JCI insight
@insight.jci.org
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
In RA, fibroblast-like synoviocytes promote inflammation, but no medications target these cells.
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice: insight.jci.org/articles/vie...
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice: insight.jci.org/articles/vie...
November 12, 2025 at 2:03 PM
In RA, fibroblast-like synoviocytes promote inflammation, but no medications target these cells.
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice: insight.jci.org/articles/vie...
Ramsey et al. optimize a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors in mice: insight.jci.org/articles/vie...
A high percentage of neonatal seizures resist treatment
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
November 11, 2025 at 2:03 PM
A high percentage of neonatal seizures resist treatment
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Podocyte injury and loss are key events in the progression of chronic kidney disease.
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases.
insight.jci.org/articles/vie...
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases.
insight.jci.org/articles/vie...
November 10, 2025 at 5:15 PM
Podocyte injury and loss are key events in the progression of chronic kidney disease.
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases.
insight.jci.org/articles/vie...
This issue’s cover features work by Ika N. Kadariswantiningsih et al. on the selective upregulation of CCL5 in podocytes during human glomerular diseases.
insight.jci.org/articles/vie...
Previously shared: Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
November 9, 2025 at 2:01 PM
Previously shared: Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
From earlier this week: Wiedemann Steiner syndrome is a rare genetic disorder.
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction: insight.jci.org/articles/vie...
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction: insight.jci.org/articles/vie...
November 8, 2025 at 2:01 PM
From earlier this week: Wiedemann Steiner syndrome is a rare genetic disorder.
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction: insight.jci.org/articles/vie...
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction: insight.jci.org/articles/vie...
Cell-free DNA methylomics identify tissue injury patterns in pediatric ARDS
In this Research Letter, Nadir Yehya & team assessed 24 children with ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls: insight.jci.org/articles/vie...
In this Research Letter, Nadir Yehya & team assessed 24 children with ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls: insight.jci.org/articles/vie...
November 7, 2025 at 2:04 PM
Cell-free DNA methylomics identify tissue injury patterns in pediatric ARDS
In this Research Letter, Nadir Yehya & team assessed 24 children with ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls: insight.jci.org/articles/vie...
In this Research Letter, Nadir Yehya & team assessed 24 children with ARDS in a pilot study comparing hypoinflammatory ARDS, hyperinflammatory ARDS, and non-ARD controls: insight.jci.org/articles/vie...
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
November 6, 2025 at 2:03 PM
Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Here, Richard Bucala & team show combined anti-MIF and anti–PD-1 reduces tumor growth and improves survival in melanoma & colorectal cancer mouse models: insight.jci.org/articles/vie...
Reposted by JCI insight
Congrats to #LaitilaJenni & colleagues for their new @JCI_insight paper: Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy. #Myoblue tinyurl.com/yyuthutn
JCI Insight -
Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy
tinyurl.com
November 4, 2025 at 5:32 PM
Congrats to #LaitilaJenni & colleagues for their new @JCI_insight paper: Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy. #Myoblue tinyurl.com/yyuthutn
Recently, a rare pediatric case revealed a role for Site1-protease in development and lipid metabolism.
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
November 5, 2025 at 2:03 PM
Recently, a rare pediatric case revealed a role for Site1-protease in development and lipid metabolism.
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
An extensive analysis of germinal center dynamics in lung-draining lymph nodes from COVID19 autopsies…
Cloé Brenna et al. reveal how COVID-19 reshapes follicles in lung LNs & identify pathways controlling antibody responses to viral infection: insight.jci.org/articles/vie...
Cloé Brenna et al. reveal how COVID-19 reshapes follicles in lung LNs & identify pathways controlling antibody responses to viral infection: insight.jci.org/articles/vie...
November 4, 2025 at 2:03 PM
An extensive analysis of germinal center dynamics in lung-draining lymph nodes from COVID19 autopsies…
Cloé Brenna et al. reveal how COVID-19 reshapes follicles in lung LNs & identify pathways controlling antibody responses to viral infection: insight.jci.org/articles/vie...
