Chris Greene
@chrisgreene.bsky.social
Lecturer in Physiology at RCSI. Researcher at FutureNeuro. Neuroscience, blood-brain barrier, long Covid, TBI... beer, coffee. #NewPI
Reposted by Chris Greene
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
go.nature.com
October 29, 2025 at 12:11 PM
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/47zrzYZ
go.nature.com/47zrzYZ
Reposted by Chris Greene
Ok so this is almost certainly not up your street but I LOVE this paper because it is simple, beautifully written and super clear. It's just a good paper and I fangirled the senior author about it in an email to him
www.jneurosci.org/content/40/2...
www.jneurosci.org/content/40/2...
Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and cognition. In vulnerable individuals, acute...
www.jneurosci.org
October 3, 2025 at 9:18 AM
Ok so this is almost certainly not up your street but I LOVE this paper because it is simple, beautifully written and super clear. It's just a good paper and I fangirled the senior author about it in an email to him
www.jneurosci.org/content/40/2...
www.jneurosci.org/content/40/2...
Reposted by Chris Greene
Researchers, including several from FutureNeuro, found people with temporal lobe epilepsy experience more widespread brain changes across adulthood, highlighting the importance of early diagnosis and treatment: futureneurocentre.ie/publications...
@researchireland.ie @epilepsyireland.bsky.social
@researchireland.ie @epilepsyireland.bsky.social
September 17, 2025 at 8:32 AM
Researchers, including several from FutureNeuro, found people with temporal lobe epilepsy experience more widespread brain changes across adulthood, highlighting the importance of early diagnosis and treatment: futureneurocentre.ie/publications...
@researchireland.ie @epilepsyireland.bsky.social
@researchireland.ie @epilepsyireland.bsky.social
Come join my Department in @rcsi.bsky.social @futureneuro.bsky.social. We're especially interested in people with backgrounds in neuropsychiatry, neural engineering or digital health. Tenure track, start-up funding and protected time for research. Deadline this week.
🚨 Applications close this week. If you work in neuropsychiatry, neural engineering, or digital health, consider the StAR Lecturer role at @rcsi.bsky.social. Hear how Dr @chrisgreene.bsky.social’s research and career have grown through this position 👇
⭐ We’re hiring a StAR Lecturer at @rcsi.bsky.social with expertise in neuropsychiatry, neural engineering, or digital health. Dr @chrisgreene.bsky.social, last year’s StAR Lecturer, talks about how this role has accelerated his career growth. Apply by August 29: www.linkedin.com/jobs/view/42...
August 25, 2025 at 2:17 PM
Come join my Department in @rcsi.bsky.social @futureneuro.bsky.social. We're especially interested in people with backgrounds in neuropsychiatry, neural engineering or digital health. Tenure track, start-up funding and protected time for research. Deadline this week.
Reposted by Chris Greene
ICYMI: Temporal lobe epilepsy affects ~50 million people globally
@brennan-lab-ucd.bsky.social @futureneuro.bsky.social & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models: buff.ly/odAaTRs
@brennan-lab-ucd.bsky.social @futureneuro.bsky.social & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models: buff.ly/odAaTRs
August 9, 2025 at 3:13 PM
ICYMI: Temporal lobe epilepsy affects ~50 million people globally
@brennan-lab-ucd.bsky.social @futureneuro.bsky.social & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models: buff.ly/odAaTRs
@brennan-lab-ucd.bsky.social @futureneuro.bsky.social & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models: buff.ly/odAaTRs
Reposted by Chris Greene
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience
Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...
www.nature.com
August 5, 2025 at 10:26 AM
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
Reposted by Chris Greene
🚨 Review Alert
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain
The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...
www.frontiersin.org
July 22, 2025 at 6:48 AM
🚨 Review Alert
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*
Congratulations Audrey Chagnot!! 🥳
Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊
www.frontiersin.org/journals/cel...
Reposted by Chris Greene
🚨 We’re hiring! FutureNeuro is looking for a StAR Lecturer to lead research in neuropsychiatry, neural engineering, or digital health. Join us at RCSI. Apply by August 29: www.linkedin.com/jobs/view/42...
@rcsi.bsky.social @rcsi-research.bsky.social
@rcsi.bsky.social @rcsi-research.bsky.social
Royal College of Surgeons in Ireland (RCSI) hiring FutureNeuro StAR Lecturer in Dublin, County Dublin, Ireland | LinkedIn
Posted 10:10:05 AM. Job Title: FutureNeuro StAR LecturerReporting To: Head of Department or nomineeLocation:…See this and similar jobs on LinkedIn.
www.linkedin.com
July 8, 2025 at 8:32 AM
🚨 We’re hiring! FutureNeuro is looking for a StAR Lecturer to lead research in neuropsychiatry, neural engineering, or digital health. Join us at RCSI. Apply by August 29: www.linkedin.com/jobs/view/42...
