAN published in Nature. These resources combine single-cell and spatial technologies to track how brain cell types emerge, diversify, and organize during development. 🧪
BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
go.nature.com
November 5, 2025 at 11:47 PM
barbmarte.bsky.social
new out in Nature: BICAN: A cell census of the developing human brain
www.nature.com/collections/...
BICAN: A cell census of the developing human brain
Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...
www.nature.com
November 6, 2025 at 7:43 AM
barbmarte.bsky.social
new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...
Anti-progestin therapy targets hallmarks of breast cancer risk - Nature
Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...
www.nature.com
November 6, 2025 at 7:42 AM
barbmarte.bsky.social
new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting FSP1 triggers ferroptosis in lung cancer - Nature
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...
www.nature.com
November 6, 2025 at 7:39 AM
Reposted by Barbara Marte
magdalenaskipper.bsky.social
In praise of fundamental research
Our editorial this week argues that I n these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different
🧪
@nature.com
www.nature.com/articles/d41...
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
www.nature.com
October 30, 2025 at 1:53 PM
Reposted by Barbara Marte
magdalenaskipper.bsky.social
We asked physicists which are the sci-fi films they like the most - two were consistently highlighted in interviews for their depictions of science: 2014’s Interstellar and 2006’s The Prestige — both of which were directed and co-written by Christopher Nolan
🧪
www.nature.com/articles/d41...
The sci-fi films that physicists love to watch — from Interstellar to Spider-Man
Nature surveyed scientists about their favourite cinematic moments to celebrate the International Year of Quantum Science and Technology.
www.nature.com
October 28, 2025 at 6:07 AM
barbmarte.bsky.social
and the News story www.nature.com/articles/d41...
People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.
www.nature.com
October 23, 2025 at 8:30 AM
barbmarte.bsky.social
and the Clinical Briefing www.nature.com/articles/d41...
Tumours might be sensitized to immune therapy by COVID mRNA vaccines
COVID vaccines enhance the antitumour response of immunotherapies and result in increased patient survival.
www.nature.com
October 23, 2025 at 8:29 AM
barbmarte.bsky.social
new out in Nature www.nature.com/articles/s41...
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 23, 2025 at 8:29 AM
barbmarte.bsky.social
new out in Nature, a News & Views www.nature.com/articles/d41...
Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity
Communication between epithelial and mesenchymal cells in pancreatic cancer leads to a poor prognosis. The molecular basis for this signalling has now been revealed.
www.nature.com
October 23, 2025 at 8:29 AM
Reposted by Barbara Marte
vibtrainconf.bsky.social
Tumors are complex ecosystems, where #cancer and non-cancer cells interact, shaping how tumors grow, evolve, and respond to treatment. At #THPT25, Prof. Itay Tirosh will reveal the secrets to fighting back smarter. Want to join this fight? Register before the deadline on 26 Nov: vibbio.tech/49aIDGS
October 22, 2025 at 12:36 PM
barbmarte.bsky.social
new out in Nature www.nature.com/articles/s41...
Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers - Nature
Nature - Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers
www.nature.com
October 21, 2025 at 7:23 AM
barbmarte.bsky.social
new out in Nature www.nature.com/articles/d41...
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
www.nature.com
October 21, 2025 at 7:22 AM
barbmarte.bsky.social
new out in Nature www.nature.com/articles/s41...
Parity and lactation induce T cell mediated breast cancer protection - Nature
Nature - Parity and lactation induce T cell mediated breast cancer protection
www.nature.com
October 21, 2025 at 7:14 AM
barbmarte.bsky.social
it was a pleasure! Thanks everyone for attending and contributing. And a big thanks to the EACR staff !
helloeacr.bsky.social EACR - European Association for Cancer Research @helloeacr.bsky.social · 24d
We want to say a huge thank you to all who attended and helped organise Cancer Neuroscience this week in Bilbao 🎉

The next EACR conference is virtual and just around the corner - register for Patient Involvement in Cancer Research by Monday! eacr.org/conference/p...
October 18, 2025 at 8:56 AM
barbmarte.bsky.social
a new News & Views out in Nature www.nature.com/articles/d41...
Clues to why the weight-loss condition cachexia arises when cancer occurs
Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting, a condition called cachexia.
www.nature.com
October 9, 2025 at 7:17 AM
barbmarte.bsky.social
new out in Nature www.nature.com/articles/s41...
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
www.nature.com
September 26, 2025 at 7:55 AM
barbmarte.bsky.social
and the News & Views www.nature.com/articles/d41...
A drug–diet combination could improve childhood cancer treatment
Mouse studies show that depriving neuroblastoma of certain amino acids causes a switch in protein synthesis to suppress tumour growth and promote cell differentiation.
www.nature.com
September 26, 2025 at 7:52 AM
barbmarte.bsky.social
new out in Nature www.nature.com/articles/s41...
Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
www.nature.com
September 26, 2025 at 7:52 AM
barbmarte.bsky.social
and the News & Views www.nature.com/articles/d41...
Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing
Immune cells can target cancer in the clinic. The ability to test a gene-editing technology in mice on a large scale should improve such immunotherapies.
www.nature.com
September 26, 2025 at 7:43 AM
barbmarte.bsky.social
new out in Nature www.nature.com/articles/s41...
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
www.nature.com
September 26, 2025 at 7:42 AM
barbmarte.bsky.social
new out in Nature www.nature.com/articles/s41...
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
www.nature.com
September 26, 2025 at 7:42 AM
Reposted by Barbara Marte
annettedittert.bsky.social
Will Dunn is right. An awful new trend. Lovely column.
September 20, 2025 at 3:46 PM