Roman Sankowski
@rsankowski.bsky.social
Neuropathologist | #clinicianScientist | #singleCell | Neuro-immunologist | Neuro-oncologist @ University Clinic of Freiburg
Dad | Foodie | hobby barista | views my own
Dad | Foodie | hobby barista | views my own
Pinned
Roman Sankowski
@rsankowski.bsky.social
· May 20
#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com
Reposted by Roman Sankowski
1/12 What is “CHIP” in blood sequencing, and why does it mess up mutation calls?
Not every mutation is created equal.
Quick explainer for oncologists, cardiologists, and genomics folks 👇
Not every mutation is created equal.
Quick explainer for oncologists, cardiologists, and genomics folks 👇
January 31, 2026 at 2:45 PM
1/12 What is “CHIP” in blood sequencing, and why does it mess up mutation calls?
Not every mutation is created equal.
Quick explainer for oncologists, cardiologists, and genomics folks 👇
Not every mutation is created equal.
Quick explainer for oncologists, cardiologists, and genomics folks 👇
Important insights into the tumor #microenvironment of spinal bone #metastases.
A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine
www.cell.com/cell-reports...
A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine
www.cell.com/cell-reports...
A pan-cancer single-cell transcriptomic atlas of human bone metastases
This study constructs a pan-cancer single-cell atlas of human bone metastases, revealing
niche-specific stromal and immune programs that drive tumor proliferation and immunotherapy
resistance. Combine...
www.cell.com
January 31, 2026 at 7:02 PM
Important insights into the tumor #microenvironment of spinal bone #metastases.
A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine
www.cell.com/cell-reports...
A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine
www.cell.com/cell-reports...
Reposted by Roman Sankowski
The world feels like its on fire, but things like this is why im thankful to be born in this day and age with science advancing like it has been. These are heroes
www.unilad.com/news/health/...
www.unilad.com/news/health/...
Scientists successfully achieve 'permanent disappearance of pancreatic cancer' in new study for cure
The team searching for a pancreatic cancer cure included the ‘renowned Dr Mariano Barbacid,' a legend in the cancer research field
www.unilad.com
January 30, 2026 at 9:31 PM
The world feels like its on fire, but things like this is why im thankful to be born in this day and age with science advancing like it has been. These are heroes
www.unilad.com/news/health/...
www.unilad.com/news/health/...
Reposted by Roman Sankowski
Don was taken into custody by federal agents last night in Los Angeles.
January 30, 2026 at 12:58 PM
Don was taken into custody by federal agents last night in Los Angeles.
Reposted by Roman Sankowski
The arrest of Don Lemon is textbook fascism—a brazen attempt to silence reporting on a criminal regime. Stand up for Don, because our rights stand and fall with those of courageous journalists throughout this country.
January 30, 2026 at 7:18 PM
The arrest of Don Lemon is textbook fascism—a brazen attempt to silence reporting on a criminal regime. Stand up for Don, because our rights stand and fall with those of courageous journalists throughout this country.
Reposted by Roman Sankowski
January 30, 2026 at 9:33 AM
Reposted by Roman Sankowski
Vous en avez marre des GAFAM et de l’ultra dépendance aux services US ? Voici des solutions, toutes présentes dans notre fiction en accès libre « GAFAM : 24h dans la peau d’un repenti ».
Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼
Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼
January 24, 2026 at 8:52 AM
Vous en avez marre des GAFAM et de l’ultra dépendance aux services US ? Voici des solutions, toutes présentes dans notre fiction en accès libre « GAFAM : 24h dans la peau d’un repenti ».
Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼
Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼
Does the neuronal ‘aggregome’ explain neurodegeneration? A ne study from the Wyss-Coray lab suggest so using a novel methodology
Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature
www.nature.com/articles/s41...
Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature
www.nature.com/articles/s41...
Ageing promotes microglial accumulation of slow-degrading synaptic proteins - Nature
Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.
www.nature.com
January 21, 2026 at 9:41 PM
Does the neuronal ‘aggregome’ explain neurodegeneration? A ne study from the Wyss-Coray lab suggest so using a novel methodology
Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature
www.nature.com/articles/s41...
Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature
www.nature.com/articles/s41...
Important new findings on #choroid #plexus #macrophages - good Job Simone Brioschi and Marco Colonna!
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience
www.nature.com/articles/s41...
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience
www.nature.com/articles/s41...
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins - Nature Neuroscience
The choroid plexus is a vital brain ventricular organ that produces cerebrospinal fluid. This study shows how developmental origins and local niches shape the specialization of choroid plexus macropha...
www.nature.com
January 21, 2026 at 9:34 PM
Important new findings on #choroid #plexus #macrophages - good Job Simone Brioschi and Marco Colonna!
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience
www.nature.com/articles/s41...
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience
www.nature.com/articles/s41...
Coo study showing how pregnancy reduces #MS relapses by 80%. Mechanisms: Specialized brainstem neurons detect the fetal signal GDF-15 and specifically dampen inflammatory cells through the sympathetic nervous system—preventing their entry into the CNS.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation - Nature Immunology
Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...
www.nature.com
January 18, 2026 at 11:48 AM
Coo study showing how pregnancy reduces #MS relapses by 80%. Mechanisms: Specialized brainstem neurons detect the fetal signal GDF-15 and specifically dampen inflammatory cells through the sympathetic nervous system—preventing their entry into the CNS.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interesting approach looking at animal origins as driven by a smartphone-like animalOS. So can I put a catOS into a mouse?
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 15, 2026 at 12:23 PM
Interesting approach looking at animal origins as driven by a smartphone-like animalOS. So can I put a catOS into a mouse?
link.springer.com/article/10.1...
link.springer.com/article/10.1...
It’s Kind of cute and hard to imagine in Europe or the US..
Prime Minister Sanae Takaichi of Japan and President Lee Jae Myung of South Korea jammed to BTS and “KPop Demon Hunters,” in a display meant to show warming ties between their countries at a time of deep geopolitical and economic uncertainty.
Watch the Leaders of Japan and South Korea Jam to K-pop on the Drums
Prime Minister Sanae Takaichi of Japan and President Lee Jae Myung of South Korea played along to BTS and “KPop Demon Hunters,” in a display meant to show warming ties.
trib.al
January 14, 2026 at 12:35 PM
It’s Kind of cute and hard to imagine in Europe or the US..
This study shows mechanistic links between #multiple #sclerosis and #EBV Epstein-Barr Virus that reveals..
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation | @cellpress.bsky.social
authors.elsevier.com/sd/article/S...
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation | @cellpress.bsky.social
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
January 14, 2026 at 9:17 AM
This study shows mechanistic links between #multiple #sclerosis and #EBV Epstein-Barr Virus that reveals..
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation | @cellpress.bsky.social
authors.elsevier.com/sd/article/S...
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation | @cellpress.bsky.social
authors.elsevier.com/sd/article/S...
Reposted by Roman Sankowski
Prof. Bo Peng’s work is truly inspiring. His research on microglia replacement shows how fundamental neuroimmunology can be translated into real clinical impact. I listened to the seminar on my way to the clinic this morning and was very glad to be introduced to his work.👏🏻
youtu.be/wt4JkX3fNKg?...
youtu.be/wt4JkX3fNKg?...
European Microglia Webinar Series, by Prof. Bo Peng (2026-01-13)
YouTube video by Achucarro Basque Center for Neuroscience
youtu.be
January 14, 2026 at 9:04 AM
Prof. Bo Peng’s work is truly inspiring. His research on microglia replacement shows how fundamental neuroimmunology can be translated into real clinical impact. I listened to the seminar on my way to the clinic this morning and was very glad to be introduced to his work.👏🏻
youtu.be/wt4JkX3fNKg?...
youtu.be/wt4JkX3fNKg?...
Reposted by Roman Sankowski
Unexpected Side Effects: Vaccines Protect the Aging Brain and Heart
open.substack.com/pub/drericdi...
open.substack.com/pub/drericdi...
