Nature Genetics
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Nature Genetics
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Nature Genetics is a monthly journal publishing high impact research in genetics and genomics. Part of @natureportfolio.bsky.social
Repost/like=interesting/relevant, not necessarily endorsement.
Pinned
📢The September issue of @natgenet.nature.com is out!

Featuring:

✅multiomic analysis in NSCLC
✅ancestral recombination graphs with SINGER
✅mutational landscape of TNBC in African American women
✅scDNAme&3Dgenome atlas of human SAT
✅avena super-pangenome

&more!

⬇️

www.nature.com/ng/volumes/5...
Reposted by Nature Genetics
🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...
Cell-type- and locus-specific epigenetic editing of memory expression - Nature Genetics
CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.
www.nature.com
October 29, 2025 at 11:11 AM
📢OUT TODAY @natgenet.nature.com

📰Limited overlap between genetic effects on disease susceptibility and disease survival.

By Zhiyu Yang, Nina Mars, Andrea Ganna and colleagues.

⬇️

www.nature.com/articles/s41...
Limited overlap between genetic effects on disease susceptibility and disease survival - Nature Genetics
Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.
www.nature.com
September 30, 2025 at 12:12 PM
📢OUT @natgenet.nature.com

📰Bryophytes hold a larger gene family space than vascular plants.

By Shanshan Dong, Yang Liu and colleagues.

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www.nature.com/articles/s41...
Bryophytes hold a larger gene family space than vascular plants - Nature Genetics
A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.
www.nature.com
September 30, 2025 at 7:33 AM
📢PUBLISHED @natgenet.nature.com

📰Rapid epigenomic classification of acute leukemia

By Til L. Steinicke, Gabriel K. Griffin, Volker Hovestadt and colleagues.

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www.nature.com/articles/s41...
Rapid epigenomic classification of acute leukemia - Nature Genetics
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
September 29, 2025 at 1:53 PM
📢PUBLISHED @natgenet.nature.com

📰Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.

By Konrad J. Karczewski, Alicia R. Martin and colleagues.

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www.nature.com/articles/s41...
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects - Nature Genetics
Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse populations.
www.nature.com
September 29, 2025 at 1:51 PM
📢PUBLISHED @natgenet.nature.com

📰Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks.

By Ching-Huang Ho, John P. Ray and colleagues.

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www.nature.com/articles/s41...
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics
Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate T cell gene expression and proliferation.
www.nature.com
September 29, 2025 at 1:50 PM
📢PUBLISHED @natgenet.nature.com

📰 Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes.

By Camiel M. van der Laan, Dorret I. Boomsma and colleagues.

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www.nature.com/articles/s41...
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes - Nature Genetics
Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.
www.nature.com
September 29, 2025 at 1:48 PM
📢📢REVIEW PUBLISHED TODAY @natgenet.nature.com

📰Advancing biological understanding of cellular senescence with computational multiomics.

By Sheng Li, SenNet Consortium, and colleagues!

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www.nature.com/articles/s41...
Advancing biological understanding of cellular senescence with computational multiomics - Nature Genetics
This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that high...
www.nature.com
September 15, 2025 at 11:56 AM
📢OUT @natgenet.nature.com

📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.

By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues.

⬇️

www.nature.com/articles/s41...
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution - Nature Genetics
Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.
www.nature.com
September 15, 2025 at 11:53 AM
📢OUT @natgenet.nature.com

📰Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.

By Aliza P. Wingo, Thomas S. Wingo and colleagues.

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www.nature.com/articles/s41...
Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions - Nature Genetics
Multiancestry fine-mapping of brain protein quantitative trait loci coupled with Mendelian randomization analyses identifies protein–trait pairs consistent with causal effects across neurological and ...
www.nature.com
September 15, 2025 at 11:51 AM
📢The September issue of @natgenet.nature.com is out!

Featuring:

✅multiomic analysis in NSCLC
✅ancestral recombination graphs with SINGER
✅mutational landscape of TNBC in African American women
✅scDNAme&3Dgenome atlas of human SAT
✅avena super-pangenome

&more!

⬇️

www.nature.com/ng/volumes/5...
September 15, 2025 at 11:46 AM
📢 OUT TODAY @natgenet.nature.com

🐄A multi-tissue single-cell expression atlas in cattle🐄

By Bo Han, Dongxiao Sun, Lingzhao Fang and colleagues.

⬇️

www.nature.com/articles/s41...
A multi-tissue single-cell expression atlas in cattle - Nature Genetics
This study introduces the Cattle Cell Atlas, a single-cell expression resource including 1,793,854 cells from 59 tissues. Integrative analyses leveraging this atlas provide insights into the biology u...
www.nature.com
September 5, 2025 at 12:38 PM
📢ONLINE @natgenet.nature.com

📰DNA methylation influences human centromere positioning and function.

By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues.

