David A. Hill, MD, PhD
@drdavidhill.bsky.social
Physician-Scientist and Attending Physician at the University of Pennsylvania and Children's Hospital of Philadelphia studying how #diet and #metabolism influence #immune #health and #inflammatory #disease.
Web: https://www.med.upenn.edu/hilllab/
Web: https://www.med.upenn.edu/hilllab/
Pinned
Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner
We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ-inducible transcriptional elements....
onlinelibrary.wiley.com
Just in time for the holidays...🚨New publication alert!🚨
Our latest paper is out in Clinical and Experimental Allergy!
The esophagus is not just for food transport! Esophageal epithelial cells help to control allergic inflammation via expression of MHCII!
onlinelibrary.wiley.com/doi/10.1111/...
Our latest paper is out in Clinical and Experimental Allergy!
The esophagus is not just for food transport! Esophageal epithelial cells help to control allergic inflammation via expression of MHCII!
onlinelibrary.wiley.com/doi/10.1111/...
Excited to share our latest work, soon to be published in Diagnostics!
This trial of >200 patients showed high performance for the #EoE #Food #Test! This transformational technology is now under development by the CHOP Clinical Immunology Lab.
Stay tuned to know when the paper drops!
This trial of >200 patients showed high performance for the #EoE #Food #Test! This transformational technology is now under development by the CHOP Clinical Immunology Lab.
Stay tuned to know when the paper drops!
December 26, 2025 at 4:39 PM
Just in time for the holidays...🚨New publication alert!🚨
Our latest paper is out in Clinical and Experimental Allergy!
The esophagus is not just for food transport! Esophageal epithelial cells help to control allergic inflammation via expression of MHCII!
onlinelibrary.wiley.com/doi/10.1111/...
Our latest paper is out in Clinical and Experimental Allergy!
The esophagus is not just for food transport! Esophageal epithelial cells help to control allergic inflammation via expression of MHCII!
onlinelibrary.wiley.com/doi/10.1111/...
Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner
We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ-inducible transcriptional elements....
onlinelibrary.wiley.com
December 23, 2025 at 9:09 PM
Just in time for the holidays...🚨New publication alert!🚨
Our latest paper is out in Clinical and Experimental Allergy!
The esophagus is not just for food transport! Esophageal epithelial cells help to control allergic inflammation via expression of MHCII!
onlinelibrary.wiley.com/doi/10.1111/...
Our latest paper is out in Clinical and Experimental Allergy!
The esophagus is not just for food transport! Esophageal epithelial cells help to control allergic inflammation via expression of MHCII!
onlinelibrary.wiley.com/doi/10.1111/...
Excited to share our latest work, soon to be published in Clinical & Experimental Allergy!
We uncover a protective role for #IFN-γ–induced epithelial MHCII in limiting eosinophilic inflammation in #EoE!
Big thanks to the funders including @aaaaiorg.bsky.social!
Stay tuned to know when it drops!
We uncover a protective role for #IFN-γ–induced epithelial MHCII in limiting eosinophilic inflammation in #EoE!
Big thanks to the funders including @aaaaiorg.bsky.social!
Stay tuned to know when it drops!
December 12, 2025 at 4:41 PM
Excited to share our latest work, soon to be published in Clinical & Experimental Allergy!
We uncover a protective role for #IFN-γ–induced epithelial MHCII in limiting eosinophilic inflammation in #EoE!
Big thanks to the funders including @aaaaiorg.bsky.social!
Stay tuned to know when it drops!
We uncover a protective role for #IFN-γ–induced epithelial MHCII in limiting eosinophilic inflammation in #EoE!
Big thanks to the funders including @aaaaiorg.bsky.social!
Stay tuned to know when it drops!
Way to go, @childrensphila.bsky.social Allergy and Immunology!
nam10.safelinks.protection.outlook.com?url=https%3A...
nam10.safelinks.protection.outlook.com?url=https%3A...
Feeding kids with food allergies can be expensive. So CHOP opened a pantry to help families access allergen-free staples
Households that struggle to pay for items like egg substitute and soy milk can find them at the health system's Buerger Center. And a delivery program is in the works.
nam10.safelinks.protection.outlook.com
December 12, 2025 at 3:45 PM
Way to go, @childrensphila.bsky.social Allergy and Immunology!
nam10.safelinks.protection.outlook.com?url=https%3A...
nam10.safelinks.protection.outlook.com?url=https%3A...
Check out @chopresearch.bsky.social Allergy/Immunology Dr. Stan Gabryszewski speaking on Katie Lockwood’s Primary Care Perspectives Podcast about our latest peanut allergy study!
podcasts.apple.com/us/podcast/p...
podcasts.apple.com/us/podcast/p...
Peanut Allergy Prevention: What we have learned from early introduction (Episode 206)
Podcast Episode · Primary Care Perspectives · 12/09/2025 · 30m
podcasts.apple.com
December 9, 2025 at 4:28 PM
Check out @chopresearch.bsky.social Allergy/Immunology Dr. Stan Gabryszewski speaking on Katie Lockwood’s Primary Care Perspectives Podcast about our latest peanut allergy study!
podcasts.apple.com/us/podcast/p...
podcasts.apple.com/us/podcast/p...
It’s paper submission (and resubmission) day!
December 7, 2025 at 8:34 PM
It’s paper submission (and resubmission) day!
I really enjoyed speaking with Stephanie on Public Health On Call. Please help to get the word out that early allergen introduction is safe and effective!
Official recommendations encourage introducing peanuts to children’s diets at around 4 to 6 months old.
