AI x Bio Discovery
@aixbiobot.bsky.social
Automated discovery of AI x Bio papers, blogs, and news.
Physically Grounded Generative Modeling of All-Atom Biomolecular Dynamics [new]
predicts continuous, all-atom kinetic pathways via diffusion & hierarchical forecasting, facilitating exploration of complex structure-function dynamics.
predicts continuous, all-atom kinetic pathways via diffusion & hierarchical forecasting, facilitating exploration of complex structure-function dynamics.
February 16, 2026 at 3:07 AM
Physically Grounded Generative Modeling of All-Atom Biomolecular Dynamics [new]
predicts continuous, all-atom kinetic pathways via diffusion & hierarchical forecasting, facilitating exploration of complex structure-function dynamics.
predicts continuous, all-atom kinetic pathways via diffusion & hierarchical forecasting, facilitating exploration of complex structure-function dynamics.
LinkedNN: a neural model of linkage disequilibrium decay for recent effective population size inference [new]
...inference using a neural network to automatically compute LD decay features from sparse, unphased genomic data for molecular ecology.
...inference using a neural network to automatically compute LD decay features from sparse, unphased genomic data for molecular ecology.
February 16, 2026 at 2:23 AM
LinkedNN: a neural model of linkage disequilibrium decay for recent effective population size inference [new]
...inference using a neural network to automatically compute LD decay features from sparse, unphased genomic data for molecular ecology.
...inference using a neural network to automatically compute LD decay features from sparse, unphased genomic data for molecular ecology.
Accelerating Mathematical and Scientific Discovery with Gemini Deep Think [blog]
Accelerating mathematical and scientific discovery, its impact is growing across diverse research fields.
Accelerating mathematical and scientific discovery, its impact is growing across diverse research fields.
February 15, 2026 at 10:54 PM
Accelerating Mathematical and Scientific Discovery with Gemini Deep Think [blog]
Accelerating mathematical and scientific discovery, its impact is growing across diverse research fields.
Accelerating mathematical and scientific discovery, its impact is growing across diverse research fields.
Gemini 3 Deep Think: Advancing science, research and engineering [blog]
...its specialized reasoning mode is updated to tackle modern science, research, and engineering challenges.
...its specialized reasoning mode is updated to tackle modern science, research, and engineering challenges.
February 15, 2026 at 10:53 PM
Gemini 3 Deep Think: Advancing science, research and engineering [blog]
...its specialized reasoning mode is updated to tackle modern science, research, and engineering challenges.
...its specialized reasoning mode is updated to tackle modern science, research, and engineering challenges.
Terray says its AI model beats Boltz-2 at binding affinity prediction [blog]
...via a contrarian AI drug discovery approach, diverging from prevalent diffusion models inspired by AlphaFold.
...via a contrarian AI drug discovery approach, diverging from prevalent diffusion models inspired by AlphaFold.
February 15, 2026 at 10:52 PM
Terray says its AI model beats Boltz-2 at binding affinity prediction [blog]
...via a contrarian AI drug discovery approach, diverging from prevalent diffusion models inspired by AlphaFold.
...via a contrarian AI drug discovery approach, diverging from prevalent diffusion models inspired by AlphaFold.
GATSBI: Improving context-aware protein embeddingsthrough biologically motivated data splits [new]
Protein embeddings from diverse biol. networks. Task-aligned splits ensure utility for various pred tasks, esp. understudied proteins.
Protein embeddings from diverse biol. networks. Task-aligned splits ensure utility for various pred tasks, esp. understudied proteins.
February 15, 2026 at 8:06 PM
GATSBI: Improving context-aware protein embeddingsthrough biologically motivated data splits [new]
Protein embeddings from diverse biol. networks. Task-aligned splits ensure utility for various pred tasks, esp. understudied proteins.
Protein embeddings from diverse biol. networks. Task-aligned splits ensure utility for various pred tasks, esp. understudied proteins.
February 15, 2026 at 5:38 PM
Heuristics for lab robotics, and where its future may go [new]
...explores strategies (software, hardware, AI) to lower automation barriers, fostering centralized cloud labs for more impactful R&D.
...explores strategies (software, hardware, AI) to lower automation barriers, fostering centralized cloud labs for more impactful R&D.
February 15, 2026 at 4:13 PM
Heuristics for lab robotics, and where its future may go [new]
...explores strategies (software, hardware, AI) to lower automation barriers, fostering centralized cloud labs for more impactful R&D.
...explores strategies (software, hardware, AI) to lower automation barriers, fostering centralized cloud labs for more impactful R&D.
February 15, 2026 at 4:12 PM
Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans [new]
Integrating drift & sparse measurements, prob. framework refines clonal trees linking lineage hist. & cell state in health/disease.
Integrating drift & sparse measurements, prob. framework refines clonal trees linking lineage hist. & cell state in health/disease.
February 15, 2026 at 4:04 PM
Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans [new]
Integrating drift & sparse measurements, prob. framework refines clonal trees linking lineage hist. & cell state in health/disease.
