Neville Sanjana
@nevillesanjana.bsky.social
Scientist at the New York Genome Center & NYU.
http://sanjanalab.org
http://sanjanalab.org
Thrilled to be a co-organizer (w/ #SidiChen, #CathBollard, #HongboChi) of the first CSHL meeting on Immune Engineering & Cellular Immunotherapy, which kicks off this evening.
Looking forward to a great meeting — and please come introduce yourself if you're attending! #immeng25
Looking forward to a great meeting — and please come introduce yourself if you're attending! #immeng25
October 28, 2025 at 10:03 PM
Thrilled to be a co-organizer (w/ #SidiChen, #CathBollard, #HongboChi) of the first CSHL meeting on Immune Engineering & Cellular Immunotherapy, which kicks off this evening.
Looking forward to a great meeting — and please come introduce yourself if you're attending! #immeng25
Looking forward to a great meeting — and please come introduce yourself if you're attending! #immeng25
Reposted by Neville Sanjana
⏰Final call! Talk submission for #GenReg26 closes tomorrow, 17 October - don’t miss your chance to be part of the programme.
Check out the initial schedule & explore discounts & grants available👉 bit.ly/4eWDxin
Flyer below with all the key info! #FusionGenomics
Check out the initial schedule & explore discounts & grants available👉 bit.ly/4eWDxin
Flyer below with all the key info! #FusionGenomics
October 16, 2025 at 2:08 PM
⏰Final call! Talk submission for #GenReg26 closes tomorrow, 17 October - don’t miss your chance to be part of the programme.
Check out the initial schedule & explore discounts & grants available👉 bit.ly/4eWDxin
Flyer below with all the key info! #FusionGenomics
Check out the initial schedule & explore discounts & grants available👉 bit.ly/4eWDxin
Flyer below with all the key info! #FusionGenomics
Updated data & analyses for Cas13 lncRNA study
For those who read our group's lncRNA study published last year, we have recently learned that the Cas13 library included some gRNAs that were not properly filtered for potential off-targets (as described in the Methods).
For those who read our group's lncRNA study published last year, we have recently learned that the Cas13 library included some gRNAs that were not properly filtered for potential off-targets (as described in the Methods).
October 16, 2025 at 7:55 PM
Updated data & analyses for Cas13 lncRNA study
For those who read our group's lncRNA study published last year, we have recently learned that the Cas13 library included some gRNAs that were not properly filtered for potential off-targets (as described in the Methods).
For those who read our group's lncRNA study published last year, we have recently learned that the Cas13 library included some gRNAs that were not properly filtered for potential off-targets (as described in the Methods).
Congrats to our lab's recent MD-PhD grad Rachel Yan (
@rachelyan.bsky.social) on the beautiful cover art accompanying her MultiPerturb-seq study!
@rachelyan.bsky.social) on the beautiful cover art accompanying her MultiPerturb-seq study!
The October issue is live nature.com/nbt/volumes/...
The cover shows perturbations that convert stem-like, atypical teratoid rhabdoid tumor (AT/RT) cells into a more differentiated, neuron-like state go.nature.com/4hXER5O
The cover shows perturbations that convert stem-like, atypical teratoid rhabdoid tumor (AT/RT) cells into a more differentiated, neuron-like state go.nature.com/4hXER5O
October 14, 2025 at 6:41 PM
Congrats to our lab's recent MD-PhD grad Rachel Yan (
@rachelyan.bsky.social) on the beautiful cover art accompanying her MultiPerturb-seq study!
@rachelyan.bsky.social) on the beautiful cover art accompanying her MultiPerturb-seq study!
Night Science is coming to NYGC!
NYC Postdocs! Join us for Night Science at the New York Genome Center on June 2nd for a discussion on the creative process of finding novel questions. This time we hit the bar after! Register: docs.google.com/forms/d/1s9W...
@stearnslab.bsky.social @kelseymonson.bsky.social @rmassonix.bsky.social
@stearnslab.bsky.social @kelseymonson.bsky.social @rmassonix.bsky.social
May 15, 2025 at 4:12 PM
Night Science is coming to NYGC!
Reposted by Neville Sanjana
Whimsical footnote from my CRICK biography. Amber was a renowned mutation in a bacteriophage virus that stopped protein synthesis (so, “end of message” or “stop”). Its RNA codon is UAG.
May 7, 2025 at 7:44 AM
Whimsical footnote from my CRICK biography. Amber was a renowned mutation in a bacteriophage virus that stopped protein synthesis (so, “end of message” or “stop”). Its RNA codon is UAG.
