JCI insight
@insight.jci.org
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
First-in-child phase I trial of p-STAT3 inhibitor WP1066 in pediatric brain tumor patients
Tobey J. MacDonald & team report WP1066 is safe, has minimal toxicity, and induces antitumor immune responses in pediatric brain tumor patients: doi.org/10.1172/jci....
Tobey J. MacDonald & team report WP1066 is safe, has minimal toxicity, and induces antitumor immune responses in pediatric brain tumor patients: doi.org/10.1172/jci....
February 11, 2026 at 9:01 PM
First-in-child phase I trial of p-STAT3 inhibitor WP1066 in pediatric brain tumor patients
Tobey J. MacDonald & team report WP1066 is safe, has minimal toxicity, and induces antitumor immune responses in pediatric brain tumor patients: doi.org/10.1172/jci....
Tobey J. MacDonald & team report WP1066 is safe, has minimal toxicity, and induces antitumor immune responses in pediatric brain tumor patients: doi.org/10.1172/jci....
A new angle on sleep and politics
In this Clinical Research and Public Health article, Stephen Y. Chan & team report on health outcomes after national acute sleep deprivation events among the American public: doi.org/10.1172/jci....
In this Clinical Research and Public Health article, Stephen Y. Chan & team report on health outcomes after national acute sleep deprivation events among the American public: doi.org/10.1172/jci....
February 10, 2026 at 9:02 PM
A new angle on sleep and politics
In this Clinical Research and Public Health article, Stephen Y. Chan & team report on health outcomes after national acute sleep deprivation events among the American public: doi.org/10.1172/jci....
In this Clinical Research and Public Health article, Stephen Y. Chan & team report on health outcomes after national acute sleep deprivation events among the American public: doi.org/10.1172/jci....
Reposted by JCI insight
🚨Happy to share that our research on splice modulation therapy for X-linked Alport syndrome using organoid models has just been published!
I am grateful to all co-authors!
@institutimagine.bsky.social @insight.jci.org @gdorval.bsky.social @hkd-l.bsky.social
insight.jci.org/articles/vie...
I am grateful to all co-authors!
@institutimagine.bsky.social @insight.jci.org @gdorval.bsky.social @hkd-l.bsky.social
insight.jci.org/articles/vie...
February 9, 2026 at 9:53 PM
🚨Happy to share that our research on splice modulation therapy for X-linked Alport syndrome using organoid models has just been published!
I am grateful to all co-authors!
@institutimagine.bsky.social @insight.jci.org @gdorval.bsky.social @hkd-l.bsky.social
insight.jci.org/articles/vie...
I am grateful to all co-authors!
@institutimagine.bsky.social @insight.jci.org @gdorval.bsky.social @hkd-l.bsky.social
insight.jci.org/articles/vie...
Reposted by JCI insight
New Paper Alert! Hard getting this one out... Huge kudos to Paul Carter for immense amounts of experimentation - Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis. insight.jci.org/articles/vie...
❤️@thebhf.bsky.social 💰
❤️@thebhf.bsky.social 💰
JCI Insight -
Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis.
insight.jci.org
February 9, 2026 at 5:27 PM
New Paper Alert! Hard getting this one out... Huge kudos to Paul Carter for immense amounts of experimentation - Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis. insight.jci.org/articles/vie...
❤️@thebhf.bsky.social 💰
❤️@thebhf.bsky.social 💰
Microcephaly-lymphedema-chorioretinopathy syndrome (MLC) is an autosomal dominant condition.
This issue’s cover: Ogmen et al. report on clinical features and disease mechanisms in MLC involving KIF11 pathogenic variants. doi.org/10.1172/jci....
This issue’s cover: Ogmen et al. report on clinical features and disease mechanisms in MLC involving KIF11 pathogenic variants. doi.org/10.1172/jci....
February 9, 2026 at 5:15 PM
Microcephaly-lymphedema-chorioretinopathy syndrome (MLC) is an autosomal dominant condition.
This issue’s cover: Ogmen et al. report on clinical features and disease mechanisms in MLC involving KIF11 pathogenic variants. doi.org/10.1172/jci....
This issue’s cover: Ogmen et al. report on clinical features and disease mechanisms in MLC involving KIF11 pathogenic variants. doi.org/10.1172/jci....
Reposted by JCI insight
Our work characterizing the respiratory depression caused by opioids and alcohols is finally out in the world! pubmed.ncbi.nlm.nih.gov/41632547/
Potentiation of fentanyl-induced respiratory depression by alcohol is not fully reversed by naloxone - PubMed
The high frequency of opioid overdose deaths often involves co-use of alcohol, which is reported in approximately 30% of fentanyl fatalities. Both substances depress respiratory function, and their combined effects can be lethal. The present study investigated physiological parameters of respiratory …
pubmed.ncbi.nlm.nih.gov
February 7, 2026 at 3:13 AM
Our work characterizing the respiratory depression caused by opioids and alcohols is finally out in the world! pubmed.ncbi.nlm.nih.gov/41632547/
From earlier this week: TRPV4 skeletal disorders are currently treated by bracing and with surgery.