Cloé Brenna et al. reveal how COVID-19 reshapes follicles in lung LNs & identify pathways controlling antibody responses to viral infection: insight.jci.org/articles/vie...
Wiedemann Steiner syndrome is a rare genetic disorder.
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction.
insight.jci.org/articles/vie...
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction.
insight.jci.org/articles/vie...
November 3, 2025 at 2:03 PM
Wiedemann Steiner syndrome is a rare genetic disorder.
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction.
insight.jci.org/articles/vie...
Here, Hans T. Bjornsson & team generated a WDSTS mouse model, showing restoration of KMT2A during gestation rescues postnatal neurological dysfunction.
insight.jci.org/articles/vie...
ICYMI: Is the answer to increasing vaccine responses right under our noses?
John V. Williams & team report on the downregulation of nasal IFN production in mice with human metapneumovirus infection & reveal the ability to bolster mucosal vaccine efficacy with IFN as an adjuvant: buff.ly/JkiQ7Kn
John V. Williams & team report on the downregulation of nasal IFN production in mice with human metapneumovirus infection & reveal the ability to bolster mucosal vaccine efficacy with IFN as an adjuvant: buff.ly/JkiQ7Kn
November 2, 2025 at 2:01 PM
ICYMI: Is the answer to increasing vaccine responses right under our noses?
John V. Williams & team report on the downregulation of nasal IFN production in mice with human metapneumovirus infection & reveal the ability to bolster mucosal vaccine efficacy with IFN as an adjuvant: buff.ly/JkiQ7Kn
John V. Williams & team report on the downregulation of nasal IFN production in mice with human metapneumovirus infection & reveal the ability to bolster mucosal vaccine efficacy with IFN as an adjuvant: buff.ly/JkiQ7Kn
This paper made it to the top of our readership list:
Icosapent ethyl–induced lipoprotein remodeling and its impact on cardiovascular disease risk markers in normolipidemic individuals
@martinalorey.bsky.social @katioorni.bsky.social
insight.jci.org/articles/vie...
Icosapent ethyl–induced lipoprotein remodeling and its impact on cardiovascular disease risk markers in normolipidemic individuals
@martinalorey.bsky.social @katioorni.bsky.social
insight.jci.org/articles/vie...
November 1, 2025 at 1:01 PM
This paper made it to the top of our readership list:
Icosapent ethyl–induced lipoprotein remodeling and its impact on cardiovascular disease risk markers in normolipidemic individuals
@martinalorey.bsky.social @katioorni.bsky.social
insight.jci.org/articles/vie...
Icosapent ethyl–induced lipoprotein remodeling and its impact on cardiovascular disease risk markers in normolipidemic individuals
@martinalorey.bsky.social @katioorni.bsky.social
insight.jci.org/articles/vie...
A potential new target in inflammatory bowel disease!
Agnieszka K. Czopik & team reveal the microRNA miR-147 protects intestinal integrity during inflammation: insight.jci.org/articles/vie...
Agnieszka K. Czopik & team reveal the microRNA miR-147 protects intestinal integrity during inflammation: insight.jci.org/articles/vie...
October 31, 2025 at 4:16 PM
A potential new target in inflammatory bowel disease!
Agnieszka K. Czopik & team reveal the microRNA miR-147 protects intestinal integrity during inflammation: insight.jci.org/articles/vie...
Agnieszka K. Czopik & team reveal the microRNA miR-147 protects intestinal integrity during inflammation: insight.jci.org/articles/vie...
Peanut extract increases RPS6 phosphorylation in peanut-allergic blood, but the clincial relevance was unclear
Florent Fauchère & team now show histamine-induced RPS6 phosphorylation in DCs is associated with the severity of peanut allergic reactions: insight.jci.org/articles/vie...
Florent Fauchère & team now show histamine-induced RPS6 phosphorylation in DCs is associated with the severity of peanut allergic reactions: insight.jci.org/articles/vie...
October 31, 2025 at 1:05 PM
Peanut extract increases RPS6 phosphorylation in peanut-allergic blood, but the clincial relevance was unclear
Florent Fauchère & team now show histamine-induced RPS6 phosphorylation in DCs is associated with the severity of peanut allergic reactions: insight.jci.org/articles/vie...
