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Nature Neuroscience
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News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience.

https://www.nature.com/neuro/
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TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD

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TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD - Nature Neuroscience
TDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based...
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November 14, 2025 at 2:48 PM
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Chief Editor Shari Wiseman @shariwiseman.bsky.social will be at the @sfn.org meeting! She'll be at the @springernature.com booth (#2220) from 2-4 pm on Sunday and Tuesday, and from 10 am-12 pm on Monday and Wednesday. If you’d like to set up a one-on-one meeting, please email her.

#SfN2025
November 13, 2025 at 2:23 PM
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Attentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain–body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations

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Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature Neuroscience
Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...
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November 12, 2025 at 8:18 PM
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🥳Please join us in welcoming Ana Uzquiano @uzquianoa.bsky.social to our editorial team! Ioana is handling transcriptomics, neurodevelopment, and cellular and molecular neuroscience. She's based in the Madrid office.
November 12, 2025 at 6:44 PM
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The brain’s wake-to-sleep transition follows bifurcation dynamics with a distinct tipping point preceded by a critical slowing down

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Falling asleep follows a predictable bifurcation dynamic - Nature Neuroscience
Li et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s nonlinear wake-to-sleep transiti...
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November 11, 2025 at 2:32 PM
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Connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictions of activity in unrecorded neurons

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Prediction of neural activity in connectome-constrained recurrent networks - Nature Neuroscience
The authors show that connectome datasets alone are generally not sufficient to predict neural activity. However, pairing connectivity information with neural recordings can produce accurate predictio...
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November 10, 2025 at 10:12 PM
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Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation

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Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation - Nature Neuroscience
Working memory improves during adolescent brain development. Zhu et al. tracked monkeys through adolescence, revealing that maturation of white matter tracts and refinement of neural firing patterns s...
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November 6, 2025 at 7:52 PM
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Large-scale chromatin accessibility profiling (ATAC-seq) of neurons and non-neurons from 2 human neocortical regions from 469 unique donors, comprising controls and individuals diagnosed with schizophrenia and bipolar disorder

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The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development - Nature Neuroscience
This study maps chromatin accessibility in neurons and glia in schizophrenia, revealing fetal-like regulatory patterns in adult neurons enriched for genetic risk variants, linking early brain developm...
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November 5, 2025 at 12:22 PM
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Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI

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Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI - Nature Neuroscience
The brain is constantly monitoring the systems in the body. Here the authors use 7 Tesla functional magnetic resonance imaging to map a large-scale brain system for body regulation in humans, includin...
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November 4, 2025 at 7:04 PM
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Our November issue is now live!

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November 4, 2025 at 5:33 PM
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Characterization of the circadian translatomes of astrocytes and microglia in mouse cortex in the setting of amyloid pathology or aging, revealing cell and disease-specific circadian reprogramming of neurodegeneration-related pathways

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A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging - Nature Neuroscience
Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and disease-specific reprogra...
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November 3, 2025 at 8:22 PM
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A pair of papers on how TDP-43 loss in ALS/FTD causes changes in mRNA polyadenylation

This one from Aaron Gitler's group

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TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes - Nature Neuroscience
Zeng et al. show that TDP-43, known for repressing cryptic exon usage in frontotemporal dementia/amyotrophic lateral sclerosis, also controls alternative polyadenylation, impacting expression of disea...
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October 31, 2025 at 2:39 PM
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Leptin-sensitive neuronal subpopulations in the lateral hypothalamus enable adaptive fulfillment of vital needs despite anxiogenic conditions

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A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses - Nature Neuroscience
Figge-Schlensok et al. show that leptin-sensitive neurons in the lateral hypothalamus encode anxiogenic stimuli and facilitate adaptive strategies to enable an animal to overcome anxiety in threatenin...
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October 30, 2025 at 5:11 PM
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Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway

@julie.buron.bsky.social @inmed.bsky.social @insermpacacorse.bsky.social D54@incia-neurocampus.bsky.social

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Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway - Nature Neuroscience
Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a hypothalamus–brainstem ...
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October 29, 2025 at 1:16 PM
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🥳Please join us in welcoming Ioana Marin to our editorial team! Ioana is handling neuroimmunology and cellular and molecular neuroscience. She's based in the NYC office.
October 27, 2025 at 3:33 PM
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High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN), a common target for Parkinson’s disease, activates afferent axons while inhibiting STN neurons

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Differential synaptic depression mediates the therapeutic effect of deep brain stimulation - Nature Neuroscience
The authors show that deep brain stimulation (DBS) inhibits local neural activity via differential suppression of glutamate and GABA release, and they developed a chemogenetic therapy as a less invasi...
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October 27, 2025 at 2:25 PM
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A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels

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Region-specific drivers of CSF mobility measured with MRI in humans - Nature Neuroscience
Brain clearance mechanisms are challenging to visualize in humans. Using magnetic resonance imaging, the authors noninvasively mapped cerebrospinal fluid motion across the brain, showing region-specif...
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October 24, 2025 at 4:02 PM
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C9orf72 mutations impair immune activation in ALS, highlighting key differences in the cellular and molecular pathways underlying sporadic and genetics forms of the disease

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C9orf72 hexanucleotide repeat expansions impair microglial response in ALS - Nature Neuroscience
This study shows that C9orf72 mutations impair immune activation in ALS, affecting how brain cells communicate, and highlights key differences in the cellular and molecular pathways underlying sporadi...
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October 23, 2025 at 7:25 PM
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Nature Neuroscience is happy to now offer Transparent Peer Review, in which authors can choose for us to publish details about the peer review process (including reviews, rebuttal letters, and editorial decision letters). More info at the link below:

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Peer Review | Nature Neuroscience
Peer Review
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October 23, 2025 at 3:29 PM
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Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of mouse and human brain function

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Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function - Nature Neuroscience
Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI studies of psychedelics.
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October 22, 2025 at 7:10 PM
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Astrocytic Ca2+ prevents synaptic depotentiation by limiting repetitive activity in dendrites during motor learning

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Astrocytic Ca2+ prevents synaptic depotentiation by limiting repetitive activity in dendrites during motor learning - Nature Neuroscience
Lai et al. show a function of astrocytic Ca2+ in preventing synaptic depotentiation by reducing repetitive dendritic activity in the motor cortex during motor training, thereby contributing to learnin...
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October 21, 2025 at 6:58 PM
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Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape

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Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape - Nature Neuroscience
Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.
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October 10, 2025 at 9:10 PM
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Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models

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Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models - Nature Neuroscience
Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.
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October 9, 2025 at 11:06 AM
Reposted by Nature Neuroscience
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Want to close the gender gap in research? Start with the data.

Our Springer Nature report: Closing the Gender Gap highlights where change is needed most — and how you can be part of it. Read the report: spklr.io/63324ByG4y
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October 7, 2025 at 12:50 PM
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A single dose of #psilocybin induces a rapid and sustained reversal of both mechanical allodynia (pain) and anxiodepression-like states in adult male and female mice

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Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain - Nature Neuroscience
Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal activity through partial agonism at 5-HT2A and 5-HT1A receptors.
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October 7, 2025 at 5:31 PM