Reposted by Neville Sanjana
This is wild
Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy - @jaweinst.bsky.social @uchicagopme.bsky.social go.nature.com/42hJ1Q2
Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy - Nature Biotechnology
Volumetric DNA microscopy captures spatial information of RNA within an intact organism.
go.nature.com
March 27, 2025 at 11:57 PM
This is wild
Amazing addition to @nygenome.org — very lucky to have a pioneer in functional genomics joining us.
Welcome Bing! 🚀🚀🚀
Welcome Bing! 🚀🚀🚀
We are proud to announce Bing Ren, PhD, as the new Scientific Director & CEO of the New York Genome Center
Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment.
For more on Dr. Ren: bit.ly/3DJXtah
Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment.
For more on Dr. Ren: bit.ly/3DJXtah
Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center - March 27, 2025
Read about Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center at the New York Genome Center on March 27, 2025
bit.ly
March 28, 2025 at 12:38 AM
Amazing addition to @nygenome.org — very lucky to have a pioneer in functional genomics joining us.
Welcome Bing! 🚀🚀🚀
Welcome Bing! 🚀🚀🚀
Enjoyed participating in this far-ranging podcast about CRISPR and genome editing and its transformative impact on human health — and even more important in these challenging times.
www.thenakedscientists.com/podcasts/nak...
www.thenakedscientists.com/podcasts/nak...
CRISPR, and the ethics of gene editing
The potential and the philosophy...
www.thenakedscientists.com
March 12, 2025 at 2:36 AM
Enjoyed participating in this far-ranging podcast about CRISPR and genome editing and its transformative impact on human health — and even more important in these challenging times.
www.thenakedscientists.com/podcasts/nak...
www.thenakedscientists.com/podcasts/nak...
Reposted by Neville Sanjana
A patient reminded me of science’s power: 2 doses of immunotherapy and a fatal cancer GONE. Immunotherapy exists BECAUSE of basic research—work that can seem esoteric or wasteful. Before dismissing it, ask a scientist why it matters. Or ask the Nobel who discovered immunotherapy.
March 7, 2025 at 3:02 PM
A patient reminded me of science’s power: 2 doses of immunotherapy and a fatal cancer GONE. Immunotherapy exists BECAUSE of basic research—work that can seem esoteric or wasteful. Before dismissing it, ask a scientist why it matters. Or ask the Nobel who discovered immunotherapy.
🔷 📰 BLUETORIAL time! 📰 🔷
Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR perturbations of the MYC TAD (~3 Mb) in 6 different human cancer cell lines
www.nature.com/articles/s41...
Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR perturbations of the MYC TAD (~3 Mb) in 6 different human cancer cell lines
www.nature.com/articles/s41...
Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers - Nature Communications
The oncogene MYC plays a key role in cancer initiation and progression. Using thousands of CRISPR perturbations, the authors investigate regulators of MYC in six different cancers. These tumor-specifi...
www.nature.com
March 3, 2025 at 2:40 AM
🔷 📰 BLUETORIAL time! 📰 🔷
Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR perturbations of the MYC TAD (~3 Mb) in 6 different human cancer cell lines
www.nature.com/articles/s41...
Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR perturbations of the MYC TAD (~3 Mb) in 6 different human cancer cell lines
www.nature.com/articles/s41...
Wise words from Tom Maniatis — who helped launch the biotech revolution, which brought SO MANY health & tech advances in the ~50 years since the advent of programmable gene manipulation.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
March 1, 2025 at 7:23 PM
Wise words from Tom Maniatis — who helped launch the biotech revolution, which brought SO MANY health & tech advances in the ~50 years since the advent of programmable gene manipulation.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Neville Sanjana
Precise RNA targeting with CRISPR–Cas13d - @nevillesanjana.bsky.social go.nature.com/4gEn95x
Precise RNA targeting with CRISPR–Cas13d - Nature Biotechnology
Careful selection of Cas13 variants and delivery methods minimizes collateral RNA degradation.
go.nature.com
February 11, 2025 at 3:29 PM
Precise RNA targeting with CRISPR–Cas13d - @nevillesanjana.bsky.social go.nature.com/4gEn95x
🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
December 26, 2024 at 3:01 AM
🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
Delighted to share new work from our lab:
MultiPerturb-seq 🎛️ ❌ ↕️
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
MultiPerturb-seq 🎛️ ❌ ↕️
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling - Nature Biotechnology
MultiPerturb-seq profiles gene expression and chromatin accessibility in single-cell pooled CRISPR screen.
go.nature.com
November 26, 2024 at 1:42 PM
Delighted to share new work from our lab:
MultiPerturb-seq 🎛️ ❌ ↕️
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
MultiPerturb-seq 🎛️ ❌ ↕️
Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
Reposted by Neville Sanjana
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling - Nature Biotechnology
MultiPerturb-seq profiles gene expression and chromatin accessibility in single-cell pooled CRISPR screen.
go.nature.com
November 21, 2024 at 2:26 PM
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O