Elias Adriaenssens
@elias-adriaenssens.bsky.social
Postdoc with Sascha Martens and Tim Clausen at the Vienna BioCenter (VBC). #MSCA Fellow. Formerly University of Oxford and University of Antwerp.
Pinned
And it's out!
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).
This paper describes a new mechanism for the initiation of autophagosome biogenesis.
We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
Reposted by Elias Adriaenssens
Looking for some Thanksgiving reading? 🦃🦃🦃
🚨Check out our new preprint on CRISPore-seq!🚨
Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.
🚨Check out our new preprint on CRISPore-seq!🚨
Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.
November 27, 2025 at 11:40 AM
Looking for some Thanksgiving reading? 🦃🦃🦃
🚨Check out our new preprint on CRISPore-seq!🚨
Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.
🚨Check out our new preprint on CRISPore-seq!🚨
Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.
Reposted by Elias Adriaenssens
Hi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity.
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
November 26, 2025 at 5:12 PM
Hi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity.
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks.
(whiteboard art from Zhuonan Li)
Reposted by Elias Adriaenssens
And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport.
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
November 27, 2025 at 10:41 AM
And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport.
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
Reposted by Elias Adriaenssens
☕Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of #proinsulin. #PhaseSeparation
bit.ly/44mX1bW
bit.ly/44mX1bW
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding - Nature Cell Biology
Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones t...
bit.ly
November 27, 2025 at 9:31 AM
☕Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of #proinsulin. #PhaseSeparation
bit.ly/44mX1bW
bit.ly/44mX1bW
Reposted by Elias Adriaenssens
Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings!
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Charge segregation in the C-terminal linker of FtsZ enables Z-ring scaling with prokaryotic cell width
Bacterial cytokinesis is orchestrated by the Z-ring, a cytoskeletal structure formed by treadmilling filaments of the tubulin-like GTPase FtsZ. During assembly, filament curvature must match the cell ...
www.biorxiv.org
November 26, 2025 at 9:29 PM
Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings!
Preprint: www.biorxiv.org/content/10.1...
Preprint: www.biorxiv.org/content/10.1...
Reposted by Elias Adriaenssens
#NewResearch
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
#MicroSky 🦠
www.nature.com/articles/s41...
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
#MicroSky 🦠
www.nature.com/articles/s41...
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
www.nature.com
November 26, 2025 at 3:51 PM
#NewResearch
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
#MicroSky 🦠
www.nature.com/articles/s41...
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
#MicroSky 🦠
www.nature.com/articles/s41...
Reposted by Elias Adriaenssens
New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD
November 26, 2025 at 4:14 PM
New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD
Reposted by Elias Adriaenssens
Thrilled to share that the work from @cristianrocharoa.bsky.social, identifying TMEM170 proteins as lipid scramblases that associate with bridge lipid transporters, is now out in @natsmb.nature.com
Unexpectedly, the scrambling pathway does not "feed" directly into the BLTP cavity...
rdcu.be/eRSst
Unexpectedly, the scrambling pathway does not "feed" directly into the BLTP cavity...
rdcu.be/eRSst
November 26, 2025 at 5:01 PM
Thrilled to share that the work from @cristianrocharoa.bsky.social, identifying TMEM170 proteins as lipid scramblases that associate with bridge lipid transporters, is now out in @natsmb.nature.com
Unexpectedly, the scrambling pathway does not "feed" directly into the BLTP cavity...
rdcu.be/eRSst
Unexpectedly, the scrambling pathway does not "feed" directly into the BLTP cavity...
rdcu.be/eRSst
Reposted by Elias Adriaenssens
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
November 26, 2025 at 4:21 PM
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
👉 doi.org/10.1038/s41586-025-09779-1
Reposted by Elias Adriaenssens
⚡ How conserved is respiratory complex I (CI) across #eukaryotes — and where does #evolution leave its mark? This review by @lettsscience.bsky.social compares CI across seven lineages, revealing variation in core subunits and lineage-specific accessory proteins.
➡️ doi.org/10.1002/1873-3468.70181
➡️ doi.org/10.1002/1873-3468.70181
November 25, 2025 at 7:38 PM
⚡ How conserved is respiratory complex I (CI) across #eukaryotes — and where does #evolution leave its mark? This review by @lettsscience.bsky.social compares CI across seven lineages, revealing variation in core subunits and lineage-specific accessory proteins.
➡️ doi.org/10.1002/1873-3468.70181
➡️ doi.org/10.1002/1873-3468.70181
Reposted by Elias Adriaenssens
🧬Kinase inhibitors that degrade?
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1
November 26, 2025 at 4:08 PM
🧬Kinase inhibitors that degrade?
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1
New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research.
➡️ More: bit.ly/3LY6jor
📄 Paper: bit.ly/43MffU1
Reposted by Elias Adriaenssens
Come join us! Soon I will be advertising a postdoc vacancy in my group as part of my @erc.europa.eu AdG project 'DARK ROOTS'. Focus of the project will be on phylo- and metagenomic mining of novel prokaryotic lineages. I will soon post a link here - stay tuned, and please repost! #asgardarchaea
a man walking in a field with an umbrella
ALT: a man walking in a field with an umbrella
media.tenor.com
November 26, 2025 at 3:39 PM
Come join us! Soon I will be advertising a postdoc vacancy in my group as part of my @erc.europa.eu AdG project 'DARK ROOTS'. Focus of the project will be on phylo- and metagenomic mining of novel prokaryotic lineages. I will soon post a link here - stay tuned, and please repost! #asgardarchaea
Reposted by Elias Adriaenssens
BoltzGen: Toward Universal Binder Design www.biorxiv.org/content/10.1...
