UPENN_ITMAT
@itmat.bsky.social
ITMAT was launched formally in January 2005; the first Institute of Translational Medicine And Therapeutics in the world.
#Tryptophan supplementation may attenuate #Naproxen adverse effects and widen its #TherapeuticIndex www.nature.com/articles/s41... @FitzGerald__Lab #Pharmacology #DrugMechanism #DrugSafety #TranslationalScience
Depression of tryptophan may contribute to adverse effects of naproxen - Nature Communications
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have been associated with adverse effects affecting both the cardiovascular and gastrointestinal systems. Here the authors show that NSAIDs lower plasma ...
www.nature.com
February 18, 2026 at 9:33 PM
#Tryptophan supplementation may attenuate #Naproxen adverse effects and widen its #TherapeuticIndex www.nature.com/articles/s41... @FitzGerald__Lab #Pharmacology #DrugMechanism #DrugSafety #TranslationalScience
#Drosophila model updates our understanding of brain–periphery interactions: www.nature.com/articles/s41... @amitaseh #BrainHealth #Neurobiology #SleepResearch #Neuroscience #TranslationalScience
Sleep-dependent clearance of brain lipids by peripheral blood cells - Nature
Peripheral macrophage-like haemocytes in Drosophila promote sleep by clearing lipid buildup in the brain, helping to maintain metabolic homeostasis and brain function and fitness.
www.nature.com
February 12, 2026 at 10:33 PM
#Drosophila model updates our understanding of brain–periphery interactions: www.nature.com/articles/s41... @amitaseh #BrainHealth #Neurobiology #SleepResearch #Neuroscience #TranslationalScience
Revising the model for #SurfactantProteinC maturation: doi.org/10.1016/j.jb... #PulmonaryFibrosis #CellBiology #ProteinTrafficking #AT2Cells #LungDisease #TranslationalScience
Redirecting
doi.org
February 10, 2026 at 10:17 PM
Revising the model for #SurfactantProteinC maturation: doi.org/10.1016/j.jb... #PulmonaryFibrosis #CellBiology #ProteinTrafficking #AT2Cells #LungDisease #TranslationalScience
#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/vie... #BromodomainContainingProtein4 #TranslationalScience
JCI Insight -
BRD4 promotes endodermal cell fate during mammalian lung development
insight.jci.org
February 5, 2026 at 8:26 PM
#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/vie... #BromodomainContainingProtein4 #TranslationalScience
#1 in Medical Breakthroughs: Seven of the top 20 papers honored by the Clinical Research Forum (CRF) are from Penn @CRForumUS #TranslationalScience
February 3, 2026 at 9:16 PM
#1 in Medical Breakthroughs: Seven of the top 20 papers honored by the Clinical Research Forum (CRF) are from Penn @CRForumUS #TranslationalScience
#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome www.jci.org/articles/vie... @FitzGerald__Lab #TranslationalScience
JCI -
Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use
www.jci.org
January 29, 2026 at 6:54 PM
#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome www.jci.org/articles/vie... @FitzGerald__Lab #TranslationalScience
Can #BrownAdipose tissue be activated for therapeutic benefit in #MetabolicDisease? Possibly by harnessing cell-autonomous pathways: doi.org/10.1016/j.mo... @BaurLab #TranslationalScience
Redirecting
doi.org
January 22, 2026 at 7:52 PM
Can #BrownAdipose tissue be activated for therapeutic benefit in #MetabolicDisease? Possibly by harnessing cell-autonomous pathways: doi.org/10.1016/j.mo... @BaurLab #TranslationalScience
How your neighborhood modulates genetically determined disease risk jamanetwork.com/journals/jam... #HypertrophicCardiomyopathy #HCM #TranslationalScience
Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy
This cohort study using data from the Sarcomeric Human Cardiomyopathy Registry determines the association of area-based social determinants of health with clinical outcomes in patients with hypertroph...