Integrating drift & sparse measurements, prob. framework refines clonal trees linking lineage hist. & cell state in health/disease.
A scalable approach to resolving variants of uncertain significance [new]
...leveraging comprehensive experimental & predictive data across 40 genes to reclassify existing VUS and preclassify future variants.
...leveraging comprehensive experimental & predictive data across 40 genes to reclassify existing VUS and preclassify future variants.
February 15, 2026 at 11:03 AM
A scalable approach to resolving variants of uncertain significance [new]
...leveraging comprehensive experimental & predictive data across 40 genes to reclassify existing VUS and preclassify future variants.
...leveraging comprehensive experimental & predictive data across 40 genes to reclassify existing VUS and preclassify future variants.
dsRBD Redesign: A Targeted Strategy for Inhibition of RNA Helicase DHX9 [new]
uses computationally designed protein binders to block DHX9's autoregulatory dsRBD2-core interface preventing interaction and inhibiting helicase activity.
uses computationally designed protein binders to block DHX9's autoregulatory dsRBD2-core interface preventing interaction and inhibiting helicase activity.
February 15, 2026 at 11:01 AM
dsRBD Redesign: A Targeted Strategy for Inhibition of RNA Helicase DHX9 [new]
uses computationally designed protein binders to block DHX9's autoregulatory dsRBD2-core interface preventing interaction and inhibiting helicase activity.
uses computationally designed protein binders to block DHX9's autoregulatory dsRBD2-core interface preventing interaction and inhibiting helicase activity.
The generation and validation of a de novo-designed titin binder for use in fluorescence microscopy [new]
Binder labels M10 domain in M-band, enabling Ab-free vis. validating in silico prot. design for complex bio targets.
Binder labels M10 domain in M-band, enabling Ab-free vis. validating in silico prot. design for complex bio targets.
February 15, 2026 at 3:09 AM
The generation and validation of a de novo-designed titin binder for use in fluorescence microscopy [new]
Binder labels M10 domain in M-band, enabling Ab-free vis. validating in silico prot. design for complex bio targets.
Binder labels M10 domain in M-band, enabling Ab-free vis. validating in silico prot. design for complex bio targets.
Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologies [new]
Compares HTS validating comp. des. miniprot. binder libs, addressing exp. bottleneck to scale therapy disc.
Compares HTS validating comp. des. miniprot. binder libs, addressing exp. bottleneck to scale therapy disc.
February 15, 2026 at 1:58 AM
Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologies [new]
Compares HTS validating comp. des. miniprot. binder libs, addressing exp. bottleneck to scale therapy disc.
Compares HTS validating comp. des. miniprot. binder libs, addressing exp. bottleneck to scale therapy disc.
Genome-wide single-cell perturbation screens with VIPerturb-seq [new]
...are now routine through probe-based detection and phenotypic enrichment, using combinatorial indexing for expanded throughput.
...are now routine through probe-based detection and phenotypic enrichment, using combinatorial indexing for expanded throughput.
February 14, 2026 at 11:56 AM
Genome-wide single-cell perturbation screens with VIPerturb-seq [new]
...are now routine through probe-based detection and phenotypic enrichment, using combinatorial indexing for expanded throughput.
...are now routine through probe-based detection and phenotypic enrichment, using combinatorial indexing for expanded throughput.
Unifying Non-Equilibrium Information Thermodynamics and Genome Engine Dynamics: Maxwell's Demon Control of Cancer Cell Fates [new]
Maxwell's Demon crit. pt., orders cancer genome dynamics for global coherence & irreversible fate.
Maxwell's Demon crit. pt., orders cancer genome dynamics for global coherence & irreversible fate.
February 14, 2026 at 11:54 AM
Unifying Non-Equilibrium Information Thermodynamics and Genome Engine Dynamics: Maxwell's Demon Control of Cancer Cell Fates [new]
Maxwell's Demon crit. pt., orders cancer genome dynamics for global coherence & irreversible fate.
Maxwell's Demon crit. pt., orders cancer genome dynamics for global coherence & irreversible fate.
CodonRL: Multi-Objective Codon Sequence Optimization Using Demonstration-Guided Reinforcement Learning [new]
...learns struct. priors from folding feedback & expert sequences, enabling user-ctrl tradeoffs for enhanced mRNA design.
...learns struct. priors from folding feedback & expert sequences, enabling user-ctrl tradeoffs for enhanced mRNA design.
February 14, 2026 at 11:30 AM
CodonRL: Multi-Objective Codon Sequence Optimization Using Demonstration-Guided Reinforcement Learning [new]
...learns struct. priors from folding feedback & expert sequences, enabling user-ctrl tradeoffs for enhanced mRNA design.
...learns struct. priors from folding feedback & expert sequences, enabling user-ctrl tradeoffs for enhanced mRNA design.
