Reika Watanabe
@reikawatanabe.bsky.social
Biologist fascinated by and specialized in cellular cryo-electron tomography @ljiresearch.bsky.social. #teamtomo, #cryoET, #virology
Pinned
Reika Watanabe
@reikawatanabe.bsky.social
· Dec 24
Hello, old and new friends in Bluesky.
Using cryo-FIB-ET, we revealed a 9Å structure, identifying novel layers and conserved interfaces that may serve as antiviral targets. #Ebola #Virology #StructuralBiology
The full manuscript is available here
authors.elsevier.com/sd/article/S...
Using cryo-FIB-ET, we revealed a 9Å structure, identifying novel layers and conserved interfaces that may serve as antiviral targets. #Ebola #Virology #StructuralBiology
The full manuscript is available here
authors.elsevier.com/sd/article/S...
Reposted by Reika Watanabe
In situ structure of a gap junction-stomatin complex pubmed.ncbi.nlm.nih.gov/41191766/ #cryoem
November 6, 2025 at 10:49 PM
In situ structure of a gap junction-stomatin complex pubmed.ncbi.nlm.nih.gov/41191766/ #cryoem
Reposted by Reika Watanabe
Hey #TeamTomo 🧪🔬, ICECREAM is getting tastier! Please give it a try on your tomograms and send us feedback so we can get the recipe just right 🍦😋
I'm pleased to announce 🍦 Icecream 🍨 v0.3!
New features include:
* Training on multiple tomograms (same training time, with linear increase in RAM) 🚀
* Logging and plotting of the loss function 📉
* The --scale option is now called --eq-weight for clarity 😉
We'd love to hear your feedback! 🙏🏽
New features include:
* Training on multiple tomograms (same training time, with linear increase in RAM) 🚀
* Logging and plotting of the loss function 📉
* The --scale option is now called --eq-weight for clarity 😉
We'd love to hear your feedback! 🙏🏽
November 6, 2025 at 8:39 AM
Hey #TeamTomo 🧪🔬, ICECREAM is getting tastier! Please give it a try on your tomograms and send us feedback so we can get the recipe just right 🍦😋
Reposted by Reika Watanabe
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
Reposted by Reika Watanabe
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
November 6, 2025 at 3:46 PM
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
Reposted by Reika Watanabe
The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2
October 21, 2025 at 9:47 PM
The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2
Reposted by Reika Watanabe
mRNA vaccines 🤝 designed nanoparticle immunogens
This week's issue of #ScienceTranslationalMedicine has arrived!
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
October 15, 2025 at 10:00 PM
mRNA vaccines 🤝 designed nanoparticle immunogens
Reposted by Reika Watanabe
Opportunity in computational structural biology at ISTA (Vienna Austria) duration: 5 years with possibility of permanent contract #StructBiol #cryoEM #cryoET #chemsky 🧪
ista.ac.at/en/job/tenur...
ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 16, 2025 at 6:30 AM
Opportunity in computational structural biology at ISTA (Vienna Austria) duration: 5 years with possibility of permanent contract #StructBiol #cryoEM #cryoET #chemsky 🧪
ista.ac.at/en/job/tenur...
ista.ac.at/en/job/tenur...
Reposted by Reika Watanabe
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
beta.ideas.lego.com
October 16, 2025 at 8:07 AM
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...
beta.ideas.lego.com/product-idea...
Reposted by Reika Watanabe
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
今年のノーベル生理学、医学賞を受賞された、坂口先生のインタビューが見れます！おめでとうございます！🎉 www.osaka-u.ac.jp/ja/news/topi...
【速報】坂口志文先生 ノーベル生理学・医学賞受賞決定！！！
www.osaka-u.ac.jp
October 7, 2025 at 1:12 AM
今年のノーベル生理学、医学賞を受賞された、坂口先生のインタビューが見れます！おめでとうございます！🎉 www.osaka-u.ac.jp/ja/news/topi...
Reposted by Reika Watanabe
This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi
Medicine Nobel goes to three researchers who identified immune system’s security guards
Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease
scim.ag
October 6, 2025 at 1:45 PM
This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi
Reposted by Reika Watanabe
UMass Amherst Microbiology is hiring a tenure-track virologist. Come work with me! 🦠🧪
careers.umass.edu/amherst/en-u...
careers.umass.edu/amherst/en-u...
Details - Assistant Professor - Virology | Human Resources | UMass Amherst
careers.umass.edu
October 2, 2025 at 2:51 PM
UMass Amherst Microbiology is hiring a tenure-track virologist. Come work with me! 🦠🧪
careers.umass.edu/amherst/en-u...
careers.umass.edu/amherst/en-u...
Reposted by Reika Watanabe
This is a fucking tragedy www.cbc.ca/news/canada/...
Premature baby dies of measles in Alberta outbreak's 1st death | CBC News
Alberta is reporting its first measles death since outbreaks of the highly contagious illness began in March. The province says a baby, who was born prematurely after the mother became sick, died shor...
www.cbc.ca
October 2, 2025 at 11:41 PM
This is a fucking tragedy www.cbc.ca/news/canada/...
Reposted by Reika Watanabe
⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
OGA - Only Good Antibodies Community
onlygoodantibodies.co.uk
September 29, 2025 at 6:34 PM
⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes | Nature Communications share.google/1S8f1xeAJa0E...