jamanetwork.com
January 21, 2026 at 3:21 PM
How your neighborhood modulates genetically determined disease risk jamanetwork.com/journals/jam... #HypertrophicCardiomyopathy #HCM #TranslationalScience
Regulating acetyl-CoA levels through Acetyl-CoA Synthetase 2 emerges as potential safeguard for #CognitiveFunction www.pnas.org/doi/10.1073/... #ACSS2 #Neurodegeneration #Tauopathy #TranslationalScience
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 14, 2026 at 1:48 PM
Regulating acetyl-CoA levels through Acetyl-CoA Synthetase 2 emerges as potential safeguard for #CognitiveFunction www.pnas.org/doi/10.1073/... #ACSS2 #Neurodegeneration #Tauopathy #TranslationalScience
Need to consider pharmacokinetic & -dynamic properties & patient-specific risk factors when comparing the cardiovascular risk associated with specific #NSAIDs www.ahajournals.org/doi/epub/10.... @ktheken @TiloGrosser #TranslationalScience
Degree of Cyclooxygenase-2 Inhibition Modulates Blood Pressure Response
www.ahajournals.org
January 8, 2026 at 9:25 PM
Need to consider pharmacokinetic & -dynamic properties & patient-specific risk factors when comparing the cardiovascular risk associated with specific #NSAIDs www.ahajournals.org/doi/epub/10.... @ktheken @TiloGrosser #TranslationalScience
Happy New Year from ITMAT!
January 6, 2026 at 7:55 PM
Happy New Year from ITMAT!
Characterizing individual contributions of the different components of #mRNA #vaccine to mount #ImmuneResponse doi.org/10.1016/j.ce... #mRNAvaccine @Loccilab #TranslationalScience
Redirecting
doi.org
December 18, 2025 at 9:11 PM
Characterizing individual contributions of the different components of #mRNA #vaccine to mount #ImmuneResponse doi.org/10.1016/j.ce... #mRNAvaccine @Loccilab #TranslationalScience
#TargetedGeneTherapy for partial restoration of #MitochondrialFunction and protection against #DilatedCardiomyopathy www.nature.com/articles/s41... #MitochondrialCardiomyopathy #CardiacFunction #PGC1α #TranslationalScience
Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice - Nature Communications
Patients with primary mitochondrial disease manifesting cardiomyopathy are twice as likely to die compared to those without cardiomyopathy. Here, the authors show that a modest increase in cardiac mit...
www.nature.com
December 16, 2025 at 8:35 PM
#TargetedGeneTherapy for partial restoration of #MitochondrialFunction and protection against #DilatedCardiomyopathy www.nature.com/articles/s41... #MitochondrialCardiomyopathy #CardiacFunction #PGC1α #TranslationalScience
Defining the role of #ApolipoproteinL1 (#APOL1) #RiskVariants on #BloodPressure www.ahajournals.org/doi/10.1161/... @ksusztak.bsky.social #HealthEquity #KidneyHealth #TranslationalScience
Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage | Circulation
BACKGROUND: Black people bear a disproportionate burden of hypertension and hypertension-attributed
chronic kidney disease. A role of apolipoprotein L1 (APOL1) risk variants (RVs; G1 and G2) in these ...
www.ahajournals.org
December 11, 2025 at 5:09 PM
Defining the role of #ApolipoproteinL1 (#APOL1) #RiskVariants on #BloodPressure www.ahajournals.org/doi/10.1161/... @ksusztak.bsky.social #HealthEquity #KidneyHealth #TranslationalScience
Scaling personalized gene-editing therapy into a future of “interventional genetics” through “umbrella of umbrellas” master protocol clinical trial approaches doi.org/10.1016/j.aj... @ahrensnicklas.bsky.social @kiranmusunuru.bsky.social #CRISPR #TranslationalScience
Redirecting
doi.org
December 9, 2025 at 10:37 PM
Scaling personalized gene-editing therapy into a future of “interventional genetics” through “umbrella of umbrellas” master protocol clinical trial approaches doi.org/10.1016/j.aj... @ahrensnicklas.bsky.social @kiranmusunuru.bsky.social #CRISPR #TranslationalScience
Honing in on characterizing biological implications of the #hepatic #Mitochondria NAD+ pool www.nature.com/articles/s42... #OrganRegeneration #MembraneTransporter #TranslationalScience
Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration - Nature Metabolism
Modulating mitochondrial NAD+ levels by changing the expression of the mitochondrial NAD+ transporter, SLC25A51, Mukherjee et al. demonstrate that mitochondrial, rather than cytosolic or nuclear, NAD+...