@rcsi.bsky.social @rcsi-research.bsky.social
@rcsi.bsky.social @rcsi-research.bsky.social
Reposted by Chris Greene
We are very excited to be hiring a Postdoc to our expanding team! Are you interested in neuroinflammation, immunometabolism and/or epilepsy research?? 🧠 Apply now my.corehr.com/pls/coreportal……
@Futureneuro_ie @RCSIPharmBioMol
***Closing date 16th July***
@Futureneuro_ie @RCSIPharmBioMol
***Closing date 16th July***
July 2, 2025 at 9:53 PM
We are very excited to be hiring a Postdoc to our expanding team! Are you interested in neuroinflammation, immunometabolism and/or epilepsy research?? 🧠 Apply now my.corehr.com/pls/coreportal……
@Futureneuro_ie @RCSIPharmBioMol
***Closing date 16th July***
@Futureneuro_ie @RCSIPharmBioMol
***Closing date 16th July***
New paper led by Avril Reddy in @mattcampbelltcd.bsky.social lab showing IPS derived human RPE cells expressing aflibercept and/or soluble CD59 can attenuate lesions in mouse model of age-related macular degeneration. Cool project to help out with. www.cell.com/molecular-th...
Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease
Age-related macular degeneration (AMD) is one of the leading causes of central retinal
blindness. Here, Campbell and colleagues show that transplanted retinal pigment epithelial
cells can be engineere...
www.cell.com
March 19, 2025 at 11:41 AM
New paper led by Avril Reddy in @mattcampbelltcd.bsky.social lab showing IPS derived human RPE cells expressing aflibercept and/or soluble CD59 can attenuate lesions in mouse model of age-related macular degeneration. Cool project to help out with. www.cell.com/molecular-th...
Reposted by Chris Greene
IL-1- and IL-6-related systemic inflammation in #COVID19 is associated with #microglia dysfunction, neurovascular inflammation, and focal neuropathologies 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 - Nature Neuroscience
The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascul...
www.nature.com
March 10, 2025 at 1:21 PM
IL-1- and IL-6-related systemic inflammation in #COVID19 is associated with #microglia dysfunction, neurovascular inflammation, and focal neuropathologies 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chris Greene
Made some science books for kids #worldbookday
March 6, 2025 at 4:43 PM
Made some science books for kids #worldbookday
Reposted by Chris Greene
The gut microbiota: an amazing technicolour dream coat or the emperor's new clothes? physoc.onlinelibrary.wiley.com/doi/full/10.... - an excellent corrective to the relentless hype
The gut microbiota: an amazing technicolour dream coat or the emperor's new clothes?
Click on the article title to read more.
physoc.onlinelibrary.wiley.com
March 4, 2025 at 9:51 AM
The gut microbiota: an amazing technicolour dream coat or the emperor's new clothes? physoc.onlinelibrary.wiley.com/doi/full/10.... - an excellent corrective to the relentless hype
Reposted by Chris Greene
So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI
www.nature.com/articles/s41...
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI
www.nature.com/articles/s41...
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience
The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...
www.nature.com
February 27, 2025 at 11:52 AM
So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI
www.nature.com/articles/s41...
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI
www.nature.com/articles/s41...
Reposted by Chris Greene
New RCSI research has uncovered how T cells may contribute to blood clot risk in inflammatory bowel disease.
The findings, published in @NatureComms also suggest a potential treatment approach to manage this risk.
Read more 🔗 www.rcsi.com/dublin/news-...
#RCSIdiscover @rcsi-research.bsky.social
The findings, published in @NatureComms also suggest a potential treatment approach to manage this risk.
Read more 🔗 www.rcsi.com/dublin/news-...
#RCSIdiscover @rcsi-research.bsky.social
New RCSI research identifies key role of T cells in blood clot risk for inflammatory bowel disease patients
Researchers from RCSI University of Medicine and Health Sciences have uncovered a novel mechanism linking inflammatory bowel disease (IBD) with an increased risk of a serious blood clotting disorder, ...
www.rcsi.com
February 21, 2025 at 9:47 AM
New RCSI research has uncovered how T cells may contribute to blood clot risk in inflammatory bowel disease.
The findings, published in @NatureComms also suggest a potential treatment approach to manage this risk.
Read more 🔗 www.rcsi.com/dublin/news-...
#RCSIdiscover @rcsi-research.bsky.social
The findings, published in @NatureComms also suggest a potential treatment approach to manage this risk.
Read more 🔗 www.rcsi.com/dublin/news-...
#RCSIdiscover @rcsi-research.bsky.social
Reposted by Chris Greene
A gene linked to age-related cognitive decline, APOE ε4, is also associated with cognitive advantage below the age of 50 in women, according to data from the @ukbiobank.bsky.social, a finding that could explain APOE ε4’s persistence in the human genome. In PNAS: www.pnas.org/doi/10.1073/...