Unexpected Side Effects: Vaccines Protect the Aging Brain and Heart
Anti-vaxxers don't want you to know about off-target benefits.
open.substack.com
January 14, 2026 at 5:35 AM
Unexpected Side Effects: Vaccines Protect the Aging Brain and Heart
open.substack.com/pub/drericdi...
open.substack.com/pub/drericdi...
Reposted by Roman Sankowski
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 13, 2026 at 4:25 PM
3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Roman Sankowski
ICYMI: New online! Harnessing the microbiome for cancer therapy
Harnessing the microbiome for cancer therapy
Nature Reviews Microbiology, Published online: 05 January 2026; doi:10.1038/s41579-025-01268-6In this Review, Hajjar, Mars and Kashyap discuss the role of the microbiome in cancer development and progression and in treatment response. They also consider the potential of the microbiome as a therapeutic target and as a prognostic and predictive biomarker, and outline major knowledge gaps in the field.
dlvr.it
January 12, 2026 at 9:31 AM
ICYMI: New online! Harnessing the microbiome for cancer therapy
Reposted by Roman Sankowski
Next week, we welcome Giacomo Cavalli from @cnrs.fr | @umontpellier.bsky.social.
He joins our Special Guest Seminar Series to give a talk on »Epigenetic memory of past events mediated by modification of Polycomb components & histone acetylation«
Thanks to @iovino-lab.bsky.social for organizing. 🤗
He joins our Special Guest Seminar Series to give a talk on »Epigenetic memory of past events mediated by modification of Polycomb components & histone acetylation«
Thanks to @iovino-lab.bsky.social for organizing. 🤗
January 12, 2026 at 9:49 AM
Next week, we welcome Giacomo Cavalli from @cnrs.fr | @umontpellier.bsky.social.
He joins our Special Guest Seminar Series to give a talk on »Epigenetic memory of past events mediated by modification of Polycomb components & histone acetylation«
Thanks to @iovino-lab.bsky.social for organizing. 🤗
He joins our Special Guest Seminar Series to give a talk on »Epigenetic memory of past events mediated by modification of Polycomb components & histone acetylation«
Thanks to @iovino-lab.bsky.social for organizing. 🤗
Reposted by Roman Sankowski
#APPLYNOW
📣 The CIBSS Team is hiring! We are looking for someone passionate about helping early-career researchers develop their skills, qualifications and career prospects🧑🏽🔬🧬
➡️ Coordinator of Early-Career Programs and Diversity Management
🗓️Deadline: Jan 18, 2026
🔗 uni-freiburg.de/en/job/00004767/
📣 The CIBSS Team is hiring! We are looking for someone passionate about helping early-career researchers develop their skills, qualifications and career prospects🧑🏽🔬🧬
➡️ Coordinator of Early-Career Programs and Diversity Management
🗓️Deadline: Jan 18, 2026
🔗 uni-freiburg.de/en/job/00004767/
January 12, 2026 at 8:01 AM
#APPLYNOW
📣 The CIBSS Team is hiring! We are looking for someone passionate about helping early-career researchers develop their skills, qualifications and career prospects🧑🏽🔬🧬
➡️ Coordinator of Early-Career Programs and Diversity Management
🗓️Deadline: Jan 18, 2026
🔗 uni-freiburg.de/en/job/00004767/
📣 The CIBSS Team is hiring! We are looking for someone passionate about helping early-career researchers develop their skills, qualifications and career prospects🧑🏽🔬🧬
➡️ Coordinator of Early-Career Programs and Diversity Management
🗓️Deadline: Jan 18, 2026
🔗 uni-freiburg.de/en/job/00004767/
Reposted by Roman Sankowski
New Year, new series of talks 🎉.
Monthly seminars at the intersection of metabolism, cell bio & dev bio.
Join us next week 👇
Apply to give a talk in this series : docs.google.com/forms/d/e/1F...
Monthly seminars at the intersection of metabolism, cell bio & dev bio.
Join us next week 👇
Apply to give a talk in this series : docs.google.com/forms/d/e/1F...