Here, Daniel H Cohn & team @uclaupdates.bsky.social rescue the skeletal dysplasia phenotype of Trpv4 mutant mice—a new mouse model—using small molecule inhibition: doi.org/10.1172/jci....
Here, Daniel H Cohn & team @uclaupdates.bsky.social rescue the skeletal dysplasia phenotype of Trpv4 mutant mice—a new mouse model—using small molecule inhibition: doi.org/10.1172/jci....
February 8, 2026 at 2:01 PM
From earlier this week: TRPV4 skeletal disorders are currently treated by bracing and with surgery.
Here, Daniel H Cohn & team @uclaupdates.bsky.social rescue the skeletal dysplasia phenotype of Trpv4 mutant mice—a new mouse model—using small molecule inhibition: doi.org/10.1172/jci....
Here, Daniel H Cohn & team @uclaupdates.bsky.social rescue the skeletal dysplasia phenotype of Trpv4 mutant mice—a new mouse model—using small molecule inhibition: doi.org/10.1172/jci....
ICYMI: Don’t overlook the kidney in SARS-CoV-2 pneumonia—even in the absence of overt acute kidney injury
@olilen.bsky.social, @tharaux-lenoir-lab.bsky.social & team report on a strong association between kidney-derived proteins & IL-10 levels & mortality: doi.org/10.1172/jci....
@olilen.bsky.social, @tharaux-lenoir-lab.bsky.social & team report on a strong association between kidney-derived proteins & IL-10 levels & mortality: doi.org/10.1172/jci....
February 7, 2026 at 2:01 PM
ICYMI: Don’t overlook the kidney in SARS-CoV-2 pneumonia—even in the absence of overt acute kidney injury
@olilen.bsky.social, @tharaux-lenoir-lab.bsky.social & team report on a strong association between kidney-derived proteins & IL-10 levels & mortality: doi.org/10.1172/jci....
@olilen.bsky.social, @tharaux-lenoir-lab.bsky.social & team report on a strong association between kidney-derived proteins & IL-10 levels & mortality: doi.org/10.1172/jci....
Reposted by JCI insight
#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/vie... #BromodomainContainingProtein4 #TranslationalScience
JCI Insight -
BRD4 promotes endodermal cell fate during mammalian lung development
insight.jci.org
February 5, 2026 at 8:26 PM
#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/vie... #BromodomainContainingProtein4 #TranslationalScience
Can we target glioblastoma through diet?
Prakash Chinnaiyan & team show enhanced lipid metabolism in glioblastoma creates vulnerability to polyunsaturated fatty acids, enabling a dietary approach that enhances tumor control in mice: doi.org/10.1172/jci....
Prakash Chinnaiyan & team show enhanced lipid metabolism in glioblastoma creates vulnerability to polyunsaturated fatty acids, enabling a dietary approach that enhances tumor control in mice: doi.org/10.1172/jci....
February 6, 2026 at 1:02 PM
Can we target glioblastoma through diet?
Prakash Chinnaiyan & team show enhanced lipid metabolism in glioblastoma creates vulnerability to polyunsaturated fatty acids, enabling a dietary approach that enhances tumor control in mice: doi.org/10.1172/jci....
Prakash Chinnaiyan & team show enhanced lipid metabolism in glioblastoma creates vulnerability to polyunsaturated fatty acids, enabling a dietary approach that enhances tumor control in mice: doi.org/10.1172/jci....
Current treatments for gout are limited and can have severe side effects.
Here, Lintao Qu & team illuminate a neuroimmune mechanism in a mouse gout model involving MRGPRX2 signaling in synovial mast cells that drives pain and joint inflammation: doi.org/10.1172/jci....
Here, Lintao Qu & team illuminate a neuroimmune mechanism in a mouse gout model involving MRGPRX2 signaling in synovial mast cells that drives pain and joint inflammation: doi.org/10.1172/jci....
February 5, 2026 at 1:02 PM
Current treatments for gout are limited and can have severe side effects.
Here, Lintao Qu & team illuminate a neuroimmune mechanism in a mouse gout model involving MRGPRX2 signaling in synovial mast cells that drives pain and joint inflammation: doi.org/10.1172/jci....
Here, Lintao Qu & team illuminate a neuroimmune mechanism in a mouse gout model involving MRGPRX2 signaling in synovial mast cells that drives pain and joint inflammation: doi.org/10.1172/jci....
Few studies report on urinary microbiota, especially in pediatric conditions.
