JCI insight
@insight.jci.org
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
Count down: Our top 5 most-accessed manuscripts of 2025!
#5: An insider’s guide to understanding and obtaining an NIH K career development award: doi.org/10.1172/jci....
#5: An insider’s guide to understanding and obtaining an NIH K career development award: doi.org/10.1172/jci....
December 27, 2025 at 2:02 PM
Count down: Our top 5 most-accessed manuscripts of 2025!
#5: An insider’s guide to understanding and obtaining an NIH K career development award: doi.org/10.1172/jci....
#5: An insider’s guide to understanding and obtaining an NIH K career development award: doi.org/10.1172/jci....
Here is a solid sub-analysis of a landmark clinical trial✨✨
Johann de Bono & team reveal circulating tumor cells with features of chromosomal instability predicts resistance to chemotherapy in patients with prostate cancer: doi.org/10.1172/jci....
Johann de Bono & team reveal circulating tumor cells with features of chromosomal instability predicts resistance to chemotherapy in patients with prostate cancer: doi.org/10.1172/jci....
December 26, 2025 at 2:01 PM
Here is a solid sub-analysis of a landmark clinical trial✨✨
Johann de Bono & team reveal circulating tumor cells with features of chromosomal instability predicts resistance to chemotherapy in patients with prostate cancer: doi.org/10.1172/jci....
Johann de Bono & team reveal circulating tumor cells with features of chromosomal instability predicts resistance to chemotherapy in patients with prostate cancer: doi.org/10.1172/jci....
In #Sjögren’s disease CD4+ T cells infiltrate the salivary glands, but little is known about their distinguishing receptors.
Here, A. Darise Farris & team provide a comprehensive characterization comparing tissue and blood samples: doi.org/10.1172/jci....
Here, A. Darise Farris & team provide a comprehensive characterization comparing tissue and blood samples: doi.org/10.1172/jci....
December 25, 2025 at 2:02 PM
In #Sjögren’s disease CD4+ T cells infiltrate the salivary glands, but little is known about their distinguishing receptors.
Here, A. Darise Farris & team provide a comprehensive characterization comparing tissue and blood samples: doi.org/10.1172/jci....
Here, A. Darise Farris & team provide a comprehensive characterization comparing tissue and blood samples: doi.org/10.1172/jci....
When to target the most abundant protein in the heart?
@droch.bsky.social & team show myosin becomes maladaptive in X-linked myotubular myopathy, consuming excessive energy, and inhibiting its ATPase activity in mice partly rescues the molecular defects: doi.org/10.1172/jci....
@droch.bsky.social & team show myosin becomes maladaptive in X-linked myotubular myopathy, consuming excessive energy, and inhibiting its ATPase activity in mice partly rescues the molecular defects: doi.org/10.1172/jci....
December 24, 2025 at 2:01 PM
When to target the most abundant protein in the heart?
@droch.bsky.social & team show myosin becomes maladaptive in X-linked myotubular myopathy, consuming excessive energy, and inhibiting its ATPase activity in mice partly rescues the molecular defects: doi.org/10.1172/jci....
@droch.bsky.social & team show myosin becomes maladaptive in X-linked myotubular myopathy, consuming excessive energy, and inhibiting its ATPase activity in mice partly rescues the molecular defects: doi.org/10.1172/jci....
KID mutations in mice provide insight into the insulin/IGF1R paradox of aging
Here, Andrey A. Parkhitko & team show mutation in kinase insert domain (KID) of IR or IGF1R produces features of long-lived mice while maintaining metabolic health: doi.org/10.1172/jci....
Here, Andrey A. Parkhitko & team show mutation in kinase insert domain (KID) of IR or IGF1R produces features of long-lived mice while maintaining metabolic health: doi.org/10.1172/jci....
December 23, 2025 at 2:02 PM
KID mutations in mice provide insight into the insulin/IGF1R paradox of aging
Here, Andrey A. Parkhitko & team show mutation in kinase insert domain (KID) of IR or IGF1R produces features of long-lived mice while maintaining metabolic health: doi.org/10.1172/jci....
Here, Andrey A. Parkhitko & team show mutation in kinase insert domain (KID) of IR or IGF1R produces features of long-lived mice while maintaining metabolic health: doi.org/10.1172/jci....