www.nature.com
December 4, 2025 at 8:51 PM
Honing in on characterizing biological implications of the #hepatic #Mitochondria NAD+ pool www.nature.com/articles/s42... #OrganRegeneration #MembraneTransporter #TranslationalScience
#CARTCell based hyperlocalized targeting of #InflammatoryPathways involved in development of #AtheroscleroticPlaque doi.org/10.1161/CIRC... @IAmDrDex @PoseyLab #CellTherapy #ImmunoTherapy #Atherosclerosis #TranslationalScience
December 3, 2025 at 5:31 PM
#CARTCell based hyperlocalized targeting of #InflammatoryPathways involved in development of #AtheroscleroticPlaque doi.org/10.1161/CIRC... @IAmDrDex @PoseyLab #CellTherapy #ImmunoTherapy #Atherosclerosis #TranslationalScience
Wishing you a joyful and restful Thanksgiving!
November 25, 2025 at 10:27 PM
Wishing you a joyful and restful Thanksgiving!
Ilucidating the critical interplay between environmental timing cues and endogenous #CircadianRhythms for #Influenza outcomes www.jci.org/articles/vie... @sengupta_shaon #ImmuneResponse #Chronobiology #CircadianMedicine #TranslationalScience
JCI -
Effect of external cues on clock-driven protection from influenza A infection
www.jci.org
November 20, 2025 at 9:49 PM
Ilucidating the critical interplay between environmental timing cues and endogenous #CircadianRhythms for #Influenza outcomes www.jci.org/articles/vie... @sengupta_shaon #ImmuneResponse #Chronobiology #CircadianMedicine #TranslationalScience
#ICU patients w/ reverse #BloodPressure dipping at 40% higher risk to be diagnosed w/ #Delirium & 13% increased #RiskOfDeath www.nature.com/articles/s41... @Nadimeljamal @carstenskarke.bsky.social #CriticalCare #BiologicalRhythm #Cognition #TranslationalScience
Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death - Scientific Reports
Scientific Reports - Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death
www.nature.com
November 18, 2025 at 4:12 PM
#ICU patients w/ reverse #BloodPressure dipping at 40% higher risk to be diagnosed w/ #Delirium & 13% increased #RiskOfDeath www.nature.com/articles/s41... @Nadimeljamal @carstenskarke.bsky.social #CriticalCare #BiologicalRhythm #Cognition #TranslationalScience
Determinants of receptiveness to respiratory care in patients w/ diagnosis of #AmyotrophicLateralSclerosis www.neurology.org/doi/10.1212/... #ALS #ALSResearch #LouGehrigDisease #ImplementationScience #TranslationalScience
How Patients With Amyotrophic Lateral Sclerosis Perceive Respiratory Interventions | Neurology Clinical Practice
Background and ObjectivesAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that commonly leads
to respiratory failure. Early respiratory interventions that may improve symptoms
and ou...
www.neurology.org
November 13, 2025 at 7:09 PM
Determinants of receptiveness to respiratory care in patients w/ diagnosis of #AmyotrophicLateralSclerosis www.neurology.org/doi/10.1212/... #ALS #ALSResearch #LouGehrigDisease #ImplementationScience #TranslationalScience
Remote incentivized trialing raises #PhysicalActivity levels by ≈30% in #ParkinsonsDisease jamanetwork.com/journals/jam... #Parkinsons #TranslationalScience
Remote, Automated Gamification and Community-Based Physical Activity in Parkinson Disease
This nonrandomized clinical trial tests the efficacy of a remote, automated gamification intervention for increasing daily steps in people with Parkinson disease.
jamanetwork.com
November 6, 2025 at 8:35 PM
Remote incentivized trialing raises #PhysicalActivity levels by ≈30% in #ParkinsonsDisease jamanetwork.com/journals/jam... #Parkinsons #TranslationalScience
Circumventing #CancerTherapyResistance: #NanoMedicine to engage #Tcells with CD19+tumor cells for #Tumor #CellLysis www.pnas.org/doi/10.1073/pnas.2409564122 @MJMitchell_Lab #TranslationalScience
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 4, 2025 at 1:43 PM
Circumventing #CancerTherapyResistance: #NanoMedicine to engage #Tcells with CD19+tumor cells for #Tumor #CellLysis www.pnas.org/doi/10.1073/pnas.2409564122 @MJMitchell_Lab #TranslationalScience