Here, Miguel Verbitsky & team show genetic variations influence bacterial composition of urine in children with recurrent urinary infections and vesicoureteral reflux: doi.org/10.1172/jci....
Here, Miguel Verbitsky & team show genetic variations influence bacterial composition of urine in children with recurrent urinary infections and vesicoureteral reflux: doi.org/10.1172/jci....
February 4, 2026 at 1:02 PM
Few studies report on urinary microbiota, especially in pediatric conditions.
Here, Miguel Verbitsky & team show genetic variations influence bacterial composition of urine in children with recurrent urinary infections and vesicoureteral reflux: doi.org/10.1172/jci....
Here, Miguel Verbitsky & team show genetic variations influence bacterial composition of urine in children with recurrent urinary infections and vesicoureteral reflux: doi.org/10.1172/jci....
Don’t overlook the kidney in SARS-CoV-2 pneumonia—even in the absence of overt acute kidney injury
@olilen.bsky.social, Pierre-Louis Tharaux & team report on a strong association between kidney-derived proteins and IL-10 levels and mortality: doi.org/10.1172/jci....
@olilen.bsky.social, Pierre-Louis Tharaux & team report on a strong association between kidney-derived proteins and IL-10 levels and mortality: doi.org/10.1172/jci....
February 3, 2026 at 1:02 PM
Don’t overlook the kidney in SARS-CoV-2 pneumonia—even in the absence of overt acute kidney injury
@olilen.bsky.social, Pierre-Louis Tharaux & team report on a strong association between kidney-derived proteins and IL-10 levels and mortality: doi.org/10.1172/jci....
@olilen.bsky.social, Pierre-Louis Tharaux & team report on a strong association between kidney-derived proteins and IL-10 levels and mortality: doi.org/10.1172/jci....
TRPV4 skeletal disorders are currently treated by bracing and with surgery.
Here, Daniel H Cohn & team @uclaupdates.bsky.social rescue the skeletal dysplasia phenotype of Trpv4 mutant mice—a new mouse model—using small molecule inhibition: doi.org/10.1172/jci....
Here, Daniel H Cohn & team @uclaupdates.bsky.social rescue the skeletal dysplasia phenotype of Trpv4 mutant mice—a new mouse model—using small molecule inhibition: doi.org/10.1172/jci....
February 2, 2026 at 1:01 PM
TRPV4 skeletal disorders are currently treated by bracing and with surgery.
Here, Daniel H Cohn & team @uclaupdates.bsky.social rescue the skeletal dysplasia phenotype of Trpv4 mutant mice—a new mouse model—using small molecule inhibition: doi.org/10.1172/jci....
Here, Daniel H Cohn & team @uclaupdates.bsky.social rescue the skeletal dysplasia phenotype of Trpv4 mutant mice—a new mouse model—using small molecule inhibition: doi.org/10.1172/jci....
ICYMI: For decades, memory-like responses in immune cells have remained unexplained
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
February 1, 2026 at 2:00 PM
ICYMI: For decades, memory-like responses in immune cells have remained unexplained
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
From earlier this week: Immune checkpoint inhibitor therapies for cancer can induce unintended immune related adverse events (irAEs).
Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
January 31, 2026 at 2:00 PM
From earlier this week: Immune checkpoint inhibitor therapies for cancer can induce unintended immune related adverse events (irAEs).
Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
In 1950, the Noyes criteria was established for determining the optimal window of implantation
@gregoryburns.bsky.social, @emmanuelpaul.bsky.social, Nataki C. Douglas & team now identify an epithelial receptivity signature & stromal changes supporting embryo implantation: doi.org/10.1172/jci....
@gregoryburns.bsky.social, @emmanuelpaul.bsky.social, Nataki C. Douglas & team now identify an epithelial receptivity signature & stromal changes supporting embryo implantation: doi.org/10.1172/jci....
January 30, 2026 at 2:14 PM
In 1950, the Noyes criteria was established for determining the optimal window of implantation
@gregoryburns.bsky.social, @emmanuelpaul.bsky.social, Nataki C. Douglas & team now identify an epithelial receptivity signature & stromal changes supporting embryo implantation: doi.org/10.1172/jci....
@gregoryburns.bsky.social, @emmanuelpaul.bsky.social, Nataki C. Douglas & team now identify an epithelial receptivity signature & stromal changes supporting embryo implantation: doi.org/10.1172/jci....
Reposted by JCI insight
🎉 Excited to share that our newest manuscript has been accepted in @insight.jci.org!
We identify CD9 as a key regulator of macrophage-driven adipose remodeling, linking immune–stromal crosstalk to metabolic dysfunction in obesity!
Stay tuned!
#obesity #immunometabolism #macrophages #adiposetissue
We identify CD9 as a key regulator of macrophage-driven adipose remodeling, linking immune–stromal crosstalk to metabolic dysfunction in obesity!
Stay tuned!