Florent Fauchère & team now show histamine-induced RPS6 phosphorylation in DCs is associated with the severity of peanut allergic reactions: insight.jci.org/articles/vie...
A stretch for gut cells extends our understanding in #BowelDisease
Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
October 30, 2025 at 1:04 PM
A stretch for gut cells extends our understanding in #BowelDisease
Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
Robert O. Heuckeroth & team subjected human intestinal smooth muscle cells to pathological stretch, revealing gene-expression changes and a proinflammatory phenotype: insight.jci.org/articles/vie...
In recognition of #BreastCancerAwarenessMonth, we’re highlighting our recent publications:
insight.jci.org/articles/vie...
www.jci.org/articles/vie...
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JCI Insight - Co-phagocytosis of VEGFA with HER2-overexpressing cancer cells induced by HER2-VEGFA–bispecific antibodies improves antitumor responses
Research ArticleClinical ResearchImmunologyOncology Open Access | 10.1172/jci.insight.194494
insight.jci.org
October 29, 2025 at 4:15 PM
In recognition of #BreastCancerAwarenessMonth, we’re highlighting our recent publications:
insight.jci.org/articles/vie...
www.jci.org/articles/vie...
www.jci.org/articles/vie...
insight.jci.org/articles/vie...
www.jci.org/articles/vie...
www.jci.org/articles/vie...
John V. Williams & team report on the downregulation of nasal IFN production in mice with human metapneumovirus infection & reveal the ability to bolster mucosal vaccine efficacy with IFN as an adjuvant: insight.jci.org/articles/vie...
October 29, 2025 at 1:05 PM
John V. Williams & team report on the downregulation of nasal IFN production in mice with human metapneumovirus infection & reveal the ability to bolster mucosal vaccine efficacy with IFN as an adjuvant: insight.jci.org/articles/vie...
The proteins that hold your gut together…
Asma Nusrat & team report on CRB3 and NF2 as a dynamic duo that control epithelial barrier assembly: insight.jci.org/articles/vie...
The figure: murine colonic tissue sections labeled for CRB3A (green), β-catenin (red).
Asma Nusrat & team report on CRB3 and NF2 as a dynamic duo that control epithelial barrier assembly: insight.jci.org/articles/vie...
The figure: murine colonic tissue sections labeled for CRB3A (green), β-catenin (red).
October 28, 2025 at 1:03 PM
The proteins that hold your gut together…
Asma Nusrat & team report on CRB3 and NF2 as a dynamic duo that control epithelial barrier assembly: insight.jci.org/articles/vie...
The figure: murine colonic tissue sections labeled for CRB3A (green), β-catenin (red).
Asma Nusrat & team report on CRB3 and NF2 as a dynamic duo that control epithelial barrier assembly: insight.jci.org/articles/vie...
The figure: murine colonic tissue sections labeled for CRB3A (green), β-catenin (red).
Does vitamin D protect against kidney injury?
Here, David E. Leaf & team conduct a phase 2 trial in critically ill adults. While treatment with calcifediol or calcitriol upregulated genes in several pathways, it did not prevent acute kidney injury: insight.jci.org/articles/vie...
Here, David E. Leaf & team conduct a phase 2 trial in critically ill adults. While treatment with calcifediol or calcitriol upregulated genes in several pathways, it did not prevent acute kidney injury: insight.jci.org/articles/vie...
October 27, 2025 at 1:04 PM
Does vitamin D protect against kidney injury?
Here, David E. Leaf & team conduct a phase 2 trial in critically ill adults. While treatment with calcifediol or calcitriol upregulated genes in several pathways, it did not prevent acute kidney injury: insight.jci.org/articles/vie...
Here, David E. Leaf & team conduct a phase 2 trial in critically ill adults. While treatment with calcifediol or calcitriol upregulated genes in several pathways, it did not prevent acute kidney injury: insight.jci.org/articles/vie...
ICYMI: Geneva guidelines recommend live vaccines against TB include 2 or more gene knockouts for attenuation.
Deepak Kaushal & team generate double and triple KO mutants in Mtb, performing safety tests in a macaque model & indicating immune protection.
insight.jci.org/articles/vie...
