GuccioneLab
@guccionelab.bsky.social
We work to identify and validate new targets in oncology.
Our objective is to discover innovative and personalized cancer therapies.
Our objective is to discover innovative and personalized cancer therapies.
Reposted by GuccioneLab
Excited for this summer’s NYC Chromatin Club!
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
May 5, 2025 at 3:01 AM
Excited for this summer’s NYC Chromatin Club!
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Reposted by GuccioneLab
🚨 New meeting this fall in Brussels! 🚨
Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩
#epigenetics2025
Registration is open!!
@epicypher.bsky.social
xcellsconferences.com/epigenetics2025
Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩
#epigenetics2025
Registration is open!!
@epicypher.bsky.social
xcellsconferences.com/epigenetics2025
June 3, 2025 at 11:45 AM
🚨 New meeting this fall in Brussels! 🚨
Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩
#epigenetics2025
Registration is open!!
@epicypher.bsky.social
xcellsconferences.com/epigenetics2025
Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩
#epigenetics2025
Registration is open!!
@epicypher.bsky.social
xcellsconferences.com/epigenetics2025
Reposted by GuccioneLab
NOAA Cuts Leave Wind Chimes As Sole Predictor Of Approaching Hurricanes
NOAA Cuts Leave Wind Chimes As Sole Predictor Of Approaching Hurricanes
SILVER SPRING, MD—As mass firings of career experts and scientists continued to roil the federal government, officials confirmed Friday that cuts to the National Oceanic and Atmospheric Administration...
theonion.com
February 28, 2025 at 8:01 PM
NOAA Cuts Leave Wind Chimes As Sole Predictor Of Approaching Hurricanes
Reposted by GuccioneLab
Very sad to see that #RareDiseaseDay event at FDA-NIH has been cancelled. Cuts that limit rare disease research and cures (1) leave patients behind, and (2) forfeit precious opportunity to learn more about common human diseases.
udnf.org/udnf-stateme...
udnf.org/udnf-stateme...
Statement on Rare Disease Day, Research and Funding - UDNF
UDNF Statement on Rare Disease Day 2025 Cancellation, Research Funding, and Policy Impacts on the Ultra-Rare and Undiagnosed Community
udnf.org
February 27, 2025 at 11:21 PM
Very sad to see that #RareDiseaseDay event at FDA-NIH has been cancelled. Cuts that limit rare disease research and cures (1) leave patients behind, and (2) forfeit precious opportunity to learn more about common human diseases.
udnf.org/udnf-stateme...
udnf.org/udnf-stateme...
Here we characterize PRDM10 as an essential maternal transcription factor and dissect its role in regulating oocyte maturarion and oocyte-to-embryo transition!
On to the next!
Congrats to Daniel Messerschmidt the true mastermind behind this work and the whole team!
www.nature.com/articles/s41...
On to the next!
Congrats to Daniel Messerschmidt the true mastermind behind this work and the whole team!
www.nature.com/articles/s41...
Maternal PRDM10 activates essential genes for oocyte-to-embryo transition - Nature Communications
The oocyte-to-embryo transition marks the beginning of development but the mechanisms underlying this process are incompletely described. Here they show that PRDM10 activates Septin11 and is required ...
www.nature.com
February 28, 2025 at 12:14 PM
Here we characterize PRDM10 as an essential maternal transcription factor and dissect its role in regulating oocyte maturarion and oocyte-to-embryo transition!
On to the next!
Congrats to Daniel Messerschmidt the true mastermind behind this work and the whole team!
www.nature.com/articles/s41...
On to the next!
Congrats to Daniel Messerschmidt the true mastermind behind this work and the whole team!
www.nature.com/articles/s41...
Reposted by GuccioneLab
NYC!!! Start spreading the news, show up! If you can make it here, you'll make it anywhere! ! It's up to you, New York, New York!! www.eventbrite.com/e/stand-up-f...
Stand Up for Science 2025 - NYC
Stand up for science with us on March 7th, 2025, because science is for everyone! More info at www.standupforscience2025.org
www.eventbrite.com
February 26, 2025 at 2:34 AM
NYC!!! Start spreading the news, show up! If you can make it here, you'll make it anywhere! ! It's up to you, New York, New York!! www.eventbrite.com/e/stand-up-f...
Reposted by GuccioneLab
Another article detailing anxiety among young researchers. Future careers are at stake with the US funding cuts, and talented young researchers are already being driven to pursue opportunities abroad.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
www.nature.com
February 25, 2025 at 2:21 PM
Another article detailing anxiety among young researchers. Future careers are at stake with the US funding cuts, and talented young researchers are already being driven to pursue opportunities abroad.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Now more than ever the message is: this research can soon have an impact on people’s lives. Proud of this rewarding collaboration with former Sinai colleague @kimioishi and the whole #RNA modulation for therapeutics Lab (kudos to JinRong in particular!) www.journal-of-hepatology.eu/article/S016...