BoltzGen: Toward Universal Binder Design
We introduce BoltzGen, an all-atom generative model for designing proteins and peptides across all modalities to bind a wide range of biomolecular targets. BoltzGen builds strong structural reasoning ...
www.biorxiv.org
November 26, 2025 at 1:45 PM
BoltzGen: Toward Universal Binder Design www.biorxiv.org/content/10.1...
Reposted by Elias Adriaenssens
Reposted by Elias Adriaenssens
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Elias Adriaenssens
Each such discovery is a game changer for our understanding of eukaryote evolution, and this paper is no exception. Meet Solarion, which displays yet again novel types of subcellular structures. Congrats to all authors on a fascinating story. #protistsonsky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rare microbial relict sheds light on an ancient eukaryotic supergroup - Nature
The discovery of an unusual protist named Solarion arienae, which has a mitochondrial genome with some intriguing features, provides insight into the early radiation of eukaryotic groups.
www.nature.com
November 21, 2025 at 9:30 AM
Each such discovery is a game changer for our understanding of eukaryote evolution, and this paper is no exception. Meet Solarion, which displays yet again novel types of subcellular structures. Congrats to all authors on a fascinating story. #protistsonsky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Elias Adriaenssens
Work I co-led with @jnoms.bsky.social is now online at
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.
www.sciencedirect.com/science/arti...
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.
www.sciencedirect.com/science/arti...
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to …
www.sciencedirect.com
November 25, 2025 at 9:10 PM
Work I co-led with @jnoms.bsky.social is now online at
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.
www.sciencedirect.com/science/arti...
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.
www.sciencedirect.com/science/arti...
Reposted by Elias Adriaenssens
ProteinCHAOS runs entirely in the browser and lets you choose how to visualize your protein structures.
It supports PDB files from the PDB and AlphaFold servers and offers several visual themes so you can "paint" abstract art with protein traces. I hope it helps you create some interesting images!
It supports PDB files from the PDB and AlphaFold servers and offers several visual themes so you can "paint" abstract art with protein traces. I hope it helps you create some interesting images!
November 23, 2025 at 11:18 PM
ProteinCHAOS runs entirely in the browser and lets you choose how to visualize your protein structures.
It supports PDB files from the PDB and AlphaFold servers and offers several visual themes so you can "paint" abstract art with protein traces. I hope it helps you create some interesting images!
It supports PDB files from the PDB and AlphaFold servers and offers several visual themes so you can "paint" abstract art with protein traces. I hope it helps you create some interesting images!
Reposted by Elias Adriaenssens
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
Reposted by Elias Adriaenssens
Wow! that's a super interesting discovery and concept 👇
1/5
🚨🚨 preprint alert! 🚨🚨
I wish to introduce CARDIB, not the singer, but the protein.
CARDIB=CARD Inhibitory Binding protein.
In our new work we discover this antiviral protein that is found in all Anthozoa (sea anemones and corals 🪸) but not in other animals.
www.biorxiv.org/content/10.1...
🚨🚨 preprint alert! 🚨🚨
I wish to introduce CARDIB, not the singer, but the protein.
CARDIB=CARD Inhibitory Binding protein.
In our new work we discover this antiviral protein that is found in all Anthozoa (sea anemones and corals 🪸) but not in other animals.
www.biorxiv.org/content/10.1...
An ancient anthozoan protein reveals an alternative evolutionary path of antiviral signaling
How antiviral immunity first arose in animals is a central question in evolutionary biology. Using the sea anemone Nematostella vectensis, we identify CARDIB, a previously uncharacterized gene located...
www.biorxiv.org
November 25, 2025 at 12:17 PM
Wow! that's a super interesting discovery and concept 👇
Reposted by Elias Adriaenssens
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Elias Adriaenssens
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis - Nature Ecology & Evolution
In Caenorhabditis tropicalis, three toxin–antidote elements arose via gene duplication from the essential tRNA-synthetase subunit FARS-3. The ancestral antidote probably acquired affinity for FARS-3, ...
www.nature.com
November 24, 2025 at 9:10 PM
Happy to share that my PhD project is finally published!🪱✨
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?
Reposted by Elias Adriaenssens
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
ZAK activation at the collided ribosome - Nature
The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
www.nature.com
November 24, 2025 at 9:12 PM
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
Reposted by Elias Adriaenssens
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Seeding biosensor cell line that reproduces the Alzheimer tau fold
The assembly of tau protein into amyloid filaments through templated seeding is believed
to underlie the propagation of pathology in neurodegenerative diseases, such as Alzheimer’s
disease (AD) and ot...
www.jbc.org
November 21, 2025 at 5:08 PM
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Reposted by Elias Adriaenssens
I am pleased to announce the release of ProteinDJ v2! This is a major update that integrates BindCraft into the pipeline as an alternative to RFdiffusion for binder generation. You can try it out here: github.com/PapenfussLab/proteindj
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
November 25, 2025 at 3:01 AM
I am pleased to announce the release of ProteinDJ v2! This is a major update that integrates BindCraft into the pipeline as an alternative to RFdiffusion for binder generation. You can try it out here: github.com/PapenfussLab/proteindj
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social
#ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social