Dawid Zyla
@dzyla.bsky.social
Instructor in the Saphire lab at La Jolla Institute for Immunology, working on the structural biology of viral glycoproteins. ETH Zürich alumnus. In my free time, a photographer and programmer. #cryoem #python http://dzyla.com
Pinned
Dawid Zyla
@dzyla.bsky.social
· Jun 28
A neutralizing antibody prevents postfusion transition of measles virus fusion protein
Measles virus (MeV) presents a public health threat that is escalating as vaccine coverage in the general population declines and as populations of immunocompromised individuals, who cannot be vaccina...
doi.org
I am excited to share our study in Science on #measles fusion glycoprotein in complex with the first neutralizing antibody described for this virus! doi.org/10.1126/scie...
Reposted by Dawid Zyla
It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know.
#virology #cryoEM
go.bsky.app/Qxv95BL
#virology #cryoEM
go.bsky.app/Qxv95BL
November 25, 2025 at 9:46 AM
It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know.
#virology #cryoEM
go.bsky.app/Qxv95BL
#virology #cryoEM
go.bsky.app/Qxv95BL
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
November 23, 2025 at 11:18 PM
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
Reposted by Dawid Zyla
#NZ measles 🦠
- Now 14 cases
- Needs a week-plus to know if there will be a surge in cases (owing to the non-symptomatic phase), and how widespread
- vaccination is free
RNZ: Extent of measles outbreak will be confirmed over coming days, an epidemiologist says ⬇️
- Now 14 cases
- Needs a week-plus to know if there will be a surge in cases (owing to the non-symptomatic phase), and how widespread
- vaccination is free
RNZ: Extent of measles outbreak will be confirmed over coming days, an epidemiologist says ⬇️
Extent of measles outbreak will be confirmed over coming days, an epidemiologist says
There are currently no hospitalisations linked to the outbreak.
www.rnz.co.nz
October 31, 2025 at 5:30 AM
#NZ measles 🦠
- Now 14 cases
- Needs a week-plus to know if there will be a surge in cases (owing to the non-symptomatic phase), and how widespread
- vaccination is free
RNZ: Extent of measles outbreak will be confirmed over coming days, an epidemiologist says ⬇️
- Now 14 cases
- Needs a week-plus to know if there will be a surge in cases (owing to the non-symptomatic phase), and how widespread
- vaccination is free
RNZ: Extent of measles outbreak will be confirmed over coming days, an epidemiologist says ⬇️
Reposted by Dawid Zyla
Interesting side-quest.
Has #measles immunity in children declined in Austria due to the #COVID19 pandemic, driving measles outbreaks? (It also tangentially addresses a group's assumption that SARS-CoV-2 "destroys our immune system" and is "airborne AIDS" or whatever).
Answer: no, it did not.
1/2
Has #measles immunity in children declined in Austria due to the #COVID19 pandemic, driving measles outbreaks? (It also tangentially addresses a group's assumption that SARS-CoV-2 "destroys our immune system" and is "airborne AIDS" or whatever).
Answer: no, it did not.
1/2
April 25, 2025 at 2:05 AM
Reposted by Dawid Zyla
Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo https://www.biorxiv.org/content/10.1101/2025.10.07.681039v1
October 9, 2025 at 10:15 AM
Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In Vivo https://www.biorxiv.org/content/10.1101/2025.10.07.681039v1
Reposted by Dawid Zyla
Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
September 25, 2025 at 3:01 PM
Huntingtin binds and bundles F-actin!
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery.
We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead!
#TeamTomo #CryoET #HTT #actin
doi.org/10.1126/scia...
Reposted by Dawid Zyla
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology
imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for
>4,400 viruses, allowing mapping of form and function across the human and animal
virosphere. Viro3D i...
www.embopress.org
September 28, 2025 at 5:39 AM
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Our second paper explores the mechanism by which fusion-targeting antibodies neutralize the measles virus. It was exciting to integrate structural biology, virology, and biophysics to demonstrate that these F-targeting antibodies can provide complete protection against measles infection.
Structural and Mechanistic Basis for Antibody Neutralization of the Measles Fusion Protein https://www.biorxiv.org/content/10.1101/2025.09.11.675466v1
September 17, 2025 at 12:58 AM
Our second paper explores the mechanism by which fusion-targeting antibodies neutralize the measles virus. It was exciting to integrate structural biology, virology, and biophysics to demonstrate that these F-targeting antibodies can provide complete protection against measles infection.
One of our new manuscripts is now available on bioRxiv! Stay tuned!
Uncovering the features of Measles-targeting human antibodies elicited by the MMR vaccine https://www.biorxiv.org/content/10.1101/2025.09.09.675230v1
September 16, 2025 at 5:30 AM
One of our new manuscripts is now available on bioRxiv! Stay tuned!
