Gabriel Rocklin
@grocklin.bsky.social
Digests proteins. High-throughput protein biophysics and design, Northwestern University. www.rocklinlab.org
Pinned
Gabriel Rocklin
@grocklin.bsky.social
· Mar 26
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
Reposted by Gabriel Rocklin
Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1
November 13, 2025 at 1:47 AM
Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1
Reposted by Gabriel Rocklin
quick reminder to come see @grocklin.bsky.social tonight at @mit.edu!
Join us in Room 181, Building 68 @mit.edu on October 22nd 2025 @ 7pm EDT to see @grocklin.bsky.social present a mind blowing amount of data and learn what becomes possible at this scale
"Predicting protein folding stability and aggregation propensity using large-scale experiments"
bpdmc.org
"Predicting protein folding stability and aggregation propensity using large-scale experiments"
bpdmc.org
schedule
introduction and membership
Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...
bpdmc.org
October 22, 2025 at 2:55 PM
quick reminder to come see @grocklin.bsky.social tonight at @mit.edu!
Reposted by Gabriel Rocklin
Join us in Room 181, Building 68 @mit.edu on October 22nd 2025 @ 7pm EDT to see @grocklin.bsky.social present a mind blowing amount of data and learn what becomes possible at this scale
"Predicting protein folding stability and aggregation propensity using large-scale experiments"
bpdmc.org
"Predicting protein folding stability and aggregation propensity using large-scale experiments"
bpdmc.org
schedule
introduction and membership
Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...
bpdmc.org
October 17, 2025 at 8:27 PM
Join us in Room 181, Building 68 @mit.edu on October 22nd 2025 @ 7pm EDT to see @grocklin.bsky.social present a mind blowing amount of data and learn what becomes possible at this scale
"Predicting protein folding stability and aggregation propensity using large-scale experiments"
bpdmc.org
"Predicting protein folding stability and aggregation propensity using large-scale experiments"
bpdmc.org
Reposted by Gabriel Rocklin
Announcing such a major change to NSF GRFP this late in the cycle is incredibly cruel. 2nd yr students (mine included) have been working so hard on their proposals despite ongoing uncertainty. They are driven and passionate about being outstanding scientists and helping those coming up behind them.
September 26, 2025 at 5:46 PM
Announcing such a major change to NSF GRFP this late in the cycle is incredibly cruel. 2nd yr students (mine included) have been working so hard on their proposals despite ongoing uncertainty. They are driven and passionate about being outstanding scientists and helping those coming up behind them.
Reposted by Gabriel Rocklin
Cecilia Payne-Gaposchkin ✨ figured out what stars are made of ✨ when she was just 25. 🔭🧪
Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students.
I wrote this little profile to mark the 100th anniversary of her thesis:
Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students.
I wrote this little profile to mark the 100th anniversary of her thesis:
September 24, 2025 at 9:14 AM
Cecilia Payne-Gaposchkin ✨ figured out what stars are made of ✨ when she was just 25. 🔭🧪
Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students.
I wrote this little profile to mark the 100th anniversary of her thesis:
Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students.
I wrote this little profile to mark the 100th anniversary of her thesis:
Reposted by Gabriel Rocklin
Vought and his “no more NIH money out the door” footnote is a power struggle. Between R’s getting antsy about hard votes and Senate signaling support for science funding, Vought had to signal his dominance in some way.
Now is the real test: are R’s more afraid of Trump et al. or their constituents?
Now is the real test: are R’s more afraid of Trump et al. or their constituents?
July 30, 2025 at 12:44 AM
Vought and his “no more NIH money out the door” footnote is a power struggle. Between R’s getting antsy about hard votes and Senate signaling support for science funding, Vought had to signal his dominance in some way.
Now is the real test: are R’s more afraid of Trump et al. or their constituents?
Now is the real test: are R’s more afraid of Trump et al. or their constituents?
Reposted by Gabriel Rocklin
The NIH can’t award ANY grants to outside researchers under new WH restriction, reports @wsj.com.
The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH.
Prelude to rescissions, especially after his comments over the weekend?
The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH.
Prelude to rescissions, especially after his comments over the weekend?