#obesity #immunometabolism #macrophages #adiposetissue
January 29, 2026 at 2:33 PM
🎉 Excited to share that our newest manuscript has been accepted in @insight.jci.org!
We identify CD9 as a key regulator of macrophage-driven adipose remodeling, linking immune–stromal crosstalk to metabolic dysfunction in obesity!
Stay tuned!
#obesity #immunometabolism #macrophages #adiposetissue
We identify CD9 as a key regulator of macrophage-driven adipose remodeling, linking immune–stromal crosstalk to metabolic dysfunction in obesity!
Stay tuned!
#obesity #immunometabolism #macrophages #adiposetissue
Reposted by JCI insight
Happy to share our latest work on the epigenetic basis of trained immunity in hematopoietic stem cells! @bcmhouston.bsky.social @texaschildrens.bsky.social
For decades, memory-like responses in immune cells have remained unexplained
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
January 29, 2026 at 1:35 PM
Happy to share our latest work on the epigenetic basis of trained immunity in hematopoietic stem cells! @bcmhouston.bsky.social @texaschildrens.bsky.social
TNF is a driver of rheumatoid arthritis, but the pathway details remain incomplete
@SLG1717.bsky.social & team now report Arid5a as an activator of TNF signaling elevated in human RA tissues. And its loss in mice results in resistance to arthritis: doi.org/10.1172/jci....
@SLG1717.bsky.social & team now report Arid5a as an activator of TNF signaling elevated in human RA tissues. And its loss in mice results in resistance to arthritis: doi.org/10.1172/jci....
January 29, 2026 at 1:02 PM
TNF is a driver of rheumatoid arthritis, but the pathway details remain incomplete
@SLG1717.bsky.social & team now report Arid5a as an activator of TNF signaling elevated in human RA tissues. And its loss in mice results in resistance to arthritis: doi.org/10.1172/jci....
@SLG1717.bsky.social & team now report Arid5a as an activator of TNF signaling elevated in human RA tissues. And its loss in mice results in resistance to arthritis: doi.org/10.1172/jci....
Immune checkpoint inhibitor therapies for cancer can induce unintended immune related adverse events (irAEs).
Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
January 28, 2026 at 1:02 PM
Immune checkpoint inhibitor therapies for cancer can induce unintended immune related adverse events (irAEs).
Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
Reposted by JCI insight
@insight.jci.org the CORIMUNO-19 collaborative group releases a predictive score for COVID-19 and unravels the overlooked impact of subclinical acute kidney injury. @inserm.fr @ap-hp.bsky.social @inserm.fr @frm-officiel.bsky.social @anrs-mie.bsky.social
10.1172/jci.insight.198244
10.1172/jci.insight.198244
January 26, 2026 at 10:39 PM
@insight.jci.org the CORIMUNO-19 collaborative group releases a predictive score for COVID-19 and unravels the overlooked impact of subclinical acute kidney injury. @inserm.fr @ap-hp.bsky.social @inserm.fr @frm-officiel.bsky.social @anrs-mie.bsky.social
10.1172/jci.insight.198244
10.1172/jci.insight.198244
For decades, memory-like responses in immune cells have remained unexplained
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
January 27, 2026 at 1:01 PM
For decades, memory-like responses in immune cells have remained unexplained
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
Reposted by JCI insight
Thrilled to share our latest @JCI_Insight paper with @NatakiDouglas and team! We mapped human endometrial cell states across the menstrual cycle and defined the GERM (glandular epithelium receptivity module) — a 556-gene signature marking the window of implantation.
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
JCI Insight -
Single-cell mapping of human endometrium and decidua reveals epithelial and stromal contributions to fertility
insight.jci.org
January 23, 2026 at 8:33 PM
Thrilled to share our latest @JCI_Insight paper with @NatakiDouglas and team! We mapped human endometrial cell states across the menstrual cycle and defined the GERM (glandular epithelium receptivity module) — a 556-gene signature marking the window of implantation.
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Variable length dystrophin constructs have recently been characterized in Duchenne muscular dystrophy models
Hichem Tasfaout & team now present a method for using proteomics to evaluate the efficacy of 3 dystrophin-replacement AAV approaches: doi.org/10.1172/jci....
Hichem Tasfaout & team now present a method for using proteomics to evaluate the efficacy of 3 dystrophin-replacement AAV approaches: doi.org/10.1172/jci....
January 26, 2026 at 1:02 PM
Variable length dystrophin constructs have recently been characterized in Duchenne muscular dystrophy models
Hichem Tasfaout & team now present a method for using proteomics to evaluate the efficacy of 3 dystrophin-replacement AAV approaches: doi.org/10.1172/jci....
Hichem Tasfaout & team now present a method for using proteomics to evaluate the efficacy of 3 dystrophin-replacement AAV approaches: doi.org/10.1172/jci....