A strategy to protect pancreatic beta cells from lipotoxicity…
This Issue’s Cover: Kyu-Sang Park & team show that palmitate triggers ROS-induced Ca2+ overload and mTORC1 activation at the lysosomal membrane, resulting in autophagy defects: doi.org/10.1172/jci....
This Issue’s Cover: Kyu-Sang Park & team show that palmitate triggers ROS-induced Ca2+ overload and mTORC1 activation at the lysosomal membrane, resulting in autophagy defects: doi.org/10.1172/jci....
December 22, 2025 at 5:15 PM
A strategy to protect pancreatic beta cells from lipotoxicity…
This Issue’s Cover: Kyu-Sang Park & team show that palmitate triggers ROS-induced Ca2+ overload and mTORC1 activation at the lysosomal membrane, resulting in autophagy defects: doi.org/10.1172/jci....
This Issue’s Cover: Kyu-Sang Park & team show that palmitate triggers ROS-induced Ca2+ overload and mTORC1 activation at the lysosomal membrane, resulting in autophagy defects: doi.org/10.1172/jci....
The BabyGRO cohort included 80 children born at term following pregnancies with suboptimal fetal growth risk
Reena Perchard & team report genes connecting poor growth in the womb to higher BP in children & teens, helping detect heart health risks earlier: doi.org/10.1172/jci....
Reena Perchard & team report genes connecting poor growth in the womb to higher BP in children & teens, helping detect heart health risks earlier: doi.org/10.1172/jci....
December 22, 2025 at 2:02 PM
The BabyGRO cohort included 80 children born at term following pregnancies with suboptimal fetal growth risk
Reena Perchard & team report genes connecting poor growth in the womb to higher BP in children & teens, helping detect heart health risks earlier: doi.org/10.1172/jci....
Reena Perchard & team report genes connecting poor growth in the womb to higher BP in children & teens, helping detect heart health risks earlier: doi.org/10.1172/jci....
ICYMI: After blood stem cell transplants, T cells change metabolism
Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci.insight.192774
Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci.insight.192774
December 21, 2025 at 2:00 PM
ICYMI: After blood stem cell transplants, T cells change metabolism
Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci.insight.192774
Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci.insight.192774
From earlier this week: A power move in the study of sepsis-associated acute kidney injury
Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci.insight.177004
Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci.insight.177004
December 20, 2025 at 2:02 PM
From earlier this week: A power move in the study of sepsis-associated acute kidney injury
Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci.insight.177004
Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci.insight.177004
Should we treat blood donors with iron?
Steven L. Spitalnik & team report on a double-blind randomized trial for iron-deficient blood donors, finding treatment appears to affect brain function, brain iron, and myelin levels: doi.org/10.1172/jci....
Steven L. Spitalnik & team report on a double-blind randomized trial for iron-deficient blood donors, finding treatment appears to affect brain function, brain iron, and myelin levels: doi.org/10.1172/jci....
December 19, 2025 at 2:02 PM
Should we treat blood donors with iron?
Steven L. Spitalnik & team report on a double-blind randomized trial for iron-deficient blood donors, finding treatment appears to affect brain function, brain iron, and myelin levels: doi.org/10.1172/jci....
Steven L. Spitalnik & team report on a double-blind randomized trial for iron-deficient blood donors, finding treatment appears to affect brain function, brain iron, and myelin levels: doi.org/10.1172/jci....
After blood stem cell transplants, T cells change metabolism
Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci....
Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci....
December 18, 2025 at 2:03 PM
After blood stem cell transplants, T cells change metabolism
Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci....
Here, Hemn Mohammadpour, @plmbuffalo.bsky.social & team find blocking 6PGD, an enzyme in the pentose phosphate pathway, lessens GVHD without losing the anti-tumor response in mice: doi.org/10.1172/jci....
Enhancing antibiotic efficacy in sepsis
Daniele G. Souza & team find BDKRB1 activation contributes to sepsis-induced hyperinflammation and impairs neutrophil migration via PI3Kγ & CXCR2—with its pharmacological inhibition improving survival in mice: doi.org/10.1172/jci....