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www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 5, 2025 at 12:32 PM
📢PUBLISHED @natgenet.nature.com

📰Mutational landscape of triple-negative #breastcancer in African American women.

By Song Yao, John D. Carpten and colleagues.

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www.nature.com/articles/s41...
Mutational landscape of triple-negative breast cancer in African American women - Nature Genetics
This study explores the genomic and transcriptomic landscapes of triple-negative breast cancer in African American women. The authors show that the mutational profile is broadly similar to that observ...
www.nature.com
August 27, 2025 at 1:47 PM
✨PUBLISHED @natgenet.nature.com

📰Tamoxifen induces PI3K activation in #uterinecancer.

By Kirsten Kübler, Gad Getz, Rinath Jeselsohn and colleagues.

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www.nature.com/articles/s41...
Tamoxifen induces PI3K activation in uterine cancer - Nature Genetics
Sequencing analysis of tamoxifen-associated uterine cancers and further in vivo analyses suggest that the drug tamoxifen can activate the PI3K pathway in the absence of oncogenic mutations.
www.nature.com
August 27, 2025 at 1:41 PM
📢PUBLISHED @natgenet.nature.com

📰Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue.

By Zeyuan Johnson Chen, Päivi Pajukanta and colleagues.

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www.nature.com/articles/s41...
Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue - Nature Genetics
This multiomic study, including single-nucleus DNA methylation and chromatin conformation matched with single-nuclei RNA sequencing, provides insights into the epigenomic landscape of human subcutaneo...
www.nature.com
August 27, 2025 at 1:37 PM
Reposted by Nature Genetics
📣New @natgenet.nature.com The Hartwig group @mpipz.bsky.social and colleagues @hhu.de unveil a scalable way to map plant genomic "switches" - these overlooked regions hold huge promise for crop breeding & climate resilience. 👉http://bit.ly/41BmCwD #plantsci
www.nature.com/articles/s41...
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize - Nature Genetics
Pan-cistrome of the maize leaf under well-watered and drought conditions profiled by haplotype-specific MOA-seq highlights the relevance of transcription factor binding QTLs for understanding phenotyp...
www.nature.com
August 20, 2025 at 10:20 AM
💫PUBLISHED @natgenet.nature.com

📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.

By Kaden M. Southard, @normanlab.bsky.social and colleagues!

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www.nature.com/articles/s41...
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states - Nature Genetics
CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.
www.nature.com
August 27, 2025 at 1:26 PM
📢PUBLISHED @natgenet.nature.com

📰Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression.

By Anjali Chawla, Gustavo Turecki and colleagues.

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www.nature.com/articles/s41...
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression - Nature Genetics
Integration of snATAC-seq and snRNA-seq data from brains of individuals with major depressive disorder identifies chromatin accessibility alterations and functional enrichment of risk variants in deep...
www.nature.com
August 27, 2025 at 1:22 PM
Nature Genetics editor Margot Brandt will be attending the @fusionconf.bsky.social “Endogenous Retrotransposable Elements & Human Diseases Conference” bit.ly/45iiYbY. Please feel free to reach out to her if you would like to discuss your research!
Endogenous Retrotransposable Elements & Human Diseases Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
bit.ly
August 25, 2025 at 5:40 PM
Reposted by Nature Genetics
#NatMicroPicks

Decoding Shigella’s Virulence Blueprint 🦠🧬

Combining organoid infection models with genome-wide mutagenesis allows mapping the full set of Shigella genes required for human gut colonization

www.nature.com/articles/s41...

@sellinlab.bsky.social @natgenet.nature.com
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen - Nature Genetics
A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for epithelial colonization.
www.nature.com
August 1, 2025 at 2:35 PM
📢 PUBLISHED @natgenet.nature.com

📰The LISTEN principles for genetic sequence data governance and database engineering.

A Perspective by Colin J. Carlson, @ctrlalttim.com and colleagues.

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www.nature.com/articles/s41...
July 29, 2025 at 1:00 PM
📢PUBLISHED @natgenet.nature.com

📰Large-scale genome-wide analyses of stuttering.

By Hannah G. Polikowsky, Jennifer E. Below and colleagues.

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www.nature.com/articles/s41...
Large-scale genome-wide analyses of stuttering - Nature Genetics
Genome-wide analyses in over one million self-reported cases and controls identify genetic variants associated with stuttering and find genetic correlations with autism, depression and impaired musica...
www.nature.com
July 29, 2025 at 12:52 PM
📢PUBLISHED @natgenet.nature.com

📰Massively parallel immunopeptidome by DNA sequencing provides insights into #cancer antigen presentation.

By Quanming Shi, Howard Y. Chang and colleagues.

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www.nature.com/articles/s41...
Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation - Nature Genetics
ESCAPE-seq (enhanced single-chain antigen presentation sequencing) is a massively parallel platform for screening of class I HLA–peptide combinations for antigen presentation. The authors assess more ...
www.nature.com
July 29, 2025 at 12:50 PM