Deepak Kaushal & team generate double and triple KO mutants in Mtb, performing safety tests in a macaque model & indicating immune protection.
insight.jci.org/articles/vie...
October 26, 2025 at 1:01 PM
ICYMI: Geneva guidelines recommend live vaccines against TB include 2 or more gene knockouts for attenuation.
Deepak Kaushal & team generate double and triple KO mutants in Mtb, performing safety tests in a macaque model & indicating immune protection.
insight.jci.org/articles/vie...
Deepak Kaushal & team generate double and triple KO mutants in Mtb, performing safety tests in a macaque model & indicating immune protection.
insight.jci.org/articles/vie...
From earlier this week: Thyroid hormones are important for neurodevelopment during the first trimester of pregnancy.
Federico Salas-Lucia & team now reveal an unappreciated role for T4 in promoting early fetal cerebral cortex development: insight.jci.org/articles/vie...
Federico Salas-Lucia & team now reveal an unappreciated role for T4 in promoting early fetal cerebral cortex development: insight.jci.org/articles/vie...
October 25, 2025 at 1:02 PM
From earlier this week: Thyroid hormones are important for neurodevelopment during the first trimester of pregnancy.
Federico Salas-Lucia & team now reveal an unappreciated role for T4 in promoting early fetal cerebral cortex development: insight.jci.org/articles/vie...
Federico Salas-Lucia & team now reveal an unappreciated role for T4 in promoting early fetal cerebral cortex development: insight.jci.org/articles/vie...
A co-phagocytosis strategy for metastatic cancer
Zhen Fan & team validate the design—a bispecific antibody that links a solid (HER2-expressing tumor cells) with a soluble tumor microenvironment component (VEGFA)—in a breast cancer mouse model: insight.jci.org/articles/vie...
Zhen Fan & team validate the design—a bispecific antibody that links a solid (HER2-expressing tumor cells) with a soluble tumor microenvironment component (VEGFA)—in a breast cancer mouse model: insight.jci.org/articles/vie...
October 24, 2025 at 4:15 PM
A co-phagocytosis strategy for metastatic cancer
Zhen Fan & team validate the design—a bispecific antibody that links a solid (HER2-expressing tumor cells) with a soluble tumor microenvironment component (VEGFA)—in a breast cancer mouse model: insight.jci.org/articles/vie...
Zhen Fan & team validate the design—a bispecific antibody that links a solid (HER2-expressing tumor cells) with a soluble tumor microenvironment component (VEGFA)—in a breast cancer mouse model: insight.jci.org/articles/vie...
@tomgillingwater.bsky.social @dibbouk.bsky.social et al. @euanscentre.bsky.social @edinburgh-uni.bsky.social & @cmvm-edinburghuni.bsky.social show in utero delivery of SMN-restoring therapy corrects neurodevelopmental defects affecting primary cilia in SMA mice: insight.jci.org/articles/vie...
October 24, 2025 at 1:04 PM
@tomgillingwater.bsky.social @dibbouk.bsky.social et al. @euanscentre.bsky.social @edinburgh-uni.bsky.social & @cmvm-edinburghuni.bsky.social show in utero delivery of SMN-restoring therapy corrects neurodevelopmental defects affecting primary cilia in SMA mice: insight.jci.org/articles/vie...
Reposted by JCI insight
New paper from @tomgillingwater.bsky.social: Federica Genovese's fantastic PhD, showing reversible prenatal primary cilia defects in the Taiwanese mouse model of SMA. Lots of work still to be done to understand how low levels of SMN lead to the cellular defects we know; this project is part of it🙌
JCI Insight -
Prenatal SMN-dependent defects in translation uncover reversible primary cilia phenotypes in spinal muscular atrophy
insight.jci.org
October 23, 2025 at 2:17 PM
New paper from @tomgillingwater.bsky.social: Federica Genovese's fantastic PhD, showing reversible prenatal primary cilia defects in the Taiwanese mouse model of SMA. Lots of work still to be done to understand how low levels of SMN lead to the cellular defects we know; this project is part of it🙌