We’re back with the Metabolism in Development & Physiology online seminar series 🎉
Thu 15 Jan 2025, 16:00 CET
Speakers:
Heidi Lempradl (Professor, VAI)
Diego Sainz de la Maza (PostDoc, UCL)
Thu 15 Jan 2025, 16:00 CET
Speakers:
Heidi Lempradl (Professor, VAI)
Diego Sainz de la Maza (PostDoc, UCL)
January 9, 2026 at 4:30 PM
New Year, new series of talks 🎉.
Monthly seminars at the intersection of metabolism, cell bio & dev bio.
Join us next week 👇
Apply to give a talk in this series : docs.google.com/forms/d/e/1F...
Monthly seminars at the intersection of metabolism, cell bio & dev bio.
Join us next week 👇
Apply to give a talk in this series : docs.google.com/forms/d/e/1F...
Reposted by Roman Sankowski
“The question is whether we will act while AI governance frameworks are still forming or will normalize preventable deaths, discrimination, and erosion of public trust”. Every scientist should read this piece by @alondra.bsky.social arguing for an ELSI for AI. This work is essential.
🧵 The summer of 2025 has been AI's "cruel summer"—wrongful deaths, dangerous therapy chatbots, medical misinformation, facial recognition failures. These aren't isolated glitches but predictable harms from systems deployed without adequate oversight. www.science.org/doi/10.1126/...
An ELSI for AI: Learning from genetics to govern algorithms
In the United States, the summer of 2025 will be remembered as artificial intelligence’s (AI’s) cruel summer—a season when the unheeded risks and dangers of AI became undeniably clear. Recent months h...
www.science.org
January 11, 2026 at 4:47 PM
“The question is whether we will act while AI governance frameworks are still forming or will normalize preventable deaths, discrimination, and erosion of public trust”. Every scientist should read this piece by @alondra.bsky.social arguing for an ELSI for AI. This work is essential.
This book on #reproducible #data #science looks like something every scientist should at least be aware of. Can’t wait to read it in the coming days.
Reproducible Polyglot Data Science
still a WIP, but I think there's already quite a lot of useful content. Will stay free forever: reproducible-data-science.dev
buy me an espresso to show your support: buymeacoffee.com/brodriguesco
still a WIP, but I think there's already quite a lot of useful content. Will stay free forever: reproducible-data-science.dev
buy me an espresso to show your support: buymeacoffee.com/brodriguesco
January 11, 2026 at 7:56 PM
This book on #reproducible #data #science looks like something every scientist should at least be aware of. Can’t wait to read it in the coming days.
Wondering which single-cell assay to choose for your experimental design? Here is a valuable guide:
Evaluating the practical aspects and performance of commercial single-cell RNA sequencing technologies | NAR Genomics and Bioinformatics | Oxford Academic
academic.oup.com/nargab/artic...
Evaluating the practical aspects and performance of commercial single-cell RNA sequencing technologies | NAR Genomics and Bioinformatics | Oxford Academic
academic.oup.com/nargab/artic...
Evaluating the practical aspects and performance of commercial single-cell RNA sequencing technologies
Abstract. The rapid development of updated and new commercially available single-cell transcriptomics platforms provides users with a range of experimental
academic.oup.com
January 11, 2026 at 8:56 AM
Wondering which single-cell assay to choose for your experimental design? Here is a valuable guide:
Evaluating the practical aspects and performance of commercial single-cell RNA sequencing technologies | NAR Genomics and Bioinformatics | Oxford Academic
academic.oup.com/nargab/artic...
Evaluating the practical aspects and performance of commercial single-cell RNA sequencing technologies | NAR Genomics and Bioinformatics | Oxford Academic
academic.oup.com/nargab/artic...
Decoding brain border immunity to enable future therapeutic avenues: Trends in Immunology
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Decoding brain border immunity to enable future therapeutic avenues
The brain is no longer viewed as immunologically isolated but as an organ surrounded
by dynamic border compartments that coordinate surveillance, drainage, and communication
with the periphery. Key in...
www.cell.com
January 10, 2026 at 7:32 AM
Decoding brain border immunity to enable future therapeutic avenues: Trends in Immunology
www.cell.com/trends/immun...
www.cell.com/trends/immun...