Developing splice-switching oligonucleotides for urea cycle disorder using an integrated diagnostic and therapeutic platform
Citrin deficiency (CD) is an autosomal recessive urea cycle disorder caused by biallelic
loss-of-function variants in the SLC25A13 gene, leading to life-threatening hyperammonemia
and hypoglycemia. Va...
www.journal-of-hepatology.eu
February 25, 2025 at 6:05 PM
Now more than ever the message is: this research can soon have an impact on people’s lives. Proud of this rewarding collaboration with former Sinai colleague @kimioishi and the whole #RNA modulation for therapeutics Lab (kudos to JinRong in particular!) www.journal-of-hepatology.eu/article/S016...
Reposted by GuccioneLab
The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether.
https://go.nature.com/43ao2zq
https://go.nature.com/43ao2zq
Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
go.nature.com
February 24, 2025 at 9:39 PM
The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether.
https://go.nature.com/43ao2zq
https://go.nature.com/43ao2zq
Celebrating the Nature Genetics manuscript on CRC OncoFetal reprogramming. Good to smile together and be reminded that what makes our jobs rewarding is being surrounded by talented smart people who are very committed to what they do! Especially in the current climate!
February 20, 2025 at 2:29 PM
Celebrating the Nature Genetics manuscript on CRC OncoFetal reprogramming. Good to smile together and be reminded that what makes our jobs rewarding is being surrounded by talented smart people who are very committed to what they do! Especially in the current climate!
Reposted by GuccioneLab
Epigenetics Update - Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer go.nature.com/40W2vry
Slim Mzoughi and Ernesto Guccione reporting in Nature Genetics
#Epigenetics #Cancer #Reprogramming
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Discover the Paired-tag breakthrough at epigenome.us
Slim Mzoughi and Ernesto Guccione reporting in Nature Genetics
#Epigenetics #Cancer #Reprogramming
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Discover the Paired-tag breakthrough at epigenome.us
February 19, 2025 at 8:48 AM
Epigenetics Update - Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer go.nature.com/40W2vry
Slim Mzoughi and Ernesto Guccione reporting in Nature Genetics
#Epigenetics #Cancer #Reprogramming
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Discover the Paired-tag breakthrough at epigenome.us
Slim Mzoughi and Ernesto Guccione reporting in Nature Genetics
#Epigenetics #Cancer #Reprogramming
---
Discover the Paired-tag breakthrough at epigenome.us
Reposted by GuccioneLab
Donald Trump and Elon Musk’s idea of efficiency is stopping research on curing cancer.
February 14, 2025 at 1:59 AM
Donald Trump and Elon Musk’s idea of efficiency is stopping research on curing cancer.
What an amazing cover! Congrats @gloglita.bsky.social
February 12, 2025 at 8:54 PM
What an amazing cover! Congrats @gloglita.bsky.social
Reposted by GuccioneLab
Reposted by GuccioneLab
📢ONLINE @naturegenet.bsky.social
📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
February 11, 2025 at 7:56 AM
📢ONLINE @naturegenet.bsky.social
📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer.
By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Reposted by GuccioneLab
1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
February 10, 2025 at 3:18 PM
1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
@owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
February 10, 2025 at 3:15 PM
Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social
First post on Bluesky: Finally out! If you look for a reliable reporter system for your Nucleic Acid Therapeutics needs, we got you covered!
The NATURA system is available (Addgene or reach out). Congrats to Tommaso Tabaglio for leading this incredible effort! www.sciencedirect.com/science/arti...
The NATURA system is available (Addgene or reach out). Congrats to Tommaso Tabaglio for leading this incredible effort! www.sciencedirect.com/science/arti...
Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform
Chemical optimization of ribose has significantly advanced nucleic acid therapeutics (NATs) by improving the stability, specificity, and safety of the…
www.sciencedirect.com
February 5, 2025 at 1:54 AM
First post on Bluesky: Finally out! If you look for a reliable reporter system for your Nucleic Acid Therapeutics needs, we got you covered!
The NATURA system is available (Addgene or reach out). Congrats to Tommaso Tabaglio for leading this incredible effort! www.sciencedirect.com/science/arti...
The NATURA system is available (Addgene or reach out). Congrats to Tommaso Tabaglio for leading this incredible effort! www.sciencedirect.com/science/arti...