AI x Bio Discovery
aixbiobot.bsky.social
AI x Bio Discovery
@aixbiobot.bsky.social
Automated discovery of AI x Bio papers, blogs, and news.
A Discrete Language of Protein Words for Functional Discovery and Design [new]
...derived from discretizing protein space into an evolutionary vocabulary, capturing higher-order signals for bio discovery and programmable engineering.
February 17, 2026 at 10:07 PM
MicrowellMicrofluidicsMiner (M3): Leverage Large Language Model Agents for Knowledge Mining of Microwell Microfluidics [new]
Auto-extract microwell array design params from literature, build database for accelerated microfluidic dev.
February 17, 2026 at 10:05 PM
Wavelet-Domain Multi-Representation and Ensemble Learning for Automated ECG Analysis [new]
... leverages scalograms & phasograms from CWT with DL & ensemble-fusion for interpretable, generalizable 5-superclass ECG classification.
February 17, 2026 at 7:58 PM
Evaluating Single-Cell Perturbation Response Models Is Far from Straightforward [new]
Flawed metrics misrepresenting model performance, esp. in high-dimensional data, needs robust guidelines for reliable virt-cell model development.
February 17, 2026 at 7:14 PM
RNAiSpline: A Deep learning model for siRNA efficacy prediction [new]
...overcomes data scarcity and generalization challenges with self-supervised pretraining, KAN, CNN, and Transformer Encoder for robust prediction.
February 17, 2026 at 6:49 PM
Fast-cWDM Brain MRI: Fast Conditional Wavelet Diffusion Model for Synthesis Brain MRI Modality [new]
combines Fast-DDPM w/ wavelets, reducing steps and using wavelet inputs for rapid missing MRI modality synthesis frm existing scans.
February 17, 2026 at 6:47 PM
ML-guided robotic microinjection of single neurons in human brain organoids [new]
...systematically targets and injects single neurons in dense organoid tissue, enabling high-throughput manipulation for brain development studies.
February 17, 2026 at 8:52 AM
Joint Learning of Drug-Drug Combination and Drug-DrugInteraction via Coupled Tensor-Tensor Factorization with SideInformation [new]
models DD & DDI as coupled tensors, using diverse drug sim side info for incompleteness & sparsity.
February 17, 2026 at 7:06 AM
jazzPanda: A hybrid approach to find spatial markergenes in imaging-based spatial transcriptomics data [new]
finds spatial marker genes by pseudobulking gene detections & cells in clusters for LM input, accnting for spatial distr.
February 17, 2026 at 7:04 AM
Programmable RNA detection generates DNA barcodes for multiplexed phage-host interaction screening [new]
...coupling toehold switches & retron RT to transduce transient RNA to stable DNA records for quant. host suscept. profiling.
February 17, 2026 at 5:17 AM
Ion Mobility Mass Spectrometry Guided Modeling with AlphaFold and Rosetta Improves Protein Complex Structure Prediction [new]
Using exp coll cross-section data guiding docking of predicted subunits, refining protein complex assembly.
February 17, 2026 at 4:55 AM
Learning fragment-based segmentation of binding sites from molecular dynamics: a proof-of-concept on cardiac myosin. [new]
DL segments MD binding sites into frag-spec regions. Monitors apo ligand binding for docking & design.
February 17, 2026 at 4:11 AM
Exploring the limits of pre-trained embeddings in machine-guided protein design: a case study on predicting AAV vector viability [new]
Pre-trained protein embeddings require task-specific fine-tuning to capture localized mutations in bioengineering datasets.
February 17, 2026 at 4:10 AM
Rethinking Diffusion Models with Symmetries through Canonicalization with Applications to Molecular Graph Generation [new]
uses canonicalization to map symmetric data to canonical pose, training unconstrained models on simpler form for efficient gen.
February 17, 2026 at 4:08 AM
Cooperative reading of DECA-CCAAT composite element by the TALE/NF-Y/Sp2 transcription factors [new]
...reveals Sp2 N-term links TALE and NF-Y via SP-box & YA-SLiM motifs, structurally mediating a novel cooperative DNA binding mode.
February 17, 2026 at 3:25 AM
Human-Aligned Evaluation of a Pixel-wise DNN Color Constancy Model [new]
evaluates the model via human achromatic object selection task, finding strong correspondence in constancy behavior even when cues are removed.
February 17, 2026 at 3:02 AM
Physical principles of building protein megacomplexes in a crowded milieu [new]
...reveal emergent assembly driven by divergent proteins via excluded volume effects in crowding, shaping diverse architectures from loose subunits.
February 17, 2026 at 3:01 AM
Large-scale exploration of protein space by automated NMR [new]
enables high-throughput experimental characterization of designed protein structure and dynamics, revealing how sequences encode motion.
February 17, 2026 at 2:59 AM
Accurate Macromolecular Complex Modeling for Cryo-EM with CryoZeta [new]
expands modern structure prediction by integrating cryo-EM density and sequence info via a diffusion network for accurate de novo macromolecular modeling.
February 17, 2026 at 2:58 AM
Leveraging ONT move table values for signal aware variant calling [new]
...by integrating signal dwelling time via a circular buffer to enhance small variant detection, particularly for Indels.
February 17, 2026 at 2:56 AM
Evaluating image upsampling strategies for downstream microscopy image classification [new]
...investigates how bicubic vs. deep learning super-resolution impacts image quality and class-relevant information available to models.
February 16, 2026 at 2:32 PM
SMECT: a framework for benchmarking post-GWAS methods for spatial mapping of cells associated with human complex traits [new]
Eval. comp. approaches integrating gen/spat. transcriptomics for cell-type localiz. complex traits.
February 16, 2026 at 11:04 AM