Daniele G. Souza & team find BDKRB1 activation contributes to sepsis-induced hyperinflammation and impairs neutrophil migration via PI3Kγ & CXCR2—with its pharmacological inhibition improving survival in mice: doi.org/10.1172/jci....
December 17, 2025 at 2:01 PM
Enhancing antibiotic efficacy in sepsis
Daniele G. Souza & team find BDKRB1 activation contributes to sepsis-induced hyperinflammation and impairs neutrophil migration via PI3Kγ & CXCR2—with its pharmacological inhibition improving survival in mice: doi.org/10.1172/jci....
Daniele G. Souza & team find BDKRB1 activation contributes to sepsis-induced hyperinflammation and impairs neutrophil migration via PI3Kγ & CXCR2—with its pharmacological inhibition improving survival in mice: doi.org/10.1172/jci....
A new therapeutic target in renal clear cell carcinoma
Boa Kim & team report on a mechanism underlying kidney tumor cell growth involving the cancer-driving protein HIF2α that blocks clustering/activation of glutaminase: doi.org/10.1172/jci....
Boa Kim & team report on a mechanism underlying kidney tumor cell growth involving the cancer-driving protein HIF2α that blocks clustering/activation of glutaminase: doi.org/10.1172/jci....
December 16, 2025 at 2:02 PM
A new therapeutic target in renal clear cell carcinoma
Boa Kim & team report on a mechanism underlying kidney tumor cell growth involving the cancer-driving protein HIF2α that blocks clustering/activation of glutaminase: doi.org/10.1172/jci....
Boa Kim & team report on a mechanism underlying kidney tumor cell growth involving the cancer-driving protein HIF2α that blocks clustering/activation of glutaminase: doi.org/10.1172/jci....
A power move in the study of sepsis-associated acute kidney injury
Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci....
Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci....
December 15, 2025 at 2:02 PM
A power move in the study of sepsis-associated acute kidney injury
Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci....
Using a new strategy for quantifying mitochondrial DNA, Kumar et al. show its release from the kidney directly contributes to IL-6 release in sepsis-associated AKI: doi.org/10.1172/jci....
From earlier this week: You're only as old as your organs
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
December 14, 2025 at 2:00 PM
From earlier this week: You're only as old as your organs
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
Previously shared: A study to take to heart
This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....
This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....
December 13, 2025 at 2:01 PM
Previously shared: A study to take to heart
This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....
This issue’s cover features work by Jiaxi Guo et al. on the protective role of lipin1 in the heart following ischemic injury via preserving lipid homeostasis: doi.org/10.1172/jci....
Reposted by JCI insight
Could TRPV4 blockers benefit patients with pancreatic cancer?
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
December 12, 2025 at 5:05 PM
Could TRPV4 blockers benefit patients with pancreatic cancer?
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
ASCI member Rodger A. Liddle & team @DukeMedSchool find TRPV4 KO in mice reduces pancreatic tumor size & metastasis & improves survival in a PDAC model: doi.org/10.1172/jci....
Reposted by JCI insight
In a new @insight.jci.org study co-led by @yaleneuro.bsky.social's Amy Arnsten, @yaleschoolofmed.bsky.social researchers uncover how the brain 🧠 uses GLO1 protein to buffer calcium buildup & protect 🛡️against neurodegenerative diseases like #Alzheimer's!
More 👇
medicine.yale.edu/news-article...
More 👇
medicine.yale.edu/news-article...
How the Brain Protects Itself from Alzheimer’s Disease
Researchers discovered a protective mechanism used by the brain to mitigate calcium dysfunction, a risk factor for neurodegeneration.
medicine.yale.edu
December 12, 2025 at 1:06 PM
In a new @insight.jci.org study co-led by @yaleneuro.bsky.social's Amy Arnsten, @yaleschoolofmed.bsky.social researchers uncover how the brain 🧠 uses GLO1 protein to buffer calcium buildup & protect 🛡️against neurodegenerative diseases like #Alzheimer's!
More 👇
medicine.yale.edu/news-article...
More 👇
medicine.yale.edu/news-article...
You're only as old as your organs
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
December 11, 2025 at 2:02 PM
You're only as old as your organs
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
Morgan E. Grams & team find organ ages, as estimated using levels of circulating proteins, are useful in predicting subsequent development of chronic disease: doi.org/10.1172/jci....