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes - Nature Communications
Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure balance, and how deviations emerge during pathophysiological states like senescence.
share.google
September 27, 2025 at 3:01 PM
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes | Nature Communications share.google/1S8f1xeAJa0E...
Reposted by Reika Watanabe
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
September 23, 2025 at 10:42 AM
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
Reposted by Reika Watanabe
Our second paper explores the mechanism by which fusion-targeting antibodies neutralize the measles virus. It was exciting to integrate structural biology, virology, and biophysics to demonstrate that these F-targeting antibodies can provide complete protection against measles infection.
Structural and Mechanistic Basis for Antibody Neutralization of the Measles Fusion Protein https://www.biorxiv.org/content/10.1101/2025.09.11.675466v1
September 17, 2025 at 12:58 AM
Our second paper explores the mechanism by which fusion-targeting antibodies neutralize the measles virus. It was exciting to integrate structural biology, virology, and biophysics to demonstrate that these F-targeting antibodies can provide complete protection against measles infection.
Reposted by Reika Watanabe
One of our new manuscripts is now available on bioRxiv! Stay tuned!
Uncovering the features of Measles-targeting human antibodies elicited by the MMR vaccine https://www.biorxiv.org/content/10.1101/2025.09.09.675230v1
September 16, 2025 at 5:30 AM
One of our new manuscripts is now available on bioRxiv! Stay tuned!
Reposted by Reika Watanabe
Vaccination of frontline health workers and contacts of people infected with #Ebola has begun in the #DRC’s Kasai Province where an outbreak of the disease has been declared: www.afro.who.int/countries/de...
September 14, 2025 at 1:06 PM
Vaccination of frontline health workers and contacts of people infected with #Ebola has begun in the #DRC’s Kasai Province where an outbreak of the disease has been declared: www.afro.who.int/countries/de...
Reposted by Reika Watanabe
📢 Conduct your PhD thesis research at Janelia.
🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology.
🌐 Collaborate across disciplines
🛠️ Work with tool builders
🤝 Train in a supportive environment
➡️ janelia.org/graduate
🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology.
🌐 Collaborate across disciplines
🛠️ Work with tool builders
🤝 Train in a supportive environment
➡️ janelia.org/graduate
September 5, 2025 at 3:00 PM
📢 Conduct your PhD thesis research at Janelia.
🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology.
🌐 Collaborate across disciplines
🛠️ Work with tool builders
🤝 Train in a supportive environment
➡️ janelia.org/graduate
🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology.
🌐 Collaborate across disciplines
🛠️ Work with tool builders
🤝 Train in a supportive environment
➡️ janelia.org/graduate
Reposted by Reika Watanabe
Important and timely study
Pregnant women face higher risks from Ebola: maternal mortality up to 89%, and nearly all pregnancies lost. Until now, they’ve been excluded from Ebola vaccine trials. A landmark phase 3 RCT in Rwanda changes that.@natureportfolio.nature.com
www.nature.com/articles/s41...
Pregnant women face higher risks from Ebola: maternal mortality up to 89%, and nearly all pregnancies lost. Until now, they’ve been excluded from Ebola vaccine trials. A landmark phase 3 RCT in Rwanda changes that.@natureportfolio.nature.com
www.nature.com/articles/s41...
Heterologous two-dose Ebola vaccine regimen in pregnant women in Rwanda: a randomized controlled phase 3 trial - Nature Medicine
In this phase 3 trial, a two-dose Ebola vaccine regimen in healthy pregnant women in Rwanda was found to be safe and immunogenic in women and offspring through passive transfer.
www.nature.com
September 9, 2025 at 4:26 PM
Important and timely study
Pregnant women face higher risks from Ebola: maternal mortality up to 89%, and nearly all pregnancies lost. Until now, they’ve been excluded from Ebola vaccine trials. A landmark phase 3 RCT in Rwanda changes that.@natureportfolio.nature.com
www.nature.com/articles/s41...
Pregnant women face higher risks from Ebola: maternal mortality up to 89%, and nearly all pregnancies lost. Until now, they’ve been excluded from Ebola vaccine trials. A landmark phase 3 RCT in Rwanda changes that.@natureportfolio.nature.com
www.nature.com/articles/s41...
Reposted by Reika Watanabe
Identification of a novel biological role of arenavirus NP exonuclease (exoN) activity in a safe Pichinde virus model https://www.biorxiv.org/content/10.1101/2025.09.09.675144v1
September 10, 2025 at 4:18 AM
Identification of a novel biological role of arenavirus NP exonuclease (exoN) activity in a safe Pichinde virus model https://www.biorxiv.org/content/10.1101/2025.09.09.675144v1
Reposted by Reika Watanabe
We are hiring-join us!
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
September 8, 2025 at 10:31 AM
We are hiring-join us!
Reposted by Reika Watanabe
Ultracold cryogenic TEM with liquid helium and high stability pubmed.ncbi.nlm.nih.gov/40911601/ #cryoem
September 7, 2025 at 4:54 AM
Ultracold cryogenic TEM with liquid helium and high stability pubmed.ncbi.nlm.nih.gov/40911601/ #cryoem