Reposted by Dawid Zyla
"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET - Nature Communications
This study delineates the full sequence of SARS-CoV-2 spike-mediated membrane fusion and shows how S2-targeting antibodies inhibit this process, using a near-native functional fusion system and cryo-e...
www.nature.com
June 15, 2025 at 2:04 PM
"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dawid Zyla
Hi everyone! I’m a #NewPI just starting my lab and would love to hear your advice on lab management and building the lab culture. Any tips, lessons learned, or resources you’ve found helpful are very welcome! Feel free to reply, message me, or email me at rcastellsg(at)cnio.es
thanks a lot!! 🤗
thanks a lot!! 🤗
a cat is sitting in front of a laptop computer asking for advice
ALT: a cat is sitting in front of a laptop computer asking for advice
media.tenor.com
May 7, 2025 at 10:47 PM
Hi everyone! I’m a #NewPI just starting my lab and would love to hear your advice on lab management and building the lab culture. Any tips, lessons learned, or resources you’ve found helpful are very welcome! Feel free to reply, message me, or email me at rcastellsg(at)cnio.es
thanks a lot!! 🤗
thanks a lot!! 🤗
Reposted by Dawid Zyla
My colleagues @phaips.vd.st and @florentwaltz.bsky.social have put together this wonderful website with step-by-step tutorials for in situ subtomogram averaging using different software packages 🤩
Check it out, especially if you are a newcomer to the field!
#CryoET #TeamTomo #ChlamyDataset
Check it out, especially if you are a newcomer to the field!
#CryoET #TeamTomo #ChlamyDataset
Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Welcome to TomoGuide
A step-by-step Cryo-ET guide
tomoguide.github.io
May 7, 2025 at 6:28 AM
My colleagues @phaips.vd.st and @florentwaltz.bsky.social have put together this wonderful website with step-by-step tutorials for in situ subtomogram averaging using different software packages 🤩
Check it out, especially if you are a newcomer to the field!
#CryoET #TeamTomo #ChlamyDataset
Check it out, especially if you are a newcomer to the field!
#CryoET #TeamTomo #ChlamyDataset
Reposted by Dawid Zyla
“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬
Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!
tomoguide.github.io
Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Welcome to TomoGuide
A step-by-step Cryo-ET guide
tomoguide.github.io
May 7, 2025 at 10:56 AM
“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬
Reposted by Dawid Zyla
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
May 2, 2025 at 2:39 PM
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
1/5: Over the last few months, I have been working on an update for the #FollowRelionGracefully dashboard, which offers improved real-time job previews for #cryoEM #Relion jobs.
April 27, 2025 at 8:49 PM
1/5: Over the last few months, I have been working on an update for the #FollowRelionGracefully dashboard, which offers improved real-time job previews for #cryoEM #Relion jobs.
Reposted by Dawid Zyla
Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction.
👏 Tatjana v. Rosen, Rafal Zdanowicz & @yasser-elhadeg.bsky.social
🔗 www.nature.com/articles/s41...
👏 Tatjana v. Rosen, Rafal Zdanowicz & @yasser-elhadeg.bsky.social
🔗 www.nature.com/articles/s41...
Substrates bind to residues lining the ring of asymmetrically engaged bacterial proteasome activator Bpa - Nature Communications
Mycobacterium tuberculosis has a proteasome similar to eukaryotes. This study reveals how the activator Bpa recruits its substrate HspR, providing structural and mechanistic insights. The authors iden...
www.nature.com
March 28, 2025 at 4:02 PM
Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction.
👏 Tatjana v. Rosen, Rafal Zdanowicz & @yasser-elhadeg.bsky.social
🔗 www.nature.com/articles/s41...
👏 Tatjana v. Rosen, Rafal Zdanowicz & @yasser-elhadeg.bsky.social
🔗 www.nature.com/articles/s41...
Reposted by Dawid Zyla
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
April 11, 2025 at 9:04 AM
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
Reposted by Dawid Zyla
Check out our new story led by @aesully98.bsky.social describing how bacteria turn immune evasion against phage! In collaboration with @benmorehouse.bsky.social lab, we discover that bacteria guard their nucleotide second messenger pool using a nucleotidyltransferase related to Cas10/CRISPR enzymes
Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.
A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins
Bacteria use antiphage systems to combat phages, their ubiquitous competitors, and evolve new defenses through repeated reshuffling of basic functional units into novel reformulations. A common theme ...
www.biorxiv.org
April 8, 2025 at 2:52 AM
Check out our new story led by @aesully98.bsky.social describing how bacteria turn immune evasion against phage! In collaboration with @benmorehouse.bsky.social lab, we discover that bacteria guard their nucleotide second messenger pool using a nucleotidyltransferase related to Cas10/CRISPR enzymes
Reposted by Dawid Zyla
✨✨ It's #glycotime for #HIV Env ✨✨
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
March 28, 2025 at 4:23 AM
✨✨ It's #glycotime for #HIV Env ✨✨
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
N-linked glycans modulate flexibility & MPER epitope exposure #glycotime
Huge effort by @shehata92.bsky.social @lcasalino88.bsky.social with cryoET of Env in VLPs by @thevillalab.bsky.social & team 💪
Would love feedback!
www.biorxiv.org/content/10.1...