@drdavidhill.bsky.social explains how early introduction has reduced peanut allergies.
podcast.publichealth.jhu.edu/980-why-earl...
@drdavidhill.bsky.social explains how early introduction has reduced peanut allergies.
podcast.publichealth.jhu.edu/980-why-earl...
November 24, 2025 at 5:42 PM
I really enjoyed speaking with Stephanie on Public Health On Call. Please help to get the word out that early allergen introduction is safe and effective!
Thanks for a great visit, UAB and Children’s of Alabama! Such a phenomenal group doing inspiring work.
November 18, 2025 at 9:14 PM
Thanks for a great visit, UAB and Children’s of Alabama! Such a phenomenal group doing inspiring work.
Cool new technology that holds promise for asthma and other antigen-driven allergic conditions!
pubmed.ncbi.nlm.nih.gov/40985871/
pubmed.ncbi.nlm.nih.gov/40985871/
Allergen-specific mRNA-lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice - PubMed
Allergic diseases have reached epidemic proportions globally, calling attention to the need for better treatment and preventive approaches. Herein, we developed allergen-encoding messenger RNA (mRNA)-lipid nanoparticle (LNP) strategies for both therapy and prevention of allergic responses. Immunizat …
pubmed.ncbi.nlm.nih.gov
November 10, 2025 at 12:06 PM
Cool new technology that holds promise for asthma and other antigen-driven allergic conditions!
pubmed.ncbi.nlm.nih.gov/40985871/
pubmed.ncbi.nlm.nih.gov/40985871/
Reposted by David A. Hill, MD, PhD
And now! A link! slate.com/podcasts/wha...
October 23, 2025 at 12:33 PM
And now! A link! slate.com/podcasts/wha...
Really enjoyed speaking with @slate.com 's Mary Harris (@maryharris.bsky.social) this morning about the science behind #early #allergen #introduction in infants, being a #doctor, and the current #public #health climate. Grateful for the thoughtful conversation!
October 22, 2025 at 2:24 PM
Really enjoyed speaking with @slate.com 's Mary Harris (@maryharris.bsky.social) this morning about the science behind #early #allergen #introduction in infants, being a #doctor, and the current #public #health climate. Grateful for the thoughtful conversation!
youtu.be/nGmH2lMWIp8?...
BIG thanks to @chopresearch.bsky.social for putting together this science snapshot!
BIG thanks to @chopresearch.bsky.social for putting together this science snapshot!
Are Early Food Allergen Introduction Guidelines Helping to Reduce IgE-mediated Food Allergy?
YouTube video by CHOP Research Institute
youtu.be
October 22, 2025 at 2:19 PM
youtu.be/nGmH2lMWIp8?...
BIG thanks to @chopresearch.bsky.social for putting together this science snapshot!
BIG thanks to @chopresearch.bsky.social for putting together this science snapshot!
Really enjoyed speaking with @npr.org’s Leila Fadel this morning about the science behind early allergen introduction in infants — and why it's both safe and effective. Grateful for the thoughtful conversation!
October 21, 2025 at 11:11 AM
Really enjoyed speaking with @npr.org’s Leila Fadel this morning about the science behind early allergen introduction in infants — and why it's both safe and effective. Grateful for the thoughtful conversation!
Reposted by David A. Hill, MD, PhD
New analysis links early peanut introduction to fewer peanut allergies, informed by AAAAI member input. https://ow.ly/XFu550Xf9Kk
Some 60,000 kids have avoided peanut allergies due to landmark 2015 advice, study finds
About 60,000 children have avoided developing peanut allergies after 2015 guidance upended medical practice by recommending introducing the allergen to infants starting as early as 4 months, a new study finds.
ow.ly
October 20, 2025 at 7:13 PM
New analysis links early peanut introduction to fewer peanut allergies, informed by AAAAI member input. https://ow.ly/XFu550Xf9Kk
Peanut Allergies Have Plummeted in Children, Study Shows www.nytimes.com/2025/10/20/w...
Thanks @nytimes.com!
Thanks @nytimes.com!
Peanut Allergies Have Plummeted in Children, Study Shows
www.nytimes.com
October 20, 2025 at 10:04 AM
Peanut Allergies Have Plummeted in Children, Study Shows www.nytimes.com/2025/10/20/w...
Thanks @nytimes.com!
Thanks @nytimes.com!
Our lab’s latest paper is out now in @ameracadpeds.bsky.social Pediatrics!
We find that peanut and all-cause anaphylactic food allergy prevalence has reduced in US kids under 3 since the issuing of early allergenic food introduction guidelines!
Read here: publications.aap.org/pediatrics/a...
We find that peanut and all-cause anaphylactic food allergy prevalence has reduced in US kids under 3 since the issuing of early allergenic food introduction guidelines!
Read here: publications.aap.org/pediatrics/a...
Guidelines for Early Food Introduction and Patterns of Food Allergy
10.1542/6374765900112Video AbstractPEDS-VA_2024-0705166374765900112OBJECTIVE. We aimed to determine whether rates of peanut (or any) immunoglobulin E–mediated food allergy (IgE-FA) changed following t...
publications.aap.org
October 20, 2025 at 10:03 AM
Our lab’s latest paper is out now in @ameracadpeds.bsky.social Pediatrics!
We find that peanut and all-cause anaphylactic food allergy prevalence has reduced in US kids under 3 since the issuing of early allergenic food introduction guidelines!
Read here: publications.aap.org/pediatrics/a...
We find that peanut and all-cause anaphylactic food allergy prevalence has reduced in US kids under 3 since the issuing of early allergenic food introduction guidelines!
Read here: publications.aap.org/pediatrics/a...