The figure shows a spider plot of three patient clusters.
Reposted by JCI insight
Researchers make strides toward preventing #parenteralNutrition-associated #liverDisease. G. Guthrie, D. Burrin et al #BCMDeptMedicine @insight.jci.org @bcmhouston.bsky.social blogs.bcm.edu/2025/12/09/f...
Researchers make strides toward preventing parenteral nutrition-associated liver disease
This research paves the way for new clinical interventions that could dramatically improve outcomes in this vulnerable pediatric population.
blogs.bcm.edu
December 10, 2025 at 9:23 PM
Researchers make strides toward preventing #parenteralNutrition-associated #liverDisease. G. Guthrie, D. Burrin et al #BCMDeptMedicine @insight.jci.org @bcmhouston.bsky.social blogs.bcm.edu/2025/12/09/f...
Reposted by JCI insight
A ten-year analysis of #HIV-1 reservoir cells in two elite controllers
ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....
ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....
December 10, 2025 at 5:05 PM
A ten-year analysis of #HIV-1 reservoir cells in two elite controllers
ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....
ASCI member Xu G. Yu & team @BrighamWomens discover elite controllers possess fewer genome-intact proviruses in lymphoid tissues than in blood, and these proviruses decline over time: doi.org/10.1172/jci....
Advanced methods allow a deeper understanding of T cells that guide antibody responses in malaria
Here, @drmichelleboyle.bsky.social & team use scRNAseq & spectral flow cytometry to identify two Tfh2 cell phenotypes that associate with Ab-mediated immunity in malaria: doi.org/10.1172/jci....
Here, @drmichelleboyle.bsky.social & team use scRNAseq & spectral flow cytometry to identify two Tfh2 cell phenotypes that associate with Ab-mediated immunity in malaria: doi.org/10.1172/jci....
December 10, 2025 at 5:15 PM
Advanced methods allow a deeper understanding of T cells that guide antibody responses in malaria
Here, @drmichelleboyle.bsky.social & team use scRNAseq & spectral flow cytometry to identify two Tfh2 cell phenotypes that associate with Ab-mediated immunity in malaria: doi.org/10.1172/jci....
Here, @drmichelleboyle.bsky.social & team use scRNAseq & spectral flow cytometry to identify two Tfh2 cell phenotypes that associate with Ab-mediated immunity in malaria: doi.org/10.1172/jci....
Reposted by JCI insight
New publication in @insight.jci.org! 🎉 We uncover a key role for #Nectin-4 in #PancreaticCancer, opening the door to new therapeutic strategies.
Read the full paper here: insight.jci.org/articles/vie...
Stay tuned — our multicenter phase II clinical trial #NEC4NEOP is coming next year! 🔬✨
Read the full paper here: insight.jci.org/articles/vie...
Stay tuned — our multicenter phase II clinical trial #NEC4NEOP is coming next year! 🔬✨
December 9, 2025 at 7:08 PM
New publication in @insight.jci.org! 🎉 We uncover a key role for #Nectin-4 in #PancreaticCancer, opening the door to new therapeutic strategies.
Read the full paper here: insight.jci.org/articles/vie...
Stay tuned — our multicenter phase II clinical trial #NEC4NEOP is coming next year! 🔬✨
Read the full paper here: insight.jci.org/articles/vie...
Stay tuned — our multicenter phase II clinical trial #NEC4NEOP is coming next year! 🔬✨
Co-first authors Emmanuel Rapp and Jiayi Pang tell us about their discovery on Carnosic acid in topical rosemary extracts and how it reduces scar formation in injured skin: doi.org/10.1172/jci....
December 9, 2025 at 5:15 PM
Co-first authors Emmanuel Rapp and Jiayi Pang tell us about their discovery on Carnosic acid in topical rosemary extracts and how it reduces scar formation in injured skin: doi.org/10.1172/jci....
Reposted by JCI insight
JCI Insight - Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism insight.jci.org/articles/vie...
JCI Insight -
Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism
insight.jci.org
December 8, 2025 at 6:31 PM
JCI Insight - Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism insight.jci.org/articles/vie...