Happy to share that our manuscript on the anti-measles antibody is mentioned in this article:
Measles can ravage the immune system and brain, causing long-term damage – a virologist explains theconversation.com/measles-can-...
Measles can ravage the immune system and brain, causing long-term damage – a virologist explains theconversation.com/measles-can-...
Measles can ravage the immune system and brain, causing long-term damage – a virologist explains
Complications from measles infection are surprisingly common.
theconversation.com
April 1, 2025 at 11:09 PM
Happy to share that our manuscript on the anti-measles antibody is mentioned in this article:
Measles can ravage the immune system and brain, causing long-term damage – a virologist explains theconversation.com/measles-can-...
Measles can ravage the immune system and brain, causing long-term damage – a virologist explains theconversation.com/measles-can-...
Reposted by Dawid Zyla
Herpes viruses are among the most widespread human viruses. Scientists have shown how HSV-1, known for oral and genital sores, assembles in cells thanks to advanced imaging techniques.
Viruses: How herpes is assembled
A combination of imaging techniques reveals how herpes simplex virus type 1 assembles within infected cells, highlighting the roles of essential viral proteins in viral assembly and exit.
buff.ly
March 29, 2025 at 9:01 PM
Herpes viruses are among the most widespread human viruses. Scientists have shown how HSV-1, known for oral and genital sores, assembles in cells thanks to advanced imaging techniques.
Reposted by Dawid Zyla
Press release from @unibas.ch and @biozentrum.unibas.ch about our new #cryoET study on mitochondrial respirasomes. Led by the unstoppable @florentwaltz.bsky.social 🙌
🧪🧶🧬 #TeamTomo
🧪🧶🧬 #TeamTomo
#Mitochondria power our cells, but how? Using cryo-electron tomography, @cellarchlab.com and <a href="https://bsky.app/profile/did:plc:mhpz7gfc4j2xb525uro3udnj" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@florentwaltz.bsky.social report in <a href="https://bsky.app/profile/did:plc:vqgovau5gkirnk3ss5qwjdmz" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@science.org that energy-producing proteins form supercomplexes, optimizing ATP production.
The cell’s powerhouses: Molecular machines enable efficient energy production
Mitochondria are the powerhouses in our cells, producing the energy for all vital processes. Using cryo-electron tomography, researchers at th...
www.unibas.ch
March 21, 2025 at 8:41 AM
Press release from @unibas.ch and @biozentrum.unibas.ch about our new #cryoET study on mitochondrial respirasomes. Led by the unstoppable @florentwaltz.bsky.social 🙌
🧪🧶🧬 #TeamTomo
🧪🧶🧬 #TeamTomo
Reposted by Dawid Zyla
I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
March 21, 2025 at 2:09 PM
I'm super happy that our story is now published!
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
📖 www.science.org/doi/10.1126/...
But what changed compared to the original preprint?
Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.
Reposted by Dawid Zyla
New in @elife.bsky.social:
LJI Instructor Dawid Zyla (@dzyla.bsky.social) highlights recent research into how herpes simplex virus type 1 assembles within infected cells — revealing the roles of essential viral proteins in viral assembly and exit.
elifesciences.org/articles/106... #virology
LJI Instructor Dawid Zyla (@dzyla.bsky.social) highlights recent research into how herpes simplex virus type 1 assembles within infected cells — revealing the roles of essential viral proteins in viral assembly and exit.
elifesciences.org/articles/106... #virology
March 18, 2025 at 8:40 PM
New in @elife.bsky.social:
LJI Instructor Dawid Zyla (@dzyla.bsky.social) highlights recent research into how herpes simplex virus type 1 assembles within infected cells — revealing the roles of essential viral proteins in viral assembly and exit.
elifesciences.org/articles/106... #virology
LJI Instructor Dawid Zyla (@dzyla.bsky.social) highlights recent research into how herpes simplex virus type 1 assembles within infected cells — revealing the roles of essential viral proteins in viral assembly and exit.
elifesciences.org/articles/106... #virology
Reposted by Dawid Zyla
New Curebound grants may lead to new approaches to fight breast cancer, lung tumors and more! bit.ly/4ixZGVd
#Cancer #Oncology #BreastCancer #SanDiego
#Cancer #Oncology #BreastCancer #SanDiego
LJI scientists receive Curebound funding to advance cancer research
Curebound grants may lead to new approaches to fight breast cancer, lung tumors and more
bit.ly
March 17, 2025 at 6:18 PM
New Curebound grants may lead to new approaches to fight breast cancer, lung tumors and more! bit.ly/4ixZGVd
#Cancer #Oncology #BreastCancer #SanDiego
#Cancer #Oncology #BreastCancer #SanDiego