Trump Administration Puts New Chokehold on Billions in Health-Research Funding
The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.
www.wsj.com
July 30, 2025 at 12:44 AM
The NIH can’t award ANY grants to outside researchers under new WH restriction, reports @wsj.com.
The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH.
Prelude to rescissions, especially after his comments over the weekend?
The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH.
Prelude to rescissions, especially after his comments over the weekend?
Reposted by Gabriel Rocklin
One might think, oh the fiscal year is only two months. But many of our grants are already delayed by weeks to months and we are on borrowed time as is. This is devastating and heralds darker times ahead.
NEW
The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year
Chokes off billions in research funding
Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social
The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year
Chokes off billions in research funding
Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social
Trump Administration Puts New Chokehold on Billions in Health-Research Funding
The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.
www.wsj.com
July 30, 2025 at 12:22 AM
One might think, oh the fiscal year is only two months. But many of our grants are already delayed by weeks to months and we are on borrowed time as is. This is devastating and heralds darker times ahead.
Reposted by Gabriel Rocklin
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
July 23, 2025 at 7:35 PM
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
Reposted by Gabriel Rocklin
NCI's payline will be the 4th percentile. The Trump administration has effectively killed Cancer Research in the US
www.cancer.gov/grants-train...
www.cancer.gov/grants-train...
Funding Policy - Research Grants
NCI funding policy for research project grant (RPG) awards reflects the funding goals of the institute, NIH, and HHS.
www.cancer.gov
July 24, 2025 at 12:48 AM
NCI's payline will be the 4th percentile. The Trump administration has effectively killed Cancer Research in the US
www.cancer.gov/grants-train...
www.cancer.gov/grants-train...
Reposted by Gabriel Rocklin
A motivating quote from @carolynbertozzi.bskyverified.social:
“…You are discovering knowledge and gifting that to humanity for all of posterity. Once you learn something no one can take that away. It is not an object. It is an intellectual currency that will be shared throughout the generations…”
“…You are discovering knowledge and gifting that to humanity for all of posterity. Once you learn something no one can take that away. It is not an object. It is an intellectual currency that will be shared throughout the generations…”
July 15, 2025 at 11:59 PM
A motivating quote from @carolynbertozzi.bskyverified.social:
“…You are discovering knowledge and gifting that to humanity for all of posterity. Once you learn something no one can take that away. It is not an object. It is an intellectual currency that will be shared throughout the generations…”
“…You are discovering knowledge and gifting that to humanity for all of posterity. Once you learn something no one can take that away. It is not an object. It is an intellectual currency that will be shared throughout the generations…”
Reposted by Gabriel Rocklin
#MorganLabatND is hiring a research technician!! We are looking for an aspiring biochemistry researcher that shares our community values, is curious about the world around them, and brings a unique perspective to our team. (1/2)
jobs.smartrecruiters.com/UniversityOf...
jobs.smartrecruiters.com/UniversityOf...
Research Technician
Company Description: The University of Notre Dame is more than a workplace; it is a vibrant, mission-driven community where every employee is valued and supported. Rooted in a tradition of excellence ...
jobs.smartrecruiters.com
July 3, 2025 at 11:37 AM
#MorganLabatND is hiring a research technician!! We are looking for an aspiring biochemistry researcher that shares our community values, is curious about the world around them, and brings a unique perspective to our team. (1/2)
jobs.smartrecruiters.com/UniversityOf...
jobs.smartrecruiters.com/UniversityOf...
Reposted by Gabriel Rocklin
Although 500 new NSF GRFPs were added in June, the total number of fellowships in 2025 remains ~500 fewer than in 2024. Some fields—like CS and Physics—still saw net increases in total awards.
But others, including Life Sciences & Psychology, have taken hits of 50% or more compared to last year.
But others, including Life Sciences & Psychology, have taken hits of 50% or more compared to last year.
June 26, 2025 at 4:32 PM
Although 500 new NSF GRFPs were added in June, the total number of fellowships in 2025 remains ~500 fewer than in 2024. Some fields—like CS and Physics—still saw net increases in total awards.
But others, including Life Sciences & Psychology, have taken hits of 50% or more compared to last year.