February 18, 2025 at 6:19 PM
A gene linked to age-related cognitive decline, APOE ε4, is also associated with cognitive advantage below the age of 50 in women, according to data from the @ukbiobank.bsky.social, a finding that could explain APOE ε4’s persistence in the human genome. In PNAS: www.pnas.org/doi/10.1073/...
Reposted by Chris Greene
Thanks @blacoste.bsky.social! I want to highlight that it's a new peer-reviewed, interdisciplinary open access journal: #Glia #Health #Research 🧪
All articles submitted before April 30, 2026 are 🚨 free, no publication fees! 🤑
All articles submitted before April 30, 2026 are 🚨 free, no publication fees! 🤑
Super cool new review by @caromenard666.bsky.social’s team on neuro-glio-vascular alterations #cerebrovascular
Neurogliovascular alterations in brain pathologies across lifespan
Neurological and psychiatric illnesses present significant challenges across different stages of life. Adolescence is associated with a high incidence…
www.sciencedirect.com
February 6, 2025 at 12:41 PM
Thanks @blacoste.bsky.social! I want to highlight that it's a new peer-reviewed, interdisciplinary open access journal: #Glia #Health #Research 🧪
All articles submitted before April 30, 2026 are 🚨 free, no publication fees! 🤑
All articles submitted before April 30, 2026 are 🚨 free, no publication fees! 🤑
Reposted by Chris Greene
Nature research paper: CD45-PET is a robust, non-invasive tool for imaging inflammation
https://go.nature.com/4jmStIF
https://go.nature.com/4jmStIF
CD45-PET is a robust, non-invasive tool for imaging inflammation - Nature
A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.
go.nature.com
January 27, 2025 at 9:03 AM
Nature research paper: CD45-PET is a robust, non-invasive tool for imaging inflammation
https://go.nature.com/4jmStIF
https://go.nature.com/4jmStIF
Reposted by Chris Greene
A new collaborative study led by FutureNeuro researchers at RCSI offers hope for predicting and preventing the development of epilepsy following traumatic brain injury.
The research identifies an important role for a brain receptor called P2X7.
More ➡️ www.rcsi.com/dublin/news-...
#RCSIdiscover
The research identifies an important role for a brain receptor called P2X7.
More ➡️ www.rcsi.com/dublin/news-...
#RCSIdiscover
New research offers hope for preventing epilepsy after traumatic brain injury
A new international study has unveiled critical insights in understanding post-traumatic epilepsy, a condition that can develop following traumatic brain injury.
www.rcsi.com
January 27, 2025 at 9:20 AM
A new collaborative study led by FutureNeuro researchers at RCSI offers hope for predicting and preventing the development of epilepsy following traumatic brain injury.
The research identifies an important role for a brain receptor called P2X7.
More ➡️ www.rcsi.com/dublin/news-...
#RCSIdiscover
The research identifies an important role for a brain receptor called P2X7.
More ➡️ www.rcsi.com/dublin/news-...
#RCSIdiscover
Reposted by Chris Greene
Check out this paper and tool that we worked on with @sloanlab.bsky.social and Ye Zhang.
Think of it as 'the Barres datasets 2.0'
Lots of input and feedback from the amazing #Glia community.
Think of it as 'the Barres datasets 2.0'
Lots of input and feedback from the amazing #Glia community.
Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net
WEBseq
share freely
www.webseq.net
January 15, 2025 at 4:29 PM
Check out this paper and tool that we worked on with @sloanlab.bsky.social and Ye Zhang.
Think of it as 'the Barres datasets 2.0'
Lots of input and feedback from the amazing #Glia community.
Think of it as 'the Barres datasets 2.0'
Lots of input and feedback from the amazing #Glia community.
Reposted by Chris Greene
The blood-brain barrier can prevent therapeutic drugs from reaching the brain.
Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6
Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6
A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro
A claudin5 binding peptide enhances transport across the blood-brain barrier by transiently permeabilizing tight junctions.
scim.ag
January 15, 2025 at 5:46 PM
The blood-brain barrier can prevent therapeutic drugs from reaching the brain.
Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6
Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6
Reposted by Chris Greene
In vivo hyperphosphorylation of #tau is associated with synaptic loss and behavioral abnormalities even in the absence of tau seeds 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience
Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...
www.nature.com
January 6, 2025 at 2:13 PM
In vivo hyperphosphorylation of #tau is associated with synaptic loss and behavioral abnormalities even in the absence of tau seeds 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chris Greene
A single-cell mass cytometry-based atlas of the developing mouse brain 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A single-cell mass cytometry-based atlas of the developing mouse brain - Nature Neuroscience
In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based single-cell profiling ...
www.nature.com
January 2, 2025 at 3:28 PM
A single-cell mass cytometry-based atlas of the developing mouse brain 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