Discovery of TDP-43 aggregation inhibitors via a hybrid machine learning framework [new]
integrating GNN, descriptors, & annotations to identify berberrubine & PE859, inhibiting aggregation in cells and C. elegans.
integrating GNN, descriptors, & annotations to identify berberrubine & PE859, inhibiting aggregation in cells and C. elegans.
February 14, 2026 at 11:08 AM
Discovery of TDP-43 aggregation inhibitors via a hybrid machine learning framework [new]
integrating GNN, descriptors, & annotations to identify berberrubine & PE859, inhibiting aggregation in cells and C. elegans.
integrating GNN, descriptors, & annotations to identify berberrubine & PE859, inhibiting aggregation in cells and C. elegans.
Feature-based in-silico model to predict the Mycobacterium tuberculosis bedaquiline phenotype associated with Rv0678 variants [new]
Uses 5 feats (evo conserv, funct site prox) to interpret Rv0678 var impact & guide clin mgmt.
Uses 5 feats (evo conserv, funct site prox) to interpret Rv0678 var impact & guide clin mgmt.
February 14, 2026 at 11:06 AM
Feature-based in-silico model to predict the Mycobacterium tuberculosis bedaquiline phenotype associated with Rv0678 variants [new]
Uses 5 feats (evo conserv, funct site prox) to interpret Rv0678 var impact & guide clin mgmt.
Uses 5 feats (evo conserv, funct site prox) to interpret Rv0678 var impact & guide clin mgmt.
February 14, 2026 at 11:04 AM
Democratised single cell proteomics uncovers tumor associated macrophage signature in CYLD cutaneous syndrome skin tumors [new]
Accessible, cost-effective, label-free tech found novel TME remodeling macrophage pop in CCS skin tumors.
Accessible, cost-effective, label-free tech found novel TME remodeling macrophage pop in CCS skin tumors.
February 14, 2026 at 11:03 AM
Democratised single cell proteomics uncovers tumor associated macrophage signature in CYLD cutaneous syndrome skin tumors [new]
Accessible, cost-effective, label-free tech found novel TME remodeling macrophage pop in CCS skin tumors.
Accessible, cost-effective, label-free tech found novel TME remodeling macrophage pop in CCS skin tumors.
Evolution of oncogene amplification across 86,000 cancer cell genomes [new]
...shows distinct evo paths for ICamp & ecDNA amplifications: ICamp has subclonal spec.; ecDNA has variable, rearrangement-driven, tissue-spec. evolution.
...shows distinct evo paths for ICamp & ecDNA amplifications: ICamp has subclonal spec.; ecDNA has variable, rearrangement-driven, tissue-spec. evolution.
February 14, 2026 at 10:40 AM
Evolution of oncogene amplification across 86,000 cancer cell genomes [new]
...shows distinct evo paths for ICamp & ecDNA amplifications: ICamp has subclonal spec.; ecDNA has variable, rearrangement-driven, tissue-spec. evolution.
...shows distinct evo paths for ICamp & ecDNA amplifications: ICamp has subclonal spec.; ecDNA has variable, rearrangement-driven, tissue-spec. evolution.
Cell phenotypes in the biomedical literature: a systematic analysis and text mining corpus [new]
Annotated corpus of literature cell phenotypes links them to Cell Ontology, revealing naming patterns and enabling ontology expansion.
Annotated corpus of literature cell phenotypes links them to Cell Ontology, revealing naming patterns and enabling ontology expansion.
February 14, 2026 at 9:14 AM
Cell phenotypes in the biomedical literature: a systematic analysis and text mining corpus [new]
Annotated corpus of literature cell phenotypes links them to Cell Ontology, revealing naming patterns and enabling ontology expansion.
Annotated corpus of literature cell phenotypes links them to Cell Ontology, revealing naming patterns and enabling ontology expansion.
ChatDIA: A zero-shot large language model workflow for targeted analysis of data-independent acquisition mass spectrometry data [new]
automates targeted DIA peptide ID & interactive data expl. via zero-shot LLM reason chromatograms.
automates targeted DIA peptide ID & interactive data expl. via zero-shot LLM reason chromatograms.
February 14, 2026 at 9:01 AM
ChatDIA: A zero-shot large language model workflow for targeted analysis of data-independent acquisition mass spectrometry data [new]
automates targeted DIA peptide ID & interactive data expl. via zero-shot LLM reason chromatograms.
automates targeted DIA peptide ID & interactive data expl. via zero-shot LLM reason chromatograms.
A single-cell atlas and aging clock define biological age and risk-associated stem cell states in human hematopoiesis [new]
HSPC atlas to define age programs. An ML aging clock predicts age; AML dev. links to gen. risk & survival.
HSPC atlas to define age programs. An ML aging clock predicts age; AML dev. links to gen. risk & survival.
February 14, 2026 at 8:59 AM
A single-cell atlas and aging clock define biological age and risk-associated stem cell states in human hematopoiesis [new]
HSPC atlas to define age programs. An ML aging clock predicts age; AML dev. links to gen. risk & survival.
HSPC atlas to define age programs. An ML aging clock predicts age; AML dev. links to gen. risk & survival.