But others, including Life Sciences & Psychology, have taken hits of 50% or more compared to last year.
Reposted by Gabriel Rocklin
Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation.
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
Targeted Inhibition of Translation Initiation via 2'O-Methylation of Start Codons https://www.biorxiv.org/content/10.1101/2025.06.14.659565v1
June 18, 2025 at 11:17 AM
Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation.
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
Reposted by Gabriel Rocklin
We are excited to share our new preprint, “An improved model for prediction of de novo designed proteins with diverse geometries”. (1/9) www.biorxiv.org/content/10.1...
An improved model for prediction of de novo designed proteins with diverse geometries
Nature uses structural variations on protein folds to fine-tune the geometries of proteins for diverse functions, yet deep learning-based de novo protein design methods generate highly regular, ideali...
www.biorxiv.org
June 10, 2025 at 6:28 PM
We are excited to share our new preprint, “An improved model for prediction of de novo designed proteins with diverse geometries”. (1/9) www.biorxiv.org/content/10.1...
Reposted by Gabriel Rocklin
Keep in mind: these are AWARDED grants, with Notice of Awards. The federal government is not honoring existing contracts with this university, refusing to reimburse for costs charge on awarded grants.
Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
June 7, 2025 at 8:30 PM
Keep in mind: these are AWARDED grants, with Notice of Awards. The federal government is not honoring existing contracts with this university, refusing to reimburse for costs charge on awarded grants.
Reposted by Gabriel Rocklin
Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
June 7, 2025 at 7:48 PM
Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
Reposted by Gabriel Rocklin
Note that this (exceptional) visualization does not appear to account for the Harvard, Brown, Northwestern terminations. This is a major underestimate
The gutting of US biomedical research with loss of ~2,500 grants affecting research for cancer, Alzheimer’s, infectious disease, global health and much more
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
June 4, 2025 at 3:50 PM
Note that this (exceptional) visualization does not appear to account for the Harvard, Brown, Northwestern terminations. This is a major underestimate
Reposted by Gabriel Rocklin
Do you love flow cytometry, cell sorting and other quantitative, biophysical approaches for measuring cells and their biomolecules? Join our team at Notre Dame!
www.linkedin.com/posts/ndbic_...
www.linkedin.com/posts/ndbic_...
Postdoctoral Research Associate | ND Biophysics Instrumentation Core Facility
Join our team at the ND Biophysics Instrumentation Core Facility! We're seeking a Postdoctoral Scholar to work at the forefront of optical and other techniques to measure biomolecular structure an...
www.linkedin.com
June 2, 2025 at 7:08 PM
Do you love flow cytometry, cell sorting and other quantitative, biophysical approaches for measuring cells and their biomolecules? Join our team at Notre Dame!
www.linkedin.com/posts/ndbic_...
www.linkedin.com/posts/ndbic_...
Reposted by Gabriel Rocklin
our lab is blessed to have 3 new postdoctoral fellow positions. we would welcome scientists interested in...
June 2, 2025 at 2:29 PM
our lab is blessed to have 3 new postdoctoral fellow positions. we would welcome scientists interested in...
Reposted by Gabriel Rocklin
The notion that private institutions need to toe the party line is so fundamentally un-American it is almost unbelievable
Linda McMahon: "Universities should continue to be able to do research as long as they're abiding by the laws and in sync, I think, with the administration and what the administration is trying to accomplish."
May 28, 2025 at 3:04 PM
The notion that private institutions need to toe the party line is so fundamentally un-American it is almost unbelievable
Reposted by Gabriel Rocklin
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
May 24, 2025 at 5:47 PM
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
Reposted by Gabriel Rocklin
Reposted by Gabriel Rocklin
The Ivy League should be preparing mutual defense agreements that would allow students to transfer, even just nominally, to any other Ivy.
Then the Big10 should do the same. We succeed together, we fail apart.
Then the Big10 should do the same. We succeed together, we fail apart.
May 23, 2025 at 11:49 AM
The Ivy League should be preparing mutual defense agreements that would allow students to transfer, even just nominally, to any other Ivy.
Then the Big10 should do the same. We succeed together, we fail apart.
Then the Big10 should do the same. We succeed together, we fail apart.